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All Journal Majalah Farmaseutik JMM (Jurnal Masyarakat Mandiri) CERATA Jurnal Ilmu Farmasi Jurnal Abdi Insani HERBAPHARMA : Journal of Herb Farmacological Indonesian Journal of Global Health research Jurnal Kesehatan Tambusai Nusantara Hasana Journal Jurnal Impresi Indonesia Prosiding University Research Colloquium Journal of Engineering Science and Technology Management Business and Economic Publication CERATA Advances in Healthcare Research IJF (Indonesia Jurnal Farmasi) Journal of Social Science and Multidisciplinary Analysis SEARCH: Science Education Research Jurnal Informatika dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan Multicore International Journal of Multidisciplinary (MIJM) Jurnal Abdimas Indonesia
Muhammad Nurul Fadel
Universitas Muhammadiyah Kudus
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Journal : Journal of Social Science and Multidisciplinary Analysis

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ANALISIS KRONOFARMAKOLOGI PENGGUNAAN PARACETAMOL PADA PASIEN COVID-19 DI RSUD DR. SOEDOMO TRENGGALEK Prasetyawan, Fendy; Saristiana, Yuneka; Muslikh, Faisal Akhmal; Mildawati, Ratna; Oktadiana, Isma; Arifin, Chandra; Rofiq, Abd; Febriana, Laela; Besan, Emma jayanti; Fadel, Muhammad Nurul
Journal of Social Science and Multidisciplinary Analysis Vol. 1 No. 1 (2024): Journal of Social Science and Multidisciplinary Analysis (Jossama), February 20
Publisher : Noble Cendekia Indonesia

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Abstract

The global COVID-19 pandemic has presented complex challenges to global health. Dr. Soedomo Regional General Hospital in Trenggalek has actively engaged in managing COVID-19 patients. This study aims to analyze the chronopharmacology of paracetamol usage in COVID-19 patients at the hospital, focusing on the body's biological response to the drug at various time points within the 24-hour cycle. In the treatment of COVID-19, the use of paracetamol has become a primary strategy for addressing symptoms such as fever. However, it is crucial to understand how the timing of paracetamol administration can influence the body's response to the treatment. A chronopharmacological study involving 100 patients analyzed body temperature before and after therapy at three different times: 08:00 AM, 04:00 PM, and 10:00 PM. The results revealed a significant decrease in body temperature after therapy, particularly at 04:00 PM. These findings support the concept of "the right time, the right dose" in clinical practice. Analysis of the body's circadian rhythm emphasizes the need to consider the timing of drug administration to achieve optimal outcomes. Despite the limited sample size, this research provides a foundation for the development of more precise practical guidelines for administering paracetamol to COVID-19 patients.
Co-Authors ABDUL ROKHMAN Achmad Ridwan Adhimi, Cici Sayyidatul Afina Mahmudah Ahmad Kholis Ahmad Kholis Akbar Seno Syafriansyah Akhyasin Akhyasin Alya Narulita Andriyani, Yunita Anisa Sholikhati Aqfianti Fadilatunnisa Ardianto, Nanda Astutik, Widhi Aulia Nur Mustaanah Ayuningsih, Safitri Besan, Ema Jayanti Besan, Emma Jayanti Besan, Ulfa Nabila Bintari Tri Sukoharjanti Bintari Tri Sukoharjanti Chandra Arifin Charliandri Saputra Wahab Dahbul, Nura Ali Dameria, Gempita Hutami Eko Retnowati Elfanesya Silva Emma Jayanti Besan Emma Jayanti Besan Endang Setyowati Endang Setyowati Endang Setyowati Fahrudin Arif Faisal Akhmal Muslikh Febriana, Laela Febrianisa, Sabila Fendy Prasetyawan Findasari Firdyansyah, Diah Aprilia Fitri Apriliani Fitri Apriliani Fransisca Dita Mayangsari GALIH KURNIAWAN Galih Kurniawan Hamzah, Hasyrul Hardiyani Presticasari Hasriyani Hasriyani Hasriyani, Hasriyani Husna, Ulviani Yulia Ika Mulyasari Imtiyaaz, Moh Thaariq Zelda Intan Adevia Rosnarita Intansari Setyaningrum Irawati Indrianingrum Irvan Shahrul Hidayat Julia Megawati Djamal Kadir, Mujtahid Bin And Lailatul Farikah Lathifatun Nida Noor M. Wahyu Ariawan Manik, Nirmala Mega Putri Utami Mildawati, Ratna Muhamad Khudzaifi Muhammad Abdul Rozaq Muhammad Alviyan Shutiawan Muhammad Lathoiful Minan Muhammad Zielal Askari Mulyasari, Ika Mustaanah, Aulia Nur Nauval Alfarizi Nihayatus Sholekhah Nirmala Manik Noor, Lathifatun Nida Nurin, Eka Filza Nurul Huda Oktadiana, Isma Presticasari, Hardiyani Rahma, Siti Sofia Rahmawati, Izda Ratna Mildawati Rhomah, Eka Hayati Riana Putri Rahmawati Ridwanto, Muhammad Rika Wahyu Pujiastini Rofiq, Abd Sabaan, Wahid Safira Selly Sakila Jauza Adiba Sakti, Aditya Sindu Salmasfattah, Novyananda Salmasfattah, Novynanda Salsabila Khairunnisa savitri, Lisa Setianingsih, Elfrida Rosselly Sholekhah, Nihayatus Siti Mutamimah, Siti Siti Sofia Rahma Sri Bintang Sahara Mahaputra Kusumanegara Tsamrotul Ilmi Ummi Nurus Salamah Utami, Mega Putri Viren Ramadhan Wijaya, Nadela Wahyu Yuliasari, Aulia Wahyu Yulis Trinovitawati Yuneka Saristiana Zahra, Ilhawa Zuhri, Mukhammad Syaifuddin