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Exploring the Antioxidant and Anti-proliferative Effects of Murraya koenigii (L.) Leaves Methanol Extract on T47D Breast Cancer Cell Lines Nisa, Mutia Khoirun; Salamah, Rohmi; Wijayanti, Nastiti
GHMJ (Global Health Management Journal) Vol. 8 No. 1 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-811204

Abstract

Background: Murraya koenigii (Curry) leaves are herbal plants that have bioactive compounds such as phenolics, flavonoids, and alkaloids that function as antioxidants and anti-cancers. Aims: This study aimed to quantitatively determine the bioactive compounds in curry leaves by calculating phenolic, flavonoid, and alkaloid content. Its potential as an antioxidant and anti-proliferative compound in T47D breast cancer cell lines was also analyzed. Methods: Murraya koenigii leaves extract was obtained by maceration using 80% methanol (1:5 w/v), then the antioxidant and anti-proliferative test was carried out using the 1,1-Diphenyl-2-Pycrylhidracyl (DPPH) and MTT (-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay, respectively, followed by flow cytometry to determine the apoptotic activity of the extract on T47D breast cancer cell lines. Results: The results for the bioactive compounds in the methanol extract of Murraya koenigii leaves were 156.62±1.49 mg/g phenolics, 99.19±0.25 mg/g flavonoids, and 2.90±0.01 mg/g alkaloids. The IC50 value for antioxidant activity was 25.058±2.2 μg/ml and showed an anti-proliferative effect on T47D cells in a dose-dependent manner with IC50 74.71±5.45 μg/ml for cytotoxicity. Furthermore, flow cytometry showed that a concentration of 1/16 IC50 has the best results for apoptosis. Conclusion: The methanol extract of Murraya koenigii leaves has the potential as an antioxidant and anti-proliferative agent and can induce apoptosis of T47D cells.
Co-Authors . Sismindari Abdul Rahman Siregar, Abdul Rahman Abrory Agus Cahya Pramana Adi Sofyan Ansori, Muhammad Aeniah, Siti Agustiningsih Agustiningsih Akira Hosoyama Allimi, Hayu Swari Amalia, Nur Rofika Ayu Shinta Andi Mahendra Andrian, Krisna Noli Apriliyani, Tia Ardaning Nuriliani ARI SUSILOWATI Ariesti, Wiwin Arif Luthfi Nurul Huda Aris Haryanto Atsushi Yamazoe Aushia Tanzih Al Haq Bambang Hariwiyanto Bambang Retnoaji BUDI SAKSONO Camelia Herdini Ch. Retna Handayani Dafip, Muchamad Diani Mentari Dwi Liliek Kusindarta Dyah Widiastuti Empra, Desi Eka Putri ERLIN LISTIYANINGSIH Fajar Sofyantoro Halim, Shuha Ma’muriyah Hanbal, Mayland Muhammad Hendry Tri Sakti Saragih Hera Nirwati Heriyanto, Didik S. Hevi Wihadmadyatami Hideaki Nojiri Ibnu Agus Ariyanto Jajah Fachiroh, Jajah JAKA WIDADA Juliadmi, Dian Karlina, Ina Karnati, Srikanth Kartika W. Taroeno-Hariadi Kartika, Aprilia I. Lisna Hidayati Mei Ria Santi Michael Kann Muhammad Adnan Mumtazah, Dzul Fithria Munawir Sazali Murwantoko . Naima, Mirtani Nenny Sri Mulyani Ni Wayan Erly Sintya Dewi Nisa, Mutia Khoirun Nuhamunada, Matin Peni Indrayudha Pertiwi, Gian Aditya Pradnya Paramita Pratitis, Visi Endah Priyambada, Fajar Purnomo Hadi Pusparini, Nur Ainun Oktavia Puspitasari, Pinki Anggrahini Putra, Hendy Eka R.C. Hidayat Soesilohadi Ramadhani, Eka Rarastoeti Pratiwi Rinda Binugraheni, Rinda Rohmah, Zuliyati Saeed, Faisal Salamah, Rohmi Sari, Ria Vinola Septhya Saribu, Ruth Liananda Citra Dolok Septriani, Nur Indah Setiawibawa, Raden Aditya Aryandi Shinta Hartanto Simanungkalit, Eben Ezer Slamet Widiyanto Sofia M. Haryana Sofia Mubarika Haryana Subchan, Aditya Nur Supraitno, Murtiadi Erlan Sutaryo1 S, Sutaryo1 T. Trijoko Tasania, Nadia Nisa Titis Widowati, Titis To'bungan, Nelsiani Tri Rini Nuringtyas Tri Wibawa Triska Desi Sundari Tsabitah, Khansa Wulansari, Riska Yundari, Yundari Zulfa, Amania Zulfadhli Zulfadhli Zumrotus Sholichah Zusrina, Laili Mufli ‘Aliyah, Siti Hamidatul