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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Harmoni Sosial: Jurnal Pendidikan IPS Folia Medica Indonesiana Jurnal Terapan Abdimas Jurnal Farmasi Sains dan Komunitas Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Syntax Literate: Jurnal Ilmiah Indonesia Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Ilmiah Cendekia Eksakta Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat Multidisiplin Jurnal Kajian Ilmiah Prima Abdika: Jurnal Pengabdian Masyarakat Journal La Lifesci Journal of Instructional Mathematics Jurnal Penelitian Inovatif Indo-MathEdu Intellectuals Journal Journal Of Human And Education (JAHE) Duta Pharma Journal Journal of Food and Pharmaceutical Sciences Jurnal Farmasi Galenika Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Contemporary Education and Community Engagement
Kintoko Kintoko
Prodi Magister Pendidikan Matematika, Pascasarjana, FKIP – UNS
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Antioxidant Activity and Lipid Content of Aurantiochytrium sp. from Raja Ampat and Kepulauan Seribu Witasari, Hardi Astuti; Kintoko, Kintoko; Mahfudh, Nurkhasanah; Suhendra, Suhendra; Rangkuti, Ahmad Faizal; Ilmia, Nisrien; Santoso, Blegoh Iwan; Hutari, Andri
Squalen, Buletin Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 20, No 2 (2025): August 2025
Publisher : :Agency for Marine and Fisheries Research and Human Resources, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/squalen.1015

Abstract

Raja Ampat (Southwest Papua Province) and Kepulauan Seribu (Jakarta Raya Province) are part of Indonesia#39;s territory, which includes the mangrove forest area. This habitat supports a diverse array of animals, plants, and microalgae, including Aurantiochytrium sp. It has antioxidant activity related to lipid content. This study aims to identify the lipid content and the antioxidant effects of the microalgae Aurantiochytrium sp.’s extract isolated from the mangrove forest areas of Raja Ampat and Kepulauan Seribu. The extraction process was conducted using the Folch method, which involves a 2:1 (v/v) chloroform-methanol solvent ratio. The microalgae Aurantiochytrium sp. extract of Raja Ampat (MAERA) and microalgae Aurantiochytrium sp. extract of Kepulauan Seribu (MAEKS) were analyzed using GC-MS, antioxidant potential tested in silico by target proteins (5ZLG, 2A1X, 3VLN, and 1EEM) using Autodock Tools, and in vitro by DPPH and ABTS radicals and the carotenoid bleaching method. The results showed that total squalene and fatty acids in MAERA and MAEKS were at different levels. Squalene as a ligand had the lowest binding energy (-9.4, -6.6, -7.7, and -6.5) compared to the native ligand (-5.6, -4.4, -5.2, and -5.2) and ascorbic acid (-5.6, -4.8, -5.3, and -4.9) by in silico antioxidant activity. The in vitro antioxidant activities by DPPH, ABTS, and ß-caroteen bleaching were 103.00 ± 3.75, 216.39 ± 367, 214.62 ± 7,07 (MAERA); and 131.85 ± 23.48, 225.50 ± 3.36, 251.69 ± 5.39 (MAEKS) were not significantly different (pgt;0.05) by all methods. These findings showed that the Aurantiochytrium sp. strains Raja Ampat and Kepulauan Seribu contained diverse levels of fatty acids and squalene. In the in silico study, squalene was evaluated and in vitro, the MAERA and MAEKS extracts showed moderate antioxidant activity.
Pemberdayaan Perempuan Melalui Kelompok Wanita Tani Sunanti, Titis; Aviory, Koryna; Kintoko, Kintoko; Nuryani, Eva; Gunawan, Gunawan; Widyaningsih, Nina
Journal Of Human And Education (JAHE) Vol. 4 No. 1 (2024): Journal Of Human And Education (JAHE)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jh.v4i1.629

