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All Journal International Journal of Public Health Science (IJPHS) Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia Ilmu Gizi Indonesia Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia JURNAL FARMASIMED (JFM) Indonesian Journal of Halal Research Journal of halal product and research (JHPR) Community Empowerment Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Jurnal Kajian Islam Modern Journal of Halal Science and Research Open Community Service Journal Journal of Pharmaceutical and Sciences. Riwayat: Educational Journal of History and Humanities Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmacy and Halal Studies (JPHS)
Nina Salamah
Fakultas Farmasi, Universitas Ahmad Dahlan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Acute Toxicity Test of Healthy Drink of Anthocyanin Pigmented Polyphenols from Black Rice and Sprouts Soybean Kintoko, Kintoko; Salamah, Nina; Witasari, Hardi Astuti; Maulizah, Rizlah
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25784

Abstract

Black rice and sprouted soybean (BRiSS) can be formulated into a healthy drink BRiSS. The safety of this novel combination must be rigorously tested. Therefore, this study was designed to conduct a comprehensive acute toxicity test of the healthy drink flavylium anthocyanins from black rice (Oryza sativa L. indica) pigmented polyphenols from soybean sprouts (Glycine max L.). The black rice was extracted with a 96% ethanol solution in 3% citric acid. The pigmentation process was achieved by adding hydroxyl groups from soybean polyphenols. The active material was mixed with 20% maltodextrin, shaken, poured into a pan, and dried with a cabinet dryer (60° C). The mixture was stirred with 0.3% sodium, 0.1% citric acid, 50% active ingredients, 5% sucrose as a sweetener, 0.05% sodium benzoate, and water, 100 ml. The five groups of male Wistar rats were acclimatized. Group 1 was a control, and groups 2, 3, 4, and 5 were sequentially treated with a healthy drink containing extract doses of 5, 50, 300, and 2000 mg/kg BW. The acute toxicity test results at 30 minutes, 3 to 24 hours, day 3, and day 14 were written on the acute toxicity test clinical symptom observation sheet. All test animals, including both the control and test groups with various dosage variations, did not exhibit changes in skin, fur, eyes, behavior, respiratory systems, and did not experience weight loss, seizures, tremors, lethargy, or diarrhea. The limitation was that the macropathology examination of internal organs (kidneys, liver, heart, brain, stomach, intestines, pancreas) was not performed. Not all animals have mortality in a 5-3000 (mg/kg BW) extract dose.
Formulation And Antibacterial Activity Test Of Betel Leaf (Piper Betle L.) Essential Oil Mouthwash Against Streptococcus mutans Andini, Prasti; Firdaus, Anisa; Candra, Novita Diana Ayu; Salamah, Nina; Mulyaningisih, Sri
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.13872

Abstract

Dental caries is a prevalent oral health issue in Indonesia, largely caused by Streptococcus mutans. While Piper betle L. essential oil possesses known antibacterial properties, its utilization in a stable mouthwash formulation requires scientific validation. Objective: This study aimed to formulate Piper betle L. essential oil into a mouthwash emulsion and evaluate its antibacterial activity against S. mutans. Essential oil was obtained via steam distillation and formulated into mouthwashes at concentrations of 1%, 2%, and 4% (v/v) using Tween 80 as an emulsifier. Antibacterial activity was assessed using the well-diffusion method against S. mutans (0.5 McFarland standard) in independent triplicate wells (n=3). Vehicle control (without essential oil) and Povidone-Iodine 10% (positive control) were used for comparison. Data were analyzed using One-Way ANOVA followed by Tukey HSD post-hoc test (p<0.05). The formulation containing 4% essential oil exhibited the strongest antibacterial activity among the test groups, with an inhibition zone of 12.66 ± 1.76 mm, which was significantly higher than the vehicle control (9.29 ± 2.67 mm; p < 0.05). The positive control showed the highest inhibition (18.03 + 1.16 mm). Physical evaluation confirmed that all formulations remained stable during 7 days of storage at room temperature (27 ± 2°C), with no specific control of relative humidity, with pH values (6.46–6.82) and specific gravity (1.03–1.04 g/mL) within physiological limits. Piper betle L. essential oil mouthwash is physically stable and effective against S. mutans in a concentration-dependent manner, suggesting its promising potential as a natural alternative for oral hygiene maintenance
Antioxidant Activity Test of Black Rice (Oryza sativa L. Indica) Extract and Total Phenolic Test of Soybean Sprout (Glycine max L.) Extract Using 70%, 90%, and 96% Ethanol Variations. Maulizah, Rizlah; Kintoko; Nina Salamah; Elfi Anis Saati
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/v5bg4116

