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Journal : The Indonesian Biomedical Journal

AvrA Salmonella Increases TLR4/NF-κB/β-catenin/TGF-β Expressions of Colorectal Cancer Mice Model Bogi Pratomo Wibowo; Handono Kalim; Husnul Khotimah; Hidayat Sujuti; Ettie Rukmigarsari; Nabila Erina Erwan
The Indonesian Biomedical Journal Vol 15, No 6 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i6.2607

Abstract

BACKGROUND: Colorectal cancer (CRC) is reported as the third most frequently diagnosed cancer worldwide. Salmonella infection plays a role in developing this cancer, which is chronically related to the avirulence protein A (AvrA) effector protein produced by the bacteria. This study was conducted to point out the effect of AvrA Salmonella on the occurrence of CRC through the regulation of TLR4/NF-κB/β-catenin/TGF-β expressions in the azoxymethane (AOM)/dextran sodium sulfate (DSS) CRC model.METHODS: A randomized control group post-test-only study was conducted using male Balb/c mice with 30-gram body weight (10-12 weeks), which were divided into three groups, namely the negative control (normal mice without any treatment), positive control (AOM/DSS-treated mice), treatment 1 (T1) (AOM/DSS-treated mice + AvrA Salmonella) groups. Colon tissue was collected and then prepared for immunohistochemistry staining using TLR4, β-catenin, NF-κB, TGF-β, and Ki67 antibodies, whereas apoptotic cells were stained using TUNEL assay.RESULTS: The expressions of TLR4, β-catenin, NF-κB, TGF-β, Ki67, and apoptosis percentage indicated significant differences among the three groups, which statistically showed p<0.05 in all observed parameters. The mean of all parameters was far more significant in the T1 group than in the negative and positive control groups.CONCLUSION: The findings revealed that AvrA Salmonella could increase the expressions of TLR4, β-catenin, NF-κB, TGF-β, and Ki67 and decrease the apoptotic percentage. Thus, AvrA Salmonella influences CRC tumorigenesis through TLR4/NF-κB/β-catenin/TGF-β and is suggested as a potential target in future preventive and curative management for CRC.KEYWORDS: AvrA Salmonella, carcinogenesis, colorectal cancer 
Co-Authors A. Harijono A.A. Ketut Agung Cahyawan W Abdalrauf A Mahmud Yousif Abdalrauf A Mahmud Yousif, Abdalrauf A Mahmud Abdussalam Ashour, Abdussalam Achmad Rudijanto Adinda Chika Anindita Affandi, Haykal Agung Prasetyo Wibowo Agustiana Dwi Agustiana Dwi Indiah Ventiyaningsih Agustina Tri Endharti Ala Shukri Eshami, Ala Shukri Analis W Wardhana Anik Puryatni Anisak, Siti Ariani Ariani Ariani Ariani Arifin, Mochammad Samsul Arsinah Habibah Fitriah, Arsinah Habibah Askandar Tjokroprawiro Astika Swastirani Aulanni'am, Aulanni'am Aulia Yasmin, Aulia Bagus Hermansyah Bambang Rahardjo Bayu Kurniawan Bintang Soetjahjo Bogi Pratomo Wibowo Burhan, Niniek Chabibi, Mochamad Chabibi Chairinnisa, Elsa Safira Christina Dewi Dalhar, Mochamad Dewi, Ni Ketut Ayu Feriyanti Dian Handayani Dian Nugrahenny Diana Lyrawati Diana Lyrawati Dicky Faizal Irnandi Didi Candradikusuma Didi Candradikusuma Dwi Jayasa, Pande Made Dwi Yuni Nur Hidayati Edi Mustamsir Edi Widjajanto Edi Widjajanto Edwin Widodo Effendi, Ma'sum Eko Sulistijono Elok Zubaidah Erma Sulistyaningsih Ery Olivianto Fardizia Putri Alia Feni Istikharoh Fibrianto, Yuda Fita Shofiyah Gading, Inges Manggar Gerry Gunawan, Gerry Handono Kalim Hanif Hanif Happy Kurnia Permatasari Hara, Kenta HARI PURNOMO Hariwati Hariwati Hasfiani, Yuliatin Huda Rohmawati Husna, Ully Husnul Khotimah Ika Kustiyah Oktaviyanti Indrayanti Indrayanti Indriati Dwi Rahayu Inggita Kusumastuty Josef Sem Berth Tuda Juniartha, Putu Kalsumy, Umi Kanthi Permaningtyas Tritisari, Kanthi Permaningtyas Karyono Mintaroem Karyono Mintaroem Karyono Mintaroem Karyono mitaroem, Karyono Krisni Subandiyah Krisni Subandiyah Kusworini Handono Laily Yuliatun Lavina Sofia Ardani Lely Retno W Leny Budhi Harti Lestari, Bayu Lirawati, Diana Loeki Enggar Fitri M Rasjad Indra Machlusil Husna, Machlusil Maimun Z Arthamin, Maimun Z Masafumi Matsuo Masdar Muid Masdar Muid Masruroh Rahayu Masruroh Rahayu, Masruroh Mayangsari, Elly Mentari Sekar Arum Miftahu Soleh Moch. Aris Widodo, Moch. Aris Mochammad Dalhar Mohammad Hidayat Mohammad Hidayat Mohammad S. Rohman Muhammad Ali Faisal Muhammad Rasjad Indra Muhammad Rasjad Indra Nabila Andjani, Nabila Nabila Erina Erwan Nashi Widodo Nathania Bella Claresta Niarti Ulan Sari Siarnu Nindy Sabrina Niniek Burhan Nisrina Nur Afina, Nisrina Nur Nunuk Helilusiatiningsih Nur Kusmiyati Nur Permatasari Nura Fattah Cantika Yoga Nurshalilah Nurshalilah Pande Made Dwi Jayasa Pande Made Dwijayasa Prima Wijayanti, Prima Primawardani, Putri Puryatni, Anik - Putri, Dianita Setya Pradita Putu Juniartha Raisa, Neila Raudhatul Jannah Restuningwiyani, Sintha Retnani, Diah Prabawati Retty Ratnawati Retty Ratnawati Rizky Amalia RR. Ettie Rukmigarsari Salim, Irfan Agus Samsul Arifin Santoso, Giovani Anggasta Satrijo, Budi Selvi Marcellia Septi Nur Rachmawati Setiyaningsih, Fera Yuli Setyawati Soeharto Setyawati Soeharto, Setyawati Shintiya Dewi, Debby Shofiyah, Fita SIMON BAMBANG WIDJANARKO Sintha Restuningwiyani Siti Lintang Kawuryan Siti Narsito Wulan Soetjahjo, Bintang Sri Andarini Sutrisno Sutrisno Syahrul Chilmi, Syahrul Syarifah Rohaya Tatit Nurseta Tatit Nurseta Tatit Nurseta Tika Ardhini Wardoyo Tinny Endang Tinny Endang Hernowati Tokunaga, Chiharu Tri Dewanti Widyaningsih Triawanti Triawanti Tuda, Josef Sem Berth Umar Zein Vierlia, Wino Vrieda Widowati, Hesty Widya Rahmawati Winda Nurtika Yonezawa, Kazuyoshi Yoshino, Ken-ichi Yuda Fibrianto Yudanto, Hendy Setyo Zuly Vita Aulya, Zuly Vita