Abstract

Kelompok tani di dusun Ngentak dianggap mampu berperan penting dalam kehidupan keluarga dan bermasyarakat. Pendampingan pada kelompok ini sangat diperlukan agar dapat memberikan pengetahuan dan menjaga motivasi kelompok untuk meningkatkan kapasitas usaha. Tujuan kegiatan ini adalah meningkatkan peran kelompok wanita tani untuk mendorong para wanita tani mengelola sebuah organisasi dan meningkatkan kapasitas usaha dalam pertanian. Kegiatan ini sebagai sarana untuk belajar dan menyelesaikan permasalahan secara bersama-sama. Harapannya, kelompok ini dapat berkembang dan bertanggung jawab terhadap segala aktivitas sehingga dapat memberikan manfaat bagi para anggota dan lingkungan sekitar. Pendekatan yang digunakan dalam kegiatan ini adalah PRA (Parcitipatory Rural Appraisal). Pendekatan ini melibatkan seluruh anggota kelompok wanita tani untuk memahami masalah dan meningkatkan partisipasi anggota kelompok untuk menyelesaikan masalah mereka sendiri. Berdasarkan angket penilaian kebermanfaatan kegiatan menunjukkan bahwa kegiatan pengabdian ini sangat bermanfaat bagi anggota kelompok sasaran. Kegiatan pengabdian ini diawali dengan kegiatan peningkatan kapastitas kelompok, kemudian pelatihan budidaya tanaman hortikultur, dan pelatihan pembuatan likat kuning serta pendampingan kelompok usaha.
Potential Applications and Active Substances of Lavender Essential Oil as An Anti-Hypertension: Narrative Literature Review Setyawan, Aris; Kintoko, Kintoko
Indonesian Journal of Global Health Research Vol 6 No 4 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i4.3518

Abstract

Hypertension is one of the Cardiovascular Diseases (CVD) which is the highest cause of death, and current treatment has many side effects that can be life-threatening, so researchers are interested in providing safe treatment solutions. One of them is traditional medicine such as aromatherapy. Therefore, it is necessary to carry out narrative research in the literature reviewing the effectiveness of lavender aroma therapy in reducing blood pressure in hypertensive patients. This research uses a Narrative Review study approach which focuses on evaluating several previous research results related to the topic. Based on data used by Google Scholar, Pubmed, and Spinger between 2019 and 2024. A total of 1,394 articles were found in the initial search stage, after filtering based on title, keywords and abstract this was reduced to 10 articles. And finally only 4 articles were selected that fit the criteria. There were 2 types of lavender aromatherapy applications, namely topical and inhalation. As well as two anti-hypertension active substances, namely linalool and linalool acetate. Lavender aromatherapy is effective in lowering blood pressure in hypertensive patients. The mechanism of reduction can be explained by the active anti-hypertensive substance (linalool & linalool acetate) and its application (inhalation & topical). However, further research with better designs is still needed.
Combination of Spirulina platensis powder and Stichopus variegatus powder against Bcl2 expression in the hippocampus of dementia Rats Botutihe, Lisa Agustina; Safira, Rizka; Yuliani, Sapto; Kintoko, Kintoko
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.26205

