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All Journal Microbiology Indonesia Indonesian Journal of Human Nutrition Jurnal Biosains Pascasarjana Indonesian Journal of Tropical and Infectious Disease Majalah Kulit, Karet, dan Plastik BERITA BIOLOGI Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Health Notions Journal of Applied Food Technology Indonesian Journal of Medicine Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JPPS (Jurnal Penelitian Pendidikan Sains) JPPIPA (Jurnal Penelitian Pendidikan IPA) Majalah Biomorfologi (Biomorphology Journal) Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) MAHESA : Malahayati Health Student Journal Berkala Penelitian Hayati Jurnal Pendidikan Ilmu Pengetahuan Alam (JP-IPA) Jurnal Natural Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Folia Medica Indonesiana
SOETJIPTO .
Departemen Biokimia Kedokteran, Fakultas Kedokteran, Universitas Airlangga, Surabaya
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Energy Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Pengaruh Cara Pemakaian Produk Tabir Surya terhadap Tingkat Keparahan Hiperpigmentasi pada Pasien di Klinik Kecantikan di Surabaya Nailufa, Yuyun; Soetjipto, Soetjipto; Wahyudi, Lindung
MAHESA : Malahayati Health Student Journal Vol 4, No 4 (2024): Volume 4 Nomor 4 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i4.14371

Abstract

ABSTRACT Hyperpigmentation is a skin problem whose main cause is exposure to ultraviolet (UV) sunlight. Regular use of sunscreen with an SPF of at least 30 and a broad spectrum (protects against UVA and UVB) has been proven to be effective in preventing and treating hyperpigmentation. However, many people do not use sunscreen in the correct way, so its effectiveness in protecting the skin from UV rays is reduced. The aim of this study is to determine the effect of using sunscreen products on the severity of hyperpigmentation in patients at beauty clinics in Surabaya. This research is an analytical, cross-sectional observational study. The results of this study show that there is a significant relationship between the behavior of using sunscreen and the severity of hyperpigmentation, a significance value of 0.014 (<0.05) was obtained. There is a significant relationship between how to use sunscreen and the severity of hyperpigmentation. The better you use sunscreen, the lower the severity of hyperpigmentation, and vice versa. Keywords: How to Use, Sunscreen, Severity, Hyperpigmentation, Patients ABSTRAK Hiperpigmentasi merupakan masalah kulit yang penyebab utamanya adalah paparan sinar matahari ultraviolet (UV). Penggunaan tabir surya secara rutin dengan SPF minimal 30 dan spektrum luas (melindungi dari UVA dan UVB) terbukti efektif dalam mencegah dan mengatasi hiperpigmentasi. Namun, banyak orang yang tidak menggunakan tabir surya dengan cara yang benar, sehingga efektivitasnya dalam melindungi kulit dari sinar UV menjadi berkurang. Tujuan penelitian ini adalah untuk mengetahui pengaruh cara pemakaian produk tabir surya terhadap tingkat keparahan hiperpigmentasi pada pasien di klinik kecantikan di Surabaya. Penelitian ini merupakan penelitian yang bersifat observasi analitik dengan cross-sectional. Hasil penelitian ini menunjukkan adanya hubungan yang bermakna antara perilaku cara pemakaian tabir surya dengan keparahan hiperpigmentasi, diperoleh nilai signifikansi sebesar 0.014 (<0.05). Terdapat hubungan yang bermakna antara cara pemakaian tabir surya dengan derajat keparahan hiperpigmentasi. Semakin baik cara pemakaian tabir surya maka semakin rendah keparahan hiperpigmentasinya, dan sebaliknya. Kata Kunci: Cara Pemakaian, Tabir Surya, Tingkat Keparahan, Hiperpigmentasi, Pasien
Hyperbaric Oxygen Ameliorates The Expression of Tumor Growth Factor-β and Malondialdehyde in Pristane-induced Lupus Nephritis Mice Model Soetjipto, Soetjipto; Murbani, Indri Dwi; Harnanik, Titut
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2084

