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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Harmoni Sosial: Jurnal Pendidikan IPS Folia Medica Indonesiana Jurnal Terapan Abdimas Al-Jabar : Jurnal Pendidikan Matematika Jurnal Farmasi Sains dan Komunitas Jurnal Mercumatika : Jurnal Penelitian Matematika dan Pendidikan Matematika Syntax Literate: Jurnal Ilmiah Indonesia Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kefarmasian Indonesia Pharmacoscript Jurnal Ilmiah Cendekia Eksakta Indonesian Journal of Global Health research Jurnal Pengabdian Masyarakat Multidisiplin Jurnal Kajian Ilmiah Prima Abdika: Jurnal Pengabdian Masyarakat Journal La Lifesci Journal of Instructional Mathematics Jurnal Penelitian Inovatif Indo-MathEdu Intellectuals Journal International Journal of Islamic and Complementary Medicine Journal Of Human And Education (JAHE) Duta Pharma Journal Journal of Food and Pharmaceutical Sciences Jurnal Farmasi Galenika Contemporary Education and Community Engagement JI-KES (Jurnal Ilmu Kesehatan)
Kintoko Kintoko
Prodi Magister Pendidikan Matematika, Pascasarjana, FKIP – UNS
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Antibacterial activity of dialkyl-aginate biosurfactant cream againts Staphylococcus aureus an Pseudomonas aerugynosa Kintoko, Kintoko; Sugihartini, Nining; Rukaya, Benazir Evita
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.10337

Abstract

Dialkyl-alginate biosurfactant is an amphifilik rhamnolipid biosurfactant that has the potential to be developed into an antibacterial agent. The purpose of this study was to prove that the biosurfactant of dialkyl alginate both before and after creams has antibacterial activity especially against Staphylococcus aureus and Pseudomonas aeruginosa. Test of antibacterial activity of biosurfactant dialkyl alginate at concentrations of 5%, 10% and 20% to Staphylococcus aureus and Pseudomonas aeruginosa using Hammond, et al (2011) modified quantitative method. Enbatic® 1% is used as a positive control and sterile aquadest as a negative control. Determination of antibacterial activity of dialkyl alginate biosurfactant followed by analysis of leakage of protein and nucleic acids using UV-vis Spectrophotometry and leakage of Ca2 + and K + metal ions using Atomic Absorption Spetrophotometry (AAS). The most active concentration was formulated into cream and then performed physical evaluation (organoleptic, pH, adhesion, spreading and viscosity) and tested antibacterial activity using the well method. The test results showed that the biosurfactants of dialkyl-alginate before and after the cream was treated as antibacterial activity. The concentration of 10% was the most active concentration having activity which did not differ significantly to positive control with p value of 0,05
Emulgel Formulation of Purified Extract of Moringa (Moringa oleifera L.) Leaf Wuryandari, Tutik; Sugihartini, Nining; Kintoko, Kintoko
Folia Medica Indonesiana Vol. 55 No. 1 (2019): March
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (253.999 KB) | DOI: 10.20473/fmi.v55i1.24329

Abstract

Moringa oleifera, known as moringa, is reported to have a high source of natural antioxidants, especially vitamin E. The formulation of purified Moringa leaf extract is needed so that the vitamin E content in it is more maximal. This study aimed to determine the levels of vitamin E in extracts after purification, physical property test of emulgel with variations in extract concentration and vitamin E levels in emulsions. The study was started from the extraction using maceration method with petroleum ether solvent, followed by extract purification using column chromatography with n-hexane solvent. The results of the purified extract were then formulated into emulgel with three concentrations of 3% (F1), 6% (F2) and 9% (F3). Emulgel was then evaluated for physical characteristics (pH, viscosity, adhesion, dispersion and stability). Determination of vitamin E levels was carried out on purified extract samples and on each formula. The results of non-specific standardization of extracts included ash content, acidic insoluble ash content were higher than those of Indonesian Herbal Pharmacopoeia literature and drying losses were lower compared to literature. Specific standardization of extracts was the content of vitamin E in 1.40% PE extract and 8.02% purified extract. In the test of emulgel physical characteristics, an increase in the concentration of the extract caused an increase in viscosity and decreased emulgel dispersion power. Whereas, tthe pH and sticky power remained the same. Storage hds an effect on decreasing the physical characteristics of emulsions especially on adhesion. Increased extracts also caused an increase in the levels of vitamin E in the purified extract of moringa leaf emulgel.
E-LKPD Model Pembelajaran Discovery Berbasis STEM untuk Meningkatkan Berpikir Kritis Cahayani, Devita Mika; Istikomah, Dhian Arista; Jana, Padrul; Kintoko, Kintoko
Indo-MathEdu Intellectuals Journal Vol. 6 No. 2 (2025): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v6i2.2714

