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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Natapraja : Kajian Ilmu Administrasi Negara Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Lentera Hukum Jurnal Mahasiswa Fakultas Hukum Indonesian Journal of Urology Majalah Kedokteran Sriwijaya KOMUNIKA Padjadjaran Journal of Dentistry Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo STATOR: Jurnal Ilmiah Mahasiswa Teknik Mesin Indonesian Journal of Obstetrics & Gynecology Science EMBRIO : Jurnal Kebidanan SRIWIJAYA JOURNAL OF MEDICINE Oto Rhino Laryngologica Indonesiana Jurnal Plastik Rekonstruksi Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Jurnal Manajemen Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang geoedusains: Jurnal Pendidikan Geografi Jurnal Pengabdian Masyarakat: Humanity and Medicine JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal RSMH Palembang Pakuan Justice Journal of Law (PAJOUL) Indonesian Journal of Cancer Jurnal Sehat Indonesia (JUSINDO) SCLS Jurnal Pelita Sriwijaya Jurnal Teknik Sipil Asian Journal of Social and Humanities Lumbung Ngabdi: Jurnal Pengabdian Masyarakat
Krisna Murti
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Religion Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Veterinary Other

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Studi Meta-Analisis: Hubungan antara Defisiensi Vitamin D dan Penyakit Parkinson Putri, Siti Sarahdeaz Fazzaura; Irfannuddin, Irfannuddin; Murti, Krisna; Kesuma, Yudianita; Koibuchi, Noriyuki
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 9, No 1 (2023): JMK Yayasan RS.Dr.Soetomo, April 2023
Publisher : STIKES Yayasan RS.Dr.Soetomo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29241/jmk.v9i1.1430

Abstract

Beberapa penelitian telah dilakukan untuk mengevaluasi kadar 25(OH)D pada pasien penyakit Parkinson. Namun, hasil penelitian ini tidak konsisten. Penelitian ini melakukan meta-analisis terhadap kadar 25(OH)D pada pasien dengan penyakit Parkinson. Database PubMed digunakan untuk melakukan pencarian literatur secara sistematis. Meta-analisis dilakukan dengan menggunakan model efek acak untuk menghitung perkiraan efek gabungan. Tujuh belas artikel dimasukkan dalam penelitian ini. Meta-analisis mengungkapkan bahwa pasien dengan penyakit Parkinson memiliki kadar 25(OH)D yang lebih rendah dibandingkan dengan kontrol. Temuan dari artikel prospektif dan retrospektif sebagian besar konsisten. Besarnya respon nocebo dalam uji coba terkontrol acak yang dirancang paralel pada penyakit Parkinson sangat penting dan harus dipertimbangkan dalam interpretasi hasil keamanan dan dalam desain dan interpretasi uji klinis masa depan. 
Myeloid Sarcoma in the Sinonasal Cavity with Orbital Involvement: A Case Report Fitriani, Dianli; Murti, Krisna; Eriza, Eriza
Indonesian Journal of Cancer Vol 18, No 4 (2024): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i4.1185

Abstract

Introduction: Myeloid sarcoma (MS) is a tumor mass that arises outside of the bone marrow area and is composed of either mature or not myeloid blasts of white blood cells. Acute myeloid leukemia (AML), chronic myeloid leukemia (CML) with an imminent blast crisis, and other underlying undiagnosed myeloproliferative disorders are frequently linked to MS, an uncommon disease. Without a history of leukemia, MS is difficult to diagnose and might be misdiagnosed for lymphoma or undifferentiated carcinoma. For patients, correct tissue diagnosis based on immunohistochemistry and histomorphology is important.Case Presentation: Here, we present a 27-year-old woman who had a surgical procedure in The Department of Otorhinolaryngology-Head and Neck Surgery with the chief complaint of right nasal congestion and growing right eye protrusion. A solid mass in the right sinonasal region with infiltration into the retrobulbar area was confirmed by a head computed tomography (CT) scan. Cells with small to medium-sized cells, finely distributed chromatin, tiny nucleoli, and sparse cytoplasm were examined under a microscope. These cells were grouped in diffuse, linear, or Indian file patterns. Microscopic examination revealed morphology of myeloid tumor. Immunohistochemistry analysis emphasized the diagnosis of myeloid sarcoma. The patient then had chemotherapy, comprising of six cycles of docetaxel and carboplatin. After completing chemotherapy, a reduction in the size of the tumor mass was observed.Conclusions: MS was diagnosed based on histological, radiographic, and immunohistochemical studies. Additional immunohistochemistry analysis testing is necessary to rule out a number of differential diagnoses when diagnosing MS in patients without a history of leukemia or hematological malignancy. The positive expression of myeloid markers such as CD68, CD15, CD33, and CD34 supports a diagnosis of MS.
PERENCANAAN DAN PEMBUATAN MESIN PEMOTONG RUMPUT SEBAGAI BAHAN DASAR PAKAN TERNAK Widayanto, Erno; ,Aswatama, Ketut; Murti, Krisna; Mulyadi, Santoso
STATOR: Jurnal Ilmiah Teknik Mesin Vol 7 No 1 (2024): JURNAL STATOR
Publisher : Jurusan Teknik Mesin

