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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Natapraja : Kajian Ilmu Administrasi Negara Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Lentera Hukum Jurnal Mahasiswa Fakultas Hukum Indonesian Journal of Urology Majalah Kedokteran Sriwijaya KOMUNIKA Padjadjaran Journal of Dentistry Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo STATOR: Jurnal Ilmiah Mahasiswa Teknik Mesin Indonesian Journal of Obstetrics & Gynecology Science EMBRIO : Jurnal Kebidanan SRIWIJAYA JOURNAL OF MEDICINE Oto Rhino Laryngologica Indonesiana Jurnal Plastik Rekonstruksi Majalah Patologi Indonesia Jurnal Biomedika dan Kesehatan Jurnal Manajemen Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang geoedusains: Jurnal Pendidikan Geografi Jurnal Pengabdian Masyarakat: Humanity and Medicine JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal RSMH Palembang Pakuan Justice Journal of Law (PAJOUL) Indonesian Journal of Cancer Jurnal Sehat Indonesia (JUSINDO) SCLS Jurnal Pelita Sriwijaya Jurnal Teknik Sipil Asian Journal of Social and Humanities Lumbung Ngabdi: Jurnal Pengabdian Masyarakat
Krisna Murti
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Religion Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Veterinary Other

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Immunological Implications of Gold Weight Implantation for Lagophthalmos: A Systematic Review Iskandar, Elza; Krisna Murti; Irsan Saleh; Ramzi Amin
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1138

Abstract

Background: Gold weight implantation is a well-established surgical intervention for lagophthalmos, a condition characterized by incomplete eyelid closure. While generally safe and effective, gold implants can elicit immune responses, potentially leading to complications. This systematic review aims to comprehensively evaluate the immunological implications of gold weight implantation in lagophthalmos treatment. Methods: A systematic search of PubMed and ScienceDirect databases was conducted, encompassing studies published from 2000 to June 2024. Keywords included "gold weight implant" and "gold implant AND eyelid." Studies reporting quantitative data on immune responses to gold implants were included. Data extracted included study design, patient demographics, implant characteristics, follow-up duration, complications, and long-term outcomes. Results: Thirteen studies met the inclusion criteria, encompassing a total of 340 patients (370 eyelids). Reported complications included hypersensitivity reactions (11.9%), lymphoma (0.6%), infection (1.2%), extrusion (8.1%), and nonspecific inflammatory reactions (4.3%). Hypersensitivity reactions were mediated by T-cell and B-cell responses, leading to chronic inflammation. Lymphoma cases highlighted the potential for chronic inflammation to trigger lymphoproliferative disorders. Infections were infrequent but could necessitate implant removal. Extrusion rates varied, influenced by implant size and placement. Nonspecific inflammatory reactions were observed, often requiring implant removal or steroid treatment. Conclusion: Gold weight implantation can trigger diverse immune responses, ranging from mild inflammation to severe hypersensitivity and lymphoma. Careful patient selection, meticulous surgical technique, and vigilant postoperative monitoring are crucial to minimize complications. Further research is warranted to elucidate the precise mechanisms underlying these immune responses and develop strategies for their prevention and management.
The Association of Plasma Cell Density of the Microenvironment with Classical Hodgkin Lymphoma Stage Neti, Neti; Murti, Krisna; Kartika, Ika
Majalah Patologi Indonesia Vol. 32 No. 3, September 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i3.652

Abstract

Background Plasma cells are important prognostic factors in various malignancies including Classical Hodgkin lymphoma (CHL). In the CHL microenvironment, plasma cells are the main prognostic factors, but research of relationship between plasma cell density in the microenvironment and CHL stage is still very limited. This study aims to determine the relationship between plasma cell density in the microenvironment and the CHL stage. Methods A case series procedure was conducted. The samples were paraffin blocks of CHL patients at Anatomic Pathology Department of Faculty of Medicine Universitas Sriwijaya/Mohammad Hoesin General Hospital. Among 47 cases of CHL diagnosed from 1st Januari 2018 to 30th November 2022, only 30 cases were included. Immunohistochemistry was performed by using specific antibody of plasma cells (anti-CD138 antibody). The number of plasma cells in each sample was calculated based on the expression of CD138 in the cell membrane and cytoplasm with weak-strong intensity. Then the cut-off point value was determined based on the ROC curve to classify the high and low plasma cell densities. The density of plasma cells was correlated to clinicopathological characteristics including age, sex, tumor location, CHL subtypes and stage. Statistical analysis was performed using Spearman test of SPSS with significant consideration if p<0.05. Results A high proportion (>10,9) of tumour-associated plasma cells of the tumor microenvironment was found in CHL advanced stage. Spearman test resulted in a significant correlation between density of plasma cell with advanced stage classical Hodgkin lymphoma (p=0.000). Conclusions There is significant relationship between high density of plasma cells with CHL stage.
Perbandingan Ekspresi PD-L1 dan TILS pada Karsinoma Payudara Triple Negative dan HER2 Enriched Asprianto, Muhammad; Murti, Krisna; Dewi, Citra; Bahar, Erial
Majalah Patologi Indonesia Vol. 30 No. 3, September 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i3.480

