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All Journal JURNAL PENELITIAN SAINTIKA Journal of Agromedicine and Medical Sciences Jurnal Mirai Management Jurnal Surya Medika JURNAL PENELITIAN PENDIDIKAN MIPA Jambura Journal of Chemistry PREPOTIF : Jurnal Kesehatan Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Chemical Science and Technology Journal of Economics and Business UBS Jurnal Kesehatan Tambusai Al-Sharf: Jurnal Ekonomi Islam JOURNAL LA MEDIHEALTICO Indonesian Journal of Pharmaceutical Education JUKESHUM: Jurnal Pengabdian Masyarakat FORTE JOURNAL Jurnal Pusat Studi Pendidikan Rakyat (PUSDIKRA) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Farmanesia Jurnal Sains dan Teknologi Journal of Health and Medical Science International Journal of Public Health Excellence (IJPHE) International Journal of Health and Pharmaceutical (IJHP) SENTRI: Jurnal Riset Ilmiah ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Jurnal Farmasi Klinik dan Sains All Fields of Science Journal Liaison Academia and Sosiety Cross-border Eduvest - Journal of Universal Studies FARMASAINKES Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Analit: Analytical and Environmental Chemistry Usada Nusantara: Jurnal Kesehatan Tradisional Journal of Pharmaceutical and Sciences. JK Jurnal Kesehatan Jurnal Penelitian Pendidikan MIPA Medic Nutricia : Jurnal Ilmu Kesehatan Media Farmasi Seroja Husada: Jurnal Kesehatan Masyarakat Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Jurnal Akademika Kimia Jurnal Sains dan Kesehatan MAFEBIS: Jurnal Manajemen, Akuntansi dan Bisnis
Ridwanto Ridwanto
Universitas Muslim Nusantara Al-Washliyah Medan
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Determination Of Total Alkaloid Content Of Yellow Wood (Arcangelisia flava (L.) Merr) Extract Based On Differences In Ethanol Concentration Using Uv-Vis Spectrophotometry Method Yuliana, Rika; Daulay, Anny Sartika; Ridwanto, Ridwanto; Rahman, Fathur
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.27

Abstract

Yellow wood with its secondary metabolites is one of the plants that has the potential as a traditional medicinal plant to treat various diseases, such as cancer. The chemical compounds contained in yellow wood are alkaloids, saponins, tannins, flavonoids, steroids/triterpenoids. The objective of this research was to determine the chemical compounds contained in ethanol extract and determine the total alkaloid value of yellow wood extract. This research method is an experimental method which includes processing plant materials, making ethanol extract concentrations of 50, 70 and 96%. Characterization examination, phytochemical screening and determination of total alkaloid levels of yellow wood extract by Uv-Vis spectrophotometry method. The results of phytochemical screening on yellow wood ethanol extract contain chemical compounds such as alkaloids, saponins, tannins, flavonoids, steroids/triterpenoids. Determination of total alkaloid levels is carried out by determining the maximum wavelength of caffeine, measuring the kaffein calibration curve and calculating total alkaloid levels using the Uv-Vis spectrophotometry method. Results The determination of total alkaloid levels in ethanol solvent extract concentration of 50% is 2.9649 ± 0.1767%, ethanol solvent extract with a concentration of 70% is 6.0180 ± 0.2469% and ethanol solvent extract with a concentration of 96% is 10.92001 ± 2.7803%.
Cytotoxicity Test of Ethanol Extract of Herb Sintrong (Crassocephalum crepidioides (Benth.) S. Moore) Against Artemia Salina Leach Shrimp Larvae Using the BSLT Method Tambupolon, Sanya Tanika; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.33

