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All Journal International Journal of Public Health Science (IJPHS) VALENSI Jurnal Kimia (Journal of Chemistry) Journal of Mathematical and Fundamental Sciences PROSIDING SEMINAR KIMIA Jurnal Zarah Indonesian Journal of Chemistry ad-Dawaa : Journal of Pharmaceutical Sciences Sainstech Farma: Jurnal Ilmu Kefarmasian Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Makara Journal of Science AMMA : Jurnal Pengabdian Masyarakat Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Laode Rijai
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Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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Formulasi Nanoemulsi Kombinasi Ekstrak Bunga Mawar (Rosa damascena Mill.) dan Ekstrak Umbi Bengkuang (Pachyrhizus erosus L.) Menggunakan Minyak Pembawa Virgin Coconut Oil (VCO) Oppi Yolan Destiyana; Hajrah; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 8 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.986 KB) | DOI: 10.25026/mpc.v8i1.331

Abstract

Ekstrak bunga mawar dan umbi bengkuang telah lama dimanfaatkan dalam bidang kosmetik karena dapat mencerahkan kulit sehingga agar dapat meningkatkan penetrasi dan absorpsinya melalui kulit dapat dibuat dalam bentuk sediaan nanoemulsi. Penelitian ini bertujuan untuk memformulasi kombinasi kedua ekstrak tersebut dalam sediaan nanoemulsi kemudian dilakukan karakterisasi fisik meliputi organoleptis, persen transmitan, ukuran partikel, dan pH. Nanoemulsi terdiri atas tiga komponen utama yaitu fase minyak, surfaktan dan kosurfaktan yang diformulasi menggunakan metode sonikasi. Hasil penelitian yang diperoleh adalah, formula terbaik untuk nanoemulsi kombinasi ekstrak bunga mawar dan umbi bengkuang yaitu formula dengan bahan VCO, Cremophor RH40 dan PEG 400 (2:7:1) dengan persen transmitan 95,8% , ukuran partikel 31,3 nm , indeks polidispersibilitas 0,274 dan pH 5,33.
Optimalisasi Basis Untuk Formulasi Sediaan Lip Cream Jessica; Laode Rijai; Hanggara Arifian
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 8 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.112 KB) | DOI: 10.25026/mpc.v8i1.332

Abstract

Lip cream merupakan salah satu kosmetik jenis pewarna bibir yang saat ini banyak diminati konsumen. Kualitas lip cream salah satunya dipengaruhi oleh komponen-komponen penyusun basisnya, terutama wax sebagai thickener. Tujuan penelitian ini adalah untuk memperoleh formula optimal dari basis lip cream yang memenuhi persyaratan farmasetika. Penentuan formula basis optimal lip cream dilakukan melalui variasi jumlah thickener. Penelitian ini menggunakan carnauba wax dan microcrystaline wax sebagai thickener agent. Evaluasi karakteristik basis lip cream yang dilakukan meliputi uji organoleptis, uji homogenitas, dan uji fisika kimia (daya sebar, daya lekat, viskositas dan pH), serta uji stabilitas basis lip cream menggunakan metode Freeze-Thaw selama 16 hari. Hasil penelitian diperoleh F7 (kombinasi carnauba wax dan microcrystaline wax dengan perbandingan 6% : 9 %) sebagai formula basis lip cream paling optimal. Formula F7 menghasilkan karakteristik organoleptis berwarna putih gading, berbau khas vanilin, berbentuk semipadat, dan homogen. Kemudian hasil uji karakteristik fisika dan kimia menunjukkan daya sebar 6,1 cm, daya lekat lebih dari 60 detik, nilai viskositas 18.000 cPs dan nilai pH 4,38. Formula F7 juga stabil terhadap pengaruh perubahan suhu selama 16 hari.
Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Ekstrak Biji Ramania (Bouea macrophylla Griff) dengan Asam Oleat (Oleic Acid) sebagai Minyak Pembawa Vinny Indriani; Novita Eka Kartab Putri Tobing; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 8 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.87 KB) | DOI: 10.25026/mpc.v8i1.334

