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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Harmoni Sosial: Jurnal Pendidikan IPS Jurnal Terapan Abdimas Al-Jabar : Jurnal Pendidikan Matematika Jurnal Farmasi Sains dan Komunitas Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Syntax Literate: Jurnal Ilmiah Indonesia Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Pharmacoscript Jurnal Ilmiah Cendekia Eksakta Indonesian Journal of Global Health research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Multidisiplin Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kajian Ilmiah Prima Abdika: Jurnal Pengabdian Masyarakat Journal La Lifesci Jurnal Penelitian Inovatif Indo-MathEdu Intellectuals Journal International Journal of Islamic and Complementary Medicine Journal Of Human And Education (JAHE) Jurnal Bakti Untuk Negeri Duta Pharma Journal Jurnal Katalisator Journal of Food and Pharmaceutical Sciences Riemann : Research of Mathematics and Mathematics Education Journal of Educational Research and Practice Jurnal Farmasi Galenika Contemporary Education and Community Engagement JI-KES (Jurnal Ilmu Kesehatan) Folia Medica Indonesiana
Kintoko Kintoko
Prodi Magister Pendidikan Matematika, Pascasarjana, FKIP – UNS
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Place-based ethnomathematics for early numeracy: Geometric representations from the tugu pahlawan monument in Surabaya Yustitia, Via; Kintoko, Kintoko; Pamungkas, Megita Dwi; Wijayanti, Septiana
Al-Jabar: Jurnal Pendidikan Matematika Vol 16 No 2 (2025): Al-Jabar: Jurnal Pendidikan Matematika
Publisher : Universitas Islam Raden Intan Lampung, INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/ajpm.v16i2.29234

Abstract

Purpose: This study aims to understand how the cultural elements of Surabaya’s Tugu Pahlawan Monument can be used to introduce basic numeracy in primary school, especially concepts related to plane geometry. The goal is to show that cultural landmarks can offer real and relatable examples for young learners. Method: The research was conducted through a qualitative ethnographic approach. The researcher observed the monument directly, spoke with on-site guides and staff who were familiar with its history, and documented various architectural and visual features. All information gathered from notes, photographs, and short interviews was analyzed using the Miles and Huberman framework to identify patterns that relate to mathematical ideas. Findings: The study found that many parts of the monument display clear geometric forms. These include rectangles, squares, circles, triangles, trapezoids, rhombuses, and even a ten-sided figure. Such shapes appear in the floor patterns, plaques, murals, decorative ornaments, museum structures, and the wheels of military displays. Each of these elements can be directly connected to geometry topics taught in primary classrooms. Significance: The findings highlight the potential of local heritage as a meaningful resource for mathematics education. When students see that the shapes they learn in class appear in a monument tied to their own city’s history, mathematical concepts become easier to grasp and more engaging. This approach supports early numeracy while also helping learners build a stronger connection to their cultural environment.
Emulgel Formulation of Purified Extract of Moringa (Moringa oleifera L.) Leaf Wuryandari, Tutik; Sugihartini, Nining; Kintoko, Kintoko
Folia Medica Indonesiana Vol. 55, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Moringa oleifera, known as moringa, is reported to have a high source of natural antioxidants, especially vitamin E. The formulation of purified Moringa leaf extract is needed so that the vitamin E content in it is more maximal. This study aimed to determine the levels of vitamin E in extracts after purification, physical property test of emulgel with variations in extract concentration and vitamin E levels in emulsions. The study was started from the extraction using maceration method with petroleum ether solvent, followed by extract purification using column chromatography with n-hexane solvent. The results of the purified extract were then formulated into emulgel with three concentrations of 3% (F1), 6% (F2) and 9% (F3). Emulgel was then evaluated for physical characteristics (pH, viscosity, adhesion, dispersion and stability). Determination of vitamin E levels was carried out on purified extract samples and on each formula. The results of non-specific standardization of extracts included ash content, acidic insoluble ash content were higher than those of Indonesian Herbal Pharmacopoeia literature and drying losses were lower compared to literature. Specific standardization of extracts was the content of vitamin E in 1.40% PE extract and 8.02% purified extract. In the test of emulgel physical characteristics, an increase in the concentration of the extract caused an increase in viscosity and decreased emulgel dispersion power. Whereas, tthe pH and sticky power remained the same. Storage hds an effect on decreasing the physical characteristics of emulsions especially on adhesion. Increased extracts also caused an increase in the levels of vitamin E in the purified extract of moringa leaf emulgel.
PENINGKATAN PENGETAHUAN ANGGOTA KELOMPOK WANITA TANI GUYUP RUKUN KALIMUNDU DALAM PEMBUATAN DAN PEMASARAN TEH CELUP BUNGA TELANG Wahyuningsih, Iis; Sri Rejeki, Marsudi Endang; Kintoko, Kintoko; Khusnul, Latifah
Jurnal Bakti untuk Negeri Vol 5 No 02 (2025): Jurnal Bakti Untuk Negeri
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/ab3yf030

