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PENINGKATAN PENGETAHUAN ANGGOTA KELOMPOK WANITA TANI GUYUP RUKUN KALIMUNDU DALAM PEMBUATAN DAN PEMASARAN TEH CELUP BUNGA TELANG Wahyuningsih, Iis; Sri Rejeki, Marsudi Endang; Kintoko, Kintoko; Khusnul, Latifah
Jurnal Bakti untuk Negeri Vol 5 No 02 (2025): Jurnal Bakti Untuk Negeri
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/ab3yf030

This community service activity aimed to improve the knowledge and skills of the members of KWT Guyub Rukun in Kalimundu in the production and marketing of butterfly pea flower tea bags. A total of 20 participants took part in a series of four sessions: post-harvest handling, tea bag production, packaging, and marketing including the determination of the cost of goods sold. Pretest and posttest evaluations indicated an increase in participants’ understanding across all sessions. In the post-harvest training, participants showed better comprehension of proper harvesting time and drying methods that help maintain material quality. In the tea-making session, all indicators showed score improvement, with pretest scores ranging from 33.33% to 91.67%, and increasing to 100% on most posttest questions. During the packaging session, participants began to understand the importance of using packaging that meets standards and has attractive visual appeal. Meanwhile, the marketing and COGS session showed significant improvement, especially in identifying effective promotional media and understanding cost components, with some indicators increasing from 12 to 16 correct responses. These results reflect the effectiveness of the training in enhancing the technical and entrepreneurial capacities of KWT members, and mark a strategic step in empowering women through locally based economic development.

ANTIOXIDANT POTENTIAL OF EXTRACT OF BLACK RICE, BAJAKAH WOOD ROOT AND KEBIUL SEED Yesti, Yulia; Kintoko, Kintoko; Nugraha, Ari Satia; Putra, Billy Harnaldo; Gusriyani, Sri; Saputra, Harry Ade; Alfarisyi, Muhammad Iqbal
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3457

Exposure to free radicals and oxidative stress are major factors in various degenerative diseases, such as cardiovascular disease, diabetes, cancer, and neurodegenerative diseases. Therefore, the use of natural antioxidant sources is important to reduce the negative effects of free radicals. This study compares the natural antioxidant potential of black rice, bajakah root, and kebiul seeds, whereas previous studies have only identified the antioxidant potential of a single natural ingredient. This study aims to measure the antioxidant potential, such as total polyphenols, total flavonoids, and antioxidant activity, of these three natural materials using distilled water, 70% ethanol, and 96% ethanol as solvents. The experimental research method involved testing antioxidant activity and measuring total phenolics and flavonoids. The results showed that the 70% ethanol extract of black rice had the highest total polyphenol content at 6.83±0.28 mgGAE/g (0.007±0.00%), the 70% ethanol extract of bajakah wood root had the highest flavonoid content at 8.77±0.02 mgQE/g (0.009±0.00%), and the distilled water extract of kebiul seeds showed the strongest antioxidant activity based on an IC50 value of 5.96 ± 0.01 ppm. This study concluded that black rice has potential as a primary source of phenolics and anthocyanins, while bajakah wood root and kebiul seeds are sources of flavonoids with strong antioxidant activity.

In Silico Study of Compounds Bioactive Guava (Psidium guajava) as Antidiarrheal Assisted Liquid Chromatography-Mass Spectroscopy Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci; Ningrum, Lailatul Fitria; Hasana, Siti Nur; Wardhani, Firdha Aprillia
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.876

Guava leaves seeds (Psidium guajava) are known contain various compound potential bioactives? as antidiarrheal, such as quercetin and tannins, which work with method hinder intestinal contractions and disrupts permeability membrane cell bacteria. Research This aim for explore potential antidiarrheal from compound in leaf guava seed through identification compound using LC-MS and simulation molecular docking to six human protein target receptors, namely Cytochrome P450 1A1, Ephrin Type-B Receptor 4, Multidrug Resistance Protein 1, Dihydrofolate Reductase, Extracellular Calcium-Sensing Receptor, and Rap Guanine Nucleotide Exchange Factor 4. Extraction done with method maceration use solvent methanol, then compound analyzed using Liquid Chromatography–Mass Spectrometry (LC-MS). A total of eleven compound main chosen foranalyzed in silico using device soft AutoDockTools, PyRx, and Discovery Studio. Validation was performed through redocking of native ligands with RMSD value ? 2 Å. The results show some ligands such as Kaempferol, Cathecin, and Quercetin own affinity strong bond, with? Kaempferol show lowest binding energy of -9.72 kcal /mol against BHF receptor. Drug-likeness test based on Lipinski's rule also shows that part big compound fullfil criteria compound drug analysis? interaction amino acids show existence bond hydrogen and hydrophobic support? stability bond. This result show that compound leaf guava seeds, especially Kaempferol and Cathecin, potentially as candidate agent antidiarrheal natural. Further studies in vitro and in vivo are recommended for support findings.

Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina

Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Kintoko, Kintoko; Faisal Nur Arib; Nanik Sulistyani; Akrom
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended. Keywords: Curcuma mangga; indigenous knowledge; pharmacological evidence; phytotherapy; Vernonia amygdalina

Ethnopharmacology Analysis of Antidiabetic Medicinal Plants from Menoreh Hills: Linking Local Knowledge to Pharmacological Evidence Nur Arib, Faisal; Kintoko, Kintoko; Sulistyani, Nanik; Akrom, Akrom
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24603

Abstract: The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide and in Indonesia. Documenting locally utilized antidiabetic plants may inform evidence-based phytotherapy. This study mapped antidiabetic medicinal plants in Samigaluh (Menoreh Hills) and prioritized candidates by linking community knowledge with pharmacological data. Semi-structured interviews and observation were conducted between July and August 2025, and involved ten informants selected through purposive and snowball sampling. Quantitative ethnobotanical indices (Use Value, Relative Frequency of Citation, Fidelity Level, Plant Part Value) were calculated, followed by a PubMed-based narrative review. The Zingiberaceae family was predominant (seven species); rhizomes were the most utilized (39.58%), followed by stems (25.00%) and leaves (22.92%). Vernonia amygdalina was prioritized for diabetes-specific consensus (Fidelity Level 100%, Relative Frequency of Citation 0.7), and Curcuma mangga for its high usage and popularity (Use Value 1.3, Relative Frequency of Citation 0.6). Pharmacological evidence indicates that V. amygdalina exhibits antidiabetic effects through the inhibition of α-amylase and α-glucosidase, enhancement of GLUT4, and suppression of gluconeogenesis, supported by its antioxidant and anti-inflammatory properties, while C. mangga demonstrates hypoglycemic activities and β-cell protection, along with anti-inflammatory, antioxidant, and immunostimulant activities as supportive mechanisms. Local knowledge thus aligns with mechanistic findings, supporting a complementary pairing of V. amygdalina and C. mangga for future antidiabetic combinations; further validation through in vitro and in vivo studies is recommended.

Acute Toxicity Test of Healthy Drink of Anthocyanin Pigmented Polyphenols from Black Rice and Sprouts Soybean Kintoko, Kintoko; Salamah, Nina; Witasari, Hardi Astuti; Maulizah, Rizlah
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.25784

Black rice and sprouted soybean (BRiSS) can be formulated into a healthy drink BRiSS. The safety of this novel combination must be rigorously tested. Therefore, this study was designed to conduct a comprehensive acute toxicity test of the healthy drink flavylium anthocyanins from black rice (Oryza sativa L. indica) pigmented polyphenols from soybean sprouts (Glycine max L.). The black rice was extracted with a 96% ethanol solution in 3% citric acid. The pigmentation process was achieved by adding hydroxyl groups from soybean polyphenols. The active material was mixed with 20% maltodextrin, shaken, poured into a pan, and dried with a cabinet dryer (60° C). The mixture was stirred with 0.3% sodium, 0.1% citric acid, 50% active ingredients, 5% sucrose as a sweetener, 0.05% sodium benzoate, and water, 100 ml. The five groups of male Wistar rats were acclimatized. Group 1 was a control, and groups 2, 3, 4, and 5 were sequentially treated with a healthy drink containing extract doses of 5, 50, 300, and 2000 mg/kg BW. The acute toxicity test results at 30 minutes, 3 to 24 hours, day 3, and day 14 were written on the acute toxicity test clinical symptom observation sheet. All test animals, including both the control and test groups with various dosage variations, did not exhibit changes in skin, fur, eyes, behavior, respiratory systems, and did not experience weight loss, seizures, tremors, lethargy, or diarrhea. The limitation was that the macropathology examination of internal organs (kidneys, liver, heart, brain, stomach, intestines, pancreas) was not performed. Not all animals have mortality in a 5-3000 (mg/kg BW) extract dose.