Abstract

Advances in technology and science require students to adapt to various aspects of life, especially in the field of education. One of the abilities that needs to be improved in 21st century learning is the ability to think critically. This study aims to develop and test the validity of the Electronic Student Worksheet (E-LKPD) of the STEM-based discovery learning model to improve students' critical thinking skills. The development model used is the ADDIE model, which includes five stages: analysis, design, development, implementation, and evaluation. The data analysis technique used is descriptive. The results of the validity test by material experts and media experts show that the E-LKPD developed has a very high validity with an average score percentage of 82%. Based on these results, E-LKPD is considered very valid for use in learning
Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Abstract

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.
Pengaruh Fermentasi Laktat terhadap Kandungan Fenolik Total dan Aktivitas Antioksidan Poliherbal TBR serta Uji Profil Lipid secara in Vivo Mutti, Annisa Aulia; Kintoko, Kintoko; Sulistyani, Nanik
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i3.58198

Abstract

Lactate fermentation, such as yogurt, is known to increase antioxidant activity. In addition to yogurt, fermentation can also be applied to herbal plants. Polyherbal plants Taxus sumatrana (Sumatran cypress), jixueteng (Spatholobus suberectus), and pearl grass (Hedyotis corymbosa) (TBR) contain total phenolic compounds that act as antioxidants and can lower cholesterol levels. This study aims to analyze the effect of TBR polyherbal fermentation on total phenol content and antioxidant activity. Polyherbal extraction is carried out by the maceration method using 96% ethanol for 24 hours. Total phenolic tests were carried out using gallic acid, followed by aerobic fermentation with lactic acid bacteria Streptococcus thermophilus and Lactobacillus bulgaricus with 1%, 2%, and 3% TBR extract concentrations. Antioxidant activity was measured by the DPPH method, and lipid profile tests were performed in vivo on 35 white rats (Rattus norvegicus), which were divided into 7 treatment groups. The results showed that TBR polyherbal fermentation significantly increased the total phenolic levels, with a concentration of 3% resulting in the highest levels (41.689 ± 0.5682% GAE). Although antioxidant activity decreased slightly after fermentation, it remained in the strong category (IC50 76.816–88.283 μg/mL). In vivo tests showed that polyherbal yogurt TBR 3% lowered triglyceride and total cholesterol levels and slightly increased HDL levels, but was less effective in lowering LDL. In conclusion, TBR polyherbal fermentation increases total phenolic levels while maintaining strong antioxidant activity, with potential as a natural source of antioxidants for lipid profile improvement.
Ethnomedicine Study on Medicinal Plants in Nanggulan District, Kulon Progo Regency Kintoko, Kintoko; Saputri, Ginanjar Zukhruf; Novitasari, Putri Rachma; Desmayanti, Astri; Witasari, Hardi Astuti; Ranti, Imaniar; Yulianto, Yulianto; Febriansah, Rifki; Widyaningrum, Rachmawati; Utami, Febri; Setiyawati, Fitri Indah
Journal of Food and Pharmaceutical Sciences Vol 13, No 1 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.14189

Abstract

Despite the advancements in conventional medicine, medicinal plants continue to play an important role in treating different human ailments, particularly in developing nations. This is based on locals' knowledge of medicinal plants for treating various ailments. Ethnomedicine is a branch of research investigating society's local wisdom for maintaining its health. According to diverse field studies, 40 different varieties of plants have been discovered that the native inhabitants of Kulon Progo Regency think are medicinal. The purpose of this research was to identify therapeutic herbs used by the Kulon Progo population. Traditional healers and members of the Kulon Progo village were interviewed as part of this study. The ethnomedicine data was analyzed using Use Value (UV), Frequency of Citation (FC), and Plant Part Value (PPV). The analytical results suggest that turmeric (0.78), galangal (0.67), and ginger (0.67) are the most important plants to society. Rhizomes (38.10%) and leaves (34.52) are the most commonly employed plant parts for medicinal purposes. Boiling it (47.06%) produces herbal medication from the plant extract.
UJI AKTIVITAS SUSPENSI SERBUK SPIRULINA PLATENSIS TERHADAP KADAR HORMON TESTOSTERON DAN HISTOPATOLOGIK TESTIS TIKUS WISTAR DIABETES YANG DIINDUKSI STREPTOZOTOCIN Gunawan, Adhi; Kintoko, Kintoko; Yuliani, Sapto; Shabrina, Ayu
CENDEKIA EKSAKTA Vol. 6 No. 1 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i1.4402