Abstract

BackgroundTriple negative and positive HER 2 subtype breast carcinoma are aggressive subtype that have worst prognosis among othersubtype. High level of tumor infiltrating lymphocytes (TILs) is associated with longer disease free survival and overall survival.Breast cancer is also influenced by the presence of ligation between PD-1 and PD-L1, expressed by activated CD8+ T cells andtumor cells, consecutively. To analysed the comparison of PD-L1 expression levels in triple negative breast cancer and HER2enriched subtype.MethodsA cross sectional study was conducted with 35 samples, which were immunostained with an anti-PD-L1 antibody. TILs weremeasured on HE slides, and together with PD-L1 expression were calculated using image J. Clinicopathological data were obtainedfrom medical record. All data were analysed by SPSS V25.0ResultsA significant difference was observed between PD-L1 expression in HER2 enriched and triple negative samples, where the HER2enriched subtype had a possibility to express PD-L1 3.3 times higher than those of triple negative (p = 0.021; OR = 3.3). There wereno significant differences in clinopathological characteristics or TILs density in both subtypes. Likewise, no significant differenceswas found among PD-L1 expression, and intratumoral and stromal TILs expression.ConclusionMajority patient of both subtypes are mostly older than 40 years old, with positive LVI and higher histological grading. The HER2expression showed a higher level of PD-L1 than triple negative. There was no significant difference of TILs expression betweenthese two subtypes of breast cancer.
Mastitis Granulomatosa: Sebuah Tantangan Diagnosis Dewi, Citra; Amalia, Ella; Kurniawati, Nyiayu Fauziah; Maria Ulfa,, Maria Ulfa,; Pratama, Eka Putra; Murti, Krisna
Majalah Patologi Indonesia Vol. 31 No. 1, Januari 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i1.492

Abstract

BackgroundGranulomatous mastitis (GM) is often found in reproductive-age women. These patients are treated by the administration ofantituberculosis drugs. It is difficult to determine the exact cause of GM cytologically and histopathologically. Various etiologies i.e.,tuberculosis, sarcoidosis, foreign bodies and immunological diseases may provide granulomatous inflammation features in thetissue. High-sensitivity tests such as PCR can help to detect the presence of Mycobacterium tuberculosis (MT) as one of possibleetiologic agent. Accurate diagnosis will improve the treatment quality thus a better quality of life. The aim of this study was todetermine whether the granulomatous mastitis patients who referred to the Department of Anatomic Pathology Faculty of MedicineUniversitas Sriwijaya/Dr. Moh. Hoesin Palembang Hospital were caused by MT.MethodsA descriptive observational study was performed. Thirty paraffin blocks of GM patients during the period of 1st October 2018 to 29thSeptember 2020 were collected. DNAs were extracted from tissue scrapings of the slides. Then, PCR analysis was conducted usinga specific primer IS6110 with around 200 bp PCR product.ResultsThe mean age of the patients was 40.8 years (range: 23-67 years). There were six samples (20%) of GM produced the expectedamplicon. However, only three of six samples morphologically consistent with tuberculosis.ConclusionGranulomatous inflammatory reactions in the breast are not only caused by tuberculosis. Further study is needed to determine theexact cause of this lesion. Despite high costs, PCR examination may become an alternative approach in determining the etiology ofGM.
PENGINDRAAN HOAKS DI MEDIA SOSIAL BAGI PEMILIH PEMULA KOTA PALEMBANG Meilinda, Nurly; Farodiyah, Nanda Nurul; Murti, Krisna
Jurnal Lentera Nusantara Vol 4 No 2 (2025): Jurnal Pelita Sriwijaya: In Progress
Publisher : Asosiasi Peneliti Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51630/jps.v4i2.199