Abstract

Spirulina (Spirulina platensis) and golden sea cucumber (Stichopus variegatus) are known to have antioxidant activity that has the potential to prevent neurodegeneration disease. The aim of this study was to examine the effect of the combination of spirulina and golden sea cucumber on Bcl2 gene expression in pyramidal hippocampus cells of trimethyltin-induced dementia (TMT) rats. The study used Sprague Dawley rats  which were divided into 6 groups, namely the normal control group (CMC-Na and NaCl 0.9%), pain control (CMC-Na and TMT), positive control (citicoline dose 200 mg / kg and TMT) and test control injected with TMT and given a combination of spirulina and golden sea cucumber dose 200 mg/KgBB with three ratios namely 3: 1, 1: 1 and 1: 3. Extract and citicoline were given on day 1 to day 28, while TMT injection was given a single dose of 8 mg/KgBB on day 8. On the 36th day the rats were sacrificed, brains were removed and the right hemispherium cerebri was fed to 10% formalin in pbs. After 6 days the hippocampus was separated for immunohistochemical observation. The test result data was statistically analyzed with a one-way ANOVA test then followed by post hoc tukey to see the differences between groups. Results showed the combination of spirulina and golden sea cucumber can increase the expression of the Bcl2 gene in the hippocampus. The combination of spirulina and golden sea cucumber (ST1: 3) dose of 200 mg / kg body weight was able to increase hippocampus Bcl2 expression with the number of Bcl2 cell expression almost the same as citicoline in both CA1 and CA2-CA3 regions.
Kajian Literasi Etnomedisinal Dan Fitokimia Terhadap Potensi Terapi Poliherbal Pada Gastritis Kintoko, Kintoko; Desmayanti, Astri
JURNAL FARMASI GALENIKA Vol 10 No 1 (2023): Jurnal Farmasi Galenika Vol 10 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v10i1.246

Abstract

Saluran pencernaan merupakan salah satu organ terpenting dalam tubuh manusia dan rentan terhadap berbagai penyakit, salah satunya adalah gastritis. Gastritis merupakan suatu kondisi meradangnya lapisan mukosa lambung yang menyebabkan sakit perut, dispepsia, kembung dan mual. Kejadian gastritis di Indonesia cukup tinggi dengan prevalensi 274.396 kasus dari 238.452.952 jiwa. Obat yang tersedia seringkali memiliki kemanjuran yang rendah dan juga adanya efek samping. Obat-obatan sintetis ditemukan relatif lebih mahal dan menghasilkan banyak efek samping yang tidak diinginkan meskipun tindakan farmakologisnya kuat. Berdasarkan Literature Ayurveda, konsep poliherbalisme dipakai untuk mencapai kemanjuran terapeutik yang lebih besar. Konstituen fitokimia aktif dari masing-masing tanaman tidak cukup untuk mencapai efek terapeutik yang diinginkan, sehingga menggabungkan beberapa herbal dalam rasio tertentu akan memberikan efek terapi yang lebih baik dan mengurangi toksisitas. Kajian literasi ini terutama berfokus pada pentingnya poliherbalisme dan signifikansi klinis dalam pengobatan gastritis. Beberapa informasi etnomedisin dan fitokimia dari beberapa tanaman obat dikumpulkan dan akan dijadikan landasan dalam formulasi obat poliherbal. Sehingga obat poliherbal bisa dijadikan terapi penunjang yang aman dan efektif untuk gastritis ke depannya
Effectiveness of the Combination of Spirulina platensis and Stichopus variegatus on Prevention of Caspase-3 Gene Expression of Dementia Rat Models Safira, Rizka; Botutihe, Lisa Agustina; Yuliani, Sapto; Kintoko, Kintoko
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006051

Abstract

The death of cells in the brain, especially the hippocampus, manifests in a decrease in memory, language, and behavior. Golden sea cucumber (Stichopus variegatus) andblue-green algae (Spirulina platensis) are reported to have high antioxidant content which has the potential to prevent cell death in the brain due to oxidative stress thereby preventing memory decline.This study aimed to investigate the effect of the combination of Stichopus variegatus and Spirulina platensis on preventing caspase 3 gene expression in pyramidal hippocampal cells in a rat model of trimethlytin-induced dementia (TMT). This study used Sprague Dawley rats, about 2 months old, weighing 180-200 g, divided into 6 treatment groups, with each group consisting of 8 rats. The hippocampus was taken from the right cerebral hemisphere for histological observations of pyramidal caspase-3 gene expression in the CA1 and CA2-CA3 regions.The combination of Spirulina platensis and Stichopus variegatus with a dose 200 mg/kg BB can prevent the expression of caspase-3 in the CA1 and CA2-CA3 areas of the hippocampus. Conclusion: The combination of spirulina and golden sea cucumber extracts has the potential to prevent caspase 3 gene expression in pyramidal cells of TMT-induced dementia rat models. 
Pendampingan Pelaksanaan Proyek Penguatan Profil Pelajar Pancasila (P5) dengan Tema Kearifan Lokal Kintoko, Kintoko; Rohmah, Lely Arbiati Nur; Warniasih, Kristina
Prima Abdika: Jurnal Pengabdian Masyarakat Vol. 3 No. 4 (2023): Volume 3 Nomor 4 Tahun 2023
Publisher : Program Studi Pendidikan Guru Sekolah Dasar Universitas Flores Ende