Abstract

Ekstrak biji B.macrophylla memiliki aktivitas antioksidan yang kuat namun memiliki kelarutan dan bioavailabilitas yang rendah. Meningkatkan efektivitas ekstrak biji B.macrophylla dilakukan dengan memformulasikan ke dalam sistem SNEDDS menggunakan Asam Oleat sebagai minyak pembawa. Hasil penelitian menunjukkan bahwa komposisi formula SNEDDS ekstrak biji B.macrophylla yang paling optimal terdiri dari kombinasi tween 20 : propilenglikol : asam oleat (0,5 : 3 : 1,5 dan 0,5 : 3,38 : 1,12) dalam 5 mL yang memiliki emulsification time dengan rerata waktu 19,03 detik dan 15,2 detik; nilai transmitansi 92,8% dan 94,2%; ukuran tetesan 176,8 nm dan 161,1 nm; polidisperse index 0,357 dan 0,364; serta nilai nilai IC50 ektrak biji B.macrophylla 1,757 ?g/mL.
Gambaran Hasil Aktivitas Antioksidan Berberapa Perlakuan Teknik Preparasi Pembuatan Konsentrasi Ekstrak Kulit Buah Nanas (Ananas comosus L.Merr) Menggunakan Senyawa DPPH (1,1-diphenyl-2-picrylhydrazyl) syarifah maryam alaydrus; Wahyu Widayat; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (464.05 KB) | DOI: 10.25026/mpc.v10i1.365

Abstract

Pineapple skin (Ananas comosus L.Merr) has been known to have a category of strong antioxidant activity against reducing DPPH compounds (1,1-diphenyl-2-picrylhydrazyl). However, references to the preparation process of extract concentration making and the treatment of DPPH compounds to extracts are not much elaborated, so that it can cause errors in inferring the category of antioxidant activity. The purpose of this study was to determine the results of antioxidant activity through the treatment of preparation techniques for the concentration of pineapple peel extract concentration. Pineapple peel extract (Ananas comosus L. Merr) was prepared by maceration method using 70% ethanol solvent. Testing of antioxidant activity was carried out using the UV-Vis spectrophotometric method at a wavelength of 516.4 nm. The extract concentration to be tested was 500 ?g/mL, 250 ?g/mL, 125 ?g/mL, 62.5 ?g/mL and 31.25 ?g/mL and the concentration of DPPH compounds (1,1-diphenyl-2-picrylhydrazyl) was 45 ?g/mL. Treat the extract making concentration divided into 3 namely P1 (multilevel dilution with a volume ratio of 1: 1) P2 (normal dilution with a volume ratio of 1: 1) and P3 (DPPH solution is used to suffice the volume of the extracted test extract). The results of percent inhibitors from each treatment of making concentrations showed P1 <P2, P1 <P3, P2 <P3, and IC50 of each treatment were P1 268.07 ?g/mL, P2 was 231.28 ?g/mL, P3 was 78.403 ?g/mL. Based on the results of IC50 P3 gives the category of antioxidant activity that is 78,403.Keywords: pineapple fruit skin (Ananas comosus L. Merr), antioxidants, dpph (1,1-diphenyl-2- picrylhydrazyl), dilution.
Skrining Fitokimia Ekstrak Etanol Kulit Nanas (Ananas comosus (L.) Merr) Inul Ahmanda Reiza; Laode Rijai; Febrina Mahmudah
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (486.138 KB) | DOI: 10.25026/mpc.v10i1.371

Abstract

Pineapple (Ananas comosus (L.) Merr) is one type of fruit that is in demand by the community, both local and world. Pineapple has a waste part that is skin. Pineapple skin in Indonesia is generally just thrown away as waste, whereas pineapple skin contains chemical compounds that are known to have properties. The purpose of this study was to determine secondary metabolite compounds found in pineapple skin. This type of research is descriptive qualitative. Then the method used is phytochemical analysis. The Positive test of this method is characterized by a change in color. Pineapple skin samples were taken from Samarinda, East Kalimantan. The extract was carried out by maceration of dry samples using 96% ethanol solvent. The results of the pineapple skin extraction are then carried out phytochemical screening tests using certain reagents. Phytochemical screening tested included flavonoids, alkaloids, steroids, triterpenoids, tannins, phenolics, and saponins. Based on the results of phytochemical screening research, positive pineapple skin extracts contain flavonoids, alkaloids, tannins, and saponins, while negative results contain phenolic compounds, steroids, and triterpenoids.
Kandungan Metabolit Sekunder Tempe Kacang Merah (Phaseolus vulgaris) Lita Nur Hanifa; Sabaniah Indjar Gama; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 10 (2019): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.37 KB) | DOI: 10.25026/mpc.v10i1.375