Abstract

Kegiatan pengabdian masyarakat ini bertujuan untuk memberikan pemahaman kepada pemilih pemula di Kota Palembang akan literasi media, khususnya terkait bahaya hoax dan bagaimana cara menghindarinya sehingga dapat berkontribusi dalam menciptakan situasi damai di dunia digital di masa pemilu. Metode yang digunakan dalam ini adalah dengan melakukan pelatihan kepada 100 orang mahasiswa di Kota Palembang yang didampingi oleh fasilitator dengan menggunakan bahan ajar, video, serta simulasi terkait cara melindungi diri dari paparan informasi hoaks. Kegiatan pengabdian masyarakat ini telah berhasil memberikan pengetahuan dan pemahan baru bagi peserta yang terdiri dari generasi Z, hal ini dibuktikan dari hasil pre-test dan post-test yang diberikan sebelum dan sesudah pelatihan. Pelatihan ini mendorong peserta untuk berpikir kritis atas segala informasi yang diterima, perlunya melakukan verifikasi terhadap informasi sebelum menyebarkannya, serta pentingnya mengetahui sarana untuk melakukan pengecekan fakta secara cepat dan mudah. Pelatihan yang dilakukan pada kegiatan pengabdian masyarakat ini merupakan inisiatif yang inovatif dalam mengatasi masalah penyebaran informasi palsu atau hoaks, khususnya di kalangan pemilih pemula mengingat fokusnya yang memanfaatkan platform online serta metode interaktif untuk menjangkau dan mengedukasi peserta. Pemilihan metode dan pendekatan pelatihan tersebut dapat menjamin relevansi dan efektivitas dari kegiatan ini.
DARTOS FASCIA AS AN INTERPOSITIONAL LAYER IN HYPOSPADIAS URETHROPLASTY: A SYSTEMATIC REVIEW Marta Hendry; Krisna Murti; Besut Daryanto; Iche Andriyani Liberty
Indonesian Journal of Urology Vol 33 No 2 (2026)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v33i2.1142

Abstract

Introduction: Hypospadias is a common congenital anomaly of the male genitalia (1 in 300 births), characterized by a ventrally displaced meatus, often with chordee and a dorsal hooded prepuce. Objective: This systematic review evaluated the role of dartos fascia as an interpositional layer in primary hypospadias repair. Material & methods: Search was conducted in PubMed, EMBASE, Scopus, CENTRAL, and Web of Science (2019–2025) for studies in patients ≤18 years undergoing hypospadias repair. Primary outcomes were urethrocutaneous fistula (UCF), dehiscence, meatal/urethral stenosis, and reoperation; secondary outcomes were infection and cosmetic scores. Narrative synthesis was used. Results: Eleven studies met criteria, predominantly distal TIP. No randomized trial compared any second layer versus none; one cohort (n=425) showed similar UCF with periurethral/dartos coverage versus none (6.7% vs 7.3%). A randomized trial favored double- over single-layer dartos (3.3% vs 23.3%). Another trial found ventral preferable to dorsal dartos with fewer flap-related complications at similar UCF rates. Tunica vaginalis flap reduced UCF and improved cosmetics but is more invasive. Platelet-rich fibrin adjunct lowered UCF and infection in two studies. Spongioplasty produced comparable UCF but higher meatal stenosis, though selected robust spongiosum allowed zero fistulas. Conclusion: Dartos remains the workhorse; double-layer and ventral harvest optimize outcomes, while tunica vaginalis and PRF offer effective alternatives in selected cases. Further randomized trials are needed to clarify the necessity of a second layer. Keywords: Hypospadias, urethroplasty, dartos fascia, urethrocutaneous fistula, tunica vaginalis flap.
Hubungan Kepadatan Tumor-Associated-Macrophages dan TumorAssociated-Neutrophils dengan Karakteristik Klinikohistopatologi pada Pasien Limfoma Hodgkin Nadya Virana Putri; Neti; Riana Sari Puspita Rasyid; Krisna Murti
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.471

