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The Role of Antidepressants in a Malignancy Patient with Palliative Care: A Systematic Literature Review Yovanda, Ryandri; Arina Widya Murni; Widya Deli Satuti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1051

Abstract

Background: Depression is a common complication in malignancy patients, and can worsen their quality of life and prognosis. Palliative care aims to improve the quality of life of patients with life-limiting illnesses, and antidepressants are often used in this context. Methods: This systematic review was conducted to evaluate the effectiveness of antidepressants in malignancy patients with palliative care. A literature search was conducted in three databases: PubMed, Cochrane, and ScienceDirect. Search terms included “Antidepressants,” “Malignancies,” and “Palliatives.” Results: Two studies met inclusion criteria: First study: Randomized controlled clinical trial evaluating the effectiveness of mirtazapine compared with escitalopram in malignant patients with depression. The results showed that mirtazapine was more effective in improving quality of life and reducing depressive symptoms compared with escitalopram. Second study: a study evaluating the effectiveness of antidepressants in elderly malignancy patients with depression. The results suggest that antidepressants may be effective in reducing depressive symptoms and improving quality of life, but further research is needed to confirm their effectiveness and safety. Conclusion: Available evidence suggests that antidepressants may be effective in treating depression in malignancy patients with palliative care. However, further research is needed to identify the most effective and safe antidepressants for this patient population.
Risk Factors for Sleep Disorders in Patients with Chronic Pain: A Meta-Analysis Yoerizta Ratu, An Nissa’; Arina Widya Murni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1100

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Background: Chronic pain and sleep disorders frequently co-occur, exacerbating each other in a vicious cycle. This meta-analysis aimed to identify and quantify risk factors associated with sleep disorders in individuals experiencing chronic pain. Methods: A systematic search of PubMed, Embase, Web of Science, and Cochrane Library databases was conducted from January 2018 to June 2024. Studies assessing sleep disorders (insomnia, obstructive sleep apnea, restless legs syndrome) in adults with chronic pain (non-cancer pain lasting >3 months) were included. Data on demographics, pain characteristics, sleep measures, and potential risk factors were extracted. Meta-analyses were performed using random-effects models to estimate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: Twenty-seven studies (n = 12,453 participants) met the inclusion criteria. Chronic pain significantly increased the odds of having any sleep disorder (OR 2.83, 95% CI 2.19-3.65). Specific risk factors identified included: Female gender: OR 1.41 (95% CI 1.18-1.67); Higher pain intensity: OR 1.15 per 1-unit increase on a 0-10 scale (95% CI 1.08-1.23); Longer pain duration: OR 1.04 per year (95% CI 1.01-1.07); Presence of depression or anxiety: OR 2.32 (95% CI 1.85-2.91); Use of opioid medications: OR 1.58 (95% CI 1.23-2.04). Conclusion: Chronic pain is a substantial risk factor for sleep disorders. Gender, pain intensity, duration, comorbid mental health conditions, and opioid use emerged as modifiable risk factors. Targeted interventions addressing these factors may improve sleep outcomes in individuals with chronic pain.
Unraveling the Pathways: A Meta-Analysis Exploring the Biopsychosocial Mechanisms Linking Psychosomatic Symptoms and Systemic Lupus Erythematosus Ridho Pratama; Arina Widya Murni
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1201

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Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a complex interplay of biological, psychological, and social factors. Psychosomatic symptoms, such as depression, anxiety, and stress, are common in individuals with SLE and can significantly impact disease activity and overall well-being. This meta-analysis aims to explore the biopsychosocial mechanisms linking psychosomatic symptoms and SLE. Methods: A systematic search of PubMed, Embase, PsycINFO, and Web of Science databases was conducted from January 2013 to December 2024. Studies examining the relationship between psychosomatic symptoms and SLE were included. Data were extracted and analyzed using random-effects models to calculate pooled effect sizes. Results: Six studies met the inclusion criteria. The meta-analysis revealed a significant association between psychosomatic symptoms (depression, anxiety, and stress) and SLE disease activity (pooled effect size: r = 0.42, 95% CI: 0.31-0.53, p < 0.001). Furthermore, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, pro-inflammatory cytokine activity, and impaired coping mechanisms emerged as key biopsychosocial pathways linking these factors. Conclusion: This meta-analysis highlights the significant impact of psychosomatic symptoms on SLE and identifies potential underlying mechanisms. These findings underscore the need for integrated biopsychosocial interventions in SLE management, targeting both physical and psychological well-being to improve patient outcomes.
THE DIFFERENCE IN TOTAL IMMUNOGLOBULIN E LEVELS AND EOSINOPHIL COUNTS AMONG ELDERLY INDIVIDUALS WITH AND WITHOUT ALLERGIC DISEASES Mulyana, Roza; Rio, Yugo Berri Putra; Raveinal, Raveinal; Martini, Rose Dinda; Harun, Harnavi; Asir, Taufik Rizkian; Fadrian, Fadrian; Murni, Arina Widya
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3114

