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Journal : Narra J

Metabolomic profiling and antimicrobial investigation of Aspergillus fumigatus LBKURCC269 and Bacillus paramycoides LBKURCC218 co-culture Octarya, Zona; Nugroho, Titania T.; Nurulita, Yuana; Suraya, Nabella; Saryono, Saryono
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1647

Abstract

The increasing resistance of pathogenic microbes to antibiotics is a major public health concern, necessitating the discovery of effective antimicrobial compounds. The aim of this study was to assess the bioactive metabolites produced by Aspergillus fumigatus LBKURCC269 and Bacillus paramycoides LBKURCC218 under three fermentation conditions: monoculture of each microorganism and their co-culture. Metabolite analyses initiated with gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-high-resolution mass spectrometry (LC-HRMS) followed with molecular networking–Global Natural Products Social Molecular Networking (GNPS) and molecular docking. Antimicrobial activity of the extracts was then conducted. Metabolite analysis using GC-MS identified key antimicrobial compounds, including 2,6-bis(1,1-dimethylethyl)-4-methylphenol, pentadecanoic acid, cyclopropane pentanoic acid, and 3-piperidinol. LC-HRMS, combined with multivariate analysis and GNPS molecular networking, revealed additional antimicrobial compounds, including novel pyrazine derivatives induced in co-culture fermentation. Molecular docking analysis of 3-(propan-2-yl)-octahydropyrrolo[1,2-a]pyrazine-1,4-dione demonstrated its potential as an antimicrobial agent by inhibiting topoisomerase IV and cytochrome monooxygenase with binding affinity of -5.34 kcal/mol and -5.6 kcal/mol, respectively. The antimicrobial assays showed that the co-culture fermentation extract had the strongest activity, with inhibition zones of 20.33±0.59 mm (Escherichia coli), 14.33±0.59 mm (Staphylococcus aureus), and 25.67±0.59 mm (Candida albicans). This study highlights the advantages of co-culture fermentation in enhancing the discovery of antimicrobial compounds. The findings underscore the potential of this approach to simplify chemical isolation and accelerate the identification of novel antimicrobial agents for pharmaceutical development.
Co-Authors Adriansyah, Reksi Bimawan Ahmad Hamim Sadewa Akbariah, Ainun Alfasari Amalia, Rahma Ahsani Amir Awaluddin Anandari, Dian Anas Sumeru Andini, Sopiah Annisa, Mumtaz Ardhi, Aulia Arhamawati, Sufia Arif Imam Hidayat ARIF KURNIAWAN Arif Setyo Upoyo Arrum Firda Ayu Maqfiroch, Arrum Firda Ayu Atikah Proverawati Atikah Proverawati, Atikah Aufa, Athiatul Aulia, Dany Aulia, Putri Regina Ayuni, Sharah Budi Aji, Budi Cahyaningrum, Eka Nur Caryanto, Valerio Basuni Carlo Cipto Leksono, Cipto Danang Pujo Broto Desiyani Nani Dian Fajarwati, Dian Doni Fitri Firdaus, Doni Fitri Dyah Umiyarni Purnamasari Dyna, Fitri Edy Fachrial Eka Andriani, Eka Endiyono, Stylla Vonch Endo Dardjito Endo Dardjito Fadila Fadila, Fadila Fajarianti, Aulia faza, umi Fazria, Alisa Nur Febriani, Aan Febrina, Wetri Fitri Kurniati, Fitri Gemael, Qorry Armen hardiyanto, lutfi Hasan Hasan Henri Setiawan Heritomo, Heritomo Hikmi Muharromah Pratiwi, Hikmi Muharromah Hilwan Yuda Teruna Hopi, Zikrilla mayuli Ilhami Romus, Ilhami Indah Nuraeni Indriyani, Tutut Rizki Iriansyah, Herinto Sidik Irma, Dasih Irnawati, Amelya Irwan Irwan Ismawati ismawati Ismawati Ismawati Itnawita, Itnawita Izzuddin, Deden Akbar Jabar, Ibnu Abdul Jamilah Jamilah Jehloh, Latifah Josef M Monteiro Karsih, Okta Rizal Kartika Dewi, Gita Kholipah, Siti Ainul Kurniasari, Meli Alviana Kurniati, Pat Kurniawati, Lia Dahlia Kusuma, Muhammad Nanang Himawan kusumawardani, lita heni Laxmi Mustika Cakrawati Lohi Pani, Dintania Rambu Lovenia, Nia Made Sumarwati Maemunah, Sari Masru'ah, Iim Imas Masruah, Iim Imas Melina Melina, Melina Muharromah Pratiwi, Hikmi Mukhlis Mukhlis Muslihudin Muslihudin Mustopa, Acep Hidayatul Muszali, Rozaireen Nabila, Ananda Nawasul, Faid Nopitarose, Lia NOVA WAHYU PRATIWI, NOVA WAHYU Novita Anggraeni Nuraenah, Nuraenah Nurafriza, Widya Nurhadi, Maha Dewi Afifah Prasasi, Nabila Jihan Pudjiastuti, Sri Rahayu Putri, Khoirunnisa Rahmania Putri, Mas Fierna Janvierna Lusie Putri, Yollanda Ardhitya qohhar, wildan Retnani H. Retnani H., Retnani Rizvi, Fharisa Putri Rochadi Rochadi, Rochadi Romdanih, Romdanih Ronal Kurniawan Rubai, Windri Lesmana Rumiati, Sri Santoso D. Santoso D., Santoso Sari Astuti Sasmita, Ellen Rosyelina Septipane, Dwi shinta, dewi yudiana Shofia Amin Shorea Khaswarina Sidik Awaludin Silvera Devi Siregar, Deviana Ayushinta Sani Siti Masfiah SIWI PRAMATAMA MARS WIJAYANTI Sonata MS, Herix Sri Yanti Sridadi Sridadi Sulistiawati, Tiara suraya, nabella susi susi syahmardi yacob Syaifullah, Mhd Muslim Syamsul Arifin Titania Tjandrawati Nugroho Trianto, Endang Utami, Purwani Puji Veni Dayu Putri Vidi Ahmad Raafi Vioreza, Niken Wawan Setiawan wayan T Artama Widiati, Veronika Mutiara Wijaya, Habibi Hadi Wiryatun Lestariana, Wiryatun Yasmin, Alya Yuana Nurulita Yulyanti, Fitri Yunita Sari Yusmarini Yusmarini Zahra Setiawan, Binta Febriana Zona Octarya Zuchra Helwani, Zuchra