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All Journal Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Science and Technology Health Notions Care : Jurnal Ilmiah Ilmu Kesehatan Biomolecular and Health Science Journal JOSSAE (Journal of Sport Science and Education) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Majalah Biomorfologi (Biomorphology Journal) Multilateral: Jurnal Pendidikan Jasmani Dan Olahraga Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Indian Journal of Forensic Medicine & Toxicology Indonesian Andrology and Biomedical Journal Asian Journal of Health Research The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Sewagati Warta LPM Strada Jurnal Ilmiah Kesehatan (SJIK) Folia Medica Indonesiana

Rejeki, Purwo Sri

Departemen Ilmu Faal Dan Program Studi Magister Ilmu Kesehatan Olahraga, Fakultas Kedokteran Universitas Airlangga

Author-ID : 692834

Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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A Systematical Review of The Effect of Ketogenic Diet on Bcl-2 (B-cell lymphoma-2) Expression as An Apoptosis Marker in Cancer Treatment Vania Islamey Kusuma; Reny I’tishom; Ema Qurnianingsih; Purwo Sri Rejeki
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30173

Introduction: Ketogenic diet seems to be in a great demand nowadays as a lot of people are interested in adopting it into their lifestyle. It is also found that the ketogenic diet shows several beneficial effects including cancer prevention. However, the detail mechanism still remains unknown. Therefore, this review was aimed to find out the effect of ketogenic diet on Bcl-2 (B-cell lymphoma-2) expression in cancer.Methods: We searched published literatures in PubMed through 2011-2020 using specific keywords. The literatures were filtered according to inclusion and exclusion criteria. Animal model, total sample size, underlying condition/inflammatory process occurs, details of the intervention/diet including diet contents in control group and high-fat group, and the duration of the intervention, Bcl-2 results, and p-value were extracted.Results: 7 studies were included in this review. Bcl-2 expression found decrease in 5 out of 6 studies. Similar result also obtained in Bcl-2 protein level, which measured by western blot. Bcl-2 protein level shows a decrease in 2 out of 3 studies.Conclusion: This review shows that high-fat diet that contained in ketogenic diet most likely lead to decrease in Bcl-2 expression. Therefore, indicating the ability of ketogenic diet to affect cancer progression by inducing apoptosis process.

Pengaruh moderate intensity continuous exercise terhadap kadar irisin serum pada wanita remaja obesitas Ido Nur Abdulloh; Sugiharto Sugiharto; Purwo Sri Rejeki
Multilateral : Jurnal Pendidikan Jasmani dan Olahraga Vol 20, No 1 (2021): February
Publisher : Lambung Mangkurat University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/multilateral.v20i1.10069

Tujuan penelitian ini untuk menganalisis pengaruh latihan dengan intensitas sedang yakni Moderate Intensity Continuous Exercise (MICE) terhadap peningkatan kadar irisin serum. Metode penelitian menggunakan true experimental-randomized pretest-posttest control group design dengan partisipasi 20 subjek wanita dengan Indeks Massa Tubuh (IMT) 25-35 kg/m2. Subjek secara random dibagi menjadi 2 kelompok, yakni CONT (n= 10, kontrol tanpa intervensi), dan MICE (n= 10, Moderate Intensity Continuous Exercise). Intervensi dilakukan secara continuous selama 30 menit. Intervensi dilakukan pukul 08.00-10.00 a.m. Pengambilan darah dilakukan pre-exercise dan 15 menit post-exercise. Pengukuran kadar irisin menggunakan metode ELISA. Teknik analisis data menggunakan t-test dan Analysis of Variance (ANOVA) dengan SPSS. Hasil penelitian menunjukkan terdapat peningkatan irisin serum pre dan post-test secara signifikan pada MICE (4,31±0,49 to 5,57±0,71) (p<0,05). Sementara pada CONT tidak terjadi perbedaan yang signifikan (4,35±0,69 to 4,39±0,64) (p>0,05). Berdasarkan hasil penelitian dapat disimpulkan bahwa MICE dapat meningkatkan kadar irisin serum pada wanita remaja obesitas saat setelah latihan fisik sehingga dapat dijadikan salah satu langkah terapi nonfarmakologis dalam menghambat permasalahan obesitas.