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Abstract

Rumput merupakan salah satu permasalahan yang serius di Indonesia Saat ini sebagian besar rumput dihasilkan akibat aktivitas manusia. Adanya perubahan pola hidup dalam mengkonsumsi makanan serta kurangnya kesadaran masyarakat terhadap kebersihan lingkungan menyebabkan peningkatan jumlah dan jenis rumput. Masalah yang akan dibahas adalah bagaimana merancang mesin pencacah rumput organik yang menghancurkan dengan hasil butiran atau serpihan dengan luas 2 mm sampai 5 mm agar dalam proses fermentasi dapat berjalan dengan baik untuk hasil kompos lebih baik. Tujuan dari proyek akhir ini ialah merancang bagian dinamis mesin pencacah rumput organik sebagai bahan dasar kompos. Metode pelaksann yang dilakukan berupa pencarian data untuk pengrakitan alat yang kemudian dirakit dan dicoba terlebih dahulu. Kemudian terdapat penyempurnaan alat agar fungsinya lebih efektif lagi. Berdasarkan hasil perancangan dan pengujian mesin pencacah rumput, maka dapat disimpulkan: Daya yang diperlukan untuk mencacah rumput adalah 162 W, diameter pulley penggerak 70 mm dan diameter pulley yang digerakan adalah 100 mm., bahan poros yang digunakan adalah S30C dengan kekuatan tarik (σB) = 48 kg/mm2. Diameter poros yang digunakan 25 mm dan panjang poros 380 mm, Bantalan yang digunakan untuk menumpu poros adalah bantalan radial bola sudut dalam dengan nomor bantalan UCP205, Berdasarkan hasil pengujian, prosentase rumput yang keluar 90,69% sisanya 9,31% atau sebesar 0,6 kg tidak keluar, hal ini terjadi dalam setiap sekali proses dan Kapasitas mesin pencacah rumput sebesar 103 kg/jam. Dari hasil data tersebut mesin pencacah berfungsi dengan baik dan dapat menampung smapah dengan efektif.
THE ROLE OF BRAF V600E IN THE DEVELOPMENT OF THYROID CANCER PHENOTYPE: A SYSTEMATIC REVIEW Mega, Pratia; Aspitriani; Edi Poedjo Purnamawati, Ika Kartika; Krisna Murti
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.502

Abstract

BRAF V600E mutation in thyroid cancer is of major concern because it is associated with increased tumor aggressiveness through the MAPK pathway activation that affects phenotypic characteristics such as morphology and tissue invasion patterns. The results of studies on the effects of this mutation often vary and are influenced by differences in study design and detection methods. This systematic review aims to clarify the relationship between BRAF V600E and phenotypic characteristics of PTC, as well as identify its clinical implications. This study method was a systematic literature review using the PRISMA method, and there were 8418 journals. After exclusion, 16 articles were found that met the research objectives. Based on the results, it was found that there was a relationship between BRAF V600E and thyroid cancer phenotypes such as female gender, older age at diagnosis, larger tumor size, histological subtypes, especially tall cell, higher nuclear score, capsule, extrathyroid, vascular, nerve invasion, lymph node metastasis, higher clinical stage, recurrence, and lower survival. However, there are other inconsistent studies regarding the association of BRAF V600E with these phenotype characteristics. BRAF V600E mutation significantly affects the phenotypic characteristics of thyroid cancer and is associated with several aggressive characteristics.
Correlation of Microvessel Density with Clinicothological Features of Hodgkin Lymphoma Bima Zulfikar, M.; Murti, Krisna; Andriyani Liberty, Iche; Dewi, Citra; Sari Puspita Rasyid, Riana
Majalah Patologi Indonesia Vol. 32 No. 1, Januari 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.564

