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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Harmoni Sosial: Jurnal Pendidikan IPS Jurnal Terapan Abdimas Al-Jabar : Jurnal Pendidikan Matematika Jurnal Farmasi Sains dan Komunitas Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Syntax Literate: Jurnal Ilmiah Indonesia Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Pharmacoscript Jurnal Ilmiah Cendekia Eksakta Indonesian Journal of Global Health research Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Multidisiplin Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kajian Ilmiah Prima Abdika: Jurnal Pengabdian Masyarakat Journal La Lifesci Jurnal Penelitian Inovatif Indo-MathEdu Intellectuals Journal International Journal of Islamic and Complementary Medicine Journal Of Human And Education (JAHE) Jurnal Bakti Untuk Negeri Duta Pharma Journal Jurnal Katalisator Journal of Food and Pharmaceutical Sciences Jurnal Kesehatan dr. Soebandi Riemann : Research of Mathematics and Mathematics Education Journal of Educational Research and Practice Jurnal Farmasi Galenika Contemporary Education and Community Engagement JI-KES (Jurnal Ilmu Kesehatan) Folia Medica Indonesiana
Kintoko Kintoko
Prodi Magister Pendidikan Matematika, Pascasarjana, FKIP – UNS
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Antibacterial activity of dialkyl-aginate biosurfactant cream againts Staphylococcus aureus an Pseudomonas aerugynosa Kintoko, Kintoko; Sugihartini, Nining; Rukaya, Benazir Evita
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.10337

Abstract

Dialkyl-alginate biosurfactant is an amphifilik rhamnolipid biosurfactant that has the potential to be developed into an antibacterial agent. The purpose of this study was to prove that the biosurfactant of dialkyl alginate both before and after creams has antibacterial activity especially against Staphylococcus aureus and Pseudomonas aeruginosa. Test of antibacterial activity of biosurfactant dialkyl alginate at concentrations of 5%, 10% and 20% to Staphylococcus aureus and Pseudomonas aeruginosa using Hammond, et al (2011) modified quantitative method. Enbatic® 1% is used as a positive control and sterile aquadest as a negative control. Determination of antibacterial activity of dialkyl alginate biosurfactant followed by analysis of leakage of protein and nucleic acids using UV-vis Spectrophotometry and leakage of Ca2 + and K + metal ions using Atomic Absorption Spetrophotometry (AAS). The most active concentration was formulated into cream and then performed physical evaluation (organoleptic, pH, adhesion, spreading and viscosity) and tested antibacterial activity using the well method. The test results showed that the biosurfactants of dialkyl-alginate before and after the cream was treated as antibacterial activity. The concentration of 10% was the most active concentration having activity which did not differ significantly to positive control with p value of 0,05
E-LKPD Model Pembelajaran Discovery Berbasis STEM untuk Meningkatkan Berpikir Kritis Cahayani, Devita Mika; Istikomah, Dhian Arista; Jana, Padrul; Kintoko, Kintoko
Indo-MathEdu Intellectuals Journal Vol. 6 No. 2 (2025): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v6i2.2714

Abstract

Advances in technology and science require students to adapt to various aspects of life, especially in the field of education. One of the abilities that needs to be improved in 21st century learning is the ability to think critically. This study aims to develop and test the validity of the Electronic Student Worksheet (E-LKPD) of the STEM-based discovery learning model to improve students' critical thinking skills. The development model used is the ADDIE model, which includes five stages: analysis, design, development, implementation, and evaluation. The data analysis technique used is descriptive. The results of the validity test by material experts and media experts show that the E-LKPD developed has a very high validity with an average score percentage of 82%. Based on these results, E-LKPD is considered very valid for use in learning
Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Abstract

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.
Pengaruh Fermentasi Laktat terhadap Kandungan Fenolik Total dan Aktivitas Antioksidan Poliherbal TBR serta Uji Profil Lipid secara in Vivo Mutti, Annisa Aulia; Kintoko, Kintoko; Sulistyani, Nanik
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i3.58198