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Penyakit alergi dapat terjadi pada lansia dengan gejala yang dapat memburuk akibat adanya proses imunosenesens. Kadar IgE total dan jumlah eosinofil dapat digunakan sebagai pemeriksaan tambahan untuk penyakit alergi. Penelitian ini bertujuan untuk mengetahui perbedaan kadar IgE total dan jumlah eosinofil pada lansia dengan dan tanpa penyakit alergi. Penelitian observational analitik ini dilakukan pada lansia usia 60-80 tahun di RSUP DR. M. Djamil Padang selama Januari–Juni 2024. Sampel dikelompokkan menjadi kelompok lansia dengan penyakit alergi dan kelompok lansia tanpa penyakit alergi. Pengambilan sampel dilakukan secara consecutive sampling, melibatkan 52 partisipan (masing-masing 26 dengan dan tanpa penyakit alergi).  Kadar IgE total dan jumlah eosinofil diperiksa dengan menggunakan sampel darah vena. Analisis data menggunakan uji Mann-Whitney. Hasil penelitian menunjukkan median kadar IgE total pada kelompok alergi sebesar 1.741,1 kIU/L (minimum 517,7 kIU/L; maksimum 4843 kIU/L), sedangkan kelompok non-alergi 177,1 kIU/L (minimum 14 kIU/L; maksimum 800 kIU/L). Median jumlah eosinofil pada kelompok alergi sebesar 378 sel/µL (min: 100; maks: 950), sedangkan kelompok non-alergi 61,5 sel/µL (min: 17; maks: 189). Terdapat perbedaan signifikan kadar IgE total dan jumlah eosinofil antara lansia dengan dan tanpa penyakit alergi (p<0,001). Lansia yang mengalami Alergi menunjukkan kadar IgE  dan jumlah eosinofil lebih tinggi dibandingkan lansia yang tidak  alergi.  
Diagnostic value of Peguero-Lo Presti electrocardiographic criteria for diagnosing concentric left ventricular hypertrophy in hypertensive patients at Dr. M. Djamil General Hospital Padang Poedjijo, Yanuar Surya Saputra; Hanif, Akmal M.; Wahyudi; Murni, Arina Widya; Ahmad, Armen; Faheri, Eifel; Elvira, Dwitya; Kurniawan, Eka
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 3, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss3.art5

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Background: Hypertension is a risk factor for morbidity and mortality from cardiovascular disease. Left ventricular hypertrophy (LVH) is the main target organ due to hypertension, which is a predictor of the development of cardiovascular diseases such as heart failure. Echocardiography is the gold standard examination for determining heart geometry, and concentric LVH is often found in hypertensive patients. Electrocardiography (ECG) is a widely available, low-cost, and rapid modality for diagnosing LVH in healthcare facilities. The Peguero–Lo Presti (PLP) criteria in ECG examination have better sensitivity and specificity compared to other criteria. Objectives: This study aims to determine the diagnostic value of PLP ECG to diagnose concentric LVH.Methods: This research is an analytical observational study with a cross-sectional approach carried out at the inpatient installation of Dr. M. Djamil General Hospital Padang for 6 months, starting from April to September 2024. The study subjects who met the inclusion and exclusion criteria were 90 samples selected by consecutive sampling. An ECG examination was conducted using PLP criteria and echocardiography with the M-mode method to assess left ventricle (LV) geometry. Data were analysed using a 2x2 table to obtain sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy.Results: From 90 samples, LVH geometry was found concentric in 65.50%, eccentric 4.40%, concentric remodelling 11.10%, and normal 18.90%. In the diagnostic test, PLP criteria had 79.66% sensitivity, 90.32% specificity, 94.00% PPV, 70.00% NPV, and 83.33% accuracy to diagnose concentric LVH in hypertensive patients.Conclusion: Peguero Lo-Presti criteria on ECG can be used for screening and early diagnosis of concentric LVH in hypertensive patients.
Analysis Factors Related to Menstrual Disorders in Female Medical Students Situmorang, Risna Sari; Desmawati, Desmawati; Murni, Arina Widya
Jurnal Kebidanan dan Kesehatan Tradisional Jurnal Kebidanan dan Kesehatan Tradisional Volume 10 Number 2 Year 2025
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jkkt.v10i2.577