Abstract

Background: The human body requires external antioxidants to neutralize free radicals that cause cellular damage and degenerative diseases. Black rice contains higher anthocyanin levels than red rice, while soybean germination increases flavonoids, phenolic compounds, and secondary metabolites.Objective: This study aimed to determine the total phenolic content of germinated soybeans extracted using three ethanol solvent concentrations (70%, 90%, and 96%) and to valuate the antioxidant activity of soybean and black rice extracts as copigmentation agents. Methods: Soybean extracts were obtained by maceration using different ethanol concentrations, followed by analysis of total phenolic content and antioxidant activity. Black rice extract was evaluated for antioxidant activity using the DPPH method to obtain a stable antioxidant with a very strong IC₅₀ value. Results: The total phenolic content of germinated soybean extracts varied with solvent concentration: ethanol 70% yielded 2.24 mg GAE/g, ethanol 90% yielded 7.14 mg GAE/g, and ethanol 96% yielded 3.36 mg GAE/g. The total anthocyanin content of black rice extract determined by the pH differential method was 8.182 mg/100 g, with an antioxidant activity IC₅₀ of 82.24 ± 3.6 ppm, categorized as strong. The IC₅₀ value of the non-copigmented sample was 83.71 ± 1.6 ppm (moderate), while copigmentation ratios of 1:1, 1:2, and 1:3 resulted in IC₅₀ values of 70.83 ± 0.8 ppm (strong), 62.97 ± 1.2 ppm (strong), and 38.53 ± 0.3 ppm (very strong), respectively. Conclusion: Extraction of germinated soybeans using ethanol 90% significantly increased total phenolic content (p < 0.05). Copigmentation of black rice anthocyanin flavylium with germinated soybean polyphenols at a 1:3 ratio produced very strong antioxidant activity (p < 0.05), indicating its potential as a copigmentation agent in functional food products.
Acute Toxicity Test of Healthy Drink of Anthocyanin Pigmented Polyphenols from Black Rice and Sprouts Soybean Kintoko, Kintoko; Salamah, Nina; Witasari, Hardi Astuti; Maulizah, Rizlah
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25784

Abstract

Black rice and sprouted soybean (BRiSS) can be formulated into a healthy drink BRiSS. The safety of this novel combination must be rigorously tested. Therefore, this study was designed to conduct a comprehensive acute toxicity test of the healthy drink flavylium anthocyanins from black rice (Oryza sativa L. indica) pigmented polyphenols from soybean sprouts (Glycine max L.). The black rice was extracted with a 96% ethanol solution in 3% citric acid. The pigmentation process was achieved by adding hydroxyl groups from soybean polyphenols. The active material was mixed with 20% maltodextrin, shaken, poured into a pan, and dried with a cabinet dryer (60° C). The mixture was stirred with 0.3% sodium, 0.1% citric acid, 50% active ingredients, 5% sucrose as a sweetener, 0.05% sodium benzoate, and water, 100 ml. The five groups of male Wistar rats were acclimatized. Group 1 was a control, and groups 2, 3, 4, and 5 were sequentially treated with a healthy drink containing extract doses of 5, 50, 300, and 2000 mg/kg BW. The acute toxicity test results at 30 minutes, 3 to 24 hours, day 3, and day 14 were written on the acute toxicity test clinical symptom observation sheet. All test animals, including both the control and test groups with various dosage variations, did not exhibit changes in skin, fur, eyes, behavior, respiratory systems, and did not experience weight loss, seizures, tremors, lethargy, or diarrhea. The limitation was that the macropathology examination of internal organs (kidneys, liver, heart, brain, stomach, intestines, pancreas) was not performed. Not all animals have mortality in a 5-3000 (mg/kg BW) extract dose.
Eksplorasi Potensi Antidiabetes Gynura procumbens: Analisis Bibliometrik Berbasis Data Scopus Arib, Faisal Nur; Chotimah, Aditya Nurul; Kintoko, Kintoko; Salamah, Nina
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.98143