Abstract

Cancer is a disease that arises as a result of an error in the division system at the cell level resulting in abnormal cell growth with a continuous, uncontrolled growth rate that can change shape and spread to other organs or is called metastasis. One of the plants that has the potential as an anticancer is the herb sintrong (Crassocephalum crepidiodes (Benth.) S. Moore). The purpose of this study was to determine the class of secondary metabolites contained in the powder and ethanol extract of the herb sintrong (Crassocephalum crepidioides (benth.) S. Moore) and its cytotoxicity by looking at the LC50 value using the Brine Shrimp Lethality Test (BSLT) method.Cytotoxicity testing was carried out using the BSLT method with Artemia salina Leach shrimp larvae as test animals with concentrations of 100-1000 µg/mL, with negative control without added extract. The LC50 value was analyzed using a straight line regression equation by entering data on the probit value and the logarithm of the concentration.The secondary metabolite compounds contained in sintrong herb (Crassocephalum crepidiodes (Benth.) S. Moore) using the phytochemical screening method are flavonoids, alkaloids, tannins, saponins and steroids. Based on the results of the toxicity test using the Brine Shrimp Lethality Test (BSLT) method, the LC50 value = 295.3800 µg/mL showed that the sintrong herb extract is toxic and has the potential as an anticancer. The test compound is said to be toxic if the LC50 value is ˂1000 µg/mL.
Simultaneous Solubility Analysis of Paracetamol, Propyphenazone, and Caffeine Using Principal Component and Absorbance Ratio Regression Methods Rosaldi, Hikmah; Pulungan, Ainil Fithri; Ridwanto, Ridwanto; Daulay, Anny Sartika
Indonesian Journal of Science and Pharmacy Vol. 1 No. 2 (2023): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i2.39

Abstract

Medicines can cause changes in the physiology or psychology of an organism when consumed. In general, medicines consist of several mixtures of active ingredients such as paracetamol (PCT), propifenazone (PRO), and caffeine (KAF), which are often found in several types of branded medicines that are claimed to be able to cure or treat. This research aims to obtain a type of solvent that has the smallest photometric error value and can completely dissolve the active ingredient mixture of PCT, PRO, and KAF. In general, organic solvents such as ethanol and methanol are very often used to dissolve compounds that mix with each other, but these solvents cannot always dissolve other active substances. Therefore, researchers carried out an analysis of several types of solvents that could dissolve the three active ingredients. Solvents that can dissolve perfectly without any specification stage must go through a solvent optimization process. The types of solvents that will be tested are methanol, HCl 0.1N, phosphate buffer pH 7.2, and the ratio of phosphate buffer: methanol (DM) (DM 9:1 pH 7.4), (DM 7:3 pH 7.8), (DM 5:5 pH 8.3), (DM 3:7 pH 8.9), and (DM 1:9 pH 9.6). The results of this research show that the solvent that has the smallest photometric error value and can completely dissolve the three active substances is the DM 7:3 pH 7.8 solvent with a total percentage of 0.0846%, which is the smallest value compared to other solvents that have been optimized.
Characterization and Phytochemical Screening Of Tampala Bajakah Wood (Spatholobus littoralis Hassk) Extract With Methanol and Ethyl Acetate Solvents Alviana, Liya; Ridwanto, Ridwanto; Daulay, Anny Sartika; Rani, Zulmai
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.40

Abstract

One of the plants that contains secondary metabolite compounds is Bajakah Tampala wood (Spatholobus littoralis Hassk). The aim of this research is to determine the chemical compounds contained in methanol and ethyl acetate extracts. The stages of this research include processing plant materials, making methanol and ethyl acetate extracts, characterization examinations, and phytochemical screening. Bajakah Tampala wood extract was made using the maceration method using methanol and ethyl acetate. The extract obtained was concentrated using a rotary evaporator. The characterization of Bajakah Tampala sawdust showed that the water content test was 2%, the water soluble juice content test was 7.1%, the ethanol soluble juice content test was 12.05%, the total ash content test was 3.65%. , and testing the ash content that is insoluble in acid was 0.1%. Meanwhile, the results of the phytochemical screening of Bajakah Tampala wood showed that it contained chemical compounds such as alkaloids, flavonoids, saponins, tannins, and steroids and triterpenoids.
Isolation of Chitosan from Lake Toba Freshwater Lobster Shells (Cherax quadricarinatus) Sinaga, Novita Yulianti; Ridwanto, Ridwanto; Daulay, Anny Sartika; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.41