PEMASYARAKATAN DAN PELATIHAN OLAHRAGA ADAPTIF PADA ANAK BERKEBUTUHAN KHUSUS Purwo Sri Rejeki; Irfiansyah Irwadi; Misbakhul Munir; Hayuris Kinandita; Eka Arum Cahyaning Putri; Soffil Yudha Mulyadi; Septyaningrum Putri Purwoto
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 4 No. 1 (2020): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v4i1.2020.134-140

Inclusive children or children with special needs are those who have abnormalities in the process of growth or development; which can be physical, mental-intellectual, social, or emotional. The World Health Organization predicts that around 7% of the world's total children population is inclusive children. Exercise that are adapted and modified according to their needs, the type of abnormality and the ability of inclusive children are able to improve motor and sensory abilities so that they will improve their quality of life. The purpose of this activity is to increase the knowledge and skills of parents with inclusive children in implementing adaptive exercise for their children. The method used was seminar and training. Activity evaluation was carried out using questionnaire to observe the increase of knowledge. This activity was attended by 31 parents and 31 inclusive children, with the highest parents’ age range in 31-40 years, which is mothers 38.7%; 41.9% father. The age of expecting mothers of inclusive children mostly ranges from 31-40 years (35.5%). Increased knowledge about child development was 31% (pretest 68, posttest 91.8) and increased knowledge about adaptive sports was 72.18% (pretest 49.6, posttest 85.4).abstrakAnak Berkebutuhan Khusus (ABK) adalah anak yang dalam proses pertumbuhan atau perkembangannya mengalami kelainan atau penyimpangan; yang bisa berupa fisik, mental-intelektual, sosial, atau emosionalnya. Organisasi kesehatan dunia memprediksi sekitar 7% dari keseluruhan populasi anak dunia merupakan ABK. Olahraga yang diadaptasi dan dimodifikas sesuai dengan kebutuhan, jenis kelainan dan tingkat kemampuan ABK mampu memperbaiki kemampuan motoris dan sensoris sehingga akan meningkatkan kualitas hidupnya. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan dan ketrampilan orang tua ABK dalam melatih olahraga adaptif buat anak-anaknya. Metode yang digunakan adalah seminar dan pelatihan. Evaluasi keberhasilan kegiatan dilakukan dengan kuesioner untuk melihat peningkatan pengetahuan. Kegiatan dihadiri oleh 31 orang tua dan 31 ABK, dengan rentang usia orang tua terbanyak di 31-40 tahun yaitu ibu 38,7%; ayah 41,9%. Usia ibu mengandung ABK terbanyak di rentang 31-40 tahun (35,5%). Peningkatan pengetahuan pada materi tumbuh kembang anak sebesar 31% (pretest 68, posttest 91,8) dan peningkatan pengetahuan materi olahraga adaptif sebesar 72,18% (pretest 49,6, posttest 85,4).

Correlation Between Diabetes Mellitus and Clinical Outcome of Patients with Acute Coronary Syndrome Underwent Percutaneus Coronary Intervention Therapy in Dr Soetomo Surabaya Hospital Alanna Sari Pratikto; I Gde Rurus Suryawan; Andrianto; Purwo Sri Rejeki
Indonesian Andrology and Biomedical Journal Vol. 1 No. 2 (2020): December
Publisher : Universitas Airlangga

Introduction: Coronary heart diseases continue to be the rising cause of mortality amongst Indonesian population, alongside with the increasing number of diabetic patients. The first line management of ACS is percutaneous coronary intervention (PCI), however previous have shown that diabetic patients have worse outcomes after therapy compared to non-diabetic patients. This study aims to compare the clinical outcomes between acute coronary syndrome (ACS) patients with diabetes and those without diabetes following percutaneus coronary intervention therapy. Methods: This study used cross sectional observational approach collecting records of ACS patients that underwent percutaneous coronary intervention in RSUD Dr Soetomo Surabaya from January 2018 to December 2019. Data regarding a patient’s age, gender, diabetic status, location of lesion, revascularization status, and clinical outcome were collected. Those with missing or incomplete data were excluded from the study. A total of 55 patients were included and analyzed, Results: amongst 55 patients that underwent PCI observed, 23 were diabetic and 32 were non-diabetic. Study has shown that diabetic patients have higher mortality rate compared to those without diabetes (6 patients vs. 1 patient, p=0,072) however based on the result analysis the p value of >0,05 showed no significant relationship between patients’ diabetic status and the clinical outcome following PCI therapy. Study has also shown that diabetic patients are more likely to undergo staged PCI (56,5%), than total revascularization PCI. Conclusion: Study has found that diabetic ACS has a higher mortality rate compared to those without diabetes, however analitycal studies found no significant relationship between the two variables. Further studies should be performed with higher number of patients to accurately investigate the relationship between diabetes melitus and PCI outcomes.