Abstract

BackgroundAngiogenesis is the process of new blood vessel growth that has an important role in tumor development. Microvessel density (MVD) assessment is one of the methods to assess angiogenesis. A high MVD is associated with a poor prognosis in various types of cancer including Hodgkin lymphoma (HL). Although, HL incidence is lower in developing countries, the death rate is higher in these regions. Moreover, this type of lymphoma is higher among young and reproductive people. The aim of this study was to determine the association between microvessel density and HL clinicopathological characteristics.MethodsThis was an observational analytic study with a cross-sectional method, conducted at the Anatomical Pathology Department/Dr. Mohammad Hoesin Palembang. The samples were paraffin blocks diagnosed as HL for period 2016-2021 and had complete clinicopathological data according to the criteria of this study. The slides were immunostained with antibody anti-CD34. One microvessel was determined by observing the endothelial morphology and CD34 expression in endothelial cytoplasm and/or cell membrane, then was evaluated and calculated by Image J. Data was statistically analyzed by STATA version 15.ResultsMajority HLs in this study were discovered in the age group of <45 years (71.00%), male (61.30%), nodal location (80.60%) and lymphocyte rich classical HL (LRCHL) subtype (51.60%). Although there was no significant association between MVD and the clinicopathological characteristics of HL, high MVD tend to occur in the age <45 years, male, nodal location, and LRCHL subtype.ConclusionThere was no significant association between microvessel density and HL clinicopathological characteristics.
Predicting Free Flap Viability: Integrating Lactate and Glucose Measurements with Artificial Intelligence Muzakkie, Mufida; Murti, Krisna; Nurmaini, Siti; Soedjana, Hardi Siswo
Jurnal Plastik Rekonstruksi Vol. 12 No. 1 (2025): (2025): Jurnal Plastik Rekonstruksi
Publisher : The Lingkar Studi Bedah Plastik Foundation and is affiliated with the Department of Plastic Surgery, Faculty of Medicine, Universitas Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v12i1.388

Abstract

Introduction: In reconstructive surgery, free flaps are a superior method for resurfacing defects. While free flap viability is typically monitored by subjective clinical examination, lactate and glucose levels in free flaps, which can affect tissue metabolism during ischaemia and reperfusion, can help predict viability. This study aims to review previous research and provide a theoretical basis for using artificial intelligence in lactate and glucose measurement as a means of assessing flap viability.Method: The primary databases used to retrieve the key medical literature presented in this study were book references and Google Scholar, PubMed and Science Direct, using search terms related to the topic. Only articles written in English and published less than ten years ago were included.Results: Lactate levels detect perfusion impairment earlier than clinical signs or other biochemical markers while glucose monitoring can indicate underlying metabolic dysregulation or physiological stress, helps early detection of complications. Combining lactate and glucose measurements enhances diagnostic accuracy and allows for timely interventions for flap viability. Studies confirm this dual monitoring is a practical, unbiased, and has the potential to be developed into an artificial intelligence tool to improve patient outcomes.Conclusion: Lactate and glucose measurements in free flap monitoring have distinct benefits. Lactate detects ischaemia and reflects tissue metabolism, while glucose monitors energy metabolism and systemic health. Combining these leading to improved flap survival rates. With accessible tools, this approach improves patient care and outcomes in reconstructive surgery.
Association of Vitamin D Deficiency and Diabetic Foot Ulcer Patients in Dr Mohammad Hoesin General Hospital Palembang Dahlan, Kemas; Yususf, Fahmi Jaka; Irfannuddin, Irfannuddin; Murti, Krisna; Muradi, Akhmadu; Liberty, Iche Andriyani
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 1 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i01.149

