Article Per Year (5 Year)
p-Index From 2021 - 2026
9.313
P-Index
This Author published in this journals
All Journal AGRISAINS Jurnal Ilmiah Mahasiswa FEB Journal of Biomedicine and Translational Research English Review: Journal of English Education Jurnal The Messenger Jurnal Pendidikan Usia Dini Medika Tadulako Jurnal Online Program Studi Pendidikan Ekonomi AWLADY Jurnal Pendidikan Anak The Indonesian Biomedical Journal Indonesian Journal of Early Childhood Education Studies Jurnal Maneksi (Management Ekonomi Dan Akuntansi) Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini Eralingua : Jurnal Pendidikan Bahasa Asing dan Sastra AL-ATHFAAL : JURNAL ILMIAH PENDIDIKAN ANAK USIA DINI AL-ATHFAL : JURNAL PENDIDIKAN ANAK CIVICUS : Pendidikan-Penelitian-Pengabdian Pendidikan Pancasila dan Kewarganegaraan Jurnal Pelita PAUD Aulad : Journal on Early Childhood KOMIK (Konferensi Nasional Teknologi Informasi dan Komputer) JURIKOM (Jurnal Riset Komputer) JOURNAL OF SCIENCE AND SOCIAL RESEARCH Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan Jurnal Keperawatan dan Fisioterapi (JKF) Jurnal EnviScience (Environment Science) BERNAS: Jurnal Pengabdian Kepada Masyarakat MURHUM : JURNAL PENDIDIKAN ANAK USIA DINI JOURNAL OF LANGUAGE Widya Pranata Hukum : Jurnal Kajian dan Penelitian Hukum Jurnal Ilmiah Wahana Pendidikan Journal of Science and Education (JSE) International Journal of English and Applied Linguistics (IJEAL) Daluang: Journal of Library and Information Science Empowerment : Jurnal Pengabdian Pada Masyarakat JOURNAL OF HUMANITIES, SOCIAL SCIENCES AND BUSINESS (JHSSB) Bulletin of Data Science Procedia of Social Sciences and Humanities Majalah Ilmiah Inspiratif Al Hanin Jurnal Pengmas Kestra (JPK) Proceeding of International Conference on Science, Education, and Technology Riwayat: Educational Journal of History and Humanities Jurnal Pendidikan Anak Usia Dini Aktual : Jurnal Pengabdian Kepada Masyarakat GENIUS: Indonesian Journal of Early Childhood Education Proceeding Of International Conference On Education, Society And Humanity Jurnal Pelita PAUD PAUDIA: JURNAL PENELITIAN DALAM BIDANG PENDIDIKAN ANAK USIA DINI BACA: Jurnal Dokumentasi dan Informasi Exploration In Early Childhood Research Prosiding Seminar Nasional Keguruan dan Pendidikan (SNKP)
Sri Wulan, Sri
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 85 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : The Indonesian Biomedical Journal

 1 
Butterfly Pea and Roselle Combination Extracts Reduce V-CAM, ICAM, and IL-6 Levels in High Fat Atherogenic Diet Rats Harefa, Karnirius; Ritonga, Ahmad Hafizullah; Safitri, Riri; Aritonang, Barita; Gurusinga, Rahmad; Irmayani, Irmayani; Wulan, Sri
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3361

