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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Althea Medical Journal Nexus Biomedika Nexus Kedokteran Translasional Jurnal Riset Kesehatan Majalah Obat Tradisional Smart Medical Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Manarang Al-sihah: The Public Health Science Journal Indonesian Journal of Medicine Journal of Maternal and Child Health YARSI Medical Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) Abdimas Universal World Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Indonesian Journal of Global Health research Nusantara Science and Technology Proceedings Narra J Journal of Multidisciplinary Applied Natural Science Ahmar Metakarya: Jurnal Pengabdian Masyarakat Proceeding ISETH (International Summit on Science, Technology, and Humanity) Biocaster : Jurnal Kajian Biologi Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Literasi Kesehatan Husada: Jurnal Informasi Ilmu Kesehatan Jurnal Pendidikan Kesehatan Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan Indonesia Jurnal Kebidanan
Ida Nurwati
Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
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Journal : Journal of Multidisciplinary Applied Natural Science

 1 
Caesalpinia bonduc (L) Roxb Seed Extract Dosage and Sex Effects on Pathobiological Changes in A Rat Model of Diabetes Mellitus Sopianti, Densi Selpia; Doewes, Muchsin; Sumandjar, Tatar; Pamungkasari, Eti Poncorini; Dirgahayu, Paramasari; Febrinasari, Ratih Puspita; Nurwati, Ida
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.349

Abstract

Caesalpinia bonduc (L) Roxb is a medicinal plant commonly utilized in traditional Indonesian medicine, particularly for the treatment of diabetes mellitus (DM). This study examined the effects of varying doses C. bonduc extract on fasting blood sugar (FBS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and pancreatic histology in male and female wistar rats with diabetes. The study design included six groups of 18 male and female rats (Wistar strain) each. To develop diabetes, nicotinamide (NA) (110 mg/kg) and streptozotocin (STZ) (45 mg/kg) were supplied, followed by oral administration of C. bonduc extract at dosages of 200, 400, and 600 mg/kg for 21 days. We utilized ELISA to analyze biochemical parameters and employed H&E staining to evaluate histological changes. A factorial design was employed for the statistical analysis to examine the effects of both dosage and sex. This study offers a unique comparative examination of the antidiabetic efficacy of C. bonduc across genders, a dimension seldom explored in experimental diabetes research. The findings indicated that C. bonduc markedly reduced levels of FBS, MDA, TNF-α, and TGF-β (p < 0.05) enhanced the structural integrity of the pancreas. There were no significant differences between males and female (p > 0.05). The dosage and sex influenced MDA and TGF-β. The extract of C. bonduc shown the ability to lower blood sugar, fight free radicals, and reduce inflammation; however, the intensity of these benefits depended on the dosage given. This means that it might assist persons with diabetes minimize oxidative stress and damage to the pancreas.
Co-Authors A. Guntur Hermawan Ambar Mudigdo Anik Lestari Asrial, An A. Baihaqy, Fathu Thaariq Betty Saptiwi Betty Saptiwi Betty Saptiwi Brian Wasita Christanto, Antonius Danus Hermawan Danus Hermawan Dicky Maulana Lazuardi Diding H P Diding Heri Prasetyo Diding Heri Prasetyo Dono Indarto Dyah Rahmawatie Ratna Budi Utami Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Dyonisa Nasirochmi Pakha Eriana Melinawati Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhilah, Azzahra Nur Fahmi, Muhammad Izzul Widad Gresmita Rindi Winarti Hadi, Cahyono Hakim, Fikar Arsyad Harioputro, Dhani Redhono Hermawan, Danus Hermawan, Danus Ika Tristanti Indri Erwhani Jarot Subandono Jarot Subandono Jarot Subandono Khoirunnisa, Rahmi Lazuardi, Dicky Maulana Mahendra, Fadia Yuda Martini Martini Martini Martini Martini Martini Muchsin Doewes Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Mutmainah Mutmainah Nabila Aushaf Prasetyo Nafisa, Putri Amalina Nanang Wiyono Noni Kartika Sari Nugroho, Anung N. Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Pamungkasari, Eti P. Paramasari Dirgahayu Prihandjojo Andri Putranto Pudjiastuti, Anggit Putranto, R. Prihandjojo Andri Putranto, Wachid Rahardjo, Setyo Sri Ratih Puspita Febrinasari Ratnasari Ratnasari Reviono Reviono Risya Cilmiaty A. R. Risya Cilmiaty AR Risya Cilmiaty, Risya Rosyida, Rufaida Rusliana, Eka Sari, Noni Kartika Sarsanti, Arifa Sherina Noor Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Setiamika, Made Setianto, Budi Y. Sigit Setyawan Sineri, Dessy Ikasartika Siti Aisyah Siti Marufah Soetrisno Soetrisno Sopianti, Densi Selpia Sri Hartati Hadinoto Sri Haryati Sri Sulistyowati Sumandjar, Tatar Sumardiyono Sumardiyono Sumardiyono, S Sunggoro, Agus Jati Tonang Dwi Ardyanto Uki Retno Budihastuti Vitri Widyaningsih Wahyu Anjas Sari Wesliaprilius, Todung Antony Wiyono, Nanang Wuriani, Wuriani Yarso, Kristanto Y. yoseph Indrayanto Yudhani, Ratih Dewi Yulia Sari Yulyanti, Yulyanti