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Rimbawan ,
Department Of Community Nutrition, Faculty Of Human Ecology, Bogor Agricultural University, Bogor 16680, Indonesia
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Journal : Jurnal Ilmu-Ilmu Perairan dan Perikanan Indonesia

 1 
EKSTRAKSI KOMPONEN AKTIF SEBAGAI ANTIKANKER PADA SEL LESTARI KEONG MATAH MERAH (Cerithidea obtusa) Sri Purwaningsih; Rimbawan ,; Bambang P. Priosoeryanto
Jurnal Ilmu-Ilmu Perairan dan Perikanan Indonesia Vol. 15 No. 2 (2008): Desember 2008
Publisher : Institut Pertanian Bogor

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Abstract

ABSTRAKKomponen bioaktif dari bahan alami telah banyak diteliti untuk digunakan sebagai obat antikanker. Penelitian mengenai komponen bioaktif dari keong matah merah (Cerithidea obtusa) sebagai antikanker belum pernah dilaporkan. Penelitian ini bertujuan: (1) Menentukan cara ekstraksi keong matah merah dengan beberapa pelarut (air, air + methanol, aseton, etil asetat, dan methanol), dan (2) Uji aktivitas zat aktif dari keong matah merah dalam melawan sel lestari kanker (K562, A 549, dan HeLa/cervix cancer). Dari penelitian dapat ditentukan bahwa waktu ekstraksi terbaik yang dipilih untuk penelitian adalah 72 jam dan perbandingan antara bahan baku dengan pelarut adalah 1:6 (w/v). Hasil penelitian menunjukkan bahwa nilai terbaik adalah ekstrak keong matah merah dengan pelarut aseton yang mempunyai daya hambat terbesar pada sel kanker (90.62% untuk HeLa/cervix cancer, 79.84% kanker paru/A 549, dan 76.71% untuk leukemia/K562) pada konsentrasi 25 ppm.Kata kunci: Antikanker, Cerithidea obtuse, ekstraksi, sel tumor lestari.ABSTRACTBioactive components derive from natural substances have been widely studied for the use as an anticancer drug. A study on a bioactive component from matah merah mollusks (Cerithidea obtusa) as an anticancer has not yet been reported. This research was intended to find the best method of extraction for the bioactive components of this animal. The research were divided into of two stages: (1) an extraction of matah merah mollusks by applying various solvents (water, water and methanol, acetone, ethyl acetate, and methanol), and (2) anti-proliferation ability of matah merah mollusks against tumor cell line (HeLa/cervix cancer, A 549, and K562). The results showed that the best extraction time was is 72 hours with the ratio of main material and solvents being 1:6 (w/v). The result also found that acetone of 25 ppm was the best solution resulted the strongest inhibiting power against cancer cells (90.62% against HeLa/cervix cancer, 79.84% against lung cancer/A 549, and 76.71% against leukemia/ K562.Key words: Anti-cancer, Cerithidea obtuse, extraction, tumor cell line.
Co-Authors Adi Teruna Efendi Adi Teruna Effendi Adi Teruna Effendi Adi Winarto Agustino Agustino Ahmad Sulaeman Ainia Herminiati Ainia Herminiati Ainia Herminiati Akifa Laila Rusyda Ali Khomsan Angga Hardiansyah Angga Rizqiawan Anna Vipta Resti Mauludyani Aprinia Dian Nurhayati Ascobat, Purwantyastuti Asep Rusyana Aslis Wirda Hayati Astuti Lamid Aya Yuriestia Arifin, Aya Yuriestia Azizi, Elsa Carla Bambang P. Priosoeryanto Bambang Pontjo Priosoeryanto Betty Yosephin Simanjuntak Bibi Ahmad Chahyanto Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Budi Setiawan Cassandra Permata Nusa Cesilia M Dwiriani Clara M. Kusharto Clara Meliyanti Kusharto Dadan Rohdiana Dadang Sukandar Damayanti, Rinda Daus, Firdaus Firdaus Deddy Muchtadi Deddy Muchtadi Deni Elnovriza DEWI APRI ASTUTI Dewi Kusumawati Dewi Kusumawati Diah M. Utari Diah M. Utari Diffah Hanim Dodik Briawan Drajat Martianto Egayanti, Yusra Ekowati Handharyani Elisa Diana Julianti Emma S Wirakusumah Ennita Fahriza Eva Susanti Evi Damayanthi Evy Damayanthi Fadly, Khaerul Faisal Anwar Fajriaty, Deannisa Febrina Sulistiawati Fifi Retiaty Firdaus Firdaus Firdaus Firdaus Fitrah Ernawati Fitrah Ernawati Fivi Melva Diana, Fivi Melva Gifari, Nazhif Hadi Riyadi Hardinsyah Harianti, Rini Harianti, Rini Hidayat Syarief Hidayat Syarief I Gusti Bagus Wiksuana I.Wayan T.Wibawan, I.Wayan Ika Heri Kustanti Ikeu Ekayanti Ikeu Tanziha Ikue Ekayanti Ilmi Dewi Astuti Ilmi, Ibnu Malkan Bakhrul Indhira Shagti Iswahyudi Iswahyudi ITA DJUWITA Katrin Roosita Khairina, Dini Nur Kharisma Tamimi Kresandra, Anastasha Laeli Nur Hasanah Latifah Darusman Latifah K Darusman Latifah K. Darusman Leily Amalia Leily Amalia Furqon Lidwina Lidwina Lilik Kustiyah Linar Zalinar Udin Lubis, Anwar M. Muslim MADE ASTAWAN MARIA BINTANG Mauludiya, Putri Nur Mira Dewi Mohamad Rafi Muhamad Rizal Martua Damanik Muhammad Aries Muhilal ., Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Muhilal Mukhlidah Hanun Siregar Mulya Agustina Mury Kuswari Mury Kuswari Muti'ah Mustaqimatusy Syahadah Nasir, Syifa Qolbiyah Nasution, Zuraidah Naufal Muharam Nurdin Nazhif Gifari Ni Ketut Sutiari Ni'ma Hilyatin Noviana, Astrid Novitasari, Putri Nunung Nurjanah Nur Indrawaty Lipoeto Nurhidayati, Nuzuliyati Nuri Andarwulan Pertiwi, Fenti Dewi Picauly, Intje Pipih Suptijah Purwantyastuti Ascobat Purwantyastuti Purwantyastuti Purwantyastuti Purwantyastuti Puspo Edi Giriwono Putri Puncak Anjani Rahman, Dewi Rahmayani Rakhmawati FKR Ratu Diah Koerniawati Reisi Nurdiani, Reisi Resita Nurbayani Restu Pertiwi Riana, Nidya Ulfah Rizal M Damanik, Rizal M Rosyanne Kushargina Safitri, Debby Endayani Sari, Eny Kurnia Siti Madanijah Sri Anna Marliyati Sri Hartati R. Suradijono Sri Nur Amalia Sri Purwaningsih Sri Sumarmi Sri Wahyu Angga Dewi Subangkit, Mawar Sudjana Sibarani Suryana, Suryana Susi Desminarti Susi Desminarti Susi Nurohmi Susilawati, Esih Sutrisna, Aang SYAHRIAL SYAHRIAL Syartiwidya, Syartiwidya TATI NURHAYATI Tresnanda, Muhammad Nawaf Trini Suryowati, Trini Tunggul Waloya Umam, Hafizul V Prihananto Vetnizah Juniantito Warisanti, Dira Wiwin Winarsih Yunianto, Andi Eka Zakiudin Munasir Zakiudin Munasir