Abstract

BackgroundThe development and aggressiveness of tumor cells were influenced by tumor microenvironment. Tumor-Associated-Macrophages(TAMs) and Tumor-Associated-Neutrophils (TANs) are components of tumor microenvironment, contribute to development and growthof tumor cells. The aim of this research was to analyse correlation of TAMs and TANs densities with clinicohistopathologiccharacteristics of patients i.e. age, gender, location, and subtype.MethodsA case series was conducted. The samples were paraffin blocks of Hodgkin lymphoma patients at Anatomic Pathology DepartmentFaculty of Medicine Universitas Sriwijaya/RSUP Dr. Mohammad Hoesin Palembang. Among 44 cases of Hodgkin lymphomadiagnosed from 1stJanuari 2015 to 30th October 2019, only 31 cases were included. Immunohistochemistry was performed by usinganti-CD163 antibody and neutrophils were identified by morphologic appearances. The results were correlated to characteristicfactors. Statistical analysis was performed using Spearman and Lambda test with significant consideration if p<0.05.ResultsThe study results showed 30 cases of classical Hodgkin lymphoma (CHL) and 1 case of NLPHL. CHL has only 3 variants LR(lymphocyte-rich) (60%), MC (mixed-cellularity) (26.7%), and NS (nodular sclerosis) (13.3%). Hodgkin lymphoma is most commonlyfound in males (61.3%). Tumor were mostly found in the head and neck, and patient ages were majority in the age group 20-29 years,40-49 years, and over 50 years. Spearman test showed there was a significant correlation between density of TAMs with ages(p=0.043).ConclusionHigh density of TAM was correlated with age, however, there was no correlation between TAN and clinicohistopathologiccharacteristics of Hodgkin lymphoma.
Profil tumor neuroendokrin berdasarkan pengalaman lima tahun di rumah sakit rujukan tersier di Palembang Sandria; Krisna Murti
Majalah Patologi Indonesia Vol. 35 No. 1, Januari 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.664

Abstract

Background Neuroendocrine tumors (NET) are a type of uncommon neoplasms originating from the neuroendocrine cell system. Recent decades, the prevalence of NET gradually increases, attributing partially to the utilization of advanced detection procedures using modern methodologies. Objective The aim of this research was to assess the profile of neuroendocrine tumors of 5 years experiences in our hospital. Methods In this retrospective cross-sectional study, a thorough examination was performed on a total of 71 cases obtained from archives of the Department of Anatomic Pathology Mohammad Hoesin Hospital, over the period from 2017 to 2021. The Chi-square test was used for data analysis. Bivariate analysis was performed using binary logistic regression tests to investigate the correlation between the independent variables, including gender and tumor site, and the dependent variables. Result and Discussion Out of the 71 recorded samples, 69 samples were subjected to be analyzed while the remaining samples were excluded due to have incomplete data. Four different antibodies were evaluated to find the association between these antibodies and tumor with location (chromogranin, P=0.792; synaptophysin, P=0.100; Ki-67, P=0.026; CD56, P=0.511) and gender (chromogranin, P=0.627; synaptophysin, P=0.929; Ki-67, P=0.315; CD56, P=0.524). Conclusion: The study showed synaptophysin has the highest positive rate on NET diagnosis. There is no association was found between chromogranin, synaptophysin, and CD56 staining to tumor location, except for Ki-67. Similarly, no association was found between staining performance (chromogranin, synaptophysin, Ki-67, CD56) with gender.
Biomolecular and bioinformatics characterization of salivary matrix metalloproteinase-9 as oral cancer potential targeted therapy Dewi, Siti Rusdiana Puspa; Saleh, Muhammad Irsan; Murti, Krisna; Parisa, Nita; Rosdah, Ayeshah Augusta; Subandrate, Subandrate; Kumar, Arun
Padjadjaran Journal of Dentistry Vol 38, No 2 (2026): July 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no2.70464