Narrative Structures and Methodological Principles in Boyer and Merzbach’s Historiography for Mathematics Education Kintoko, Kintoko; Siswanto, Deny Hadi; Khuzaini, Nanang
Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Vol 10 No 2 (2026)
Publisher : Universitas Mercu Buana Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26486/r6f79y20

This study aims to analyze the narrative structure, periodization, and methodological principles in A History of Mathematics by Carl B. Boyer and Uta C. Merzbach (third edition, 2011) as a historiographical model in mathematics education. The research employs a descriptive qualitative approach using the content analysis method. Data were collected through an in-depth reading of all chapters of the book and analyzed based on two main dimensions: internal history (the development of concepts and mathematical rigor) and external history (the social, cultural, and economic influences on the emergence of mathematical ideas). The findings reveal that Boyer and Merzbach construct the historical narrative of mathematics both chronologically and thematically, tracing its evolution from ancient to modern times while emphasizing the continuity of mathematical ideas across civilizations. Merzbach’s approach, which integrates linguistic, social, and economic contexts, demonstrates that the development of mathematics is the result of an interaction between abstract ideas and human practical needs. Furthermore, the principle of “extension without correction” indicates that each new mathematical theory does not negate earlier ones but rather expands and enriches the existing scientific framework. The study concludes that A History of Mathematics possesses significant pedagogical value and is highly relevant as a learning resource for the history of mathematics, as it cultivates a philosophical and historical understanding of mathematics as both a cultural product and an ongoing intellectual process

Mathematical Processes and Modeling in Problem-Solving: Designing Learning Models for Higher-Order Thinking Nurmawati, Nurmawati; Purnomo, Eko Andy; Dian Mawarsari, Venissa; Prihaswati, Martyana; Dwi Pamungkas, Megita; Kintoko, Kintoko
IJORER : International Journal of Recent Educational Research Vol. 7 No. 4 (2026): July
Publisher : Faculty of Teacher Training and Education Muhammadiyah University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46245/ijorer.v7i4.1377

21st-century mathematics learning requires the development of Higher Order Thinking Skills (HOTS) through meaningful problem-solving and mathematical modeling. Various studies have shown that students' HOTS abilities are still in the low category, even though problem-solving models have been widely implemented. However, most existing models are still procedural and have not systematically integrated horizontal and vertical mathematization processes with mathematical modeling cycles in a single learning syntax. This study aims to develop a problem-solving learning model grounded in mathematical processes and modeling to improve students' HOTS skills. The study uses the Research and Development (R&D) approach proposed by Thiagarajan and Semmel. The developed model integrates the stages of situational orientation, horizontal mathematization, vertical mathematization, contextual interpretation, and reflection and revision in a systematic and measurable learning syntax. The validation results from nine experts showed an average score of 3.61 in the very valid category, indicating that the model meets pedagogical feasibility, mathematical substance, and evaluative criteria. The novelty of this research lies in integrating Polya's steps, the mathematization process, and the mathematical modeling cycle into a learning model explicitly designed to develop HOTS. Further research is recommended to test the model's effectiveness through experimental studies in various educational contexts to strengthen empirical evidence of its implementation.

HUBUNGAN KEMANDIRIAN BELAJAR DENGAN KEMAMPUAN BERPIKIR KRITIS SISWA KELAS VIII SMP NEGERI 2 GAMPING Suprihatiningsih, Siti; Asmah, Richatul; Kintoko, Kintoko
Bahasa Indonesia Vol 2 No 1 (2023)
Publisher : IAIN Pontianak

The study aims to find out: (1) Is there a relationship between learning independence and critical thinking skills of grade VIII students of SMP Negeri 2 Gamping, (2) How much is the relationship between learning independence and critical thinking skills of grade VIII students of SMP Negeri 2 Gamping. This research is quantitative correlational research. The population in this study was grade VIII students, with a sample of 30 students. Selected by random sampling technique. Research instruments in the form of questionnaires and tests. Data analysis techniques, validity tests and reliability tests. Prerequisite tests are in the form of normality tests and linearity tests. The hypothesis test used a t-test with a significance level of 0.05. The data analysis technique in this study uses the Product Moment correlation. Based on the results of research data analysis, it is known that: (1) there is a positive and significant relationship between learning independence and critical thinking skills of grade VIII students of SMP Negeri 2 Gamping. This can be seen from the sig value. (2-tailed) of 0.000 < 0.05 and Pearson Correlation value of 0.643 > 0.361. In addition, it can be seen from the value of calculate (4.446) > t table (2.048) (2) that the relationship between learning independence and critical thinking skills of grade VIII students of SMP Negeri 2 Gamping is quite strong with a percentage of 41.4%. The critical thinking ability of 41.4% is determined by learning independence. This can be seen from the coefficient of determination value with an R square of 0.414.

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