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Background: Every woman can experience various disorders of menstruation, ranging from amenorrhea, oligomenorrhea, polymenorrhoea, hypomenorrhea, hypermenorrhoea, and dysmenorrhoea. This study aimed to elucidate the factors related to menstrual disorders in female students of the faculty of medicine at Universitas Andalas.  Methods: The purpose of this case-control study is to determine factors that increase the likelihood of developing a disease by comparing a group of cases with a group of controls, focusing on their exposure status. The respondents to this study were teenagers aged 18-21 years. A sample of 108 female students was taken using consecutive sampling. Data collection from anthropometric measurements and questionnaires menarche age, The International Physical Activity Questionnaire (IPAQ), Food Frequencies Questionnaire (FFQ) and Pittsburg Sleep Quality Index (PSQI). The Chi-Square test was used to analyze the data.  Results: The result showed no significant relationship between menarche age (p-value 0.420), stress levels (p-value 0.406), and physical activity (p-value 0.348), with menstrual disorders. There was a relationship between nutritional status (p-value 0.001), sleep quality (p-value 0.002), and eating patterns (p-value 0.001) with menstrual disorders. Conclusion: Diet is the factor most associated with menstrual disorders in female students, followed by sleep quality and nutritional status. The study recommends preventing menstrual disorders in female students by prioritising improvements in diet, sleep quality and nutritional status.
Factors Associated With Family Caregivers’ Knowledge and Attitudes Toward Home-Based Geriatric Care in Primary Healthcare: A Cross-Sectional Study Gemini, Savitri; Lipoeto, Nur Indrawati; Machmud, Rizanda; Murni, Arina Widya
Majalah Kesehatan Indonesia Vol. 7 No. 3 (2026)
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/makein.2026324

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Family caregivers play a central role in home-based geriatric care, especially in settings where institutional long-term care remains limited. However, caregiver capacity may vary according to socio-demographic, relational, and service-related factors. This study aimed to identify factors associated with family caregivers’ knowledge and attitudes toward home-based geriatric care in a primary healthcare context. A quantitative analytic study with a cross-sectional design was conducted from September to December 2025 in two Puskesmas working areas in Batam City, Indonesia. A total of 326 family caregivers were recruited using proportional sampling. Data were collected through structured questionnaires and analyzed using univariate analysis, Chi-square tests, and multivariate logistic regression. Most caregivers had low knowledge (86.5%) and negative attitudes (61.0%) despite reporting high communication patterns and positive perceptions of healthcare facility quality. Bivariate analysis showed that economic status, caregiving duration, communication pattern, and perceived quality of healthcare facilities were significantly associated with knowledge, whereas economic status, communication pattern, and perceived quality of healthcare facilities were associated with attitudes. In the multivariate model, only caregiving duration (AOR = 15.790; p < 0.001) and communication pattern (AOR = 0.157; p = 0.013) remained independently associated with caregiver knowledge. No independent predictors were identified for attitudes. These findings indicate that caregiver knowledge was more strongly associated with experiential and relational factors, particularly caregiving duration and family communication. Structured, family-centered, and nurse-led interventions in primary healthcare may help strengthen caregiver preparedness in home-based geriatric care. Abstrak: Caregiver keluarga memainkan peran sentral dalam perawatan geriatri berbasis rumah, terutama di lingkungan yang layanan perawatan jangka panjang institusionalnya masih terbatas. Namun, kapasitas caregiver dapat bervariasi menurut faktor sosiodemografis, relasional, dan faktor terkait layanan. Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang berhubungan dengan pengetahuan dan sikap caregiver keluarga terhadap perawatan geriatri berbasis rumah dalam konteks pelayanan kesehatan primer. Penelitian kuantitatif analitik dengan desain potong lintang dilakukan dari September hingga Desember 2025 di dua wilayah kerja Puskesmas di Kota Batam, Indonesia. Sebanyak 326 caregiver keluarga direkrut menggunakan proportional sampling. Data dikumpulkan melalui kuesioner terstruktur dan dianalisis menggunakan analisis univariat, uji Chi-square, dan regresi logistik multivariat. Sebagian besar caregiver memiliki pengetahuan rendah (86,5%) dan sikap negatif (61,0%) meskipun melaporkan pola komunikasi yang tinggi dan persepsi positif terhadap kualitas fasilitas pelayanan kesehatan. Analisis bivariat menunjukkan bahwa status ekonomi, lama merawat, pola komunikasi, dan persepsi terhadap kualitas fasilitas pelayanan kesehatan berhubungan secara signifikan dengan pengetahuan, sedangkan status ekonomi, pola komunikasi, dan persepsi terhadap kualitas fasilitas pelayanan kesehatan berhubungan dengan sikap. Pada model multivariat, hanya lama merawat (AOR = 15,790; p < 0,001) dan pola komunikasi (AOR = 0,157; p = 0,013) yang tetap berhubungan secara independen dengan pengetahuan caregiver. Tidak ditemukan prediktor independen untuk sikap. Temuan ini menunjukkan bahwa pengetahuan caregiver lebih kuat berhubungan dengan faktor pengalaman dan relasional, khususnya lama merawat dan komunikasi keluarga. Intervensi yang terstruktur, berpusat pada keluarga, dan dipimpin oleh perawat di pelayanan kesehatan primer berpotensi membantu memperkuat kesiapan caregiver dalam perawatan geriatri berbasis rumah.
Diagnostic Value of Proenkephalin A 119 – 159 Serum in Early Detection of Sepsis Associated Acute Kidney Injury Wahyudi, Adefri; Priyono, Drajad; Harun, Harnavi; Viotra, Deka; Najirman, Najirman; Kurniati, Roza; Simajuntak, Rohayat Bilmahdi; Murni, Arina Widya
Indonesian Journal of Kidney and Hypertension Vol 3 No 1 (2026): Vol 3 No 1 (2026): Volume 3 No. 1, April 2026
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v3i1.239