Abstract

BACKGROUND: Lupus nephritis (LN) is associated with chronic renal failure and a high mortality rate. Tumor growth factor-β (TGF-β) plays a basic part in keeping up immune homeostasis, meanwhile extensive oxidation of the lipid membrane in LN causes the arrangement of malondialdehyde (MDA). Up to date, the mechanism of hyperbaric oxygen (HBO) therapy in LN has not been elucidated well. Hence this study was conducted to assess the impact of HBO therapy on TGF-β and MDA expression in the pristane-induced LN mice model.METHODS: Thirty-two mice aged 8-12 old weeks were isolated into 4 groups: normal saline-injected mice (group 1); pristane-injected mice (group 2); as well as pristane-injected followed by HBO-exposured with 2.4 (group 3) and 1.5 (group 4) atmosphere absolute (ATA) pressure. Pristane were injected intraperitoneal to initiate LN. Two months after pristane injection, the mice were placed within 24 hours in the special cage for metabolic examination to determined that pristane-induced LN mice model was successfully formed and marked by the occurring proteinuria. Oxidative stress was assessed by examining MDA, while systemic inflammation was assessed by examining by TGF-β. MDA and TGF-β serum were measured by enzyme-linked immunosorbent assay (ELISA).RESULTS: A significantly lower (p<0.050) MDA expression was found in group 3 in comparison with group 2. The results also showed that TGF-β level was significantly increased (p<0.050) in group 3 compared to group 2.CONCLUSION: HBO therapy ameliorates inflammation in LN by diminishing MDA and expanding TGF-β levels through activating antioxidants.KEYWORDS: lupus nephritis, hyperbaric oxygen, malondialdehyde, tumor growth factor-β
- Relevansi Klasifikasi Lesi Hemisfer Kanan dan Kiri dalam Memprediksi Gangguan Kognitif Pascastroke Dienanta, Savira; Hamdan, Muhammad; Soetjipto, Soetjipto; Machin, Abdulloh
Majalah Kedokteran Indonesia Vol 70 No 8 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.8-2020-201

Abstract

Introduction: Stroke is the fifth leading cause of disability-adjusted life years (DALYs) in the world. Cognitive impairment is one of the disabilities found in the acute phase of stroke and persists in long-term outcomes which can be assessed using the Mini-Mental State Examination (MMSE). However, a clinical classification to predict the cognitive outcome remained unclear. This study is aimed to identify differences of MMSE results in stroke patients between right and left hemisphere lesions to ensure the mentioned location classifications may contribute to cognitive outcome prediction.Method: With the cross-sectional analytic observational design, 32 acute phase patients hospitalized in the Neurology Department Soetomo General Hospital from October–December 2019 were assessed using the Indonesian version of MMSE with purposive sampling and analyzed using the chi-square test.Result: There was no significant difference between MMSE scores in right or left hemisphere lesion. This might happen because (1) MMSE was insensitive and not a domain-specific test; (2) a more specific infarct location was needed to predict cognitive outcome post-stroke, including microarchitecture of the brain especially those involved in the cortico-striato-thalamocortical loop.Conclusion: The right or left hemisphere lesion classification did not contribute significantly to predict cognitive impairment.
Prokalsitonin dan Sel Darah Putih sebagai Penanda Infeksi pada Anak dengan Ketoasidosis Diabetikum Rochmah, Nur; Faizi, Muhammad; Kurniawan, Yudhi; Choirunisa, Latifatu; Endaryanto, Anang; Soetjipto, Soetjipto
Majalah Kedokteran Indonesia Vol 70 No 12 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, V
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.12-2020-291