Abstract

Lactate fermentation, such as yogurt, is known to increase antioxidant activity. In addition to yogurt, fermentation can also be applied to herbal plants. Polyherbal plants Taxus sumatrana (Sumatran cypress), jixueteng (Spatholobus suberectus), and pearl grass (Hedyotis corymbosa) (TBR) contain total phenolic compounds that act as antioxidants and can lower cholesterol levels. This study aims to analyze the effect of TBR polyherbal fermentation on total phenol content and antioxidant activity. Polyherbal extraction is carried out by the maceration method using 96% ethanol for 24 hours. Total phenolic tests were carried out using gallic acid, followed by aerobic fermentation with lactic acid bacteria Streptococcus thermophilus and Lactobacillus bulgaricus with 1%, 2%, and 3% TBR extract concentrations. Antioxidant activity was measured by the DPPH method, and lipid profile tests were performed in vivo on 35 white rats (Rattus norvegicus), which were divided into 7 treatment groups. The results showed that TBR polyherbal fermentation significantly increased the total phenolic levels, with a concentration of 3% resulting in the highest levels (41.689 ± 0.5682% GAE). Although antioxidant activity decreased slightly after fermentation, it remained in the strong category (IC50 76.816–88.283 μg/mL). In vivo tests showed that polyherbal yogurt TBR 3% lowered triglyceride and total cholesterol levels and slightly increased HDL levels, but was less effective in lowering LDL. In conclusion, TBR polyherbal fermentation increases total phenolic levels while maintaining strong antioxidant activity, with potential as a natural source of antioxidants for lipid profile improvement.
Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Abstract

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.
UJI AKTIVITAS SUSPENSI SERBUK SPIRULINA PLATENSIS TERHADAP KADAR HORMON TESTOSTERON DAN HISTOPATOLOGIK TESTIS TIKUS WISTAR DIABETES YANG DIINDUKSI STREPTOZOTOCIN Gunawan, Adhi; Kintoko, Kintoko; Yuliani, Sapto; Shabrina, Ayu
CENDEKIA EKSAKTA Vol. 6 No. 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.4402

Abstract

Diabetes mellitus merupakan penyakit metabolik yang dapat mengganggu fungsi reproduksi pada pria yaitu penurunan kadar hormon testosteron dan kerusakan jaringan testis. Spirulina platensis mengandung fikosianin sebagai antioksidan yang efektif untuk menurunkan kadar gula darah dan kerusakan organ reproduksi pria. Tujuan dari penelitian ini untuk mengetahui efek Spirulina platensis (SP) terhadap kadar hormon testosteron serta gambaran histopatologik testis tikus jantan diabetes yang diinduksi Streptozotocin (STZ). Tikus dibagi menjadi 6 kelompok yang terdiri dari K1 (tikus diberikan suspensi CMC-Na), K2 (tikus yang diinduksi STZ dosis tunggal 45 mg/kgBB), K3 (tikus diberikan suspensi SP 36 mg/200gBB), kelompok 4; 5 dan 6 (tikus diabetes diberikan suspensi SP 36 mg/200kgBB; 72 mg/200gBB dan 144 mg/200gBB). Penelitian dilakukan selama 28 hari dengan parameter yang diamati adalah kadar gula darah, kadar testosteron dan gambaran histopatologik testis dengan Hematoksilin - Eosin (HE). Hasil peneltian ini menunjukkan bahwa kelompok perlakuan dengan Spirulina platensis mampu meningkatkan kadar hormon testosteron yaitu 0,82 µG/mL, 1,13 µG/mL dan 1,66 µG/mL (p < 0,05) dibandingkan kelompok tikus diabetes. Spirulina platensis juga mampu mencegah kerusakan epitel tubulus seminferus pada testis dibandingkan kelompok diabetes. Pada hewan uji yang diberikan dosis 144 mg/kgBB memberikan aktivitas paling baik dalam menghambat kerusakan jaringan testis disebabkan oleh induksi STZ. Kata kunci: diabetes mellitus, gangguan reproduksi, hormon testosteron, Spirulina platensis
Kajian Pengembangan Kebun Biofarmaka Jogja Agro Park dan Pemetaan Pilot Project Pelayanan Kesehatan Tradisional pada Destinasi Wisata Strategis di Wilayah Kabupaten Kulon Progo DIY Kintoko, Kintoko; Desmayanti, Astri; Novitasari, Putri Rachma; Saputri, Ginanjar Zukhruf; Witasari, Hardi Astuti; Setiyawati, Fitri Indah
Jurnal Kajian Ilmiah Vol. 24 No. 1 (2024): January 2024
Publisher : Lembaga Penelitian, Pengabdian Kepada Masyarakat dan Publikasi (LPPMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31599/v57nbz71