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Background: Sepsis asscociated acute kidney injury (SA-AKI) is common condition that found in sepsis. Due to the lack of creatinine serum, this condition possibly makes therapy delayed. Proenkephalin A 119-159 (PENK) is a breakdown product of the prohormone proenkephalin A which freely filtered at the glomerulus. In other hand, this prohormone and its receptor predominantly expressed in proximal Tubular Epythelial Cells (pTEC) of kidney. Elevated serum PENK levels are an indicator of AKI. However, previous studies have shown varies results. Objectives: This study aims to determine early detection biomarkers for the presence of AKI in sepsis. Methods: This diagnostic test was conducted at Dr. M. Djamil General Hospital Padang in sepsis patients. The diagnosis of AKI was established based on the 2012 KDIGO criteria. Results: The study involved 98 sepsis patients, 58.16% (n=57) of them experienced AKI. Serum creatinine levels at admission and within 48 hours of hospitalization were 1.0 (IQR 0.8–1.5) mg/dl and 1.6 (IQR 0.9–2.1) mg/dl, respectively. A serum PENK level ≥82.6 pmol/L at admission had sensitivity of 98.6%, specificity of 95.1%, positive predictive value of 96.1%, negative predictive value of 97.5%, and accuracy of 96.9% in early detection of AKI in sepsis. Conclusion: Serum PENK level has excellent diagnostic value in early detection of AKI in sepsis.
Korelasi Karakteristik Individu Terhadap Tingkat Depresi Pada Pasien Gagal Ginjal Kronik Havizur Rahman; Helmi Arifin; Arina Widya Murni
Journal of Pharmascience Vol. 6 No. 2 (2019): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7354