Abstract

Vitamin D plays a role in the healing process of diabetic foot ulcers (DFU); it can improve the immune system, regulate inflammation function, and regulate growth factors in diabetes mellitus (DM). The immunomodulatory effects of vitamin D include reduced production of IL-2, IL-6, and TNF-alpha and increased production of IL-10. It also increases the activity of antimicrobial peptides (AMP) such as cathelicidin, and it promotes the differentiation of monocytes into macrophages, phagocytosis, and the production of lysosomal enzymes. Furthermore, vitamin D stimulates growth factors including vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-β). In this study, the incidence of DM and DFU in DM patients at RSUP Dr. Mohammad Hoesin Palembang will be compared to serum vitamin D levels. This research uses quantitative methods with an analytical observational design. The Mean vitamin D serum level was 11,727 ng/mL, and there was a significant association between serum vitamin D deficiency and DFU (p-value; 0.036 < 0.05). There was a significant association between serum vitamin D deficiency and DFU occurrence (p-value; 0.036 < 0.05) in Mohammad Hoesin General Hospital Palembang. Based on the results of this study, we proposed that patients with diabetic foot ulcers should have their serum vitamin D levels checked, and that vitamin D should be given to them as part of their therapy.
Digital Fatigue, Burnout, and Career Setbacks in Banking Hadjri, Muhammad Ichsan; Leovani, Ega; Murti, Krisna; Adam, Ryan; Anggraini, Bean Nur
Jurnal Manajemen Vol. 29 No. 2 (2025): June 2025
Publisher : Fakultas Ekonomi dan Bisnis, Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jm.v29i2.2553

Abstract

This study examines the effects of digital fatigue, work-family conflict (WFC), and perceived role overload on career regression among banking employees, with burnout as a mediating factor. Using a cross-sectional design, data were collected from 384 banking employees in Palembang through structured questionnaires. The findings reveal that digital fatigue, WFC, and role overload significantly contribute to burnout, which mediates their impact on career regression. Grounded in the Job Demands-Resources (JD-R) Theory, the results demonstrate that excessive job demands heighten the risk of burnout when unbalanced by sufficient resources, ultimately hindering career development. The study underscores the importance of organisational efforts to minimise digital demands, promote work-life balance, and manage workloads to mitigate burnout. Limitations include reliance on self-reported data and a focus on the banking sector. Future research should explore broader populations and examine additional factors such as social support and coping strategies.
JURIDICAL REVIEW OF LAW NO. 21 OF 2007 ON THE PROTECTION AND ERADICATION OF HUMAN TRAFFICKING AS A TRANSNATIONAL HUMAN RIGHTS VIOLATION IN INDONESIA Ramadhani, Solibah; Novianti, Vera; Murti, Krisna
Sriwijaya Crimen and Legal Studies Volume 3 Issue 1 June 2025
Publisher : Faculty of Law Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28946/scls.v3i1.4785

Abstract

Human Trafficking (TPPO) is a structured and systematic form of crime that violates human rights as the inherent rights of human beings as creations of God Almighty. This crime not only occurs in Indonesia but has also become a transnational crime, in which the rampant practice of human trafficking is often not accompanied by optimal protection for victims and effective countermeasures against perpetrators. Based on this, this paper aims to examine how national law regulates the crime of human trafficking, as well as how the Indonesian national legal system provides protection and countermeasures, by considering the factors that cause the crime of human trafficking. The research method employed in this paper is a juridical-normative approach, which examines and analyzes the implementation of legal provisions in legislation concerning human trafficking crimes, utilizing secondary data derived from library research. Therefore, this paper will discuss Law No. 21 of 2007 on the Eradication of the Crime of Trafficking in Persons, which not only regulates criminal sanctions for perpetrators and the protection of victims' rights but also examines how countermeasures are taken against the crime of human trafficking. Consequently, the results of this study demonstrate that Law No. 21 of 2007 has comprehensively regulated the scope of TPPO, encompassing both criminal aspects for perpetrators and protection for victims including restitution, rehabilitation, and confidentiality of identity. Thus, this regulation becomes a concrete instrument for strengthening cooperation with various stakeholders and serves as a key factor in the success of preventing, protecting, and eradicating trafficking in persons as a transnational crime, particularly in Indonesia.
Vitamin D and its Role in Cell Cycle Dynamics: A Review of the Molecular and Clinical Studies Sastradinata, Irawan; Murti, Krisna; Saleh, Irsan; Nurseta, Tatit
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2096