Abstract

Through the use of both traditional medicine and contemporary medicine, Indonesians, particularly those in Kulon Progo Regency, have managed to maintain a high level of health. The availability of traditional health services in the community does not simply refer to inherited knowledge; it has also been developed scientifically through product saintification initiatives, their usage, and traditional healers' academic qualifications. There are numerous opportunities for traditional healthcare services to be established in the Kulon Progo Regency. Construction of the "Surgery Menoreh" route, which passes through the areas of Kapanewon Temon, Kokap, Girimulyo, Samigaluh, and Kalibawang, lends support to this. This study aims to map a traditional healthcare pilot project that has grown in the Kulon Progo Regency. The findings of this study provide an overview of the potential of Jogja Agro Park and various traditional healer treatments in Kulon Progo Regency. So that this study can be used as a reference in the region's development of traditional health services.
E-LKPD Model Pembelajaran Discovery Berbasis STEM untuk Meningkatkan Berpikir Kritis Cahayani, Devita Mika; Istikomah, Dhian Arista; Jana, Padrul; Kintoko, Kintoko
Indo-MathEdu Intellectuals Journal Vol. 6 No. 2 (2025): Indo-MathEdu Intellectuals Journal
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v6i2.2714

Abstract

Advances in technology and science require students to adapt to various aspects of life, especially in the field of education. One of the abilities that needs to be improved in 21st century learning is the ability to think critically. This study aims to develop and test the validity of the Electronic Student Worksheet (E-LKPD) of the STEM-based discovery learning model to improve students' critical thinking skills. The development model used is the ADDIE model, which includes five stages: analysis, design, development, implementation, and evaluation. The data analysis technique used is descriptive. The results of the validity test by material experts and media experts show that the E-LKPD developed has a very high validity with an average score percentage of 82%. Based on these results, E-LKPD is considered very valid for use in learning
The Potency of Microalgae as a Marine Source: A Bibliometric Analysis Witasari, Hardi Astuti; Kintoko, Kintoko; Ahda, Mustofa; Rangkuti, Ahmad Faizal; Suhendra, Suhendra; Mahfudh, Nurkhasanah
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.18870

Abstract

Microalgae were a marine source that was highly sustainable and offered numerous benefits in industrial applications. Many species were safe and effective as active ingredients in the food, cosmetics, and pharmacy industries and became raw materials for renewable energy, such as biofuel. The exploration of bioactive compounds was enticing for the research. The study of microalgae potency is a fascinating subject that deserves further exploration. The bibliometrics analysis can provide a good overview of microalgae research and its applications in industry. This overview was derived from the Scopus database, which contained all articles published between 1993 and 2023 with the keywords "microalgae" and "their application. Based on this discovery, many papers reported the potential of microalgae for antioxidants, nutrition, vaccine adjuvants, bioethanol, biofuel, and other applications for 2021-2022. This review criticizes the cultivation in a controlled environment up to the toxicity of microalgae. According to this review, many researchers focused and collaborated on exploring microalgae in the top three international journals, such as Algal Research, Marine Drugs, and Journal of Applied Phycology. Several countries, including Italy, Spain, and China, were the most focused on declaring the application of microalgae. The keywords described the core discussion and could be read generally and comprehensively. This bibliometric analysis was expected to contribute to developing microalgae for many applications.
Effectiveness of the cool-critical-creative-meaningful (3CM) learning model on enhancing students' critical thinking skills Kintoko, Kintoko; Hadi Siswanto, Deny
Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Vol 9 No 1 (2024)
Publisher : Universitas Mercu Buana Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26486/jm.v9i1.4522