Abstract

Soybean is a bean that is basically used as raw material for making tempeh, but the need for soybeans is not balanced with the amount of production in Indonesia. Therefore it is necessary to study the secondary metabolites needed in red bean tempeh (Phaseolus vulgaris) for alternatives to soybeans as another raw material from non-soy beans produced from Indonesia. The purpose of this study was to determine the content of secondary metabolites present in red bean tempeh. Samples were obtained from the Sulawesi region. The analytical method used in this study are qualitative submitting flavonoids, alkaloids, terpenoids, tannins, and saponins. The results obtained from studies that have been carried out namely red bean tempeh are proven to have all the composition of secondary metabolites with the exception of saponins.
Optimasi Basis Hand Sanitizer Gel Richardus Rayendra Euriko; Sabaniah Indjar Gama; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (942.856 KB) | DOI: 10.25026/mpc.v12i1.406

Abstract

Optimasi basis hand sanitizer gel merupakan upaya untuk menemukan formula basis gel yang optimum secara fisiko-kimia. Penelitian ini bertujuan untuk mengetahui konsentrasi basis hand sanitizer gel yang optimum. Hand sanitizer gel dibuat dalam tiga formula dengan tiga konsentrasi Carbopol 940 yang berbeda yaitu A,B dan C. Basis gel yang digunakan yaitu Carbopol 940. Optimasi basis gel meliputi evaluasi organoleptik, homogenitas, pH, daya sebar, daya lekat dan viskositas. Optimasi dilakukan selama 7 hari. Penelitian ini merupakan eksperimental laboratorium. Hasil yang diperoleh pada evaluasi uji organoleptik adalah diamati warna yang bening, bentuk sediaan semisolid dan bau Carbopol 940. Uji homogenitas untuk mengetahui homogenitas gel dengan tidak adanya butiran kasar yang tidak terlarut, Uji pH diperoleh yaitu pH sediaan gel yaitu stabil pada pH 7. Uji daya sebar diperoleh kisaran diameter yaitu 5,3-5,7 cm. Uji daya lekat diperoleh hasil yaitu lebih dari 1 detik dan memenuhi kriteria sediaan gel. Uji viskositas menunjukan viskositas gel berada pada kisaran 1.206 cps - 1,820 cps. Hasil evaluasi basis handsanitizer gel yang optimum diperoleh jika memiliki kualitas fisik yang baik dan memenuhi kriteria sediaan gel. Berdasarkan hasil evaluasi pada optimasi basis handsanitizer gel diperoleh basis gel Carbopol 940 dengan konsentrasi A telah memenuhi kriteria pembuatan sediaan gel.
Kajian Penggunaan Obat Insomnia sebagai Penyakit Penyerta pada Salah Satu Rumah Sakit Khusus Daerah di Kalimantan Timur Serly Monika Putri; Laode Rijai; Risna Agustina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2304.475 KB) | DOI: 10.25026/mpc.v12i1.415

Abstract

Insomnia is a sleep disorder such as dissatisfaction with sleep quality, difficulty in sleeping and maintaining sleep, causing physical and emotional symptoms that affect performance and also cognitivity. The existence of mental disorders such as depression, fatigue and anxiety which culminate in insomnia so that a person does not sleep soundly. The purpose of this study is to determine the characteristics, variations of the diseases that cause insomnia, drug use, and drug interactions that occur. The research method used an observational retrospective method by tracing medical record data at a special regional hospital in East Kalimantan with a total sampling technique during 2019. The results obtained for characteristic data that insomnia was greater for women (57%) at the age of 56-65 years (40%) with primary and junior high school education (30%) who do not work (77%) and who do not have a history of disease (93%) and insomnia due to anxiety (94%). For the variation of insomnia, based on the causes and history of the disease, whether there is anxiety disorder or anxiety. Treatment is done with 87% single therapy, namely using the drugs Alprazolam (8%), Clozapine (41%), Fluoxetine (4%), Risperidone (8%), Lorazepam (8%), Diazepam (11%), Zolpidem tartrate (4%), Amitripthyline (4%), Clonazepam (4%), and Clorpromazin (8%) while 13% uses 2 combination of drug therapy is using combination of Fluoxetine and Amitripthyline (25%), Clozapine and Sertraline (50%), and Maprotiline hydrochloride and Clobazam (25%). The potential interactions are entirely pharmacokinetic interactions of the metabolic phase with major severity of 75% and moderate severity of 25%.
Formulasi Sediaan Lip Cream dengan Pewarna Alami Ekstrak Buah Senggani (Melastoma malabathricum L.): Lip Cream Formulation with Natural Coloring Senggani Fruit Extract (Melastoma malabathricum L.) Khoiriyah Anbar Mufidah; Febrina Mahmudah; Laode Rijai
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (269.416 KB) | DOI: 10.25026/mpc.v13i1.451