Abstract

Gynura procumbens (Lour.) Merr., tumbuhan tropis dari famili Asteraceae, telah lama digunakan dalam pengobatan tradisional untuk berbagai penyakit. Studi praklinis menunjukkan potensi G. procumbens sebagai agen antidiabetes, yang relevan dengan tren peningkatan kasus diabetes melitus (DM) secara global. Penelitian ini bertujuan mengevaluasi perkembangan riset praklinis G. procumbens sebagai agen antidiabetes melalui analisis bibliometrik berbasis data Scopus. Sebanyak 23 artikel terpilih (2000–2024) dianalisis menggunakan perangkat lunak VOSviewer. Analisis meliputi pemetaan tren publikasi, jaringan keterkaitan kata kunci (keyword co-occurrence), distribusi negara dan institusi, artikel paling berpengaruh, hubungan referensi bersama (bibliographic coupling), dan kutipan bersama (co-citation). Hasil menunjukkan peningkatan tren publikasi sejak tahun 2000, dengan Malaysia sebagai kontributor utama, khususnya Universiti Sains Malaysia. Tema utama mencakup efek hipoglikemik, mekanisme molekuler, identifikasi senyawa aktif, serta potensi unik dalam meningkatkan fertilitas pada kondisi DM—suatu arah riset yang jarang ditemukan pada agen antidiabetes lain. Perkembangan penelitian bergerak dari studi ekstrak kasar menuju formulasi inovatif seperti nanopartikel. Analisis bibliographic coupling dan co-citation mengungkap keterkaitan antar tema, membentuk empat klaster utama yang saling beririsan. Studi ini mengidentifikasi celah penting, termasuk kurangnya data toksikologi kronis dan profil farmakokinetik. Temuan pada penelitian ini menegaskan G. procumbens sebagai kandidat terapi antidiabetes berbasis bukti ilmiah, dengan peluang pengembangan pada terapi komplikasi reproduksi akibat DM. Temuan ini menyediakan peta tematik yang dapat dimanfaatkan peneliti untuk merancang studi multidisiplin, mempercepat pemahaman mekanisme kerja, dan mendorong pengembangan formulasi G. procumbens yang efektif dan aman untuk aplikasi klinis.
Autentikasi Minyak Biji Jagung Zea mays L.: Pengaruh Metode Ekstraksi dan Analisis Komposisi Menggunakan Metode Gas Cromatoghraphy-Mass Spectrometry (GC-MS) Fadli, Justitia Cahyani; Guntarti, Any; Salamah, Nina
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 2 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i2.85367

