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Fahrul Rozi
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Journal : Jurnal Sains dan Kesehatan

 1 
Histopatologi Hati Mencit (Mus Musculus) yang Diberikan Minuman Ringan Berkarbonasi dan Ekstrak Daun Kersen (Muntingia Calabura L.): Liver Histopathology of Mice (Mus Musculus) Induced by Carbonated Soft Drink and Kersen Leaves Extract (Muntingia Calabura L.) Azhim Ash Siddiq, Muhammad Nuzul; Majiding, Chaidir Masyhuri; Rozi, Fahrul; Winarsih, Wiwin
Jurnal Sains dan Kesehatan Vol. 6 No. 2 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i2.1886

Abstract

High consumption of carbonated soft drinks (CSD) has caused risks of metabolic syndrome, obesity, various chronic diseases, and organ damage. Kersen has the potential to prevent and reduce damage to the liver caused by CSD. The study aimed to analyze the liver histopathological of mice given CSD and the effect of Kersen leaf extract. This experimental study used a completely randomized design with 25 male white mice divided into 5 groups, namely control grup (K), negative control (N), treatment 1, 2, and 3 with doses (35 mg/30g BW, 45 mg/30g BW, 65 mg/30g BB) for 30 days. The sample was terminated on the 31st day, and the liver organs were prepared to observe the microscopic of the liver. The analytical test used the ANOVA test with Duncan's multiple-range test. The results showed that the negative control group had significantly lower numbers of liver cell damage than the positive controls who were given CSD (p<0.05), and the treatment groups 2 and 3 also had significantly less cell damage than the positive control group and did not significantly different from the negative control group. Kersen leaf extract can prevent and reduce liver cell damage in carbonated soft drink-induced mice.   Keywords:          Liver, Histopathology, Kersen, Mice, Soft drink   Abstrak Konsumsi minuman berkarbonasi/ carbonated soft drink (CSD) yang berlebih berisiko menyebabkan terjadinya sindrom metabolik, obesitas, berbagai penyakit kronis, dan kerusakan organ. Kersen berpotensi mencegah dan mengurangi kerusakan pada hati yang disebabkan oleh CSD. Penelitian ini bertujuan untuk melihat gambaran histopatologi hati mencit yang diberikan minuman CSD dan efek pemberian ekstrak daun kersen. Penelitian experimental ini menggunakan rancangan acak lengkap dengan 25 mencit putih jantan yang dibagi 5 kelompok yaitu kelompok kontrol (K), kontrol negatif (N), perlakuan 1, 2, dan 3 dengan dosis (35 mg/30g BB, 45 mg/30g BB, 65 mg/30g BB) selama 30 hari. Sampel diterminasi pada hari ke 31 dan organ hepar dibuat preparat untuk diamati gambaran mikroskopis hati. Uji analisis menggunakan uji beda ANOVA dengan uji lanjut Duncan’s multiple-range test. Hasil pengamatan menunjukkan bahwa kelompok kontrol negatif memiliki jumlah kerusakan sel hati yang signifikan lebih rendah dibandingkan dengan kontrol positif yang diberikan CSD (p<0.05) dan kelompok perlakuan 2 dan 3 juga signifikan memiliki jumlah kerusakan sel yang lebih sedikit dibandingkan kelompok kontrol positif serta tidak berbeda signifikan dengan kelompok kontrol negatif. Ekstrak daun kersen memberikan pengaruh terhadap pencegahan dan mengurangi kerusakan sel hati pada mencit putih yang diberikan CSD.   Kata Kunci:         Hepar, Histopatologi, Kersen, Mencit, Carbonated Soft Drink