Abstract

This community service activity aimed to improve the knowledge and skills of the members of  KWT Guyub Rukun in Kalimundu in the production and marketing of butterfly pea flower tea bags. A total of 20 participants took part in a series of four  sessions: post-harvest handling, tea bag production, packaging, and marketing including the determination of the cost of goods sold. Pretest and posttest evaluations indicated an increase in participants’ understanding across all sessions. In the post-harvest training, participants showed better comprehension of proper harvesting time and drying methods that help maintain material quality. In the tea-making session, all indicators showed score improvement, with pretest scores ranging from 33.33% to 91.67%, and increasing to 100% on most posttest questions. During the packaging session, participants began to understand the importance of using packaging that meets standards and has attractive visual appeal. Meanwhile, the marketing and COGS session showed significant improvement, especially in identifying effective promotional media and understanding cost components, with some indicators increasing from 12 to 16 correct responses. These results reflect the effectiveness of the training in enhancing the technical and entrepreneurial capacities of KWT members, and mark a strategic step in empowering women through locally based economic development.  
ANTIOXIDANT POTENTIAL OF EXTRACT OF BLACK RICE, BAJAKAH WOOD ROOT AND KEBIUL SEED Yesti, Yulia; Kintoko, Kintoko; Nugraha, Ari Satia; Putra, Billy Harnaldo; Gusriyani, Sri; Saputra, Harry Ade; Alfarisyi, Muhammad Iqbal
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3457

Abstract

Exposure to free radicals and oxidative stress are major factors in various degenerative diseases, such as cardiovascular disease, diabetes, cancer, and neurodegenerative diseases. Therefore, the use of natural antioxidant sources is important to reduce the negative effects of free radicals. This study compares the natural antioxidant potential of black rice, bajakah root, and kebiul seeds, whereas previous studies have only identified the antioxidant potential of a single natural ingredient. This study aims to measure the antioxidant potential, such as total polyphenols, total flavonoids, and antioxidant activity, of these three natural materials using distilled water, 70% ethanol, and 96% ethanol as solvents. The experimental research method involved testing antioxidant activity and measuring total phenolics and flavonoids. The results showed that the 70% ethanol extract of black rice had the highest total polyphenol content at 6.83±0.28 mgGAE/g (0.007±0.00%), the 70% ethanol extract of bajakah wood root had the highest flavonoid content at 8.77±0.02 mgQE/g (0.009±0.00%), and the distilled water extract of kebiul seeds showed the strongest antioxidant activity based on an IC50 value of 5.96 ± 0.01 ppm. This study concluded that black rice has potential as a primary source of phenolics and anthocyanins, while bajakah wood root and kebiul seeds are sources of flavonoids with strong antioxidant activity.
The Influence of Learning Independence and Intelligence Quotient on Students’ Mathematical Creative Thinking Skills Setianingrum, Ervina; Kintoko, Kintoko; Hadi Siswanto, Deny
Riemann: Research of Mathematics and Mathematics Education Vol. 7 No. 3 (2025): EDISI DESEMBER
Publisher : Program Studi Pendidikan Matematika Universitas Katolik Santo Agustinus Hippo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38114/riemann.v7i3.113

Abstract

This study aims to examine the influence of learning independence and Intelligence Quotient (IQ) on students’ mathematical creative thinking skills. The research employed a quantitative approach with an ex post facto design and was conducted at SMPN 5 Purworejo during the odd semester of the 2024/2025 academic year. The population comprised seventh-grade students, from whom 32 participants were selected through purposive sampling based on the availability of official IQ test results from a professional psychological institution. The research instruments included an essay test measuring creative thinking skills based on four indicators, namely fluency, flexibility, elaboration, and originality; a learning independence questionnaire covering six assessment aspects; and documentation of students’ IQ scores. Data analysis consisted of descriptive statistics, prerequisite testing, and multiple linear regression analysis using SPSS version 25. The results showed that learning independence and IQ significantly affected students’ mathematical creative thinking skills, both partially and simultaneously. Learning independence had a more dominant effect than IQ. Together, both variables explained 92.5% of the variance in students’ mathematical creative thinking skills.
Studi Kopigmentasi Antosianin Beras Hitam (Oryza sativa L. indica) Dengan Polifenol Kacang Kedelai (Glycine max L.) Shary, Aprilya Kumala; Kintoko, Kintoko; Widyaningsih, Wahyu; Susanti, Hari; Pranata, Meki; Gustinanda, Rizky
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.37235

