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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Natapraja : Kajian Ilmu Administrasi Negara Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Lentera Hukum Jurnal Mahasiswa Fakultas Hukum Majalah Kedokteran Sriwijaya KOMUNIKA Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo STATOR: Jurnal Ilmiah Mahasiswa Teknik Mesin Indonesian Journal of Obstetrics & Gynecology Science EMBRIO : Jurnal Kebidanan SRIWIJAYA JOURNAL OF MEDICINE Oto Rhino Laryngologica Indonesiana Jurnal Plastik Rekonstruksi Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Manajemen Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Indonesian Journal of Global Health research geoedusains: Jurnal Pendidikan Geografi Jurnal Pengabdian Masyarakat: Humanity and Medicine JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research As-Sidanah : Jurnal Pengabdian Masyarakat Jurnal RSMH Palembang Pakuan Justice Journal of Law (PAJOUL) Indonesian Journal of Cancer Jurnal Sehat Indonesia (JUSINDO) Eduvest - Journal of Universal Studies SCLS Jurnal Teknik Sipil Asian Journal of Social and Humanities Lumbung Ngabdi: Jurnal Pengabdian Masyarakat
Krisna Murti
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Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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The Role of Proinflammatory Cytokine GM-CSF as A Therapy for Diabetic Ulcers: A Systematic Review Pariyana, Pariyana; Murti, Krisna; Liberty, Iche Andriyani; Kamaluddin, Muhammad Totong
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.5677

Abstract

Diabetic ulcers represent a prevalent complication among patients with poorly controlled diabetes mellitus, often resulting from inadequate blood glucose regulation, neuropathy, peripheral artery disease, and suboptimal wound care. This systematic review aims to evaluate the therapeutic efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) for diabetic ulcers. The review utilized databases such as PubMed, ProQuest, and Google Scholar, with only six articles meeting the eligibility criteria for analysis. The findings suggest that GM-CSF exhibits therapeutic potential by enhancing neovascularization, promoting keratinocyte proliferation, facilitating granulation tissue formation, and reducing wound diameter. These results highlight the potential of GM-CSF as a therapeutic agent for diabetic ulcers. Nevertheless, the current body of research is limited, necessitating further studies with larger populations and diverse GM-CSF administration methods to substantiate these findings.
MicroRNA-21 Expression in Prostate Cancer: A Systematic Review Ulfa, Maria; Murti, Krisna; Saleh, Irsan; Handayati, Debby
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6042

Abstract

Prostate cancer is the second most prevalent and fourth largest cause of death for men globally. Meanwhile, in Indonesia, prostate cancer ranks and is the fourth leading cause of death. Molecular studies continue to be conducted to understand the molecular heterogeneity, both genetic and epigenetic, that affects the progression of prostate cancer, one of which is the role of microRNA. This study aims to analyze the expression profile of microRNA-21 associated with the development and aggressiveness of prostate cancer. Comprehensive search into three databases; PubMed, Cochrane Library, and Science Direct was performed by authors. The study that best met the inclusion criteria was chosen from among duplicates. The QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies) tool was used to assess the risk of bias before the relevant data were retrieved for analysis. There were eleven studies that included a variety of sample sources, sample size and methods. Although a number of the studies had unclear standard reporting, the research overall quality was acceptable. For the results, Prostate cancer samples showed a significantly higher expression level of miR-21 than controls in ten of the studies, and was linked to cancer aggressiveness. In one study, the expression of miR-21 did not significantly increase, despite the use of extracellular vesicle isolation samples.
Ideal Formulation of Extraordinary Legal Remedies Review By The Public Prosecutor From The Perspective of Justice and Legal Certainty Murti, Krisna; Yusuf Hasibuan, Fauzie; Maryano, Maryano
Asian Journal of Social and Humanities Vol. 3 No. 2 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v3i2.426

