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All Journal Majalah Farmaseutik JMM (Jurnal Masyarakat Mandiri) CERATA Jurnal Ilmu Farmasi Jurnal Abdi Insani HERBAPHARMA : Journal of Herb Farmacological Indonesian Journal of Global Health research Jurnal Kesehatan Tambusai Nusantara Hasana Journal Jurnal Impresi Indonesia Prosiding University Research Colloquium Jurnal Abdimas Indonesia Journal of Engineering Science and Technology Management Business and Economic Publication CERATA Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis SEARCH: Science Education Research Jurnal Informatika dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan Multicore International Journal of Multidisciplinary (MIJM)
Muhammad Nurul Fadel
Universitas Muhammadiyah Kudus
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Journal : Journal of Engineering Science and Technology Management

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Description of Absorption Distribution Metabolism Excretion Toxicity (ADMET) of Nuciferine from Terate Flowers (Nymphaea spp.) using pkCSM Technology Prasetyawan, Fendy; Saristiana, Yuneka; Kadir, Mujtahid Bin And; Savitri, Lisa; Salmasfattah, Novyananda; Fadel, Muhammad Nurul; Besan, Emma Jayanti
Journal of Engineering Science and Technology Management (JES-TM) Vol. 5 No. 1 (2025): Maret 2025
Publisher : Journal of Engineering Science and Technology Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestm.v5i1.207

Abstract

This study evaluates the ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profile of nuciferine to assess its potential as a drug candidate. Based on in silico analysis, nuciferine demonstrates favorable oral absorption and extensive systemic distribution, including its capability to cross the blood-brain barrier into the central nervous system. Regarding metabolism, the compound acts as a substrate for CYP2D6 and CYP3A4 enzymes while serving as an inhibitor of CYP1A2 and CYP2D6, which may lead to drug-drug interactions. In terms of excretion, nuciferine displays moderate clearance values and utilizes renal transporter OCT2. However, toxicological evaluations suggest potential risks, including mutagenicity (positive AMES test), hepatotoxicity, and inhibition of hERG II potassium channels, which are associated with cardiotoxicity risks. Despite its favorable bioavailability and distribution properties, concerns about chronic toxic effects and metabolic interaction risks underscore the need for careful consideration in its development. Further research is necessary to validate its safety and efficacy for therapeutic applications.
Co-Authors Abd Rofiq ABDUL ROKHMAN Adhimi, Cici Sayyidatul Ahmad Kholis Ahmad Kholis Akbar Seno Syafriansyah Akhyasin Akhyasin Alya Narulita Andriyani, Yunita Ardianto, Nanda Arif Fahrudin Arif, Fahrudin Astutik, Widhi Ayuningsih, Safitri Besan, Ema Jayanti Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Chandra Arifin Charliandri Saputra Wahab Dahbul, Nura Ali Dameria, Gempita Hutami Eko Retnowati Emma Jayanti Besan Emma Jayanti Besan Endang Setyowati Endang Setyowati Endang Setyowati Fahrudin Arif Faisal Akhmal Muslikh Febriana, Laela Febrianisa, Sabila Fendy Prasetyawan Firdyansyah, Diah Aprilia Fitri Apriliani Fitri Apriliani Fransisca Dita Mayangsari GALIH KURNIAWAN Hamzah, Hasyrul Hasriyani Hasriyani, Hasriyani Husna, Ulviani Yulia Ika Mulyasari Imtiyaaz, Moh Thaariq Zelda Intan Adevia Rosnarita Intansari Setyaningrum Irawati Indrianingrum Irvan Shahrul Hidayat Julia Megawati Djamal Kadir, Mujtahid Bin And Khudzaifi, Muhamad Lailatul Farikah Lathifatun Nida Noor M. Wahyu Ariawan Manik, Nirmala Mega Putri Utami Mildawati, Ratna Muhamad Khudzaifi Muhammad Abdul Rozaq Muhammad Alviyan Shutiawan Muhammad Khudzaifi Muhammad Lathoiful Minan Muhammad Zielal Askari Mulyasari, Ika Mustaanah, Aulia Nur Nihayatus Sholekhah Nirmala Manik Noor, Lathifatun Nida Nurin, Eka Filza Nurul Huda Oktadiana, Isma Presticasari, Hardiyani Rahma, Siti Sofia Rahmawati, Izda Ratna Mildawati Rhomah, Eka Hayati Ridwanto, Muhammad Rika Wahyu Pujiastini Rofiq, Abd Rosnarita, Intan Adevia Sabaan, Wahid Sakti, Aditya Sindu Salmasfattah, Novyananda Salmasfattah, Novynanda Salsabila Khairunnisa savitri, Lisa Setianingsih, Elfrida Rosselly Sholekhah, Nihayatus Siti Mutamimah, Siti Sri Bintang Sahara Mahaputra Kusumanegara Tsamrotul Ilmi Ummi Nurus Salamah Utami, Mega Putri Viren Ramadhan Wijaya, Nadela Wahyu Yuliasari, Aulia Wahyu Yulis Trinovitawati Yuneka Saristiana Zahra, Ilhawa Zuhri, Mukhammad Syaifuddin