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All Journal JURNAL KIMIA SAINS DAN APLIKASI Jurnal Kesehatan Andalas Jurnal Riset Kimia Majalah Kedokteran Andalas Andalas obstetrics and gynecology journal Reswara: Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Riset Ilmiah
Dessy Arisanty
Departemen Biokimia Fakultas Kedokteran Universitas Andalas, Padang 25163, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Distribusi Mutasi Asp614Gly pada Spike Protein SARS-CoV-2 di Sumatera Barat Agustian, Dede Rahman; Putra, Andani Eka; Arisanty, Dessy
Majalah Kedokteran Andalas Vol. 47 No. 2 (2024): MKA April 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v47.i2.p163-172.2024

Abstract

Objective: This study aims to map the distribution of the Aspartate 614 to Glycine (Asp614Gly) mutation in the spike protein of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) circulating in West Sumatra, to understand the extent of its spread within the local population. Methods: RNA samples were taken from 98 confirmed COVID-19 cases across various area in West Sumatra. Genetic amplification and next-generation sequencing (NGS) were performed to identify the presence of the Asp614Gly mutation. The frequency of mutations was analyzed using bioinformatics software. Results: Out of the 98 samples analyzed, approximately 97% exhibited the Asp614Gly mutation. The geographic distribution of this mutation showed significant variation among the districts of West Sumatra, with the highest prevalence in urban areas. Conclusion: These findings indicate that the Asp614Gly mutation is highly prevalent in West Sumatra. Associated with increased virus transmissibility, this mutation dominates the circulating virus strains in the region, highlighting the need for ongoing genetic surveillance to guide public health interventions and vaccination strategies.
Program Edukasi Hidrasi Anak Sekolah Full Day di SDIT Alam Ar-Royyan Kota Padang Larasati, Aulia Sepriadina; Fasrini, Ulya Uti; Windasari, Noverika; Desmawati, Desmawati; Linosefa, Linosefa; Arisanty, Dessy
Reswara: Jurnal Pengabdian Kepada Masyarakat Vol 7, No 1 (2026)
Publisher : Universitas Dharmawangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46576/rjpkm.v7i1.7657

Abstract

Konsumsi air yang cukup sesuai rekomendasi berperan penting bagi fungsi kognitif dan kesehatan anak. Akan tetapi, masih dijumpai anak sekolah dasar yang belum memahami manfaat mencukupi kebutuhan air tubuh. Program pengabdian ini bertujuan menilai sekaligus meningkatkan pengetahuan tentang hidrasi pada siswa kelas 4 dan 5 di sekolah dasar full day berbasis alam. Mitra program adalah SDIT Alam Ar-Royyan di Kota Padang. Metode yang digunakan berupa edukasi interaktif selama tiga sesi selama tiga minggu. Setiap sesi diawali pengarahan dan pre-test, dilanjutkan penyampaian materi melalui media audio visual, permainan, serta tanya jawab. Post-test dan penguatan materi dilaksanakan dua hari setelahnya. Instrumen penilaian menggunakan kuesioner cetak dan dianalisis secara deskriptif. Sebanyak dua puluh tiga siswa mengikuti pertemuan pertama, dengan tujuh belas siswa menyelesaikan seluruh rangkaian program. Hasil menunjukkan peningkatan pengetahuan yang bermakna yaitu sebesar 96,1% siswa mengalami kenaikan skor pengetahuan dan 76,5% berpengetahuan “baik”. Ukuran kelompok yang kecil mendukung interaksi, fokus, dan umpan balik yang lebih personal. Hambatan utama adalah penjadwalan dan ketidakhadiran sebagian siswa. Penetapan jadwal melalui nota kesepahaman dengan bagian kurikulum, pelibatan orang tua dan guru melalui diskusi kelompok terarah, serta pemantauan kebiasaan minum harian di kelas diperlukan untuk keberlanjutan program.
The Effect of miR-10b Mimic Transfection on Invasion and Proliferation Gene Expression as the Direct Target of the miR-10b Pathway in T47D Breast Cancer Cell Lines Arisanty, Dessy; Eshak, Zolkapli; Wahyuni, Fatma Sri; Achyar, Afifatul; Khairani, Salsabila Putri
Jurnal Kimia Sains dan Aplikasi Vol 29, No 1 (2026): Volume 29 Issue 1 Year 2026
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.29.1.58-63

Abstract

Breast cancer remains one of the leading causes of death in women worldwide, with high incidence and mortality rates. The abnormal expression of the small non-coding RNA, microRNA-10b (miR-10b), has been associated with breast cancer progression. miR-10b is involved in various biological processes, including proliferation, metastasis, and drug resistance. However, the underlying mechanism by which miR-10b contributes to breast cancer progression remains unclear. This study aimed to investigate the effect of miR-10b on the expression of HOXD10 and PI3K genes, as well as its impact on cell viability and proliferation in breast cancer cells. In this study, T47D breast cancer cells were transfected with mimic miR-10b using the FANA-oligo transfection method at concentrations of 1, 2.5, and 5 µM. Cell viability was assessed using the MTT assay, while HOXD10 and PI3K gene expression levels were measured using RT-qPCR and ELISA. Data were analysed using paired t-tests with SPSS, and results were considered statistically significant at p < 0.05. The results showed that mimic miR-10b induced a dose-dependent increase in cell proliferation. Notably, only HOXD10 gene expression was significantly affected by the transfection, while PI3K gene expression remained unchanged. Cells transfected with 5 µM miR-10b mimic exhibited the highest proliferation rate compared to non-transfected controls (p < 0.05). In conclusion, miR-10b promotes breast cancer cell proliferation by downregulating HOXD10 expression, independent of PI3K, suggesting it is a potential target for further investigation.
Education on Exposure and Health Risks of Forever Chemicals (PFAS) for Housewives and Adolescent Girls Ilmiawati, Cimi; Silvia, Roza; Arisanty, Dessy; Usman, Elly; Masrul; Amir, Arni; Hasmiwati; Reza, Mohamad; Ariadapa Rahadi, Didan; Fauzan, Rezky; Abi Ghofari Siregar, Muhammad; Olivia, Ivonne; Dwiharyani, Yuli; Ilham, Muhammad
Warta Pengabdian Andalas Vol 33 No 1 (2026)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.33.1.28-38.2026

