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Journal : Radioterapi

AFATINIB MONOTHERAPY FOR DOUBLE-PRIMARY LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER EXON-21 L861Q MUTATION WITH HISTORY OF COLORECTAL CANCER Jamnasi, Juli; Yeoh, Rudiyo; Sudibio, Sudibio; Hendrik, Hendrik
Radioterapi & Onkologi Indonesia Vol 15, No 1 (2024): Vol.15, No. 1(2024): Volume 15 No. 1 January 2024
Publisher : Perhimpunan Dokter Spesialis Onkologi Radiasi Indonesia (PORI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32532/jori.v15i1.164

Abstract

Introduction: Uncommon mutation exon-21 L861Q is a rare type Non-Small Cell LungCancer (NSCLC). Despite the limited data regarding this type of mutation, Afatinib as one of the oral tyrosine kinase inhibitors (TKI) shows good anti-tumor activity.Clinical Features: A 50-year-old woman with a history of post-operative colorectal cancer (2014) without undergoing chemotherapy and radiotherapy; came in October 2020 with severe dyspnea due to massive pleural effusion with a right lower lung bulky mass. Histopathology in 2014 was a low-grade adenocarcinoma colorectal cancer, while the biopsy of the right lung mass in 2020 was a mucinous adenocarcinoma, ALK-negative, TPS 1.75, and exon-21 L861Q mutation.Intervention and Outcomes: The patient underwent thorax drainage to evacuate pleural effusion fluid. Through multidisciplinary discussions, the patient was recommended to take the oral drug TKI Afatinib 40 mg OD in January 2021. On the 2nd week of taking Afatinib, the patient complained of painful swallowing, mouth sores, sore tongue, and joint pain throughout the body; confirmed to be the side effects of the drug. Complaints diminished with supporting drugs, however, did not resolve completely. CT scan in April 2021 showed a significant reduction in lung mass. Due to severe side effects and drastic weight loss, the Afatinib dose was reduced to 20 mg OD. Radiotherapy was incorporated in her treatment session with IMRT to cover the whole tumor.Discussion: Determining the best treatment to treat the patient was initially difficult due to the raising doubt regarding the correlation between the current lung cancer with her previous history of colorectal cancer. Treating the newer lung mass as primary cancer was obviously different rather than treating lung metastatic colorectal cancer. This issue could then be resolved by incorporating more thorough NGS examination. With the finding of exon-21 L861Q mutation in this patient, Afatinib monotherapy is considered the therapy of choice.
