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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Althea Medical Journal Nexus Biomedika Nexus Kedokteran Translasional Jurnal Riset Kesehatan Majalah Obat Tradisional Smart Medical Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Kesehatan Manarang Al-sihah: The Public Health Science Journal Indonesian Journal of Medicine Journal of Maternal and Child Health YARSI Medical Journal Jurnal Review Pendidikan dan Pengajaran (JRPP) Abdimas Universal World Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Abdidas Indonesian Journal of Global Health research Nusantara Science and Technology Proceedings Narra J Journal of Multidisciplinary Applied Natural Science Ahmar Metakarya: Jurnal Pengabdian Masyarakat Proceeding ISETH (International Summit on Science, Technology, and Humanity) Biocaster : Jurnal Kajian Biologi Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Literasi Kesehatan Husada: Jurnal Informasi Ilmu Kesehatan Jurnal Pendidikan Kesehatan Media Penelitian dan Pengembangan Kesehatan Jurnal Info Kesehatan Indonesia Jurnal Kebidanan
Ida Nurwati
Fakultas Kedokteran, Universitas Sebelas Maret, Surakarta, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Nexus Biomedika

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Pengaruh Pemberian Ekstrak Daun Sukun (Artocarpus altilis F.) terhadap Penurunan Kadar Malondialdehid (MDA) pada Tikus (Rattus norvegicus) Model Diabetes Melitus Winarti, Gresmita Rindi; Nurwati, Ida; Hikmayani, Nur Hafidha
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Diabetes mellitus is a chronic metabolic disease that causes increased free radical activity in the body. Excessive free radicals contribute to diabetes complications. The free radicals will react with lipids and then they can form malondialdehyde. This free radicals can be neutralized by antioxidants. Breadfruit (Atrocarpus altilis F.) leaf contains flavonoids and phenolics which serve as antioxidants. This research aimed to determine the effect of breadfruit leaf extract on malondialdehyde levels in diabetic rats. Methods: This was an experimental research using posttest only control group design. Subjects were 30 male white rats, three months old with average body weight of 160-200 g. Subjects were randomly divided into five treatment groups: Normal group, negative control group, treatment group I, treatment group II, and treatment group III. All subjects of the groups, except normal group, were induced by 65 mg/kgBW streptozotocin (STZ) and 230 mg/kgBW nicotinamide (NA). Each subjects in normal and negative control group were administered 2 ml/kgBW/day Natrium Carboxymethyl Cellulose (Na-CMC), whereas treatment groups I, II, and III were administered breadfruit leaf extract at doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day, respectively. The treatments were done for 14 days. Malondialdehyde levels were measured from blood samples collected via retro-orbital veins. Data were analyzed using Kruskal-Wallis test followed by Mann-Whitney U tests (a=0.05). Results: Kruskal-Wallis test showed a significant difference of MDA levels among five groups (p<0.001). Statistically significant differences of MDA levels were further found in all pairs of two-group comparisons, except between the negative control group and the treatment group I (p=0.690). Conclusion: Breadfruit leaf extract could decrease malondialdehyde levels in diabetic rats induced by STZ-NA. The dose of 800 mg/kgBW/day of breadfruit leaf extract showed the greatest effect. Keywords: Breadfruit leaf extract, MDA, Diabetes mellitus 
Pengaruh Pemberian Ekstrak Daun Sukun (Artocarpus altilis F.) terhadap Penurunan Kadar Malondialdehid (MDA) pada Tikus (Rattus norvegicus) Model Diabetes Melitus Gresmita Rindi Winarti; Ida Nurwati; Nur Hafidha Hikmayani