Efek Suplementasi Omega 3 dan Latihan Fisik Terhadap Respon Inflamasi Novadri Ayubi; Bambang Purwanto; Purwo Sri Rejeki
Journal of Sport Science and Education Vol 5 No 2 (2020)
Publisher : Fakultas Ilmu Olahraga, Universitas Negeri Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jossae.v5n2.p116-123

The aims of this article is to find out how the effects of omega 3 supplementation and physical exercise on the inflammatory response. The method applied is literature review. The results showed that omega 3 supplementation and regular exercise can reduce the inflammatory response that is not controlled. Inflammation is a protective response caused by injury or tissue damage. After physical activity the body will experienced an increase in inflammatory markers, namely C-Reactive Protein (CRP), Interleukin 1 (IL-1), Interleukin 6 (IL-6), Interleukin 10 (IL-10) and Tumor Necrosis Factor-a (TNF-a). Physical exercise, especially high-intensity eccentric exercises, will cause damage to muscle fibers and delayed muscle pain (DOMS) which results in disruption to muscle strength. Muscle pain is caused by an inflammatory process due to increased levels (TNF-a) in response to muscle damage. Inflammatory response that is not controlled can be controlled by giving omega 3 supplementation. It can be concluded that omega 3 supplementation and regular exercise are proven to reduce the inflammatory response that is not controlled, soto reduce the intensity of pain which support the performance in carrying out the exercise program.

HYPERBARIC OXYGEN THERAPY AS AN ADJUVANT TREATMENT IN HYDROCHLORIC ACID POISONING: A LITERATURE REVIEW Desi Rahmah Sari; Ismi Dian Meiliana; Dewangga Satria Sakti Kinasih; Hamidah Kurniasari; Purwo Sri Rejeki
Majalah Biomorfologi Vol. 33 No. 1 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i1.2023.52-58

Highlights1. In Indonesia, 18.8% of all suicides were the result of chemical poisoning, such as using hydrochloric acid (HCl).2. Hyperbaric Oxygen Therapy (HBOT) can be used as an emergency therapy for acute pathology or as a supplementary treatment for chronic illness. AbstractBackground: Suicide is the second most common cause of death and is a major public health problem in many countries globally. Chemical poisoning, such as hydrochloric acid (HCl), accounted for 18.8% of the total suicide cases in Indonesia. Through ingestion, this acid chemical contributes as the most common cause of swallowing injuries that can adversely affect the gastrointestinal mucosal through various pathological processes, primarily through an excessive inflammatory process. On the other hand, hyperbaric oxygen therapy (HBOT) has been widely used as a non-pharmacological therapy in many diseases, although its mechanism for reducing inflammation in HCl poisoning has remained unclear. Objective: This study aimed to provide a better understanding on hyperbaric oxygen's biomolecular mechanism as a potential adjuvant therapy in HCl poisoning. Discussion: HCl poisoning causes an excessive inflammatory process, leading to tissue hypoxia indicated by increased expression of Hypoxia Inducible Factor 1 (HIF-1). Hyperbaric oxygen therapy decreases the expression of HIF-1 through activation of the HIF-1 hydroxylation pathway via prolyl hydroxylase (PDH) in the proline pathway and HIF inhibiting factor (FIH) in the asparagine pathway. Reactivating both pathways will decrease HIF-1 activity, eventually reducing the ongoing inflammatory process. In addition, HBOT also plays a role in wound healing by stimulating angiogenesis growth factors. Conclusion: Hyperbaric oxygen therapy has the potential to be used as adjuvant therapy in HCl poisoning due to its beneficial effects on reducing inflammatory mediators and wound healing.

Potential Molecular Interaction of Nutmeg’s (Myristica fragrans) Active Compound via Activation of Caspase-3 Ronny Lesmana; Filza Yulina Ade; Yuni Susanti Pratiwi; Hanna Goeanawan; Nova Sylviana; Sandra Megantara; Susianti Susianti; Vita Murniati Tarawan; Purwo Sri Rejeki; Hamidie Ronald Daniel Ray; Unang Supratman
Indonesian Journal of Science and Technology Vol 7, No 1 (2022): IJOST: VOLUME 7, ISSUE 1, April 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i1.45663

Myristica fragrans Houtt (belongs to the Myristicaceae family) is a Maluku Island (Indonesia) native plant. The seed of M. fragrans (Nutmeg) has been used for medicinal benefits. M. fragrans also has anti-cancer properties. The goal of this research was to use computer-aided drug design to investigate the in silico molecular docking of selected nutmeg compounds against Caspase-3. Molecular docking using Malegro Virtual Docker (MVD) software Ver 5.5 was performed to investigate binding complicated models to offer information on critical drug-receptor interactions. The most potent ligand was Licarin B, which had a docking score of -103.07 kcal/mol. The Licarin B structure formed several hydrogen bonds with Trp214 and Phe250. These findings imply that the nutmeg seed contains a prospective compound that could be a great anti-cancer agent.