Abstract

Senggani (Melastoma malabathricum L.) is a wild plant that has anthocyanin compounds which are red, purple and blue pigments in plants that can be used as natural dyes. So, to increase the use value of the senggani plant, senggani fruit extract is used as a natural coloring agent in lip cream preparations. Senggani fruit was extracted, then formulated. The quality of the preparation is determined through evaluation of physical characteristics (organoleptic test, homogeneity test, dispersion test, adhesion test, viscosity test and pH test), physical stability test (freeze thaw method and room temperature) for 16 days, evaluation of the safety of the irritation test (method patch test) and acceptability (hedonic test method). The results obtained were the lip cream preparation formula using senggani fruit extract with a concentration of 5%, 10%, and 15% producing purple, reddish purple, and purplish red colors, respectively. The results of the evaluation of the physical characteristics of all preparations included the aroma of rose flowers, semisolid consistency, homogeneous and has a viscosity, dispersibility, adhesion, and pH that meet the pharmaceutical requirements of lip cream preparations. The results of the physical stability test of the three formulas showed that all preparations were stable, with organoleptic, homogeneity, pH, and viscosity that met the range and there was no phase separation. The results of the irritation test of the preparations showed that the preparations did not irritate and the results of the acceptability of the preparations in terms of color and texture of the preparations were preferably panelists at a concentration of 10% and in terms of aroma, preferably panelists at a concentration of 5%.
Analisis Perubahan Kadar Sianida dan Aktivitas Sitotoksik pada Umbi Singkong Segar yang Diolah Menjadi Tape: Analysis of Changes in Cyanide Levels and Cytotoxic Activity in Fresh Cassava Tubers Processed into Tape Rahmat Budiman; Laode Rijai; Erwin Samsul
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.847 KB) | DOI: 10.25026/mpc.v13i1.459

