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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Althea Medical Journal Nexus Biomedika Nexus Kedokteran Translasional Jurnal Riset Kesehatan Majalah Obat Tradisional Smart Medical Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Manarang Al-sihah: The Public Health Science Journal Indonesian Journal of Medicine Journal of Maternal and Child Health YARSI Medical Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) Abdimas Universal World Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Indonesian Journal of Global Health research Nusantara Science and Technology Proceedings Narra J Ahmar Metakarya: Jurnal Pengabdian Masyarakat Proceeding ISETH (International Summit on Science, Technology, and Humanity) Biocaster : Jurnal Kajian Biologi Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Literasi Kesehatan Husada: Jurnal Informasi Ilmu Kesehatan Jurnal Pendidikan Kesehatan Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan Indonesia Jurnal Kebidanan
Ida Nurwati
Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Althea Medical Journal

 1 
Effect of Cnidoscolus aconitifolius Leaf Extract in Lowering Triglyceride Levels and Body Weight of Wistar Rats with Metabolic Syndrome Sarsanti, Arifa Sherina Noor; Putranto, R. Prihandjojo Andri; Sarsono, Sarsono; Nurwati, Ida; Baihaqy, Fathu Thaariq
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3315

Abstract

Background: Cnidoscolus aconitifolius has the potential to be antidyslipidemic which has the effect of lowering triglyceride levels. This study aimed to explore the effect of Cnidoscolus aconitifolius leaf extract on triglyceride levels and body weight of Wistar rats with metabolic syndrome.Methods: This randomized controlled trial with a pre- and posttest design was conducted in 2021 at the Center for Food and Nutrition Studies, Yogyakarta, Indonesia. Male Wistar rats were subjected into metabolic syndrome state with a high-fat and high-fructose diet (HFHFD) for 21 days, then injected with Streptozotocin (STZ, 45 mg/kg) and Nicotinamide (NA, 110 mg/kg), and designated as positive control group. The intervention group was given 150 mg/kg, 300 mg/kg, and 450 mg/kg dose of leaf extract for 28 days. Triglyceride, glucose, high-density lipoprotein or HDL, and cholesterol were measured before and after intervention, using serum samples taken from the retro-orbital vein and analyzed using an enzymatic colorimetric method. The Wistar weight was measured every week. Data was analyzed by paired T-test and One-way ANOVA with Post-hoc Bonferroni and Games-Howell.Results: There was a significant decrease in triglyceride levels after the intervention (p< 0.005). Interestingly, there was also a significant increase in weight gain in all groups after the intervention (p=0.000), both were dose dependent.Conclusion: Cnidoscolus aconitifolius leaf extract is significantly lowering triglyceride levels in the Wistar rats model. In addition, weight gain has also been observed after intervention. Clinical studies are needed to further explore the potential of Cnidoscolus aconitifolius leaves as anti-dyslipidemia.
Co-Authors A. Guntur Hermawan Ambar Mudigdo Anik Lestari Asrial, An A. Baihaqy, Fathu Thaariq Betty Saptiwi Betty Saptiwi Betty Saptiwi Brian Wasita Christanto, Antonius Danus Hermawan Danus Hermawan Dicky Maulana Lazuardi Diding H P Diding Heri Prasetyo Diding Heri Prasetyo Dono Indarto Dyah Rahmawatie Ratna Budi Utami Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Dyonisa Nasirochmi Pakha Eriana Melinawati Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhilah, Azzahra Nur Fahmi, Muhammad Izzul Widad Gresmita Rindi Winarti Hadi, Cahyono Hakim, Fikar Arsyad Harioputro, Dhani Redhono Hermawan, Danus Hermawan, Danus Ika Tristanti Indri Erwhani Jarot Subandono Jarot Subandono Jarot Subandono Khoirunnisa, Rahmi Lazuardi, Dicky Maulana Mahendra, Fadia Yuda Martini Martini Martini Martini Martini Martini Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Mutmainah Mutmainah Nabila Aushaf Prasetyo Nafisa, Putri Amalina Nanang Wiyono Noni Kartika Sari Nugroho, Anung N. Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Pamungkasari, Eti P. Paramasari Dirgahayu Prihandjojo Andri Putranto Pudjiastuti, Anggit Putranto, R. Prihandjojo Andri Putranto, Wachid Rahardjo, Setyo Sri Ratnasari Ratnasari Reviono Reviono Risya Cilmiaty A. R. Risya Cilmiaty AR Risya Cilmiaty, Risya Rosyida, Rufaida Rusliana, Eka Sari, Noni Kartika Sarsanti, Arifa Sherina Noor Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Setiamika, Made Setianto, Budi Y. Sigit Setyawan Sineri, Dessy Ikasartika Siti Aisyah Siti Marufah Soetrisno Soetrisno Sri Hartati Hadinoto Sri Haryati Sri Sulistyowati Sumardiyono Sumardiyono Sumardiyono, S Sunggoro, Agus Jati Tonang Dwi Ardyanto Uki Retno Budihastuti Vitri Widyaningsih Wahyu Anjas Sari Wesliaprilius, Todung Antony Wiyono, Nanang Wuriani, Wuriani Yarso, Kristanto Y. yoseph Indrayanto Yudhani, Ratih Dewi Yulia Sari Yulyanti, Yulyanti