Co-Authors Abdul Azis Abubakar Ach. Shodiqil Hafil Ach. Shodiqil Hafil, Ach. Shodiqil Afrida, Galuh Aghnia Dian Lestari Ahmad Ammar Amalia Khairunnisa, Amalia Andi Tenri Kawareng Andriani, Cut Yessi Anggreini, Putri Annisa, Oktavia Nasrul Aprilia Sarwani, Audi Ar-Ruhul Jadid, Muhamad Ardoni Ardoni Ariyanti, Anik Ash Siddiq, Muhammad Nuzul Azhim Aulia, Nasywa Auliya, Jumi Az, Maidy Ramadhan Azhim Ash Siddiq, Muhammad Nuzul Azriyenni Azhari Zakri Azzahra, Fatima Badawi, Satriani Bastian Nova Busyra Azheri Busyra Azheri Camara Indriani, Dilla Chaidir Masyhuri Majiding Charlina Charlina Darmanto, Rochmad Fadjar Daulay, Maraimbang Dedi Iskandar Dermawan Jihad Djaima Irirwanas, Intania Dudung Burhanuddin Dwi Saputro, Alfonsus Fadillah, M. Surya Fauzi, Ihsan Febrina, Lizma Febriyanthy, Adhiesty Syaffila Fridawati, Titit Gata, Windu Gunawan, Khairol Hafiz, Subhan El Hafiza, Nurul Hanifah, Ismi Hasanah, Dina Herman Herman I Wayan Sudiarta Ibrahim, Arsyik Ilham Mundzir Ilman, Mhd Zidni Iltizam, Muhammad Irfansyah Baharuddin Pakki Irhami Isril " Jamil, Muh Jum’ah, Jum’ah Junaidi Junaidi Junaidin, Junaidin Kadafi, Abdul Rahman Kartika, Amalinda Kasim, Agustania Paramitha Khairun Imani, Praditya Khuzaimah, Ummi Kustiawan, Winda Laode Rijai Lestari, Anggun Lila Pratiwi Majiding, Chaidir Masyhuri Maktun, Kintan Haiatul Masyhuri Majiding, Chaidir Miftahussaadah, Elma Milasari, Sri Mochamad Khalam Khahardika Attamimi Mudjiatko Mudjiatko Muhammad Abdul Halim Sani Muhammad Fikih Alpiansyah Muhammad Nuzul Azhim Ash Siddiq Muhammad, Syafiq Mukhtar, Fathurrahman Muliadi Muliadi Mutohharun Jinan Nasution, Kasron Nisaa, Nur Rezky Khairun Nugraheni, Rizka Fitri Nurani, Iyas Ali Nuzul Azhim Ash Siddiq , Muhammad Oktaviani, Dinda Nur Olivia Siregar, Vita Pamungkas, Barolym Tri Pasaribu, Mhd Saidil Priawibawa, Ghozi Putra, Arya Yuliansyah Putri, Fitriani Sukma Rahmad, Yuli Rahmadani, Aulia Tia Rahmatin, Ina Ramadhani Ramadhan, Maidy Ramadhan, Rafsanjani Ramadhani, Maudy Ramadhoan, Ramadhoan Rania Nasywa Azzahra, Rania Rashif Rijai, Hifdzur Rezky Khairun Nisaa, Nur Ridwan, M. Arif Rijai, Hifdzur Rashif Rinaldi Rinaldi Rini Andriani Rizal, Agus Rosidi, Imron Sabriana, Ofhi Sahdin Hasibuan Saifudin Saifudin Saputra, Surya Fajar Saputra, Yudhi Fajar Sari, Mila Warma Sartika, Diza Setiafindari, Widya Siddiq, Muhammad Nuzul Azhim Ash Sinthary, Venna Siti Khumayah Sriminingsih, Orien Subhan El Hafiz, Subhan Suci Ramadayani Sugama, Fauzan Sugiatma, Iksan Suleman, Angellia Sulistyowati, Daning Nur Sunarso Sunarso Susanti, Elifah Rika Syafik Ubaidila Syamsul Arifin Tri Yanti Monika Tuafiq Tyas, Ajeng Ayuning Umami, Islina Umi Fadillah, Umi Wahyuni, Leny Eka Tyas Wardi, Epi Supri Wardika, Ruzga Wijaya, Aulia Putri Pratiwi Wirawanti, Ika Wirya Wiwin Winarsih Yosellanda Al Sabina, Della Young, Felina C.