Abstract

One of the crucial issues of legal problems that is still a pro and con in society is the extraordinary legal effort of judicial review by the public prosecutor. The research research is to analyze the implementation of the submission of extraordinary legal efforts of judicial review by the public prosecutor against criminal cases based on statutory regulations and to analyze and find the formulation of the ideal criminal case review system by the public prosecutor to realize justice and legal certainty in Indonesia. This research uses a type of normative juridical legal research. Research that uses a philosophical approach, a statutory approach, a case approach and a comparative approach. The sources of legal materials collected are analyzed descriptively to answer the research problems. The results of this study conclude that the Implementation of the submission of extraordinary legal efforts of judicial review by the Public Prosecutor against criminal cases based on statutory regulations has not achieved justice and legal certainty. In practice, the addition of the prosecutor's authority to file a judicial review as stipulated in Article 30C letter h and the Explanation of Article 30C letter h of Law Number 11 of 2021 concerning Amendments to Law Number 16 of 2004 concerning the Prosecutor's Office of the Republic of Indonesia cannot be implemented because it is considered contrary to the 1945 Constitution.
The Potential of Shell Extract as a Hemostasis and Wound Healing Agent: A Literature Review Erlyn, Putri; Irfannuddin, Irfannuddin; Murti, Krisna; Lesbani, Aldes
Jurnal Kedokteran Brawijaya Vol. 33 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2023.033.01.6

Abstract

Hemostasis is an emergency medical treatment to reduce pain and patient mortality, therefore research is being developed to find effective hemostasis. The utilization of natural materials for hemostasis and wound healing is rapidly expanding, including chitosan found in shell extracts. Chitosan is obtained from chitin found in the soft shells of marine animals such as squid, shrimp, and crabs, or from hard shells such as clams, crabs, and lobsters. Chitosan offers advantages such as good biodegradability, biocompatibility, and non-toxicity, and has been widely used in biomedical, chemical, food, and cosmetic industries. This literature review aims to investigate the potential of shell extracts, particularly the characteristics of chitosan, in wound healing across hemostasis, inflammation, proliferation, and remodeling stages. The study results indicate that extracts from shells containing chitosan exhibit varying characteristics in terms of molecular weight and degree of deacetylation. Chitosan with higher molecular weight and degree of deacetylation tends to yield better outcomes in hemostasis and wound healing. The material is effective in reducing antithrombin, enhancing blood clotting processes, and aiding clot formation. Increased molecular weight contributes to stimulating various cytokines, such as TNF-α, TGF-ß1, and FGF2, which play a key role in the wound healing process. Additionally, higher degree of deacetylation chitosan is effective in stimulating fibroblast proliferation. Chitosan also influences VEGF in inducing angiogenesis and enhancing neovascularization in bone healing. Chitosan from shell extracts with certain molecular weight characteristics and degree of deacetylation has the potential to be the material of choice for accelerating hemostasis and wound healing.
Literature Review: Role of Vitamin D in Diabetic Foot Ulcer Wound Healing Dahlan, Kemas; Irfanuddin; Murti, Krisna; Muradi, Akhmadu
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5135

Abstract

DFU is a common consequence of DM. Vitamin D has multiple positive effects on DFU. Search data from; Google Scholar, Science Direct, Elsevier, EBSCO, Medline and PubMed. Publication at least ten years (2013 until 2022). Inclusion criteria; full paper in English, Study about vitamin D and DFU in human, exclusion criteria; animal model and invitro study. Results; 27 journals; Seven Randomized Controlled Trial. Vitamin D phase on DFU which one substantially smaller. Severe vitamin D insufficiency known with significance linked for an elevated risk of DFU. Vitamin D supplementation can prevent or improve diabetic foot complications
Immunological Implications of Gold Weight Implantation for Lagophthalmos: A Systematic Review Iskandar, Elza; Krisna Murti; Irsan Saleh; Ramzi Amin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1138