Abstract

Cassava in Indonesia is the third staple food after rice and corn. In addition, cassava can also be used as a process for other food products such as cassava tape, cassava crackers, opak, getuk, tapioca flour and cassava ejects. Besides containing carbohydrates, cassava also contains cyanide which is a poisonous compound. Cyanide acid is able to cause respiratory distress to death by inhibiting the performance of the respiratory enzymes, causing disturbances in the respiratory system. This study aims to determine changes in cyanide levels and cytotoxic activity in cassava tuber preparations. Qualitative analysis was performed using FeCl3 and AgNO3 reagents, quantitative tests used argentometric titration method. Meanwhile, the cytotoxic test used the Brine Shrimp Lethality Test (BSLT) method. The cyanide content test results obtained in fresh cassava were 41,56 mg, which was categorized as quite toxic, the toxicity level of fresh cassava was classified as toxic, namely 505.82 ppm. Whereas on the processed tape, the test results showed negative results containing cyanide. Cassava tuber cytotoxic test is classified as non-toxic, which is equal to 4216.96 ppm.
Co-Authors Aan Qanitina Hanif Adam M. Ramadhan Ade Purnama Septiani Aditya Fridayanti Aditya Fridayanti Adzimahtinur Pradawahyuningtyas Almeida, Maria Andi Berbi Ollan Yunus Andi Nurazmi Andini Eka Bahari Putri Anintia Nitami Faradillah Anisha Putri Anjanie Medyawati Utami Annisa Anugrah Putri Annisa Mercury Ardella Safilla Arief Fadillah Arniah Arniah Arsyik Ibrahim Aryanti Aryanti Ayu Ulfa Sari Bohari Yusuf Chairunnisa Arbain Claudea Ersamy Janafrish Deasy Novia Sari Defriana Defriana Delti Delaya Busa Desire Janetha Asdedi Destri Erawaty Desy Aulia Rahmah Desy Triary Sandi Dewi Maimunah Dewi Mayasari Dewi Nurmashita Dewi Rahmawati Dimas Aqil Fikrinda Dina Sofia Djoko Setyadi Dyera Wahyu Heraningtyas Eka Rizky Meilinda Emil Bahtiar Erwin Samsul Ester Melenya Looys Nababan Euis Julaeha Eva Hairdiana Umar Fadhli Nurrahman W Fahrul Rozi Fajar Prasetya Fatma Sari Fauziah Halimatussa’diah Febrina Mahmudah Femy Linggi Allo Fika Aryati Firzan Nainu Fisi Karimah Khoirunnisa Fitri Rhamadhani Fitriani Fitriani Florensius Rinaldi F Fush Shilat Jibalathuull Hadi Kuncoro Hajrah Hajrah Hajrah Hajrah Hanggara Arifian Hardian Hardian Hardiana Sepryanti Palinoan Hariati Hariati Helmi Helmi Herliani Herliani Herliani Herliani Herman Herman Hidayat Hidayat Hifdzur Rashif Rijai Hifdzur Rashif Rija’i Husein Hernadi Bahti Iffah Karina Ghassani Indah Puspa Dewi Indri Verrananda M Inul Ahmanda Reiza Islamudin Ahmad Iswahyudi Iswahyudi Jaka Fadraersada Jeny Maryani Liu Jessica Jumiati Catur Ningtyas Junaidin Junaidin Jusmiati Jusmiati Kartika Damasanti Mamonto Khoiriyah Anbar Mufidah Kiki Argananta Kiki Nur Azizah Hidayatul Fitria Kindi Farabi Kusnul Nurhidayah Lia Puspitasari Lilis Pania Anugrah Lisna Meylina Lita Nur Hanifa Lizma Febrina M Arifuddin M. Arifuddin Mahfuzun Bone Marlyan Bone Maya Apriliani Maziyyah Husna Mega Silvia Meilisa Athiyah Meilita Efliana Mira Susanti Mirhansyah Ardana Muhammad Rasyid Indrawan Mukti Priastomo Nadia Rahma Kusuma Dewi Nia Oktaviani Ninin Kartika Ulfa Nisa Naspiah Novalia Debora Novalinda Novalinda Novita Eka Kartab Putri Novita Sari Nunuk Hidayanti Nur Masyithah, Z Nur Mita Nur Shidiq Nurul Annisa Nurul Fitriani Nurul Hasanah Oktaviany Triana Oppi Yolan Destiyana Pasuria Panjaitan Petrina Febrianti Pindo Hardika P.A.N Puji Rahayu Putri Anggraeni Putri Purnamasari Rafika Hasdina Rahmadani, Agung Rahmat Budiman Rama Febryanto Rania Afifa Yasmin Raudhatul Munawassalmiah Richardus Rayendra Euriko Rina Adilla Akmalia Ririn Novriyanti Risa Yusnita Riska Harfiani Junaid Risna Agustina Rohani Rohani Rolan Rusli Ruli Kuswati Rullah Hermanda Rusdi, Muhammad Alhimni Rymond Jusuf Rumampuk Santy Dara Krisnawati Selvi Jumiatul Astati Serly Monika Putri Sibarani Evy Morita Siti Aisyah Siti Hardiyanti Siti Hasanah Siti Ulfah Hidayah Sri Andriani Allo Bulawan Sri Indah Mulyawan Dewi Sulistiarini, Riski Supriyatna Sutardjo Susan Susan Syarifah Hudaya syarifah maryam alaydrus Tari Maulidina I.P Tetra Hidayat Tias Puspita Sari Tina Dwi Rahayu Unang Supratman Vendryca Reckow Venna Shintary VICTORIA YULITA FITRIANI Vika Aura Rislianti Vilca Veronica Hasiani Vina Maulidya Vinny Indriani Vinny Sukma Wijayana Putri W.C. Taylor Wahyu Widayat Welinda Dyah Ayu Whenny Whenny Wijaya, Viriyanata Wisnu Cahyo Prabowo Wulan Maulida Yiska Priscilla Septilita Yoshihito Shiono Yuniarti Pudji Rahayu Yuspian Nur Yuyun Arlita