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ABSTRAK Pasien dengan penyakit kronis memiliki kecendrungan mengalami depresi, salah satunya pada pasien gagal ginjal kronis. Tujuan: mengetahui korelasi antara karakteristik pasien gagal ginjal kronis dengan terjadinya depresi. Metode penelitian: cross sectional menggunakan data primer, dengan teknik pengambilan data judgment sampling, pengukuran tingkat depresi menggunakan Beck Depression Inventory-II (BDI- II) dan data dianalisis menggunakan uji korelasi kendall’s tau-b. Hasil: karakteristik umur (sig=0.057), tingkat Pendidikan (sig=0.246), status (sig=0.484), jaminan kesehatan (sig=0.957) dan lama menjalani tindakan hemodialisis (sig=0,396) tidak memiliki hubungan dengan terjadinya depresi sedangkan karaktersitik yang memiliki hubungan dengan terjadinya depresi yaitu jenis kelamin (sig=0.028), pekerjaan (sig= 0.001) dan tindakan hemodialisa (sig= 0.05) dengan korelasi cukup kuat. Kesimpulan: beberapa karakteristik pasien yaitu jenis kelamin, pekerjaan dan tindakan hemodialisa memiliki korelasi yang cukup kuat terhadap timbulnya depresi pada pasien gagal ginjal kronis. Kata Kunci— korelasi, karaktersitik, depresi  ABSTRACT Patients with chronic diseases have a tendency to experience depression, one of them is in patients with chronic kidney failure. Objective: to determine the correlation between the characteristics of patients with chronic kidney failure with depression. Research methods: cross sectional using primary data, with judgment sampling data collection techniques, measurement of depression levels using the Beck Depression Inventory-II (BDI-II) and data analyzed using the Kendall's tau-b correlation test. Results: age characteristics (sig = 0.057), education (sig = 0.246), status (sig = 0.484), health insurance (sig = 0.957) and length of time undergoing hemodialysis (sig = 0.396) have no relationship with the occurrence of depression while the characteristics of depression which has a relationship with the occurrence of depression, namely gender (sig = 0.028), work (sig = 0.001) and hemodialysis (sig = 0.05) with a strong enough correlation. Conclusion: some of the characteristics of patients namely sex, occupation and hemodialysis have a strong correlation to the onset of depression in patients with chronic kidney failure. Keywords — correlation, characteristics, depression
Co-Authors Abdiana Abdiana, Abdiana Adnil E Nurdin, Adnil E Adnil Edwin Nurdin Afriwardi Afriwardi Agustin, Nia Mitra Ahmad, Armen Aisyah Elliyanti Akmal M. Hanif Alexander Kam Alexander Kam Alfitri Alfitri Amel Yanis Andriyan, Aric Frendi Anggi Setiawan Ardian Riza Ariani, Novita Ashal, Taufik Asir, Taufik Rizkian Athiutama, Ari Beni Indra, Beni Bobbi Hemriyantton Dea Rika Putri Purba Dedy Almasdy Deka Viotra Delmi Sulastri Desmawati Desmawati Dewi Eka Putri Dia Rofinda, Zelly Dia Dian Arfan As Bahri Dian Pertiwi Dian Pertiwi Diny Amenike Dita Nelvita Sari Dwitya Elvira, Dwitya Edison Edison Eldi Sauma Elizabeth Bahar Elmatris Sy Emil Huriani Emil Prasetyo Muhammad Ennesta Asri Erlina Rustam Ermayanti, Sabrina Eryati Darwin Esi Afriyanti Eti Yerizel Etriyel Myh Fadella, Annesa Fadhlurrahman Wide Putra Fadrian, Fadrian Faheri, Eifel Gemini, Savitri Gina Matahati Gina Sonia Gusya Liza, Rini Gusyaliza, Rini Hanum, Fathiya Juwita Harahap, Hana Yulia Rahmi Harun Harnavi Hasmiwati Havizur Rahman Havizur Rahman Helmi Arifin Hendra Permana Hendriati, Hendriati Husnil Wardiyah Indah Paradifa Sari Irlaks, Viton Surya Irwadi Irwadi Isnindiah Koerniati Julizar Julizar Julizar Julizar Kurniawan, Eka Liandhu Hakim, Sonya Lily Yanti Mardi, Tris Mar’atul Fadhilah Masrul Mona Rahmi Rulianti1 Muhamad Diva Caesar Muhammad Husnul Ikhsan Najirman, Najirman Nasrul Zubir Nur Indrawati Lipoeto Nurhajjah, Sitti Oktarina, Elvi Poedjijo, Yanuar Surya Saputra Priyono, Drajad Puja Agung Antonius Putra Rio, Yugo Berri Rafli, Rhandyka Rahman, Havizur Rahmat Syawqi Rahmat Syawqi Rahmatina B Herman Rahmi, Wahida Rahmy Nurdin RAVEINAL RAVEINAL Raveinal Raveinal Resti Yuliani Restu Susanti Ridho Berlianto Ridho Pratama Rihaliza Rihaliza Rika Fatmadona Rika Susanti Rina Gustia Rini Gusya Liza, Rini Gusya Rismawati Yaswir Rita Hamdani Rizanda Machmud Rose Dinda Martini Roza Kurniati Roza Kurniati Roza Mulyana Salma Nabilaputri Nadiaskara Saptino Miro Simajuntak, Rohayat Bilmahdi Siti Nurhajjah Situmorang, Risna Sari Sri Wahyuni Tasman Tasman Tasman Tasman Tasman Tris Mardi Ulya Uti Fasrini Vania Aresti Yendrial Vilza Maharani Syahnel Vina Muspita Viton Surya Irlaks Vokal Furkano WAHYUDI Wahyudi, Adefri Wardhy Arief Hidayat Widya Deli Satuti Wijaya, Harwin Winda Resvi Juliana Yanni, Mefri Yevri Zulfiqar Yoerizta Ratu, An Nissa’ Yovanda, Ryandri Yugo Berri Putra Rio Yui Muya Yulistini, Yulistini Yuriko Andre Yutika Jasvita Zelly Dia Rofinda