Abstract

Background: Gold weight implantation is a well-established surgical intervention for lagophthalmos, a condition characterized by incomplete eyelid closure. While generally safe and effective, gold implants can elicit immune responses, potentially leading to complications. This systematic review aims to comprehensively evaluate the immunological implications of gold weight implantation in lagophthalmos treatment. Methods: A systematic search of PubMed and ScienceDirect databases was conducted, encompassing studies published from 2000 to June 2024. Keywords included "gold weight implant" and "gold implant AND eyelid." Studies reporting quantitative data on immune responses to gold implants were included. Data extracted included study design, patient demographics, implant characteristics, follow-up duration, complications, and long-term outcomes. Results: Thirteen studies met the inclusion criteria, encompassing a total of 340 patients (370 eyelids). Reported complications included hypersensitivity reactions (11.9%), lymphoma (0.6%), infection (1.2%), extrusion (8.1%), and nonspecific inflammatory reactions (4.3%). Hypersensitivity reactions were mediated by T-cell and B-cell responses, leading to chronic inflammation. Lymphoma cases highlighted the potential for chronic inflammation to trigger lymphoproliferative disorders. Infections were infrequent but could necessitate implant removal. Extrusion rates varied, influenced by implant size and placement. Nonspecific inflammatory reactions were observed, often requiring implant removal or steroid treatment. Conclusion: Gold weight implantation can trigger diverse immune responses, ranging from mild inflammation to severe hypersensitivity and lymphoma. Careful patient selection, meticulous surgical technique, and vigilant postoperative monitoring are crucial to minimize complications. Further research is warranted to elucidate the precise mechanisms underlying these immune responses and develop strategies for their prevention and management.
The Association of Plasma Cell Density of the Microenvironment with Classical Hodgkin Lymphoma Stage Neti, Neti; Murti, Krisna; Kartika, Ika
Majalah Patologi Indonesia Vol. 32 No. 3 (2023): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i3.652

Abstract

Background Plasma cells are important prognostic factors in various malignancies including Classical Hodgkin lymphoma (CHL). In the CHL microenvironment, plasma cells are the main prognostic factors, but research of relationship between plasma cell density in the microenvironment and CHL stage is still very limited. This study aims to determine the relationship between plasma cell density in the microenvironment and the CHL stage. Methods A case series procedure was conducted. The samples were paraffin blocks of CHL patients at Anatomic Pathology Department of Faculty of Medicine Universitas Sriwijaya/Mohammad Hoesin General Hospital. Among 47 cases of CHL diagnosed from 1st Januari 2018 to 30th November 2022, only 30 cases were included. Immunohistochemistry was performed by using specific antibody of plasma cells (anti-CD138 antibody). The number of plasma cells in each sample was calculated based on the expression of CD138 in the cell membrane and cytoplasm with weak-strong intensity. Then the cut-off point value was determined based on the ROC curve to classify the high and low plasma cell densities. The density of plasma cells was correlated to clinicopathological characteristics including age, sex, tumor location, CHL subtypes and stage. Statistical analysis was performed using Spearman test of SPSS with significant consideration if p<0.05. Results A high proportion (>10,9) of tumour-associated plasma cells of the tumor microenvironment was found in CHL advanced stage. Spearman test resulted in a significant correlation between density of plasma cell with advanced stage classical Hodgkin lymphoma (p=0.000). Conclusions There is significant relationship between high density of plasma cells with CHL stage.
DARTOS FASCIA AS AN INTERPOSITIONAL LAYER IN HYPOSPADIAS URETHROPLASTY: A SYSTEMATIC REVIEW Hendry, Marta; Murti, Krisna; Daryanto, Besut; Liberty, Iche Andriyani
Eduvest - Journal of Universal Studies Vol. 5 No. 12 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i12.52502