Abstract

Introduction: Diabetic ketoacidosis (DKA), an acute complication of type 1 (insulin dependent) diabetes mellitus (T1DM), can be precipitated by infection. Procalcitonin (PCT) is an accurate marker of bacteremia, sepsis, and inflammation, however white blood cells (WBC) are still often used by clinicians. We aimed to analyze PCT levels and WBC counts in children with DKA.Methods: A cross-sectional study was conducted in Dr. Soetomo General Hospital, Surabaya, Indonesia, between 2015 and 2019. T1DM and DKA diagnosis was based on the International Society for Pediatric and Adolescent Diabetes. PCT levels and WBC counts were measured in samples from patients with and without DKA, and were compared using the Mann-Whitney test.Results: A total of 41 samples were included, with 15 samples (36.6%) from children with DKA, and 26 (63.4%) from children without DKA. PCT levels and WBC counts were significantly higher in those with DKA (p less than 0.001). The receiver operating characteristic curve analysis of WBC was lower than PCT (0.849 vs. 0.982). PCT had a higher sensitivity and spesificity as an infection marker than WBC (93.3 vs. 86.7; 92.3 vs. 88.5, respectively).Conclusion: PCT is a better infection marker in children with DKA than WBC
The Improvement of Community Knowledge, Attitudes and Practices After Covid-19 Socialization Khaerunnisa, Siti; Syafa'ah, Irmi; Wungu, Citrawati Dyah Kencono; Prabowo, Gwenny Ichsan; Handajani, Retno; Safitri, Indri; Notopuro, Harianto; Qurnianingsih, Ema; Lukitasari, Lina; Humairah, Ira; Bakhtiar, Arief; Suwandito, Suwandito; Asih, Susi Wahyuning; Anggraeni, Zuhrotul Eka Yulis; Adi, Ginanjar Sasmito; Nugrahani, Ely Rahmatika; Zulka, Ayesie Natasha; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