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/abdika.v3i4.3340

Abstract

The Pancasila Student Profile is one of the efforts that is expected to improve the quality of education in Indonesia, one of which is by developing the character of students. Character development is very necessary for students to build highly intellectual people. The media used to develop student character is the implementation of the Pancasila Student Profile Strengthening Project. This service aims to provide insight and description of the implementation of the Strengthening Pancasila Student Profile (P5) Project with the theme of local wisdom in junior high schools to realize the implementation of the independent curriculum. This service activity method is carried out through observation and mentoring. The results of the activity show that students' knowledge about the local wisdom of traditional games in the surrounding area has increased and the moral character of students in junior high school can also be developed.
Fermentasi Poliherbal TBR Terhadap Kandungan Flavonoid Total dan Aktivitas Antioksidan serta Berat Badan Secara In Vivo Atmarani, Rizki Essa; Kintoko, Kintoko; Sulistyani , Nanik; Taufik, Epi
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i3.57968

Abstract

Minuman fermentasi diketahui memiliki efek yang dapat meningkatkan kadar flavonoid total dan antioksidan,serta dapat mempengaruhi berat badan yang disebabkan oleh reaksi dari bakteri asam laktat. Antioksidan pada tanaman, Taxus Sumatrana (cemara sumatra), bajakah jixueteng (spatholobus suberectus) dan rumput mutiara (Hedyotis corymbosa) dilaporkan memiliki kandungan flavonoid total dan kadar antioksidan tinggi. Penelitian ini bertujuan untuk membuat sediaan minuman fermentasi poliherbal,serta mengukur kadar flavonoid total dan antioksidan Yoghurt Polihrerbal TBR (3:1:1) serta mengetahui pengaruhnya terhdap penurunan berat badan dan indeks organ hewan uji. Metode ekstraksi yang digunakan dalam penelitian ini adalah metode maserasi dengan menggunakan pelarut etanol 96% selama 1x24 jam, selanjutnya dilakukan pengujian flavonoid total menggunakan baku standar kuersetin, setelah itu difrementasi menggunakan Bakteri Asam Laktat (BAL) dengan konsentrasi ekstrak TBR (3:1:1) 1%, 2% dan 3% , lalu pengujian antioksidan dengan metode ABTS serta pengukuran berat badan dan indeks organ pada tikus putih (Rattus novergicus) dengan 7 kelompok perlakuan berbeda. Analisis data penelitian ini menggunakan data komputasi dan statistik menggunakan softwere SPSS VER 2.0.
Efektivitas Model Pembelajaran Think Talk Write (TTW) Terhadap Kemampuan Literasi Numerasi Matematika Siswa Kelas VIII Oktavia, Lisa; Susetyawati, MM Endang; Kintoko, Kintoko
Indo-MathEdu Intellectuals Journal Vol. 5 No. 1 (2024): Indo-MathEdu Intellectuals Journal
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v5i1.761