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Diabetes mellitus is a chronic metabolic disease that causes increased free radical activity in the body. Excessive free radicals contribute to diabetes complications. The free radicals will react with lipids and then they can form malondialdehyde. This free radicals can be neutralized by antioxidants. Breadfruit (Atrocarpus altilis F.) leaf contains flavonoids and phenolics which serve as antioxidants. This research aimed to determine the effect of breadfruit leaf extract on malondialdehyde levels in diabetic rats. Methods: This was an experimental research using posttest only control group design. Subjects were 30 male white rats, three months old with average body weight of 160-200 g. Subjects were randomly divided into five treatment groups: Normal group, negative control group, treatment group I, treatment group II, and treatment group III. All subjects of the groups, except normal group, were induced by 65 mg/kgBW streptozotocin (STZ) and 230 mg/kgBW nicotinamide (NA). Each subjects in normal and negative control group were administered 2 ml/kgBW/day Natrium Carboxymethyl Cellulose (Na-CMC), whereas treatment groups I, II, and III were administered breadfruit leaf extract at doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day, respectively. The treatments were done for 14 days. Malondialdehyde levels were measured from blood samples collected via retro-orbital veins. Data were analyzed using Kruskal-Wallis test followed by Mann-Whitney U tests (a=0.05). Results: Kruskal-Wallis test showed a significant difference of MDA levels among five groups (p<0.001). Statistically significant differences of MDA levels were further found in all pairs of two-group comparisons, except between the negative control group and the treatment group I (p=0.690). Conclusion: Breadfruit leaf extract could decrease malondialdehyde levels in diabetic rats induced by STZ-NA. The dose of 800 mg/kgBW/day of breadfruit leaf extract showed the greatest effect. Keywords: Breadfruit leaf extract, MDA, Diabetes mellitus
Co-Authors A. Guntur Hermawan Ambar Mudigdo Anik Lestari Asrial, An A. Baihaqy, Fathu Thaariq Betty Saptiwi Betty Saptiwi Betty Saptiwi Brian Wasita Christanto, Antonius Danus Hermawan Danus Hermawan Dicky Maulana Lazuardi Diding H P Diding Heri Prasetyo Diding Heri Prasetyo Dono Indarto Dyah Rahmawatie Ratna Budi Utami Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Dyonisa Nasirochmi Pakha Eriana Melinawati Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhilah, Azzahra Nur Fahmi, Muhammad Izzul Widad Gresmita Rindi Winarti Hadi, Cahyono Hakim, Fikar Arsyad Harioputro, Dhani Redhono Hermawan, Danus Hermawan, Danus Ika Tristanti Indri Erwhani Jarot Subandono Jarot Subandono Jarot Subandono Khoirunnisa, Rahmi Lazuardi, Dicky Maulana Mahendra, Fadia Yuda Martini Martini Martini Martini Martini Martini Muchsin Doewes Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Mutmainah Mutmainah Nabila Aushaf Prasetyo Nafisa, Putri Amalina Nanang Wiyono Noni Kartika Sari Nugroho, Anung N. Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nutria Widya Purna Anggraini Octavia, Dhamayanti Eka Pamungkasari, Eti P. Paramasari Dirgahayu Prihandjojo Andri Putranto Pudjiastuti, Anggit Putranto, R. Prihandjojo Andri Putranto, Wachid Rahardjo, Setyo Sri Ratih Puspita Febrinasari Ratnasari Ratnasari Reviono Reviono Risya Cilmiaty A. R. Risya Cilmiaty AR Risya Cilmiaty, Risya Rosyida, Rufaida Rusliana, Eka Sari, Noni Kartika Sarsanti, Arifa Sherina Noor Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Sarsono Selfi Handayani Selfi Handayani Selfi Handayani Selfi Handayani Setiamika, Made Setianto, Budi Y. Sigit Setyawan Sineri, Dessy Ikasartika Siti Aisyah Siti Marufah Soetrisno Soetrisno Sopianti, Densi Selpia Sri Hartati Hadinoto Sri Haryati Sri Sulistyowati Sumandjar, Tatar Sumardiyono Sumardiyono Sumardiyono, S Sunggoro, Agus Jati Tonang Dwi Ardyanto Uki Retno Budihastuti Vitri Widyaningsih Wahyu Anjas Sari Wesliaprilius, Todung Antony Wiyono, Nanang Wuriani, Wuriani Yarso, Kristanto Y. yoseph Indrayanto Yudhani, Ratih Dewi Yulia Sari Yulyanti, Yulyanti