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All Journal Nurse Media Journal of Nursing Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Andalas obstetrics and gynecology journal Jurnal Ners Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Kedokteran Hewan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan Biosaintifika: Journal of Biology & Biology Education Media Penelitian dan Pengembangan Kesehatan Cermin Dunia Kedokteran
Daan Khambri
Fakultas Kedokteran, Universitas Andalas
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Validity and reliability test of the knowledge level questionnaire of cancer patients undergoing radiotherapy Hanum, Fathiya Juwita; Machmud, Rizanda; Gondhowiardjo, Soehartati; Khambri, Daan; Harahap, Wirsma Arif; Elliyanti, Aisyah; Firdawati, Firdawati; Semiarty, Rima
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3604

Abstract

Background: Radiotherapy is one of the main modalities in cancer treatment. The success of this therapy is strongly influenced by the knowledge of patients about the disease and radiotherapy. The researcher developed a questionnaire to measure the level of knowledge among cancer patients undergoing radiotherapy. Objective: This study aimed to assess the validity and reliability of a knowledge-level questionnaire for cancer patients receiving radiotherapy at Dr. M. Djamil General Hospital, Padang. Methods: This research employed a quantitative approach with a cross-sectional design. A total of 30 cancer patients undergoing radiotherapy were included as respondents using a consecutive sampling technique. The questionnaire instrument was developed by the researcher and consisted of 25 items covering five domains of knowledge: cancer, radiotherapy, side effects, self-care, and nutrition. Results: Validity testing was conducted using Pearson’s correlation analysis, while reliability was assessed using Cronbach’s Alpha. Out of the 25 items, 19 were statistically valid (p<0.05), with correlation coefficients (r) ranging from moderate to strong (0.470–0.745). The Cronbach’s Alpha value for the valid items was 0.904, indicating excellent reliability. Conclusion: The developed questionnaire was proven to be both valid and reliable for measuring the knowledge level of cancer patients undergoing radiotherapy. This instrument has the potential to be used in clinical practice and research to support more targeted educational interventions.
Hubungan Overekspresi HER2 dengan Status Reseptor Hormonal Kanker Payudara Di RSUP Dr. M. Djamil Padang Tahun 2017-2021 Aldestra, Yudha; Yenita; Khambri , Daan; Asri, Aswiyanti; Rustam, Rony; Anggraini, Fika Tri
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1519

Abstract

Latar Belakang: Overekspresi HER2 terjadi pada sekitar 10-15% kanker payudara dan cenderung mempunyai prognosis yang buruk. Reseptor hormonal terdiri dari reseptor estrogen dan reseptor progesteron. Hubungan overekspresi dari HER2 dan reseptor hormonal digunakan untuk menilai prognostik dan prediktif pada kanker payudara. Objektif: Penelitian ini bertujuan untuk mengetahui hubunngan overekspresi HER2 dengan status reseptor hormonal kanker payudara di RSUP Dr. M. Djamil Padang tahun 2017 – 2021 Metode: Penelitian ini adalah studi analitik retrospektif dengan pendekatan cross-sectional untuk mengetahui hubungan antara overekspresi HER2 dengan reseptor hormonal di RSUP Dr. M Djamil tahun 2017 – 2021. Hasil: Berdasarkan uji Chi-Square menunjukkan terdapat hubungan antara overekspresi HER2 dengan reseptor hormonal kanker payudara (p<0,05). Kesimpulan: Terdapat hubungan antara overekspresi HER2 dengan reseptor hormonal kanker payudara.
Antiproliferative and Apoptosis-Inducing Effects of Iodine Molecule in Differentiated Primary Thyroid Cancer Cells: In Vitro Study Yulia Kurniawati; Jihan Atiqah; Malinda Meinapuri; Daan Khambri; Achmad Hussein Kartamihardja; Aisyah Elliyanti
Biosaintifika: Journal of Biology & Biology Education Vol. 18 No. 1 (2026): April 2026
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v18i1.42523

Abstract

Thyroid cancer poses a persistent clinical challenge, particularly when conventional therapies fall short. Growing evidence suggests that molecular iodine (I₂) may exert direct antitumor effects beyond its classical role in thyroid hormone synthesis. This study evaluated the antiproliferative and apoptosis-inducing effects of I₂ on primary cell cultures derived from differentiated thyroid cancer tissue and established dose- and time-response relationships. Primary cultures were exposed to I₂ at concentrations of 5, 10, 20, 40, 80, and 100 µM for 24, 48, and 72 hours. Cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, with IC₅₀ calculated accordingly. Apoptosis was characterized by acridine orange/propidium iodide (AO/PI) double-staining, analyzed by fluorescence microscopy and ImageJ software. I₂ demonstrated clear antiproliferative and apoptotic activity in a dose- and time-dependent manner. The strongest effect appeared at 100 µM after 72 hours, reducing viability to 1.39% (p < 0.001). At the IC₅₀ of 2.09 µM, iodine significantly suppressed proliferation and induced apoptosis, with an apoptosis rate of 81.77% ± 12.24% (p = 0.004). These findings confirm the meaningful antineoplastic potential of I₂ against differentiated thyroid cancer cells. This study supports SDG 3 (Good Health and Well-Being), contributing to efforts to develop more equitable, effective cancer treatment options and to reduce cancer-related morbidity globally.
Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza; Suyuthie, Heldrian Dwinanda; Oktavenra, Ari; Nora, Sondang; Khambri, Daan; Harahap, Wirsma Arif; Rustam, Rony; Azamris
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.189