Abstract

Our community service activity aimed to increase knowledge and awareness about the dangers of per- and polyfluoroalkyl substances (PFAS), known as “forever chemicals,” which are commonly found in household products, food packaging, and cosmetics. Long-term exposure to PFAS has been associated with numerous serious health effects, including an increased risk of several cancers, disruption of hormone homeostasis, liver toxicity, impaired immune function, and adverse reproductive and developmental outcomes.  The participants included housewives and adolescent girls (n = 20) who attended Padang Pasir Community Health Center, East Padang, Padang on 6 September 2025. An interactive educational session was conducted using a pre-test–post-test design to evaluate changes in knowledge and awareness. Analysis of participants who completed both assessments showed an improvement in knowledge following the intervention, with the greatest increases observed in understanding of healthy cooking utensils (50%) and the presence of persistent chemicals in cosmetics (50%). However, evaluation of awareness levels revealed only a minimal increase in median scores (from 57 to 60), which was not statistically significant (p = 0.221). We conclude that a focused educational session is effective in improving participants’ cognitive knowledge, but a more comprehensive and sustained approach is needed to promote meaningful behavioral change and deeper awareness, particularly since practicality and convenience remain major considerations when choosing household products, food packaging, and cosmetics.
Co-Authors Aaliyya, Zaki S. Abdah M.D. Akim Abi Ghofari Siregar, Muhammad Achyar, Afifatul Afriani, Nita Agustian, Dede Rahman Aizah, Havina Nurul Amel Yanis Andani Eka Putra Anggiansyah Pohan Annisa Permata Sari, Annisa Permata Aprilia Susanti, Aprilia Ariadapa Rahadi, Didan Ariesko Gunanda Rangkuti Ariouso, Al H. Arni Amir Asmah Rahmat Asmah Rahmat Budianto, Raymond E. Cimi Ilmiawati, Cimi Daan Khambri Dede Agustian Rahman Desmawati Desmawati Dina Arfiani Rusjdi Dwi Yulia Dwiharyani, Yuli Elizabeth Bahar Endrinaldi Erlina Rustam Erly Erly Eti Yerizel Eva Decroli Fadrian, Fadrian Fatma Sri Wahyuni Fauzan, Rezky Fauziah Othman Hanum, Fathiya Juwita Hasmiwati Hasnah Hasnah Hasnah, Hidayatul Havina Nurul Aizah Hirowati Ali Hirowati Ali, Hirowati Husnil Kadri Ilham Andhika Zulen Ilmiawati, Ilmiawati Kamila, Isna C. Khairani, Salsabila P. Khairani, Salsabila Putri Larasati, Aulia Sepriadina Lim, Nurul Naimah binti Muhammad Khairuddin Linosefa Linosefa Magza, Dekasih Tria Maharani, Malya CS. Malinda Meinapuri Masrul Meilisa Rahmawati Muhammad Ilham Mulfa Satria Asnel Nadya Mirenda Putri Nathaniel, Kevin Nelmi Silvia Noverika Windasari Noza Hilbertina Nugraha, Ikwandi C. Nurhayati, Nurhayati Nurmawaty - Olivia, Ivonne Pratama, Fajri Rahendra Pratama, Fajri Rahendra Puti Anggun Sari Rahmaddiansyah, Refa Rahmadian, Rizki Rahman, Awalil RK. Rahmatini . Rahmawati, Meilisa Rahmi, Wahida Rauza Sukma Rita Refa Rahmaddiansyah Refa Rahmaddiansyah Reza, Mohamad Risviani, Darayani Rizki Rahmadian Roza Silvia Rusti, Sukarsi Salsabila, Amilia Salsabila, Amilia Sari, Annisa Permata Shofiy, Alifya R. Sofia Mubarika Sofia Mubarika Haryana Suhaida. M. Jalil Sukarsi Rusti Susanti, Aprilia Syakira, Hasya Syakira, Hasya Theodora, Eillen Tofrizal Tofrizal Tofrizal Tri Anggraini, Fika Tyas, Syanindhita Wikanthining Ulya Uti Fasrini Utama, Bobby Indra Vella Amalia Wahida Rahmi Wahyudi, Dhyani P. Wirsma Arif Harahap Wiwi Pertiwi Yanwirasti - Yanwirasti - Yulia, Dwi Yuniar Lestari Yustini Alioes Zolkapli Eshak Zolkapli Eshak