Abstract

Diabetes mellitus merupakan penyakit metabolik yang dapat mengganggu fungsi reproduksi pada pria yaitu penurunan kadar hormon testosteron dan kerusakan jaringan testis. Spirulina platensis mengandung fikosianin sebagai antioksidan yang efektif untuk menurunkan kadar gula darah dan kerusakan organ reproduksi pria. Tujuan dari penelitian ini untuk mengetahui efek Spirulina platensis (SP) terhadap kadar hormon testosteron serta gambaran histopatologik testis tikus jantan diabetes yang diinduksi Streptozotocin (STZ). Tikus dibagi menjadi 6 kelompok yang terdiri dari K1 (tikus diberikan suspensi CMC-Na), K2 (tikus yang diinduksi STZ dosis tunggal 45 mg/kgBB), K3 (tikus diberikan suspensi SP 36 mg/200gBB), kelompok 4; 5 dan 6 (tikus diabetes diberikan suspensi SP 36 mg/200kgBB; 72 mg/200gBB dan 144 mg/200gBB). Penelitian dilakukan selama 28 hari dengan parameter yang diamati adalah kadar gula darah, kadar testosteron dan gambaran histopatologik testis dengan Hematoksilin - Eosin (HE). Hasil peneltian ini menunjukkan bahwa kelompok perlakuan dengan Spirulina platensis mampu meningkatkan kadar hormon testosteron yaitu 0,82 µG/mL, 1,13 µG/mL dan 1,66 µG/mL (p < 0,05) dibandingkan kelompok tikus diabetes. Spirulina platensis juga mampu mencegah kerusakan epitel tubulus seminferus pada testis dibandingkan kelompok diabetes. Pada hewan uji yang diberikan dosis 144 mg/kgBB memberikan aktivitas paling baik dalam menghambat kerusakan jaringan testis disebabkan oleh induksi STZ. Kata kunci: diabetes mellitus, gangguan reproduksi, hormon testosteron, Spirulina platensis
Kajian Pengembangan Kebun Biofarmaka Jogja Agro Park dan Pemetaan Pilot Project Pelayanan Kesehatan Tradisional pada Destinasi Wisata Strategis di Wilayah Kabupaten Kulon Progo DIY Kintoko, Kintoko; Desmayanti, Astri; Novitasari, Putri Rachma; Saputri, Ginanjar Zukhruf; Witasari, Hardi Astuti; Setiyawati, Fitri Indah
Jurnal Kajian Ilmiah Vol. 24 No. 1 (2024): January 2024
Publisher : Lembaga Penelitian, Pengabdian Kepada Masyarakat dan Publikasi (LPPMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31599/v57nbz71

Abstract

Through the use of both traditional medicine and contemporary medicine, Indonesians, particularly those in Kulon Progo Regency, have managed to maintain a high level of health. The availability of traditional health services in the community does not simply refer to inherited knowledge; it has also been developed scientifically through product saintification initiatives, their usage, and traditional healers' academic qualifications. There are numerous opportunities for traditional healthcare services to be established in the Kulon Progo Regency. Construction of the "Surgery Menoreh" route, which passes through the areas of Kapanewon Temon, Kokap, Girimulyo, Samigaluh, and Kalibawang, lends support to this. This study aims to map a traditional healthcare pilot project that has grown in the Kulon Progo Regency. The findings of this study provide an overview of the potential of Jogja Agro Park and various traditional healer treatments in Kulon Progo Regency. So that this study can be used as a reference in the region's development of traditional health services.
E-LKPD Model Pembelajaran Discovery Berbasis STEM untuk Meningkatkan Berpikir Kritis Cahayani, Devita Mika; Istikomah, Dhian Arista; Jana, Padrul; Kintoko, Kintoko
Indo-MathEdu Intellectuals Journal Vol. 6 No. 2 (2025): Indo-MathEdu Intellectuals Journal
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v6i2.2714