Abstract

This study aims to examine the effectiveness of the Cool Critical Creative Meaningful (3CM) learning model on the critical thinking skills of Grade X-A students at SMA Muhammadiyah 1 Sleman. The model is expected to promote meaningful learning and enhance students' higher-order thinking skills. This research employs a quantitative approach using a Pre-Experimental Design with a One-Group Pretest-Posttest type. The sample consisted of 28 students from class X-A. The instrument used was a critical thinking test developed based on the indicators of Focus, Reason, Inferences, Situation, Clarity, and Overview, and had been tested for validity and reliability. Pretest and posttest results were analyzed using normality tests, Paired Sample T-Test, and N-gain analysis. The findings show a significant improvement in students' critical thinking skills following the implementation of the 3CM model, with the average score increasing from 55.16 to 87.30 and an N-gain score of 0.72 (high category). All critical thinking indicators showed improvement, with the "Situation" indicator showing the highest increase. These results indicate that the 3CM learning model is effective in enhancing students' critical thinking skills and can serve as a reference in the development of innovative learning strategies and curriculum evaluation at the senior high school level.
Co-Authors Akrom, Akrom Alfarisyi, Muhammad Iqbal Ananda, Aghnia Nabila Anggraeni, Linda Suci Ari Satia Nugraha Aris Setyawan Ariyanti, Lusi Mardika Astuti, Andarweni Atmarani, Rizki Essa aviory, koryna Ayu Shabrina Billy Harnaldo Putra, Dini Fatmi, Botutihe, Lisa Agustina Cahayani, Devita Mika Cendekiawan, Khrisna Dani Kusuma Desmayanti, Astri Dhian Arista Istikomah Dian Aprilia, Dian Dona, Suzana Dwi Utami Eka Siswanto Syamsul Epi Taufik Faisal Nur Arib Fajar Fajar Farid , Muhammad Ferani Mulianingsih Gunawan Gunawan Gunawan, Adhi Gusriyani, Sri Gustinanda, Rizky Hadi Siswanto, Deny Hardi Astuti Witasari Hari Susanti Harry Ade Saputra Hasana, Siti Nur Hidayati, Eka Hutari, Andri Iis Wahyuningsih Ilmia, Nisrien Indahsari, Kharisma Safitri Nur Jana, Padrul Khrisna Agung Cendekiawan Khusnul, Latifah Kusumo, Djati Wulan Lestariningrum, Wahyu Titis M. Yogi Riyantama Isjoni Maghfirah, Yolanda Sajjida Makati, Annisa Camellia Mehta, Kunal Meki Pranata Mochammad Saiful, Bachri Muhammad Iqbal Birsyada Muldiyana, Tya Mustofa Ahda Mutti, Annisa Aulia Nanik Sulistyani Nina Widyaningsih, Nina Ningrum, Lailatul Fitria Nining Sugihartini Novitasari, Putri Rachma Nur Arib, Faisal Nurkhasanah Mahfudh Nurlita, Tasya Nuryani, Eva Oktavia, Lisa Pamungkas, Megita Dwi Poerwahyuningrum, Neny Pulhehe, Hasni Rangkuti, Ahmad Faizal Ranti, Imaniar Rejeki, Marsudi Endang Sri Restu Ayu Mumpuni, Restu Ayu Ridho, Anisa Rifka Rifki Febriansah Rohma, Siti Rohmah, Lely Arbiati Nur Rukaya, Benazir Evita Sa’adah, Hayatus Safira, Rizka Santoso, Blegoh Iwan Sapto Yuliani Saputri, Ginanjar Zukhruf Septian Aji Permana Septiana Wijayanti Setianingrum, Ervina Setiyawati, Fitri Indah Shary, Aprilya Kumala Siswanto, Deny Hadi Sri Budiarti, Nur Idha Suhendra Suhendra Sulistyani , Nanik Sunanti, Titis Supomo Supomo Suryaningsih, Andri Susetyawati, Endang Susetyawati, MM Endang Susetyawati, MM. Endang Susetyowati, MM Endang Tri Puspita Yuliana Urmatul Waznah Utami, Febri Via Yustitia Wahyu Widyaningsih Wahyuni, Dina Wardhani, Firda Aprillia Wardhani, Firdha Aprillia Warniasih, Kristina Widyaningrum, Rachmawati Wuryandari, Tutik Wuryandari, Tutik Yanti, Asti Afrida Yuli Nurullaili Efendi, Yuli Nurullaili Yulia Yesti, Yulia Yulianto Yulianto Yuni Suprapto, Yuni