Abstract

BACKGROUND: Atherosclerosis, driven by inflammation and oxidative stress, increases the risk of coronary heart disease (CHD). Flavonoids in butterfly pea and roselle are known for their potent antioxidant and anti-inflammatory properties. While their individual effects on cardiovascular health have been studied, no studies have explored the combined impact on atherosclerosis biomarkers, including vascular cell adhesion molecules (VCAM)-1, intercellular adhesion molecule (ICAM)-1, and interleukin (IL)-6. Therefore, this study was performed to evaluate the synergistic effects of butterfly pea and roselle combination extracts (BPRCE) on these biomarkers.METHODS: A study with a post-test control group design using 36 male white rats was performed. The rats were randomly assigned to 6 groups; 1 group was fed with standard feed, while 5 groups were fed with a high-fat atherogenic diet (HFAD) to create atherosclerosis rat models. The HFAD rats were given either no treatment, sodium carboxymethylcellulose (Na-CMC), 300, 400, or 500 mg/kgBW BPRCE. Serum levels of VCAM-1, ICAM-1, and IL-6 of rats were measured using enzyme-linked immunosorbent assay (ELISA) methods.RESULTS: Increasing doses of BPRCE resulted in a significant reduction in VCAM-1, ICAM-1, and IL-6 compared to the other groups. The group with the highest dose, 500 mg/kgBW BPRCE, showed the greatest reduction of VCAM-1 level (32.73±3.57 pg/mL), ICAM-1 level (5.68±1.17 ng/mL), and IL-6 levels (21.49±4.62 pg/mL).CONCLUSION: Administration of BPRCE in atherosclerosis rats model reduces VCAM-1, ICAM-1, and IL-6 in a dose-dependent manner. This study showed that using BPRCE as a traditional remedy for preventing and treating CHD at an optimal dose of 500 mg/kgBW might be a potential future application in reducing atherosclerosis biomarkers.KEYWORDS: VCAM-1, ICAM-1, IL-6, butterfly pea, rosella, atherosclerosis
Co-Authors A Difinubun, Balqis Abdul Halim Hasugian Ade Dwi Utami Adindi, Satria Ahmad Hafizullah Ritonga Ainun Jariyah Anisah Arisaputra, Muh Ilham Aritonang, Barita Arsil N. , R. Sibyan Asbi, Sherllyn Azzaharra Asep Munajat Asnani Asnani Auliyani, Siti Azka, Haula Millati Badrudin Berutu, Achmanudin Br. Girsang, Desri Meriahta Cahyani Kusuma, Tesya Christy, Naulita Dea Febriani Dede Hikmah Dedi Gumilar Desyanti - Desyanti Devi Pratiwy Dewi Fatmasari DEWI SARTIKA Dewi, Meidiana Sonya Rachma Dewi, Suci Mulia Dinar Nur Inten Ekalestari, Susi Elindra Yetti Fakhrimantho, Agus Fince Tinus Waruwu Firda Aprilia, Elsa Frastiyono, Arjun Fridani, Lara Gunarti, Winda Halim, Muliha Hapidin, Hapidin Harahap, Cindy Artika Harmonika, Sri Haryono Haryono Hasrul, Muh Haula, Haula Millati Azka Hikmah Hikmah Hilmi Najamudin, Muhammad I Gusti Agung Gede Widnyana, I Gusti Agung Gede Irmayani Irmayani Irsan Bertinus Tondowala Istanti, Jannah Triska Tri Iva Sarifah Jamaris, Martini Jayani, Rina Junia, Rita Karnirius Harefa Kesya Dia Ramadani Khairiyah, Umi Kristian, Wemni Kurniahu, Hesti Kurniati, Nina Siti Labesani, Cirtye Lisda Yuni Mardiah Livina, Meri M. Manugeren, M. Machmud Yunus Maha, Rahmadani Ningsih Mahid, Perveen Sonia Mahmudah, Zuhrotul Manugeren, M Mardiah, Lisda Yuni Maringan Sianturi Masril Aguswandi Tudjuka Mesran, Mesran Miharja, Rediawan Miranda, Mai Mochammad Imron Awalludin Mohamad Syarif Sumantri Mohd Fauzi, Mohd Muhammad Irham Mursidah, Nailul Nasution, Amanda Maulida Nasution, Cherry Adistya Nazwa, Nazwa Nirwana, Nirwana Nurani, Yuliana Nurbiana Dhieni Nurjannah Nurjannah Nurnaningsih Nurnaningsih Nurulhikmah Pardede, Desika Wali Pardi Pardi Pardi Pardi Pardi, Pardi Pratiwi, Elsa Pudjiastuti, Sri Indah Purwarno, Purwarno Putri, Dea Febriana Putri, Lusianawati Eka Putri, Nada Febriansyah Rahmad Gurusinga Rahmat Rahmat Rahmat, Dadan Riri Safitri Risa Rahmawati, Risa Riska Andriani Riskawati Riskawati, Riskawati Rita Junia Rita Suirlan Rivalri Kristianto Hondro Rohima, Yulia Kuraesin Ila Rohminatin, Rohminatin Rosa Dwi Wahyuni RR. Ella Evrita Hestiandari Sabarudin, Mohammad Saprudin, Asep Sarifah , Iva Shalwa Fatona Siti Mutiara Zam Zam Siwi, Purwanto Sofia Hartati Solehudin, Didin Sri Rosyidatul B, Eulis Sri Susanti Suci Wardani, Anggieta Suginam Suhardi Suhardi Sumadi, Tjipto Supriyadi, Deni Susanti, Plistiana Syahida, Ridha Syifauzakia, Syifauzakia Tabasi, Yosafat Tri Setyawati Vera Diana Towidjojo Wahyu Dewantoro, Gema Widjayatri, Rr. Deni Yenti Juniarti Yohan Yohan Yuliani Nurani Yuliati, Chariroh Yunus Sading Yuyun Alfasius Tobondo Zainal Zainal Zara, Mutiara Zarina Akbar