“LET’S MOVE!” CAMPAIGN: EDUCATION AND STIMULATION OF PHYSICAL EXERCISE IN OLDER ADULTS Sundari Indah Wiyasihati; Hayuris Kinandita Setiawan; Purwo Sri Rejeki; Irfiansyah Irwadi
Jurnal Layanan Masyarakat Vol. 7 No. 1 (2023): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v7i1.2023.123-130

The increase in human life expectancy has led to an increase in the number of older adults worldwide, including in Indonesia. The aging population raises sarcopenia as a further problem in geriatric medicine. Sarcopenia is a syndrome characterized by progressive skeletal muscle mass and strength loss. This syndrome is associated with reduced quality of life, increased risk of falls, and even death. Physical exercise is the only effective intervention strategy. Therefore, we designed this community service program for socializing the healthy lifestyle of the elderly with one focus on physical exercise as a promotive, preventive, and curative effort on the incidence of sarcopenia in the elderly. The method chosen was socialization and educating fifty-two pre-elderly and elderly target partners regarding the healthy lifestyle for the older adults and elderly exercise activities as stimulation. The "Let's Move!" campaign that has been implemented can socialize and increase the knowledge of target partners regarding sarcopenia and physical exercise as an intervention for prevention and treatment. The formulation of the main guidelines for safe exercise for the elderly can be useful for target partners who generally already have one type of condition that limits their ability to carry out activities of daily living.

Optimalisasi Peran Kader Kesehatan dalam Edukasi dan Implementasi Gaya Hidup Sehat Lansia Sundari Indah Wiyasihati; Hayuris Kinandita Setiawan; Purwo Sri Rejeki; Lilik Herawati
Warta LPM WARTA LPM, Vol. 26, No. 2, April 2023
Publisher : Universitas Muhammadiyah Surakarta

The health problems of the elderly in the Puskesmas Industri, Gresik work area align with the Indonesian health phenomenon where the number of elderly and degenerative diseases is high. Health cadres training in the work area of the Puskesmas Industri is needed to optimize the role of cadres in educating and implementing a healthy lifestyle in older adults. The Community Partnership Program, focusing on health as part of goal 3 of The Sustainable Development Goals (SDGs), was carried out on September 1, 2022, and was attended by 57 cadres from 6 villages. Health information was provided as a provision for cadres to provide education to the public about the healthy lifestyle of the elderly. The results showed that there was an increase of 17,26 points (34,76%) after training. The lowest post-test results were on the topic of BMI and its interpretation, as well as physical activity in the elderly, so further action is needed. During FGD, the Elderly Health Book from the Ministry of Health of the Republic of Indonesia was introduced. The results of the FGD showed that the introduction of the Elderly Health Book should be continued so that health cadres can consistently use it. Health cadres have a significant role in realizing the elderly health program from the Indonesian Ministry of Health. This health cadre training has proven to be very necessary because it can increase understanding as a provision for cadres in providing education to the public regarding the healthy lifestyle of the elderly.

EFFECT OF HEATED CANOLA OIL ON AORTA WALL THICKNESS IN RATS Aziz, Mochammad Abdul; I'tishom, Reny; Rejeki, Purwo Sri; Yuliawati, Tri Hartini
Majalah Biomorfologi Vol. 32 No. 2 (2022): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v32i2.2022.82-88

Highlights: 1. The use of re-heated cooking oil can give negative impact on health, especially on the cardiovascular system. 2. Unlike other types of cooking oil, repeated heating of canola oil did not show significant change in aortic wall thickness. Abstract Background: Structural alteration of blood vessels such as formation of atheroma or changes in the thickness of vessel walls, are heavily involved in pathogenesis of cardiovascular disease. Several studies have shown that canola oil has a positive effect on such diseases by reducing LDL and cholesterol levels. However, there may be several negative impacts on reheating canola oil upon administration, similar to other oils. Although canola oil can improve lipid profiles, studies related to how canola oil alters the structure of blood vessels are limited. Objective: The aim of this study was to investigate the effect of heated canola oil on intimal-to-medial thickness (IMT) of Thoracic aorta in high-fat diet rats. Material and Method: A total of 27 rats were divided into 3 groups, the K+, P1, and P2. Rats among the three groups were given a high-fat diet for 14 days, accompanied by consumption of canola oil without heating in the P1, and with repeated heating in the P2. Thoracic aorta was taken on the 15th day and then processed into histological preparations. IMT was measured using CellSens software on a microscope with a magnification of 400. The difference between groups was tested using the one-way ANOVA test on SPSS. Result: The mean and standard deviations of each group in a row were K+ (134.96 and 21.27) P1(132.04 and 27.30) and P2 (152.05 and 31.75). There was no significant difference in IMT between groups (p >0.05). However, the P2 group showed the highest mean of IMT. Conclusion: The consumption of canola oil with or without repeated heating did not result in the changes of the IMT in rats fed with a high-fat diet.