Abstract

Chitosan is an amine polysaccharide that is formed after chitin undergoes a deacetylation process. This compound has a significant role as a natural biopolymer which is polycationic. This research aims to make chitosan from freshwater lobster shells obtained from Lake Toba. The research method is experimental. Includes making chitosan from freshwater lobster shells. The process of making chitosan includes demineralization, deproteination and deacetylation stages. Chitosan was characterized by measuring water content, ash content, yield, solubility, and analysis using an FTIR spectrophotometer. Based on the results of research that has been carried out, it was found that the characteristics of chitosan have a yield value of 50.88%, water content 5.9%, ash content 0.67% and chitosan dissolves in glacial acetic acid. The results of the research show that chitosan has similar functional groups to standard chitosan and the degree of deacetylation is 80.25%. This research has met the chitosan standard (SNI 7949:2013) with a percentage of the degree of deacetylation of chitosan that meets the standard (>60%).
Antibacterial Activity Of Freshwater Lobster Shells (Cherax quadricarinatus) Against Escherichia coli Hafizha, Putri; Ridwanto, Ridwanto; Daulay, Anny Sartika; Nasution, Haris Munandar
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.42

Abstract

People still do not utilize freshwater lobster (Cherax quadricarinatus) shells optimally, even though the chitin compound contained in this waste can be modified into chitosan through chemical reactions. Chitosan obtained from freshwater lobster shells can be used as an antibacterial. This study aims to test the antibacterial activity of chitosan from freshwater lobster shell waste against Escherichia coli bacteria. Making chitosan is carried out through three processes, namely, demineralization, deproteination, and deacetylation stages. Then, characterization of the chitosan is carried out, which includes water content, ash content, yield, and solubility. The research results showed that the chitosan obtained in this study was 43.96%, and the degree of deacetylation value of freshwater lobster shell chitosan was 75.11%. Chitosan with a concentration of 0.3, 0.5, 0.7, and 0.9% provides an inhibition zone of 13.5, 15.9, 16.8, and 17.2 mm, respectively, against Escherichia coli. Thus, a concentration of 0.9% chitosan from freshwater lobster shells has better antibacterial activity and is categorized as having strong inhibitory power.
Isolation and Characterization of Chitosan from Kepah Shell Waste (Polymesoda erosa) Percut Sei Tuan, North Sumatera Sitorus, Dara Indah; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 1 No. 3 (2024): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v1i3.43

Abstract

Kepah clams (Polymesoda erosa) are one of the few aquatic animals that have a body and are protected by two cupped shells. Many people consume this shellfish meat, but many of the shells are thrown away by local people so that they only become waste. It is this shell waste that needs to be processed properly because it is known that shells are one of the fishery ingredients that contain chitin. One way to make kepah clams have a higher economic value is by isolating kepah clams into chitosan. The purpose of this study was to isolate and characterize chitosan from mussel shells and to determine functional groups using Fourier infrared (FTIR). The isolation methods used were deproteination, demineralization, depigmentation, deacetylation, and chitosan characterization. The results showed that the yield of the transformation of chitin into chitosan in cockles was 85.77% and had a brownish-white powder texture and no odor. The water content in the chitosan of the clam shells obtained was 1.53%, the ash content was 0.50%, and the degree of deacetylation obtained was 75%.
Antibacterial Activity Test of Ethanol, N-Hexane, and Ethyl Acetate Extracts of Lemon Peel (Citrus x limon (L.) Burm. f.) Nisa, Uswatun; Mambang, D Elysa Putri; Yuniarti, Rafita; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.88