Abstract

Advances in technology and science require students to adapt to various aspects of life, especially in the field of education. One of the abilities that needs to be improved in 21st century learning is the ability to think critically. This study aims to develop and test the validity of the Electronic Student Worksheet (E-LKPD) of the STEM-based discovery learning model to improve students' critical thinking skills. The development model used is the ADDIE model, which includes five stages: analysis, design, development, implementation, and evaluation. The data analysis technique used is descriptive. The results of the validity test by material experts and media experts show that the E-LKPD developed has a very high validity with an average score percentage of 82%. Based on these results, E-LKPD is considered very valid for use in learning
The Potency of Microalgae as a Marine Source: A Bibliometric Analysis Witasari, Hardi Astuti; Kintoko, Kintoko; Ahda, Mustofa; Rangkuti, Ahmad Faizal; Suhendra, Suhendra; Mahfudh, Nurkhasanah
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.18870

Abstract

Microalgae were a marine source that was highly sustainable and offered numerous benefits in industrial applications. Many species were safe and effective as active ingredients in the food, cosmetics, and pharmacy industries and became raw materials for renewable energy, such as biofuel. The exploration of bioactive compounds was enticing for the research. The study of microalgae potency is a fascinating subject that deserves further exploration. The bibliometrics analysis can provide a good overview of microalgae research and its applications in industry. This overview was derived from the Scopus database, which contained all articles published between 1993 and 2023 with the keywords "microalgae" and "their application. Based on this discovery, many papers reported the potential of microalgae for antioxidants, nutrition, vaccine adjuvants, bioethanol, biofuel, and other applications for 2021-2022. This review criticizes the cultivation in a controlled environment up to the toxicity of microalgae. According to this review, many researchers focused and collaborated on exploring microalgae in the top three international journals, such as Algal Research, Marine Drugs, and Journal of Applied Phycology. Several countries, including Italy, Spain, and China, were the most focused on declaring the application of microalgae. The keywords described the core discussion and could be read generally and comprehensively. This bibliometric analysis was expected to contribute to developing microalgae for many applications.
Co-Authors Ananda, Aghnia Nabila Anggraeni, Linda Suci Aris Setyawan Ariyanti, Lusi Mardika Astuti, Andarweni Atmarani, Rizki Essa aviory, koryna Ayu Shabrina Botutihe, Lisa Agustina Cahayani, Devita Mika Dani Kusuma Desmayanti, Astri Dhian Arista Istikomah Dian Aprilia, Dian Dona, Suzana Dwi Utami Eka Siswanto Syamsul Epi Taufik Fajar Fajar Farid , Muhammad Ferani Mulianingsih Gunawan Gunawan Gunawan, Adhi Hadi Siswanto, Deny Hardi Astuti Witasari Hutari, Andri Ilmia, Nisrien Indahsari, Kharisma Safitri Nur Isnaini Isnaini Jana, Padrul Khrisna Agung Cendekiawan Kusumo, Djati Wulan Lestariningrum, Wahyu Titis Maghfirah, Yolanda Sajjida Makati, Annisa Camellia Mehta, Kunal Mochammad Saiful, Bachri Muhammad Iqbal Birsyada Muldiyana, Tya Mustofa Ahda Mutti, Annisa Aulia Nanik Sulistyani Nina Widyaningsih, Nina Nining Sugihartini Novitasari, Putri Rachma Nurkhasanah Mahfudh Nurlita, Tasya Nuryani, Eva Oktavia, Lisa Pamungkas, Megita Dwi Pulhehe, Hasni Rangkuti, Ahmad Faizal Ranti, Imaniar Restu Ayu Mumpuni, Restu Ayu Ridho, Anisa Rifka Rifki Febriansah Rohma, Siti Rohmah, Lely Arbiati Nur Rukaya, Benazir Evita Sa’adah, Hayatus Safira, Rizka Santoso, Blegoh Iwan Sapto Yuliani Saputri, Ginanjar Zukhruf Septian Aji Permana Septiana Wijayanti Setiyawati, Fitri Indah Siswanto, Deni Hadi Siswanto, Deny Hadi Sri Budiarti, Nur Idha Sri Wulandari Suhendra Suhendra Sulistyani , Nanik Sunanti, Titis Supomo Supomo Suryaningsih, Andri Susetyawati, MM Endang Susetyawati, MM. Endang Susetyowati, MM Endang Tri Puspita Yuliana Urmatul Waznah Utami, Febri Via Yustitia Wahyuni, Dina Warniasih, Kristina Widyaningrum, Rachmawati Wuryandari, Tutik Wuryandari, Tutik Yanti, Asti Afrida Yuli Nurullaili Efendi, Yuli Nurullaili Yulianto Yulianto Yuni Suprapto, Yuni