Abstract

Antosianin merupakan pigmen alami yang berperan penting sebagai antioksidan namun stabilitasnya relatif rendah terhadap faktor lingkungan seperti cahaya, pH dan suhu. Upaya untuk meningkatkan stabilitas antosianin dapat dilakukan melalui mekanisme kopigmentasi dengan senyawa polifenol. Penelitian ini bertujuan untuk mengevaluasi pengaruh kopigmentasi antara antosianin beras hitam (Oryza sativa L. indica) dengan polifenol yang diperoleh dari rebusan kacang kedelai (Glycine max L.) terhadap kestabilan warna dan aktivitas antioksidan. Ekstraksi antosianin dilakukan menggunakan pelarut asam sitrat, sedangkan polifenol kacang kedelai diperoleh melalui ekstraksi maserasi dari rebusan kacang kedelai yang diperkaya senyawa fenolik. Kopigmentasi dilakukan dengan variasi rasio perbandingan 1:1, 1:2 dan 1:3, kemudian dianalisis melalui spektrofotometri UV-Vis untuk menentukan pergeseran λmaks, intensitas warna, serta kestabilan pigmen. Hasil penelitian menunjukkan bahwa penambahan polifenol kacang kedelai mampu meningkatkan intensitas warna pada antosianin beras hitam. Selain itu, aktivitas antioksidan menunjukkan peningkatan dibandingkan antosianin tunggal, menandakan adanya sinergi antara kedua senyawa bioaktif. Dengan demikian, kopigmentasi antosianin beras hitam dengan polifenol kacang kedelai berpotensi meningkatkan kestabilan pigmen alami, dengan rasio 1:1 menunjukkan keseimbangan terbaik antara stabilitas warna dan aktivitas antioksidan.
Antidiarrhoeal Potential of Secondary Metabolites in Betel Leaf (Piper betle): A Systematic Review with Radar Chart Analysis and AUC Evaluation. Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci; Wardhani, Firdha Aprillia; Poerwahyuningrum, Neny
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.594

Abstract

Diarrhoea is a widespread gastrointestinal disorder commonly caused by microbial infection, inflammation, or impaired intestinal function. While synthetic antidiarrhoeal drugs are available, their use is often limited by adverse effects and antimicrobial resistance, prompting increasing interest in medicinal plants such as Piper betle (betel leaf). This study systematically reviewed the literature to identify secondary metabolite compounds in Piper betle with antidiarrhoeal potential and to evaluate their biological activities using Radar Chart Analysis (RCA) and Area Under Curve (AUC) methods. A systematic search was performed across PubMed, Scopus, Web of Science, and Google Scholar using predefined keywords. Inclusion criteria comprised studies that investigated Piper betle or its secondary metabolites, reported antidiarrhoeal or related bioactivity, and provided quantitative data suitable for comparison. Studies were excluded if they focused solely on synthetic drugs, were not available in full text, or did not report measurable metabolite data. A total of 35 eligible studies were included after screening 176 records. The findings indicate that flavonoids, polyphenols, tannins, saponins, and catechins in Piper betle contribute to antidiarrhoeal effects through mechanisms that modulate intestinal motility, reduce fluid secretion, activate anti-inflammatory pathways, and exhibit antimicrobial activity. RCA and AUC analyses further demonstrated substantial variability in metabolite composition and antioxidant capacity across studies. Overall, Piper betle exhibits promising therapeutic potential as a natural antidiarrhoeal agent, although further mechanistic and clinical research is warranted.
In Silico Study of Compounds Bioactive Guava (Psidium guajava) as Antidiarrheal Assisted Liquid Chromatography-Mass Spectroscopy Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci; Ningrum, Lailatul Fitria; Hasana, Siti Nur; Wardhani, Firdha Aprillia
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.876