Abstract

The TTW learning model is a discovery model which includes thinking, speaking, and writing activities. This research was conducted with the aim of seeing the effectiveness of the TTW learning model in terms of the mathematics numeracy literacy abilities of class VIII students. This quantitative research uses a Quasi Experimental method with a one group posttest design. The population in this study were all class VIII students of SMP N 1 Bambanglipuro. The technique used is simple random sampling to determine the control class and experimental class. Class VIIIF has 27 students as the control class and class VIIIA has 27 students as the experimental class
Analisis Deskriptif Kompetensi Pedagogis Calon Guru: Membangun Pondasi Pendidikan yang Kuat Susetyawati, MM. Endang; Kintoko, Kintoko
Indo-MathEdu Intellectuals Journal Vol. 6 No. 1 (2025): Indo-MathEdu Intellectuals Journal
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v6i1.2480

Abstract

Effective lesson planning can guide the teaching and learning process to become more efficient, provide relevant learning experiences tailored to students' needs, and ensure the achievement of learning objectives. This study aims to analyze the ability of prospective elementary school teachers in designing lesson plans and implementing lessons in elementary schools. This research employs a descriptive qualitative approach, focusing on teacher certification program (PPG) participants who are prospective elementary school teachers. Data were collected through an analysis of lesson planning documents and classroom observation of lesson implementation. The data analyst technique is carried out with three steps of qualitative data analysis in the form of data reduction, data presentation and verification or drawing conclusions. The findings indicate that prospective elementary school teachers are capable of preparing well-structured lesson plans and executing lessons effectively according to their plans. This study suggests that both prospective and active teachers should continuously improve their pedagogical competence to support the success of the teaching and learning process in elementary schools.
Co-Authors Ananda, Aghnia Nabila Anggraeni, Linda Suci Aris Setyawan Astuti, Andarweni Atmarani, Rizki Essa aviory, koryna Ayu Shabrina Botutihe, Lisa Agustina Cahayani, Devita Mika Dani Kusuma Desmayanti, Astri Dhian Arista Istikomah Dian Aprilia, Dian Dona, Suzana Dwi Utami Epi Taufik Fajar Fajar Farid , Muhammad Ferani Mulianingsih Gunawan Gunawan Gunawan, Adhi Hadi Siswanto, Deny Hardi Astuti Witasari Hayatus Sa`adah, Hayatus Hutari, Andri Ilmia, Nisrien Indahsari, Kharisma Safitri Nur Isnaini Isnaini Jana, Padrul Khrisna Agung Cendekiawan, Khrisna Agung Kusumo, Djati Wulan Lestariningrum, Wahyu Titis Maghfirah, Yolanda Sajjida Makati, Annisa Camellia Mehta, Kunal Mochammad Saiful, Bachri Muhammad Iqbal Birsyada Muldiyana, Tya Mustofa Ahda Mutti, Annisa Aulia Nanik Sulistyani Nina Widyaningsih, Nina Nining Sugihartini Novitasari, Putri Rachma Nurkhasanah Mahfudh Nurlita, Tasya Nuryani, Eva Oktavia, Lisa Pulhehe, Hasni Rangkuti, Ahmad Faizal Ranti, Imaniar Restu Ayu Mumpuni, Restu Ayu Ridho, Anisa Rifka Rifki Febriansah Rohma, Siti Rohmah, Lely Arbiati Nur Rukaya, Benazir Evita Safira, Rizka Santoso, Blegoh Iwan Sapto Yuliani Saputri, Ginanjar Zukhruf Septian Aji Permana Setiyawati, Fitri Indah Siswanto, Deni Hadi Siswanto, Deny Hadi Siswanto, Eka Sri Wulandari Suhendra Suhendra Sulistyani , Nanik Sunanti, Titis Supomo Supomo Suryaningsih, Andri Susetyawati, MM Endang Susetyawati, MM. Endang Susetyowati, MM Endang Tri Puspita Yuliana Urmatul Waznah Utami, Febri Wahyuni, Dina Warniasih, Kristina Widyaningrum, Rachmawati Wuryandari, Tutik Wuryandari, Tutik Yanti, Asti Afrida Yuli Nurullaili Efendi, Yuli Nurullaili Yulianto Yulianto Yuni Suprapto, Yuni