Abstract

This systematic review evaluated the role of dartos fascia as an interpositional layer in primary hypospadias repair. Search was conducted in PubMed, EMBASE, Scopus, CENTRAL, and Web of Science (2019–2025) for studies in patients ≤18 years undergoing hypospadias repair. Primary outcomes were urethrocutaneous fistula (UCF), dehiscence, meatal/urethral stenosis, and reoperation; secondary outcomes were infection and cosmetic scores. Narrative synthesis was used. Results: Eleven studies met criteria, predominantly distal TIP. No randomized trial compared any second layer versus none; one cohort (n=425) showed similar UCF with periurethral/dartos coverage versus none (6.7% vs 7.3%). A randomized trial favored double- over single-layer dartos (3.3% vs 23.3%). Another trial found ventral preferable to dorsal dartos with fewer flap-related complications at similar UCF rates. Tunica vaginalis flap reduced UCF and improved cosmetics but is more invasive. Platelet-rich fibrin adjunct lowered UCF and infection in two studies. Spongioplasty produced comparable UCF but higher meatal stenosis, though selected robust spongiosum allowed zero fistulas. Conclusion: Dartos remains the workhorse; double-layer and ventral harvest optimize outcomes, while tunica vaginalis and PRF offer effective alternatives in selected cases. Further randomized trials are needed to clarify the necessity of a second layer.
Co-Authors ,Aswatama, Ketut Adam, Ryan Adi Saputra Afladhanti, Putri Mahirah Aldes Lesbani Alexandra Octnick Andarinini, Rindang Senja Andrew Sakko Andrina, Hana Andriyani Liberty, Iche Andy Alfatih Anggraini, Bean Nur Aspitriani Astrilya, Nuur Hayati Bima Zulfikar, M. Carmela Ricciardelli Chodijah, Nyimas Citra Dewi Citra Dewi Dahlan, Kemas Desi Puspitasari Devi Dwiyanti Devi Eqtriana Setyaningsih Devi, SNA Ratna Sari Dian Fitriani Dwiryanti, Rizky Edi Poedjo Purnamawati, Ika Kartika Eka Putra Pratama Ella Amalia, Ella Ellyzar Ellyzar Elza Iskandar, Elza Erial Bahar Eriza, Eriza Erno Widayanto, Erno Farah Diba, Masayu Farodiyah, Nanda Narul Fauziah Kurniawaty, Nyiayu Haloho, Agustina Br. Handayati, Debby Heni Maulani, Heni Henny Sulastri Huntari Harahap Iche Andriyani Liberty, Iche Andriyani Ika Kartika Ika Kartika Indri Seta Septadina Irfannuddin Irfannuddin Irfanuddin Irfanuddin Irfanuddin Irsan Saleh Izzudin, Muhammad Jurgen Stahl Kamaluddin, Muhammad Totong Kartika Edi Poedjo Purnamawati, Ika Kesty, Cindy Khoiri Yahya Afifah Koibuchi, Noriyuki Kurniawaty, Nyiayu Fauziah Leovani, Ega Lisa M. Butler Mahdavikia, Reza Maria Ulfa Maria Ulfa, Maria Ulfa, Mariana Mariana Marta Hendry, Marta Maryano, Maryano Marylin, Dwi Tantri Maydila Putri Millenia Mega, Pratia Meilinda, Nurly Mgs. Irsan Saleh, Mgs. Irsan Miftha Pratiwi Muhammad Asprianto Muhammad Irsan Saleh Muhammad Yusuf Abror Muradi, Akhmadu Musdalifah, Farisha Sestri Muzakkie, Mufida Nadya Virana Putri Neti Neti, Neti Nora Ramkita Nugraha, Xavier Nuur Hayati Astrilya Nyiayu Fauziah Kurniawati Pangestu, Panji pariyana, Pariyana Peby Maulina Lestari, Peby Maulina Puspa Zuleika, Puspa Putra, Mohammad Tomita Maha Putri Erlyn Putri Mirani Putri Saraswati Putri, Sarahdeaz Siti Fazzaura Ramadhani, Solibah Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Rifai Agung Prihananto Rikka Wijaya S. Nurul Amanah Ratna Sari Sandria Santoso Mulyadi Saputra Naibaho, Oldyo Sari Puspita Rasyid, Riana Sastradinata, Irawan Sherlin Tazkiya Nur Salsabila Shofia Shinta Adityaningrum Siti Nurmaini Soedjana, Hardi Siswo Sofyan Effendi Sri Santoso Sabrini Stevanny, Bella Suly Auline Rusminan Syifa Ayu Laluna Tatit Nurseta Theodorus Theodorus Tina B. Mitto Vera Novianti Wayne D. Tilley Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yenny Febrianty Yudianita Kesuma, Yudianita Yusa, Muchammad Yustian Yusuf Hasibuan, Fauzie Yususf, Fahmi Jaka Zen Hafy