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Endang Suprihati
Division Of Veterinary Parasitology, Faculty Of Veterinary Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Journal : Journal of Applied Veterinary Science and Technology

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Nephroprotective Effect of Dayak Onion (Eleutherine palmifolia) Against Monosodium Glutamate-Induced Renal Toxicity in Mice (Mus musculus) Anggreani Desi Ramadhani Rahajeng; Aldin Akbar Rahmatullah; Cindy Ercha Aulia Putri; Rahmi Sugihartuti; Endang Suprihati; Hani Plumeriastuti; Mohammad Sukmanadi; Iwan Sahrial Hamid
Journal of Applied Veterinary Science And Technology Vol. 5 No. 2 (2024): October 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/javest.V5.I2.2024.129-134

Abstract

Background: The toxicological impacts of monosodium glutamate (MSG), a commonly used food additive, present a significant public health concern. Excessive MSG consumption will increase radical oxidative species, inducing a stress oxidative condition that ultimately results in kidney damage. Purpose: This study aimed to explore the nephroprotective effects of ethanol extracts from Dayak onion (Eleutherine palmifolia) against MSG-induced renal toxicity in mice (Mus musculus). Method: Twenty-five 11 week-old male mice, weighing approximately 20 g each, were divided into five research groups. Group C- received only CMC-Na 0.5%, Group C+ received 4000 mg/kg BW MSG, while Groups T1, T2, and T3 were administered 4000 mg/kg BW MSG along with Dayak onion extract at doses of 30 mg/kg BW, 60 mg/kg BW, and 120 mg/kg BW respectively. All treatments were carried out orally for 52 days. The mice were euthanized by cervical dislocation, and their kidneys were extracted for the examination of any histopathological changes. The data underwent analysis utilizing the Kruskal-Wallis test, followed by the Mann-Whitney test. Results: The results as indicated by the histopathological evaluation of the mice’s kidneys revealed significant improvements in the histo-architecture of the kidneys. Supplementation of Dayak onion extract in mice induced with MSG decreased the degeneration and necrosis of the tubule epithelium, and it also repaired the glomerular necrosis. Conclusion: Oral administration of Dayak onion extract to mice exposed to monosodium glutamate demonstrated a notable reduction in kidney damage and helped maintain renal health significantly.
Co-Authors Adi Sofyan Ansori, Muhammad Afiyah Rahmadani Agnes Theresia Soelih Estoepangestie Akbar Wijaya Putra Purnama Al arif, Mohammad Anam Alasrorik, Muhammad Hizbulloh Aldin Akbar Rahmatullah Amara Lintang Pagati Amelia Dwita Safitri Andaru Rizki Anggreani Desi Ramadhani Rahajeng Arif Pratiwi Arimbi Arimbi Ayu, Zerlinda Dyah Azizah Bilqis Nurkarimah Azzahra, Farah Nabila Boedi Setiawan Cindy Ercha Aulia Putri Dadik Rahardjo, Dadik Dadik Raharjo David Mohamad Qadafi Dhio Asmaydo Dian Ayu Permatasari Dian Ayu Permatasari Didik Handijatno Doohan Mahendra DWI PUTRI RAHMAWATI Dyah Ayu Kurniawati Dyah Ayu Kurniawati Eduardus Bimo Aksono Herupradoto Ellza Agatha Damayanti Emy Koestanti Sabdoningrum Eny Coolfina Simarmata Erma Safitri Fadila Zikri Amanda Faisal Fikri Fedik Abdul Rantam Firman Hadi Fanani Fransiska Cicilia Beka Ghifari Lutfi Fauzi Hana Eliyani Hani Plumeriastuti Hartono Hartono Hayuning Nurrodhiya Heni Puspitasari Imam Mustofa Indasari, Elly Nur Ismudiono Ismudiono Iwan Sahrial Hamid Iwan Sahrial Hamid Jihaan Haajidah Khairullah, Aswin Rafif Kiki Amalia Rama Koesdarto Koesdarto Kuncoro Puguh Santoso Kurniawan, Muhammad 'Ahdi Kurniawati, Dyah Ayu Kusnoto Kusnoto Kusnoto Kusnoto Kusnoto, Kusnoto Kusriningrum Rochiman Legowo, Djoko Lianny Nangoi Lilik Maslachah Lilik Maslachah Lucia Tri Suwanti, Lucia Tri Marchelia Arifiandani Maudika Pamela Fiorenza Meta Aprilia Meyreta Doti Alcaterana Mochamad Lazuardi Mohammad Sukmanadi Moses, Ikechukwu Benjamin Mufasirin Muhammad Fahmi Abdillah Muhammad Hambal Mustofa Helmi Effendi Nenny Harijani Ni Komang Aprilina Widisuputri Nidom, Chairul Anwar Niluh Selly Frantika Nining Sari Virgandina Vinola Nizar Bachrudin Prihandono Nunuk D.R. Lastuti Nunuk Dyah Retno Lastuti Nunuk Dyah Retno Lastuti Nurin Ardhiani Panjaitan, Cahaya Poedji Hastutiek Praja, Ratih Novita Pratama, Bima Putra Pratama, Ponasari Galuh Pratiwi, Arif Prawasa, Ramadhiniyanti Putri Alif Pudji Srianto Puput, Sesa Rahmi Sugihartuti Rahmi Sugihartuti, Rahmi Ratna Damayanti Restiadi, Tjuk Imam Retno Wulansari Riwu, Katty Hendriana Priscilia Rochmah Kurnijasanti Romy Muhammad Dary Mufa Sandy, Berliana Dwi Nandita Sarmanu, Sarmanu Setiawan Koesdarto Setiawan Kusdarto Soeharsono Soeharsono Sri Mumpuni Sosiawati Sunarso, Agus Sunaryo Hadi Warsito Supranianondo, Koesnoto Suzanita Utama Trilas Sardjito Warsito, Sunaryo Hadi Wibawati, Prima Ayu Widodo, Oky Setyo Wiwik Misaco Yuniarti Yudhana, Aditya Yulianna Puspitasari Yunus, Muchammad