Abstract

Staphylococcus hominis and Pseudomonas aeruginosa bacteria are normal flora bacteria found on the surface of human skin, and in certain circumstances can cause infections in the body of a person with a weak immune system. Infection of both bacteria can cause body odor that can affect a person's social relationships. The use of natural antibacterials has minimal side effects, namely lemon peel which is waste from lemons. Lemon juice is commonly used by the public, but not many people know that lemon peel has great benefits like lemon juice. The objective of the research was to determine the chemical compounds contained in the n-hexane fraction, ethyl acetate of lemon peel and antibacterial activity in ethanol extract, n-hexane fraction, ethyl acetate of lemon peel (Citrus x limon (L.) Burm. f.) This research method was an experimental method that includes sample collection and processing, characterization of simple drugs, preparation of 96% ethanol extract, n-hexane fraction, ethyl acetate fraction, phytochemical screening, and antibacterial activity test using the agar diffusion method at concentrations of 10%, 20%, 30%, 40%, 50%. The results of phytochemical screening in the ethyl acetate fraction contain alkaloids, flavonoids, tannins, triterpenoids, and in the n-hexane fraction shows the presence of triterpenoid chemical compounds. Ethanol extract, n-hexane fraction and ethyl acetate fraction of lemon peel have antibacterial activity on Staphylococcus hominis and Pseudomonas aeruginosa bacteria. The results of the three samples tested for the greatest inhibitory power in the ethyl acetate fraction showed intermediate results, almost comparable to the inhibitory power of the positive control ciprofloxacin.
Antibacterial Activity Test of Ethanol Extract, n-Hexane and Ethyl Acetate Fractions of Cardamom Fruit (Amomum cardamomum Soland. Ex Maton Benth) Nada, Dina Qatrun; Mambang, D Elysa Putri; Nasution, M. Amin; Ridwanto, Ridwanto
Indonesian Journal of Science and Pharmacy Vol. 2 No. 3 (2025): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v2i3.96

Abstract

Bacterial infection is a global health problem that requires special attention, especially due to increasing resistance to antibiotics. This study aims to determine the antibacterial activity of ethanol extract, n-hexane fraction and ethyl acetate fraction of cardamom fruit (Amomum cardamomum Soland. Ex Maton Benth) against Streptococcus pyogenes and Pseudomonas aeruginosa bacteria. The extraction was done by percolation using 96% ethanol, followed by fractionation using n-hexane and ethyl acetate solvents. Phytochemical screening tests showed the presence of alkaloid, flavonoid, tannin, and saponin compounds known to have antibacterial activity. Antibacterial activity test was conducted using disc diffusion method with five concentrations (10%-50%). The results showed that the ethyl acetate fraction had the greatest inhibition, with the highest inhibition zone against Streptococcus pyogenes of 14.1 mm and Pseudomonas aeruginosa of 16.8 mm at 50% concentration. Inhibition increased with increasing concentration. The ethyl acetate fraction proved to be the most effective because it contains semipolar compounds that are able to penetrate the bacterial cell wall. This study supports the potential of cardamom fruit as an alternative natural antibacterial agent.
Penyuluhan Pembuatan Sabun Cuci Tangan dari Daun Jambu Biji Puteri, Cut Intan Annisa; Ningtias, Anggitha; Rani, Zulmai; Dalimunthe, Gabena Indrayani; Nasution, Haris Munandar; Ridwanto, Ridwanto
Jurnal Bakti Nusantara Vol. 1 No. 3 (2024): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v1i3.45