Abstract

Vitamin D is an essential nutrient that not only plays a role in calcium homeostasis and bone health, but also has broad functions in the regulation of various biological processes, including cell cycle dynamics. This study aims to examine in depth the role of vitamin D in cell cycle dynamics based on evidence from molecular and clinical studies. The method used was qualitative research with a literature study approach, where data was collected from relevant articles such as PubMed, EuropePMC, and Google Scholar. Analysis was carried out through the process of filtering, presenting data, and drawing conclusions. The results showed that vitamin D in its active form, 1,25-dihydroxyvitamin D3, interacts with the vitamin D receptor (VDR) in cells and modulates the expression of genes involved in cell proliferation. This mechanism involves an increase in the expression of cell cycle inhibitory genes, such as p21 and p27, and a decrease in the expression of cell cycle promoting genes, such as cyclin D1, which contributes to the arrest effect on the cell cycle. Thus, in addition to being important for bone health, vitamin D has a significant role in cell cycle regulation, and its deficiency can increase the risk of various diseases, including cancer. Therefore, maintaining optimal vitamin D levels through sun exposure, consumption of foods rich in vitamin D, or supplementation is essential. Further research is needed to understand the role of vitamin D in genetic regulation, particularly in relation to cancer.
Co-Authors ,Aswatama, Ketut Adam, Ryan Adi Saputra Aldes Lesbani Alexandra Octnick Andarinini, Rindang Senja Andrew Sakko Andrina, Hana Andriyani Liberty, Iche Andy Alfatih Anggraini, Bean Nur Aspitriani Asprianto, Muhammad Astrilya, Nuur Hayati Ayeshah A Rosdah Bima Zulfikar, M. Carmela Ricciardelli Chodijah, Nyimas Citra Dewi Citra Dewi Dahlan, Kemas Devi Dwiyanti Devi Eqtriana Setyaningsih Devi, SNA Ratna Sari Dwiryanti, Rizky Edi Poedjo Purnamawati, Ika Kartika Eka Putra Pratama Ella Amalia, Ella Ellyzar Ellyzar Elza Iskandar, Elza Erial Bahar Erial Bahar, Erial Eriza, Eriza Erno Widayanto Farah Diba, Masayu Farodiyah, Nanda Narul Farodiyah, Nanda Nurul Fauziah Kurniawaty, Nyiayu Haloho, Agustina Br. Harahap, Huntari Heni Maulani, Heni Henny Sulastri Iche Andriyani Liberty, Iche Andriyani Ika Kartika Ika Kartika Indri Seta Septadina Irfannuddin Irfannuddin Irfanuddin Irfanuddin Irsan Saleh Izzudin, Muhammad Jurgen Stahl Kartika Edi Poedjo Purnamawati, Ika Kesty, Cindy Khoiri Yahya Afifah Koibuchi, Noriyuki Kumar, Arun Kurniawaty, Nyiayu Fauziah Leovani, Ega Lisa M. Butler Mahdavikia, Reza Maria Ulfa, Maria Ulfa, Maria Ulfa,, Maria Ulfa, Marta Hendry Maryano, Maryano Maydila Putri Millenia Mega Fatimah Rosana Mega, Pratia Meilinda, Nurly Mgs. Irsan Saleh, Mgs. Irsan Miftha Pratiwi Muhammad Asprianto Muhammad Ichsan Hadjri Muhammad Irsan Saleh Muhammad Yusuf Abror Muradi, Akhmadu Musdalifah, Farisha Sestri Muzakkie, Mufida Nadya Virana Putri Neti Neti, Neti Nita Parisa Nora Ramkita Nugraha, Xavier Nuur Hayati Astrilya Nyiayu Fauziah Kurniawati Pangestu, Panji Peby Maulina Lestari, Peby Maulina Pratama, Eka Putra Puspa Zuleika, Puspa Putra, Mohammad Tomita Maha Putri Erlyn Putri Mirani Putri Saraswati Ramadhani, Solibah Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Rifai Agung Prihananto Rikka Wijaya S. Nurul Amanah Ratna Sari Saleh, Muhammad Irsan Sandria Sandria Santoso Mulyadi Saputra Naibaho, Oldyo Sari Puspita Rasyid, Riana Sastradinata, Irawan Sherlin Tazkiya Nur Salsabila Shofia Shinta Adityaningrum Siti Nurmaini Siti Rusdiana Puspa Dewi Siti Sarahdeaz Fazzaura Putri Soedjana, Hardi Siswo Sofyan Effendi Sri Santoso Sabrini Stevanny, Bella Subandrate Suly Auline Rusminan Syifa Ayu Laluna Tatit Nurseta Theodorus Theodorus Tina B. Mitto Vera Novianti Wayne D. Tilley Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yenny Febrianty Yudianita Kesuma, Yudianita Yusa, Muchammad Yustian Yusuf Hasibuan, Fauzie Yususf, Fahmi Jaka Zen Hafy