Abstract

Guava leaves seeds (Psidium guajava) are known contain various compound potential bioactives? as antidiarrheal, such as quercetin and tannins, which work with method hinder intestinal contractions and disrupts permeability membrane cell bacteria. Research This aim for explore potential antidiarrheal from compound in leaf guava seed through identification compound using LC-MS and simulation molecular docking to six human protein target receptors, namely Cytochrome P450 1A1, Ephrin Type-B Receptor 4, Multidrug Resistance Protein 1, Dihydrofolate Reductase, Extracellular Calcium-Sensing Receptor, and Rap Guanine Nucleotide Exchange Factor 4. Extraction done with method maceration use solvent methanol, then compound analyzed using Liquid Chromatography–Mass Spectrometry (LC-MS). A total of eleven compound main chosen foranalyzed in silico using device soft AutoDockTools, PyRx, and Discovery Studio. Validation was performed through redocking of native ligands with RMSD value ? 2 Å. The results show some ligands such as Kaempferol, Cathecin, and Quercetin own affinity strong bond, with? Kaempferol show lowest binding energy of -9.72 kcal /mol against BHF receptor. Drug-likeness test based on Lipinski's rule also shows that part big compound fullfil criteria compound drug analysis? interaction amino acids show existence bond hydrogen and hydrophobic support? stability bond. This result show that compound leaf guava seeds, especially Kaempferol and Cathecin, potentially as candidate agent antidiarrheal natural. Further studies in vitro and in vivo are recommended for support findings.
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina
Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina
Co-Authors Akrom, Akrom Alfarisyi, Muhammad Iqbal Ananda, Aghnia Nabila Anggraeni, Linda Suci Ari Satia Nugraha Aris Setyawan Ariyanti, Lusi Mardika Astuti, Andarweni Atmarani, Rizki Essa aviory, koryna Ayu Shabrina Billy Harnaldo Putra, Dini Fatmi, Botutihe, Lisa Agustina Cahayani, Devita Mika Dani Kusuma Desmayanti, Astri Dhian Arista Istikomah Dian Aprilia, Dian Dona, Suzana Dwi Utami Eka Siswanto Syamsul Epi Taufik Faisal Nur Arib Fajar Fajar Farid , Muhammad Ferani Mulianingsih Gunawan Gunawan Gunawan, Adhi Gusriyani, Sri Gustinanda, Rizky Hadi Siswanto, Deny Hardi Astuti Witasari Hari Susanti Harry Ade Saputra Hasana, Siti Nur Hidayati, Eka Hutari, Andri Iis Wahyuningsih Ilmia, Nisrien Indahsari, Kharisma Safitri Nur Jana, Padrul Khrisna Agung Cendekiawan Khusnul, Latifah Kusumo, Djati Wulan Lestariningrum, Wahyu Titis M. Yogi Riyantama Isjoni Maghfirah, Yolanda Sajjida Makati, Annisa Camellia Mehta, Kunal Meki Pranata Mochammad Saiful, Bachri Muhammad Iqbal Birsyada Muldiyana, Tya Mustofa Ahda Mutti, Annisa Aulia Nanik Sulistyani Nina Widyaningsih, Nina Ningrum, Lailatul Fitria Nining Sugihartini Novitasari, Putri Rachma Nur Arib, Faisal Nurkhasanah Mahfudh Nurlita, Tasya Nuryani, Eva Oktavia, Lisa Pamungkas, Megita Dwi Poerwahyuningrum, Neny Pulhehe, Hasni Rangkuti, Ahmad Faizal Ranti, Imaniar Rejeki, Marsudi Endang Sri Restu Ayu Mumpuni, Restu Ayu Ridho, Anisa Rifka Rifki Febriansah Rohma, Siti Rohmah, Lely Arbiati Nur Rukaya, Benazir Evita Sa’adah, Hayatus Safira, Rizka Santoso, Blegoh Iwan Sapto Yuliani Saputri, Ginanjar Zukhruf Septian Aji Permana Septiana Wijayanti Setianingrum, Ervina Setiyawati, Fitri Indah Shary, Aprilya Kumala Siswanto, Deny Hadi Sri Budiarti, Nur Idha Suhendra Suhendra Sulistyani , Nanik Sunanti, Titis Supomo Supomo Suryaningsih, Andri Susetyawati, Endang Susetyawati, MM Endang Susetyawati, MM. Endang Susetyowati, MM Endang Tri Puspita Yuliana Urmatul Waznah Utami, Febri Via Yustitia Wahyu Widyaningsih Wahyuni, Dina Wardhani, Firdha Aprillia Warniasih, Kristina Widyaningrum, Rachmawati Wuryandari, Tutik Wuryandari, Tutik Yanti, Asti Afrida Yuli Nurullaili Efendi, Yuli Nurullaili Yulia Yesti, Yulia Yulianto Yulianto Yuni Suprapto, Yuni