Co-Authors AA Sudharmawan, AA Aat Ruchiat Nugraha Abdul Aziz Afandy, Muhammad Ahmad, Hasnia Ajizah, Nur Akbar, Ari Yustisia Alfitri Alfitri Ali, Makhrus Amalia, Inda Amir Bagja Andi Harmoko Arifin Andoko, Dewanto Andriati, Novi Andry Stepahnie Titing Anshoriyah, Sofiyatul Anton PW Nomleni Ardiansyah, Rio Ardiyan Saptawan Arpandjam'an arpandjam'an, arpandjam'an Arpandjaman, Arpandjaman Asiati, Diah Isnaini Asmi, A.Syamsinar Asmi Asmita Christiany Kombong Atika, Amelia Auliah, Rezki Aulizar Arfan Awan Santosa Baso Intang Sappaile, Baso Intang Bayu Herdianto Cahyono, Andhik Budi Cahyono, Andhik Budi Chicka Willy Yanti Cintia Marendeng, Olivia Ciptasari, Nurhayati Indah Clara Yolandika Daniel Pasaribu Daud Yusuf Deglas, Welly Deni Ahmad Jakaria Desak Eka Susianawati Diah Fatma Sjoraida Dimas Fajar Imanto Durahim, Darwis Elfrida Ratnawati Eliza, Detha Fadhlan Failusuf Salam Fareski, Fahri Febriana, Eni Fernando , Rio Fernando, Putri Deniya Firman Nugroho Fitri Kumalasari, Fitri Fredy Saputra, M. Khalid Galuh Hartinah Gazali Lembah Guna, Bucky Wibawa Karya Gustini, Gustini Hakim, Supartina Hanif Hanif Hanif Kurniadi Hannan, Sjuaib Harahap, Stepandi Hasbiah Hasbiah, Hasbiah Hastiani -, Hastiani Haulah, Suci Hery Widijanto Hutasuhut, Wilda Rizkiyah Ilwandri, Ilwandri Insani, Fahrul Irving Vitra Paputungan Irwan Novianto Islam, Fahrul Isro’iyah, Latifatul Izzeti, Nadira Juli Jamnasi Juniati Juniati Junita Fabanjo, Ivonne Kalemben, Estevani Khaeril, Khaeril Lalli, Linda Lamun Bathara Lexy Kareba Liliana Puspa Sari Lilis, Lilis Lunatri, Andi M. Nurul Wathani Madehang, Madehang Mahdi, Nurzakia Malau, Ira Mawar Marchelina Rante Mardiana Panggabean, Ellis Martin Martin Ma’arif, Ahmad Fahruddin Millati, Rida' Milliana Moh Tahhir Moningkey, Shirley Moureen, Moureen Muhamad Stiadi Munthe, Desi Natalia Nababan, Roida Nasution, Tio Afandi Nasution, Tio Affandi Nengyanti Nengyanti, Nengyanti Niar Astaginy Niluh Desy Purnamasari Nordianiwati, Nordianiwati Novi Wahyu Hidayati, Novi Wahyu Nur Hidayati Nur Kholis Nur Kholis Nurhayati Usman NURUL ANNISA Pakpahan, emma martina Pararuk, Ririn Lestari Parmi, Parmi Prasetyo, Agus Budi Pristi Sahida, Adelia Octora Putri Anggraeni R. Teduh Dirgahayu Rahmad Subekti Rahmaditullah, Rahmaditullah Ramba , Yonathan Ramba, Yonathan Rara' Damba, Mitra Rasyid , Ardiansyah Ridar Hendri Rismawati, Dea Rizki, Hafizri Deni Rizky, Hafizri Deni RR. Ella Evrita Hestiandari Salsabila Purnamasari Santosa, Tomi Apra Sefrin Siang Tangkearung Setiaji, Hari Shafira Syakhnur Silaban, Yunita Feronika Br. Silitonga, Rahmi Julita Hotmaria Br. Silitubun, Evaristus Sitorus, Jenti Sjroida, Diah Fatma Soeryani, R Wianti Soesaptri Oediyani Sri Endang Kornita SRI RAHAYU Sudibio, Sudibio Sugiarti, Viki Sumanik, Ermi Dikta SUMIYATI SUMIYATI Supirno, Supirno Susanna Vonny N. Rante Susanto, Yohanes Sutrisnawati, Ika Suwardiman, Suwardiman Suwarno, Tri Suwarto Sunandar Syamsiar, Syamsiar Tadius Tamba, Orita Nadia Tang, Aco Tanga, Irma Yanti Teady Matius Surya Mulyana, Teady Matius Teduh Dirgahayu Teduh Dirgahayu Tince Sofyani Tititing, Andri Stepahnie Tongam E Panggabean Topanus Tulak Tulak, Harmelia Ufira Isbah Ulfa Amalia Nur Fatimah Unggul Priyadi Utami, Kurniati Dwi Utami, Lusia Savitri Setyo Veli Sungono Wahyu Mayangsari Windarsyah Windarsyah Wisran Wiwik Handayani Yanti Andriani, Neneng Yeoh, Rudiyo Yudomustafa, Fakhruddin Yulianda, Eni Yuslinda, Yuslinda Zaenul Amri Zulkarnain Zulkarnain