Abstract

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.
Diseksi Kelenjar Inguinal pada Keganasan: Kasus Serial Oktavenra, Ari; Khambri, Daan; Triputra, Yopiq
Cermin Dunia Kedokteran Vol 50 No 8 (2023): Dermatiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i8.1002

Abstract

Latar Belakang: Keganasan pada ekstremitas bawah, kulit penis, vulva/vagina, dan anus berisiko mengalami metastasis KGB inguinal. Diseksi KGB inguinal dapat memberikan hasil disease-free and overall survival yang baik. Tujuan: Melihat hasil pasca-operasi diseksi KGB inguinal pada kasus serial. Cara: Diseksi KGB inguinal dilakukan pada kasus melanoma maligna TxN2bM0, melanoma maligna TxN1M0, dan cutaneous apocrine carcinoma et phenoscrotal T3N1M0. Diskusi: Diseksi KGB inguinal pada kasus keganasan bermetastasis dari ekstremitas bawah, kulit penis, vulva/vagina, dan anus, memberikan hasil disease-free and overall survival yang baik, namun dengan komplikasi pasca-operasi berkurangnya kualitas hidup.   Introduction: Malignancy in lower extremities, penis skin, vulva/vagina, and anus may spread to inguinal lymph node. Inguinal lymph node dissection can provide good disease-free and overall survival results. Objective: To review postoperative results of inguinal lymph node dissection (ILND) in case series. Method: Inguinal lymph node dissection was done in cases of malignant melanoma TxN2bM0, malignant melanoma TxN1M0, and cutaneous apocrine carcinoma er phenoscrotal T3N1M0. Discussion: ILND can improve disease-free and overall survival results in malignancies cases from lower extremities, skin of the penis, vulva/vagina, and anus with metastases, albeit with postoperative complications that can decrease the quality of life.
Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Achmad Hussein Kartamihardja Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Aqeed Izreen Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Aldestra, Yudha Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Yanto Wijaya Arifin, Hidayat Arni Amir Asterina Aswiyanti Asri Azamris Azamris Azamris Aziza, Zulva Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Dia Rofinda, Zelly Dia Edison Edison Eka Putri Eka Putri Elfira Yusri Erlina Rustam Ermawati Ermawati Eryati Darwin Eti Yerizel Fadrian, Fadrian Fatma Sri Wahyuni Fika Tri Anggraini Fillia Putri Firdawati Firdawati Frengki Frengki Frengki Frengki, Frengki Hafiz, Muhammad Zaki Abdul Hafni Bachtiar Hanum, Fathiya Juwita Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Mulyani henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Hidayat, Nur Latifah Alfaina Husna Yetti Intan, Shinta Ayu Isra Analdo Arza Jamil, Mohd Jamilah Abbas Jati, Fajri Hidayat Jihan Atiqah Krisdianto, Boby Febri Leni Merdawati M. Al Farisyi Made Satya Nugraha Gautama Maisa, Esthika Ariany Malinda Meinapuri Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Mulyani , Henny Niki Astria Nina Kurniasih Nindita, Priska Audina Nirmala Sari Noni Zakiah Nora, Sondang Noza Hilbertina Noza Hilbertina, Noza Noza, Hilbertina Nurhayati Nurhayati Oktahermoniza Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Putra, Fachri Putri, Biomechy Oktomalio Putriyuni, Anandia Raden Mohamad Herdian Bhakti Ramadanus Ramadanus Ramadanus Rifa, Farras Zahra Rima Semiarty Rini Purnama Sari Rizanda Machmud Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rufi'i Rulli Firmansyah Rustam, Rony Safnita, Dewi Sari, Rini Purnama Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Soehartati Gondhowiardjo Sofia Mubarika Sofia Mubarika Haryana Sonar Panigoro Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suchitra, Avit Suyuthie, Heldrian Dwinanda Syamel Muhammad Tofrizal Tofrizal Tofrizal Triputra, Yopiq Vashti Resti Putri Firdaus Veithzal Rivai Zainal Vivi Sofia wessi windrasari Wirsma Arif Harahap Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yenita . Yenita Afriyeni Yopiq Triputra Yulia Kurniawati Yusticia Katar Yusticia Katar, Yusticia