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Profil tumor neuroendokrin berdasarkan pengalaman lima tahun di rumah sakit rujukan tersier di Palembang Sandria; Murti, Krisna
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.664

Abstract

Background Neuroendocrine tumors (NET) are a type of uncommon neoplasms originating from the neuroendocrine cell system. Recent decades, the prevalence of NET gradually increases, attributing partially to the utilization of advanced detection procedures using modern methodologies. Objective The aim of this research was to assess the profile of neuroendocrine tumors of 5 years experiences in our hospital. Methods In this retrospective cross-sectional study, a thorough examination was performed on a total of 71 cases obtained from archives of the Department of Anatomic Pathology Mohammad Hoesin Hospital, over the period from 2017 to 2021. The Chi-square test was used for data analysis. Bivariate analysis was performed using binary logistic regression tests to investigate the correlation between the independent variables, including gender and tumor site, and the dependent variables. Result and Discussion Out of the 71 recorded samples, 69 samples were subjected to be analyzed while the remaining samples were excluded due to have incomplete data. Four different antibodies were evaluated to find the association between these antibodies and tumor with location (chromogranin, P=0.792; synaptophysin, P=0.100; Ki-67, P=0.026; CD56, P=0.511) and gender (chromogranin, P=0.627; synaptophysin, P=0.929; Ki-67, P=0.315; CD56, P=0.524). Conclusion: The study showed synaptophysin has the highest positive rate on NET diagnosis. There is no association was found between chromogranin, synaptophysin, and CD56 staining to tumor location, except for Ki-67. Similarly, no association was found between staining performance (chromogranin, synaptophysin, Ki-67, CD56) with gender.
The Role of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSC) in Rheumatoid Arthritis: A Literature Review and Bibliographic Study Bastian, Bastian; Radiyati Umi Partan; Krisna Murti; Ayeshah Augusta Rosdah
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/6mrp2h76

Abstract

Umbilical Cord-derived Mesenchymal Stem Cells (UC-MSCs) are promising candidates for innovative therapy in rheumatoid arthritis (RA) due to their immunomodulatory and regenerative properties. RA is a chronic autoimmune disease characterized by persistent synovial inflammation, progressive joint destruction, and immune dysregulation involving T cells, B cells, and pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. This study aims to analyze the research development and therapeutic potential of UC-MSCs in RA through a bibliometric approach and literature review. Data were collected from PubMed, Dimensions, ScienceDirect, and Google Scholar databases covering the period 2016–2025 using relevant keywords related to UC-MSC and RA. Bibliometric analysis was performed using VOSviewer to map publication trends, scientific collaborations, and research topic clusters, while the literature review was used to evaluate the underlying mechanisms and therapeutic effectiveness. The results indicate a significant increase in UC-MSC research in recent years, with a primary focus on immunomodulatory mechanisms and clinical applications. Biologically, UC-MSCs have been shown to suppress synovial hyperplasia, inhibit pro-inflammatory cytokine production, and increase regulatory T cell (Treg/FOXP3) populations, thereby promoting immune tolerance and tissue repair. Preclinical and clinical studies have reported reductions in disease activity scores and improvements in joint function. However, the limited number of large-scale clinical trials and insufficient exploration of specific molecular mechanisms remain major challenges. Therefore, further studies are required to optimize the clinical application of UC-MSCs as a regenerative and immunomodulatory therapy for RA.
Co-Authors ,Aswatama, Ketut Adam, Ryan Adi Saputra Aldes Lesbani Alexandra Octnick Andarinini, Rindang Senja Andrew Sakko Andrina, Hana Andriyani Liberty, Iche Andy Alfatih Anggraini, Bean Nur Aspitriani Asprianto, Muhammad Astrilya, Nuur Hayati Ayeshah A Rosdah BASTIAN BASTIAN, BASTIAN Bima Zulfikar, M. Carmela Ricciardelli Chodijah, Nyimas Citra Dewi Citra Dewi Dahlan, Kemas Devi Dwiyanti Devi Eqtriana Setyaningsih Devi, SNA Ratna Sari Dian Fitriani Dwiryanti, Rizky Edi Poedjo Purnamawati, Ika Kartika Eka Putra Pratama Ella Amalia, Ella Ellyzar Ellyzar Elza Iskandar, Elza Erial Bahar Erial Bahar, Erial Eriza, Eriza Erno Widayanto, Erno Farah Diba, Masayu Farodiyah, Nanda Narul Farodiyah, Nanda Nurul Fauziah Kurniawaty, Nyiayu Haloho, Agustina Br. Handayati, Debby Heni Maulani, Heni Henny Sulastri Huntari Harahap Iche Andriyani Liberty, Iche Andriyani Ika Kartika Ika Kartika Indri Seta Septadina Irfannuddin Irfannuddin Irfanuddin Irfanuddin Irfanuddin Irsan Saleh Izzudin, Muhammad Jurgen Stahl Kamaluddin, Muhammad Totong Kartika Edi Poedjo Purnamawati, Ika Kesty, Cindy Khoiri Yahya Afifah Koibuchi, Noriyuki Kurniawaty, Nyiayu Fauziah Leovani, Ega Lisa M. Butler Mahdavikia, Reza Maria Ulfa Maria Ulfa, Maria Ulfa, Maria Ulfa,, Maria Ulfa, Marta Hendry, Marta Maryano, Maryano Maydila Putri Millenia Mega Fatimah Rosana Mega, Pratia Meilinda, Nurly Mgs. Irsan Saleh, Mgs. Irsan Miftha Pratiwi Muhammad Asprianto Muhammad Ichsan Hadjri Muhammad Irsan Saleh Muhammad Yusuf Abror Muradi, Akhmadu Musdalifah, Farisha Sestri Muzakkie, Mufida Nadya Virana Putri Neti Neti, Neti Nora Ramkita Nugraha, Xavier Nuur Hayati Astrilya Nyiayu Fauziah Kurniawati Pangestu, Panji pariyana, Pariyana Peby Maulina Lestari, Peby Maulina Pratama, Eka Putra Puspa Zuleika, Puspa Putra, Mohammad Tomita Maha Putri Erlyn Putri Mirani Putri Saraswati Radiyati Umi Partan Ramadhani, Solibah Ramzi Amin, Ramzi Rasyid, Riana Sari Puspita Riana Sari Puspita Rasyid Rifai Agung Prihananto Rikka Wijaya S. Nurul Amanah Ratna Sari Sandria Santoso Mulyadi Saputra Naibaho, Oldyo Sari Puspita Rasyid, Riana Sastradinata, Irawan Sherlin Tazkiya Nur Salsabila Shofia Shinta Adityaningrum Siti Nurmaini Siti Sarahdeaz Fazzaura Putri Soedjana, Hardi Siswo Sofyan Effendi Sri Santoso Sabrini Stevanny, Bella Suly Auline Rusminan Syifa Ayu Laluna Tatit Nurseta Theodorus Theodorus Tina B. Mitto Vera Novianti Wayne D. Tilley Wresnindyatsih Wresnindyatsih, Wresnindyatsih Yenny Febrianty Yudianita Kesuma, Yudianita Yusa, Muchammad Yustian Yusuf Hasibuan, Fauzie Yususf, Fahmi Jaka Zen Hafy