This study determined community knowledge, attitudes, and practices after COVID-19 socialization in Rambipuji and Suci Village, Jember District, East Java, Indonesia. This study used the analytic observational design study. As many as 40 people were given socialization about COVID-19 by gathering and online. The questionnaires were completed in two parts included before-socialization and after-socialization. The questionnaire data were analyzed descriptively by calculating frequency, percentage, and inferential statistics by t-test, Spearman correlation, and chi-square test. The data analysis used IBM SPSS version 23 software. The mean and standard deviation of percentage of knowledge pre-test, knowledge post-test, high attitude, moderate attitude, low attitude, very high practice, high practice, sufficient practice, and low practice were 58.33 ± 30.97, 77.70 ± 22.52, 62.5±21.7, 31±22.2, 6.5±17.1, 65±13.8, 32.3±13.8, 1.25±2.4, 1.25±1.8, respectively. Knowledge pre-test and post-test correlated 0.819 (p=0.001) and a t-test with p=0.003. Attitudes and practices correlated with p=0.001. Socialization of COVID-19 was useful to improve the community knowledge, attitudes, and practices in Rambipuji and Suci Village, Jember District, East Java, Indonesia that could prevent the transmission and inhibit the spread of the COVID-19 pandemic in Indonesia. Furthermore, continuous encouragement of COVID-19 socialization in wide areas was recommended.
PRELIMINARY LABORATORY EVALUATION OF RAPID DIAGNOSTIC TEST PROTOTYPE TO DETECT HBsAg IN WHOLE BLOOD AND SERUM Qurnianingsih, Ema; Wungu, Citrawati Dyah Kencono; Amin, Mochammad; Setyawati, Dewi; Yasan, Yanna Debby Restifanny; Lukitasari, Lina; Lusida, Maria Inge; Soetjipto, Soetjipto
Folia Medica Indonesiana Vol. 61, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Chronic hepatitis B virus (HBV) remains a major global health issue,[-10pc]AU: Please provide ORCID ID for all authors.[-7pc]AU: Please provide affiliation’s for all authors. with over 250 million people affected worldwide. In Indonesia, HBV prevalence has declined from high to moderate endemicity, but challenges persist due to regional disparities, risk of mother-to-child transmission, and the predominance of B3 and C1 sub-genotype. Despite available preventive measures and diagnostic tools, approximately 90% of cases remain undiagnosed, particularly in low-resource settings, indicating the need for improved screening and control strategies. Therefore, this study aims to conduct preliminary performance tests of KODC hepatitis B surface antigen (HBsAg) (rapid diagnostic test (RDT) prototype) produced by Konimex on serum and whole blood samples. Performance was assessed through sensitivity, precision, specificity, and comparative testing against commercial RDT. The results obtained were visually interpreted by 2 independent readers. KODC HBsAg RDT demonstrated a detection limit of 50 IU/ml in serum and 400 IU/ml in whole blood. Precision testing showed high reproducibility (RSD <3.02%), with no cross-reactivity against other pathogens. Compared with a commercial RDT, it showed equivalent performance in serum and superior specificity in whole blood. In addition, predictive value analysis confirmed excellent accuracy, with Positive predictive value (PPV) and negative predictive value (NPV) >99% in both sample types. Therefore, KODC HBsAg RDT prototype showed comparable performance to commercial tests with good sensitivity, precision, and specificity, indicating its potential as a practical tool for HBV screening in resource-limited settings.
Co-Authors Abdurachman Abdurachman Adi, Ginanjar Sasmito Aksono HP., Eduardus Bimo Amin, Indah Binti Mohd Amin, Mochammad Aminuyati Anang Endaryanto Anggraeni, Zuhrotul Eka Yulis Annis Catur Adi Annisa Rizky Maulidiana Arumisore, Netty M Asnita, Asnita Aulanni'am, Aulanni'am Ayesie Natasha Zulka Bakhtiar, Arief Bakhtiar, Arief Bayu Satria Wiratama Budi Yanti Choirunisa, Latifatu Chorisma Permata Putri Nurazizah Citriana, Mirna Yunik Dachlan Y P Damba Bestari Dienanta, Savira Eddy Bagus Wasito Eddy Wasito, Eddy Elvaretta, Clarissa Ely Rahmatika Nugrahani Ely Rahmatika Nugrahani, Ely Rahmatika Era Catur Prasetya Fedik Abdul Rantam Fitria Sarnita G. Panggabean Ginanjar Sasmito Adi HAK HOTTA HANSON, J. Harianto Notopuro Hendri Susilo Hendy Hendarto Hermanto, Fery Herniyati HERNOMO ONTOSENO KUSUMOBROTO Huda, Khusnul Humairah, Ira Ida Bagus Narmada Indri Safitri Indri Safitri, Indri Juminten Saimin Juniastuti Juniastuti Katharina Merry Apriliani Khaerunnisa, Siti Kirana, Tjandra Lukitasari, Lina Lukitasari, Lina Luqman Hakim Andira M. THAMRIN HIDAYAT Machin, Abdulloh Maghfiroh, Faridatul Marcos, Imella MARIA INGE LUSIDA Maria Inge Lusida MOCHAMAD AMIN Mufiannoor, Eddy Muhammad Amin Muhammad Faizi, Muhammad Muhammad Hamdan Murbani, Indri Dwi MUSLIMIN IBRAHIM Nailufa, Yuyun Nasronudin Nasronudin Ni Made Mertaniasih Nur Rochmah, Nur Palupi, Dian Eka Roro Poernomo Boedi Setiawan Prabowo, Gwenny Ichsan Priyo Budi Purwono Putri, Hanif Rafika Qurnianingsih, Ema Raharjo Raharjo Rahmawati, Siti Irma Rantam F A Retno Handajani Ridhwan Biosia Wiratama Rini Devijanti Ridwan Ruslan, S. Eriaty N. Saifullah Saifullah Samsriyaningsih Handayani Setiobudi, Karen Delicia Setyawati, Dewi Sidarningsih Sidarningsih, Sidarningsih Sifak Indana Siti Khaerunnisa Sufiyah, Sufiyah Sulistyorini, Anik Susi Wahyuning Asih Susi Wahyuning Asih, Susi Wahyuning Suwandito Suwandito Suwandito, Suwandito Syafa'ah, Irmi Syafa’ah, Irmi TAKAKO UTSUMI Titut Harnanik Tjandrakirana Tjandrakirana Tuti Kusumaningsih Ulfa Kholili Ummah, Fithriyah Cholifatul Ummi Maimunah W Widia Wahyudi, Lindung Wasis Wasis Waskito, Langgeng Agung WULIJARNI, N. WULUARNI, N. Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yasan, Yanna Debby Restifanny YOSHIHIKO YANO YOSHITAKE HAYASHI Yudhi Kurniawan Yudi Her Oktaviono, Yudi Her Yulia Ismail Yulia Sari Ismail Zuhrotul Eka Yulis Anggraeni Zulka, Ayesie Natasha