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All Journal Jurnal Kedokteran Syiah Kuala JURNAL PETERNAKAN Jurnal Ilmiah Mahasiswa Veteriner Biosaintifika: Journal of Biology & Biology Education AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Ilmu Bedah Indonesia Narra J Jurnal Pengabdian Mandiri Jurnal Natural Jurnal Kedokteran Hewan The International Journal of Tropical Veterinary and Biomedical Research Journal of Livestock and Animal Health (JLAH) Jurnal Medika Veterinaria Jurnal Agripet
Dasrul Dasrul
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Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Narra J

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Effect of hemp seed oil on accelerating wound healing: Evaluation of wound size reduction, epithelialization, granulation tissue formation, and vascularization in murine models Rahman, Safrizal; A. Rivai, Mohammad; Dasrul, Dasrul; Ayu, Onarisa
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v5i1.1878

Abstract

Essential oils have gained interest in wound management, with prior studies exploring combinations of hemp seed oil (Cannabis sativa) and other oils. However, single-oil strategies may offer simpler formulation, reducing the risk of interactions while preserving therapeutic benefits. The aim of this study was to explore the effect of hemp seed oil on accelerating wound healing, focusing on wound size reduction, epithelialization, granulation tissue formation, and vascularization in murine models. An in vivo with a post-test-only control group was conducted using 36 male Mus musculus mice (3−4 months, 150–250 grams) which were divided into three groups: negative control (NC), positive control (PC, treated with chloramphenicol ointment twice daily), and treatment group (TG, treated with hemp seed oil 400,000 mg/mL twice daily). Mice were euthanized on day 3, 7, 14, and 21 for wound healing assessment, including macroscopic evaluation (visual observation, wound size, and wound healing rate) and microscopic evaluation (epithelialization, granulation tissue formation, and vascularization). The present study found that the TG group demonstrated smaller wound sizes on day 14 (p<0.001) and day 21 (p<0.001). This group also enhanced wound healing rates observed on day 14 (p<0.001) and day 21 (p=0.001) compared to PC and NC groups. Epithelialization was significantly higher in the TG group compared to PC and NC groups on day 14 (p=0.007), while granulation tissue formation showed significant improvement on day 3 (p=0.045), day 14 (p=0.028), and day 21 (p=0.003). Additionally, TG group showed significantly greater new blood vessel formation on day 21 (p=0.001) compared to the PC and NC groups. In conclusion, hemp seed oil demonstrated significant potential in accelerating wound healing processes suggesting a superior effect compared to chloramphenicol ointment. Therefore, hemp seed oil may serve as a promising natural and cost-effective adjunct for wound management.
Co-Authors . Zulfan A. Rivai, Mohammad Abdul Harris Abdul Harris Abdullah Hamzah, Abdullah Abdullah, Mohd Agus Nashri Agung - Kusasti Agus Adria Alifa, Yola Amalia Sutriana Ardyes, Rizki Arman Sayuti Asnita Purnama Asri Gani Aulann&#039;iam Aulann&#039;iam Aulia, Usma Awaluddin Awaluddin Ayu, Onarisa Azhar Azhar Budianto Panjaitan Budianto Panjaitan Citra Chyntia Helwana Cut Dahlia Iskandar Cut Nila Thasmi Cut Nila Thasmi Cut Nila Thasmi Cut Nila Thasmi, Cut Nila Dedhi Yustendi Delli Lefiana, Delli Deslo, Jauhari Dian Masyitha Didy Rachmadi Dwinna Aliza Edy Fradinata Elsa Suarni Erdiansyah Rahmi Erwin Erwin Eskayanti Pasaribu Etriwati E Fatah, Khairul Fathurrahman, Fadhil Fauziah Fauziah Fitriani Fitriani Fitriani Fitriani Gholib Gholib Gholib Gholib, Gholib Ginta Riady Ginta Riady Hafizuddin Hafizuddin Hamdan Hamdan Hamdan Hamdan Hamdan Hamdan Hardjopranjot Hardjopranjot Hasan Al Aslam Hattanul Mulia HENNIVANDA HENNIVANDA Herrialfian, Herrialfian Husnurrizal, Husnurrizal Ibnu Khaldun Idawati Nasution Imam Hidayat Ismail Ismail Ismail Ismail Ismy, Jufriady Juli Melia Juli Melia Julia Kardin KARTINI ERIANI Khairul Fatah Kurniawan, Wilda Limbong, Ahmad Affandi Listin Handayani M Hasan M Yusuf M. Aman Yaman M. Aman Yaman Mahaputra L Mamfalutfi, Teuku Masda Admi Masruri Masruri Mauridatun Ramli Mefrianti Efendi Mirnasari, Mirnasari Mohd. Agus Nashri Abdullah Muhammad Hasan Muhammad Isa Muhammad Reza MUHAMMAD RIZAL Mukhlis Mukhlis Mulyadi Adam Mulyadi Adam Mulyadi Adam, Mulyadi Muslim Akmal Mustafa Mustafa Nazaruddin Nazaruddin Nellita Meutia Novi Afriani Nur Afriani Nur Novika Ayuni Rambe NURLIANA NURLIANA NURLIANA NURLIANA Pusaka, Semerdanta Qadarsina Qadarsina R. N. Selamet Raida Fuadi Rajuddin Rajuddin Rasmaidar Rasmaidar Rasmaidar Rasmaidar Razali Razali Rinidar Rinidar Riska, Raisa Mauliza Ronasky, T Roslizawaty Roslizawaty Roslizawaty Roslizawaty, Roslizawaty Rosmaidar Rosmaidar Rosmaidar Rosmaidar, Rosmaidar Rosnizar, Rosnizar Rossy Septia Putri Rurini R Rurini R Rusli Rusli Rusnawati Rusnawati, Rusnawati Safrizal Rahman, Safrizal Sari, Nisa Sariadi Sariadi Siti Aisyah Siti Rizki Hardyana Siregar Sri Wahyuni Sri Wahyuni Sri Wahyuni Sudjarwo Sudjarwo Sugito - Sugito Sugito Sugito Sugito Syafruddin Syafruddin Syafruddin Syafruddin t fadrial karmil T. Armansyah Teuku Reza Ferasyi Teuku Zahrial Helmi Titit, Marcelus Ferdinandez Tongku Nizwan Siregar Tri Putri Purnama Sari Triva Murtina Lubis Triva Murtina Lubis Triva Murtina Lubis Veithzal Rivai Zainal Wahyuni, Sri Winaruddin Winaruddin Wira Asyudi Wulandari, Firstia Ritri Y, Bangun I Yusmadi Yusmadi Zaid Zaid Zarizki Taqwa Zulfan Zulfan Zulyazaini Zulyazaini Zulyazaini, Zulyazaini Zurnila MK