Abstract

Sabun cuci tangan merupakan sabun khusus yang dapat membersihkan tangan dari kuman dan debu serta menjaga kulit agar tetap halus dan lembut. Pasca pandemik Covid-19 membuat penggunaan sabun cuci tangan semakin meningkat. Peningkatan ini terjadi karena adaptasi kebiasaan baru untuk selalu mencuci tangan sebelum dan setelah beraktivitas. Tujuan penyuluhan ini adalah agar masyarakat memahami bahwa mencuci tangan sangat penting untuk mencegah masuknya kuman, virus dan bakteri melalui mulut, hidung dan mata. Seiring berjalannya waktu, inovasi tentang tanaman herbal semakin berkembang dan telah banyak penelitian antibakteri yang diteliti. Salah satu tanaman yang terbukti dapat menghambat pertumbuhan bakteri adalah daun jambu biji. Metode yang digunakan dalam kegiatan ini adalah dengan memberikan penyuluhan berupa ceramah interaktif terkait bagaimana cara pembuatan sediaan sabun cuci tangan dari daun jambu biji. Kegiatan pengabdian dilaksanakan di Apotek Farmasi UMN Al-Washliyah. Hasil pengabdian ini diperoleh masyarakat merespon dengan cukup antusias dan merasa penuh syukur memperoleh tambahan pengetahuan terkait pembuatan sabun cuci tangan cair dari daun jambu biji.
Co-Authors Abdullah, Husaini Abdullah, Muhammad Wahyuddin Adawiyah, Marissa Tasya Adyani Maulinda Afrizani, Afrizani Agus Priyadi Akbar, Windi Hari Al Hudawi, Muhammad Al Qodri, Muhammad Alviana, Liya Amin Nasution, Muhammad Amir, Annisa Fadilah Andi Syahputra, Ricky Ani Sutiani Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Aprilia, Hijjatun Aprilia, Medhy Ardhita Arifin, Khairil Fikri Arjuniadi, Arjuniadi Audry Pratiwi Audry Pratiwi Azhar, Gustika Azri, Atika Azzahra, Fadya Cici Andriani Claudy Friesta Melanie Dalimunthe, Gabena Indriyani Damanik, Sumayyah Daniel Happy Putra Daulay , Anny Sartika Daulay, Ani Sartika Daulay, Anny S. Denni Bahari Dikki Miswanda Dina Suciati Saragih Dison Silalahi, Alistraja Elma Natasya Fadhilah M, Ihsan Fadhlah Al-Uyun Nasution Fajri, Fajrilda Aqilah Fathur Rahman Fathur Rahman Fatur Rahman Fithri Pulungan, Ainil FRANSISKA, EVA Gabena Indrayani Dalimunthe Hafizha, Putri Harahap, Ade Try Atwinda Harahap, Siti Salimah Harahap, Sumiyarni Haris Munandar Nasution Harun , Fathur Rahman Harun , Fatur Rahman Harun, Fathur Rahman Hasanah, Qori Hasibuan , Nabila Hasim Hasibuan, Sarinah Hasibuan, Supia Indah Hazizah, Mautia Hermawan, Fiqri Humairah, Dwina Angelina Imelda Natasia Br S Meliala Irvan Andreansyah Irwan Misbach Isnaria, Vita Khairunnisa Khairunnisa Lastri Afni Lince Bulutoding Lubis, Minda Sari M. Naufal Rifqi Maghfirah , Dini Makhfirah Malahayati Malahayati Mambang, D Elysa Putri Manik, Umi Chairani Manurung, Aisyah Baddriah Maryanti Yuza Melinda, Reni Meliyana Meliyana Merani Phaustina Lumban Gaol Mirna Mirna Muchlis, Syaiful Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Wahyudi Munthe, Ariska Munthe, Herlina Nada, Dina Qatrun Nadila Indra Sepvina Nasri Nasri, Nasri Nasution, Kartika Zsaskia Nasution, M. Amin Nasution, Shamila Sufi Aulia Nazirah, Nazirah Ningtias, Anggitha Nst, Haris Munandar Nur Ainun Nuraida Nuraida Nurhayati Nurhayati Nurliansyah, Nurliansyah Nurmazela, Virda Parapat , Anjarlit Romiyuliana Br Pitaloka, Syifa Amilia Pulungan, Ainil Fitri Puteri, Cut Intan Annisa Putri Khairani Putri Theresia Harianja Putriyana Putriyana Qisti Pristiwani Rahayu , Yayuk Putri Rahayu Rahayu Rahma Dona, Rahma Rahmadani , Adevika Rahmadani Rahmadani Rahmah, Ruhiya Rahmasari, Siti Rahmayanti, Putri Rambe, Robiatun Reza Irma Ricky Andi Syahputra Rika Yuliana, Rika Riski Mulyani, Riski Risma Fauziah Pasaribu Rizki, Dewi Rizki, Rahmad Rosaldi, Hikmah Rossa, Aliffa S Sumarlin Sagala , Vipi Zetiara Salwa, Shakhila Saragih, Alkausar Sari, Farida Sartika Daulay, Anny Sasnita, Merida Selfia Lestary Shilvia, Fatin Sinaga, Novita Yulianti Siradjuddin, Siradjuddin Siregar , Anisah Siregar, Muhammad Alfariz Baihaqi Sitompul, M. Saleh Sitorus, Dara Indah Sri Wahyuni Syahfitri , Adelya Syahputra, Ricky Andi Syalsabila Putri Syarifah Aulia Tamara Army Tambupolon, Sanya Tanika Trizaldi, Asep Utama, Fazrul Amin Vera Estefania Kaban Wijiyaningsih, Dinda Yanti, Rahma Yayuk Putri Rahayu Yulia Nanda Putri Yuniarti , Rafita Yuniarti, Rafita Ziza Putri Aisyia Fauzi Zulmai Rani