Abstract

Introduction: Oral cancer is the 11th most common cancer worldwide. Previous studies have reported that saliva contains biomarkers for oral cancer. MMP-9, found in saliva, is a marker that indicates and facilitates tumor development. However, comprehensive biomolecular and bioinformatics characterization of salivary MMP-9 remains limited. This study aimed to analyze the biomolecular and bioinformatics characteristics of salivary MMP-9 as an oral cancer biomarker and a potential target for therapy because it plays an important role in tumor development and management. Methods: The features of MMP-9 were obtained from the NCBI database (www.ncbi.nlm.nih.gov). Protein analyses were performed using Protparam site, PROTSCALE, TMM application, PEPTIDE CUTTER, NETNGLYC and TARGETTP. The protein model and structure of MMP-9 were evaluated using SWISSMODEL. Results: Based on the study, it showed that MMP-9 is located on 20q13.12. It is involved in extracellular matrix breakdown, and this enzyme degrades type IV and V collagens. Based on the instability index (II), the protein was found to be unstable. The hydrophobicity range of the MMP-9 protein was 0–7654. Among the 20 amino acids analyzed, the hydrophobicity of arginine was -4.500, while isoleucine was 4.500. Transmembrane helix analysis indicated the MMP-9 protein isoform is predominantly located outside of the cell. The predicted N-glycosylation site was at the 28th amino acid. The structural model analysis indicated that the protein model was of good quality. Conclusion: Biomolecular and bioinformatics characterization of salivary MMP-9 demonstrates strong potential as an oral cancer biomarker. The biomolecular and bioinformatics characteristics identified in this study support the potential utility of MMP-9 as an oral cancer biomarker and provide a foundation for future studies investigating its therapeutic relevance.
Co-Authors ,Aswatama, Ketut Adam, Ryan Adi Saputra Aldes Lesbani Alexandra Octnick Andarinini, Rindang Senja Andrew Sakko Andrina, Hana Andriyani Liberty, Iche Andy Alfatih Anggraini, Bean Nur Aspitriani Asprianto, Muhammad Astrilya, Nuur Hayati Ayeshah A Rosdah Bima Zulfikar, M. Carmela Ricciardelli Chodijah, Nyimas Citra Dewi Citra Dewi Dahlan, Kemas Devi Dwiyanti Devi Eqtriana Setyaningsih Devi, SNA Ratna Sari Dwiryanti, Rizky Edi Poedjo Purnamawati, Ika Kartika Eka Putra Pratama Ella Amalia, Ella Ellyzar Ellyzar Elza Iskandar, Elza Erial Bahar Erial Bahar, Erial Eriza, Eriza Erno Widayanto Farah Diba, Masayu Farodiyah, Nanda Narul Farodiyah, Nanda Nurul Fauziah Kurniawaty, Nyiayu Haloho, Agustina Br. Harahap, Huntari Heni Maulani, Heni Henny Sulastri Iche Andriyani Liberty, Iche Andriyani Ika Kartika Ika Kartika Indri Seta Septadina Irfannuddin Irfannuddin Irfanuddin Irfanuddin Irsan Saleh Izzudin, Muhammad Jurgen Stahl Kartika Edi Poedjo Purnamawati, Ika Kesty, Cindy Khoiri Yahya Afifah Koibuchi, Noriyuki Kumar, Arun Kurniawaty, Nyiayu Fauziah Leovani, Ega Lisa M. Butler Mahdavikia, Reza Maria Ulfa, Maria Ulfa, Maria Ulfa,, Maria Ulfa, Marta Hendry Maryano, Maryano Maydila Putri Millenia Mega Fatimah Rosana Mega, Pratia Meilinda, Nurly Mgs. Irsan Saleh, Mgs. Irsan Miftha Pratiwi Muhammad Asprianto Muhammad Ichsan Hadjri Muhammad Irsan Saleh Muhammad Yusuf Abror Muradi, Akhmadu Musdalifah, Farisha Sestri Muzakkie, Mufida Nadya Virana Putri Neti Neti, Neti Nita Parisa Nora Ramkita Nugraha, Xavier Nuur Hayati Astrilya Nyiayu Fauziah Kurniawati Pangestu, Panji Peby Maulina Lestari, Peby Maulina Pratama, Eka Putra Puspa Zuleika, Puspa Putra, Mohammad Tomita Maha Putri Erlyn Putri Mirani Putri Saraswati Ramadhani, Solibah Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Rifai Agung Prihananto Rikka Wijaya S. Nurul Amanah Ratna Sari Saleh, Muhammad Irsan Sandria Sandria Santoso Mulyadi Saputra Naibaho, Oldyo Sari Puspita Rasyid, Riana Sastradinata, Irawan Sherlin Tazkiya Nur Salsabila Shofia Shinta Adityaningrum Siti Nurmaini Siti Rusdiana Puspa Dewi Siti Sarahdeaz Fazzaura Putri Soedjana, Hardi Siswo Sofyan Effendi Sri Santoso Sabrini Stevanny, Bella Subandrate Suly Auline Rusminan Syifa Ayu Laluna Tatit Nurseta Theodorus Theodorus Tina B. Mitto Vera Novianti Wayne D. Tilley Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yenny Febrianty Yudianita Kesuma, Yudianita Yusa, Muchammad Yustian Yusuf Hasibuan, Fauzie Yususf, Fahmi Jaka Zen Hafy