Co-Authors , Sakina Abdulloh, Ido Nur Abdurachman Adi Pranoto, Adi Al arif, Mohammad Anam Alanna Sari Pratikto Alanna Sari Pratikto Amaliyah, Miftahul Nur Ananda, Naoval Diza Andrianto Andrianto Anita Faradilla Rahim Arifa Mustika Atika Atika Ayubi, Novadri Bambang Purwanto Bambang Purwanto Breklen Risal Ary Wibowo Cantika Putri Melyana Chabib Fachry Albab Chandra, Cecilia Felicia Cornelius Coli Cornelius Coli Deandra Maharani Widiatmaja Dedi Kuswandi Desi Rahmah Sari Desiana Merawati Dewangga Satria Sakti Kinasih Dewi Ratna Sari Dita Mega Utami Eka Arum Cahyaning Putri Eko Purwanto Elyana Asnar Fathil, Nur Ezza Fazleen Mohd Fathimatuzzahroh, Fathimatuzzahroh Fikri Sasongko Widyatama Filza Yulina Ade Fitry Nachamory Oemar Hakim, Faiq Amirul Hamidah Kurniasari Hamidah Kurniasari Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Hanna Goeanawan HARJANTO HARJANTO Hartono Kahar, Hartono Hasan, Helmia Hening Laswati Putra HERAWATI, LILIK Hermanto Tri Joewono Hermina Novida, Hermina Heryana, Achmad Yuniari I'tishom, Reny Ido Nur Abdulloh Ido Nur Abdulloh Imam Subadi Imam Susilo Iqbal Laksana Irmantara Subagio Irmantara Subagio Irwadi, Irfiansyah Ismi Dian Meiliana Izzatunnisa, Nabilah Karimah, Azimatul Khairina Khalfani, Muhammad Adrian Kurniasari, Hamidah Laksana, Iqbal Leonardo Lubis MEGANTARA, SANDRA Melyana, Cantika Putri Miftahul Nur Amaliyah Misbah Abdul Haris Nasution Alhanif Misbakhul Munir Mochammad Abdul Aziz, Mochammad Abdul Mohammad Anam Al-Ari Mubasyiroh, Nabila Ainaya Mufarrihul Ihsan Muhammad Adrian Khalfani Muhammad Al-Farouq Yufiro Akbar Muhammad Miftahussurur Ni Luh Putu Ayu Putrisari Putri Nova Sylviana Nur Ezza Fazleen Mohd Fathil Oemar, Fitry Nachamory Pambudi, A. Agam Haris Paulus Liben, Paulus Permana, Noah Jefferson Prasetya, Rizka Eka Qurnianingsih, Ema Raden Argarini Ray, Hamidie Ronald Daniel RizkaEka Prasetya Rizki Eka Prasetya Ronny Lesmana Rosdianto, Aziiz Mardanarian Rurus Suryawan S. Sugiharto Sakina Sakina Sakina Samsriyaningsih Handayani Saputro, Zanuar Bagus Saputro, Zanuar Bagus Sari, Gadis Meinar Savitri, Camilia Metadea Aji Septyaningrum Putri Purwoto Setiawan Setiawan Setiawan, Hayuris Kinandita Siti Khaerunnisa Soelistijo, Soebagijo Adi Soffil Yudha Mulyadi Sony Wibisono Sri Sunarti Sri Sunarti Sri Umijati Sugiharto Sugiharto Sugiharto Sugiharto Suhartati Suhartati Sukarno, Devitya Angielevi Sundari Indah Wiyasihati Suryawan, I Gde Rurus Susi Wahyuning Asih Susianti Susianti Suyoko, Andri Syahraya, Indira Texaga, Derryl Rasad Tinduh, Darmayanti Ummah, Fithriyah Cholifatul Unang Supratman Vania Islamey Kusuma Vita Murniati Tarawan Wardani, Tjitra Wardani, Tjitra Wardhani, Indrayuni Lukitra Yoshio Yamaoka, Yoshio Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Yuliawati, Tri Hartini Yuni Susanti Pratiwi

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