Abstract

Minyak jagung mengandung protein dan asam lemak yang melimpah, sehingga diperlukan metode dan kondisi ekstraksi yang tepat untuk menghasilka kualitas minyak berkualitas tinggi. Minyak dapat diperoleh dengan cara pemanasan menggunakan alat Soxhlet maupun Reflux dan akan terisolasi dengan pelarut non polar. Penelitian ini bertujuan untuk mengoptimalkan ekstraksi minyak jagung manis, membandingkan kualitas minyak jagung dari dua metode isolasi serta menganalisis komposisi asam lemak menggunakan GC-MS. Minyak jagung manis yang dihasilkan dari dua metode isolasi Reflux dan Soxhlet dibandingkan dengan parameter SNI dan diidentifikasi komposisi asam lemaknya menggunakan instrumen GC-MS. Parameter kualitas minyak biji jagung manis yang dihasilkan dari metode Soxhlet dan Reflux, memiliki karakteristik warna, bau, indeks bias, kadar air, bilangan asam, bilangan peroksida, dan bilangan iod yang memenuhi persyaratan SNI. Hasil analisis GC-MS menunjukkan metode Reflux menghasilkan 3 kandungan senyawa yaitu, asam palmiat (31,37%), linoleoyl chloride (67,15%), dan asam ftalat (1,48%), sedangkan metode Soxhlet menghasilkan 2 kandungan senyawa, yaitu asam palmiat (32,28%) dan asam linoleat (66,89%). Hasil penelitian menunjukkan bahwa variasi metode ekstraksi minyak biji jagung memengaruhi kualitas minyak serta kandungan asam lemak yang dihasilkan. 
Co-Authors A Riyanto Abdul Rohman Achmad Wahyudi Agustin LN Aminin Ajeng Dian Pertiwi, Ajeng Dian Andini, Prasti Anggita Devi Anita Wening Sejati Anjani, Ratna Annta Kern Nugrohowati Anwar, Muslih Any Guntarti Any Guntarti Any Guntarti Any Guntarti Ar Rahma, Nur Aulia Arib, Faisal Nur Banundari Rachmawati Barokati Azizah Basuki, Nazih Candra, Novita Diana Ayu Chotimah, Aditya Nurul Citra Ariani Edityaningrum, Citra Citra Dhea Cantika Danang Prasetyaning Amukti Desti Kameliani Dian Prasasti Dwi Fitriani Elfi Anis Saati Erlinda Widyasari Fadli, Justitia Cahyani Fathurohman SW, Oman Fathurrohman SW, Oman FATMAWATI, ARUM Fatriansari, Asih Fella Qulsum Maulida Firdaus, Anisa Firdaus, Rizqi Amalia Fitrah Amelia Gunawan Anugra Sumule, Joshua Guntarti , Any Hardi Astuti Witasari Hari Susanti Hayati, Farida Hikmah, Nazila Nur Ikawati, Retty Indah Pratami, Ria INNAYAH IZATI Irfan, Nawwar Ismarti Ismarti, Ismarti Jaswir, Irwandi Jufri, Sayyidah Luthfiyah Juwitaningtyas, Titisari Kaffah, Silmi karunia nining handaningrum Kasmawati, Henny Kintoko Kintoko Kintoko Kurniaty, Santyas Kurniawan, Muhammad Fariez Laela Hayu Nurani Liani Farahana Ma'ruf, Muhammad Mae Sri Hartati Wahyuningsih Mahendra, Muhammad Reza Masyithah Awaluddin, Sitti Maulizah, Rizlah Miftahul Rozak Mohamed, Farahidah Muhammad Sulkhan Muhti Al Abror Mukti Utomo, Adhitya Ilham mukti, adhitya ilham Mulyaningisih, Sri Mustofa Ahda Nanik Sulistyani Nining Sugihartini Novitasari, Putri Rachma Nurkhasanah , Nurkhasanah Nurkhasanah Mahfudh Pangaribuan, Ika S Pinus Jumariyatno Pora, Yohana Laura Silfia Pradini, Ni Komang Virginia Prasetyaning Amukti, Danang Putri, Chintiana Nindya Rajab, Muhammad Andy Ramses Firdaus, Ramses Rina Handayani Rini Rahmawati Rosyida Awalia Safitri Rozak, Miftahul Saraswati, Damai Ira SATRIYAS ILYAS Sembiring, Rinawati Sihaloho, Serli Sitarina Widyarini Siti Athiyah Umaiyah Siti Fatimah Sultan Sudibyo Martono Sudibyo Martono Sugiyanto - Sugiyanto . Sugiyanto . Sugiyanto Sugiyanto Sugiyanto Sugiyanto Sunarti Sunarti Suryani, Arman Suwidjiyo Pramono Suwidjiyo Pramono SW, Oman Fathurohman Uddin, ABM Helal Verda Farida Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyuningtyas, Nurma Widi Astuti, Silvia Ferry WULANDARI Yamin Yulianti, Rista Yuny Erwanto Yuny Erwanto Zahra Alya Putri