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Journal : Biomedika

EFFECT OF INULIN EXTRACT FROM DAHLIA TUBER (dahlia variabilis) ON CORONARY ARTERY HISTOPATHOLOGY IN RATS WITH TYPE 2 DIABETES MELLITUS (DM) Hopi, Zikrilla mayuli; Ismawati, Ismawati; Saryono, Saryono; Romus, Ilhami; Putri, Veni Dayu; Yanti, Sri; Dyna, Fitri
Biomedika Vol 17, No 2 (2025): Biomedika August 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i2.3734

Abstract

Atherosclerosis in diabetes mellitus (DM) patients is prevented by using inulin to increase glucose metabolism and reduce cholesterol synthesis. Therefore, this research aimed to analyze dahlia tuber inulin extract to determine the effect on coronary artery histopathology in type 2 DM rats. A total of 20 male Wistar rats were divided into five groups, namely negative control without treatment, DM, DM + 0.5 mg/gBW/day inulin extract, DM + 1 mg/gBW/day inulin extract, and DM + 1.5 mg/gBW/day inulin extract. Furthermore, DM induction was carried out by administering 60 mg/kgBB streptozotocin and 120 mg/kgBB nicotinamide. The results of coronary artery histopathology readings showed that the highest and lowest scores of atherosclerosis were in Groups II (0,91±0,17) and V (0,08±0,1), respectively. Data analysis using Kruskal Wallis test reported significant results (p<0.05), while Mann-Whitney test showed differences between control and DM, DM, and inulin groups (III, IV, V). In this context, the administration of dahlia tuber inulin extract to rats induced by Type 2 DM prevented atherosclerosis in histopathological image of coronary artery.
EFFECT OF DAHLIA TUBER INULIN EXTRACT ON THE THICKNESS OF THE THORACIC AORTIC TUNICA INTIMA-MEDIA IN TYPE 2 DIABETIC RATS MODEL Natswa Deanra, Cantika; Ismawati, Ismawati; Saryono, Saryono; Juananda, Desby; Anggraini, Suci; Agung S, Timotius; Dayu Putri, Veni; Yanti, Sri; Dyna, Fitri
Biomedika Vol 18, No 1 (2026): Biomedika February 2026
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Inulin is a natural polysaccharide that improves glucose metabolism and reduces cholesterol levels through the formation of short-chain fatty acids, which may contribute to preventing atherosclerosis in type 2 diabetes mellitus (T2DM). Therefore, this study aimed to evaluate the effect of dahlia tuber inulin extract on the thickness of the thoracic aortic tunica intima-media (TIM) in T2DM-induced rats. A total of 20 male Wistar rats were divided into five groups: control, T2DM, T2DM + 0.5 mg/gBW/day inulin extract, T2DM + 1.0 mg/gBW/day inulin extract, and T2DM + 1.5 mg/gBW/day inulin extract. T2DM induction was performed using 60 mg/kgBW streptozotocin and 120 mg/kgBW nicotinamide. Measurement of TIM thickness was conducted using a Leica light microscope with hematoxylin-eosin staining. The results showed no statistically significant differences among the groups (p = 0.051), although a decreasing trend in TIM thickness was observed at the 1.5 mg/gBW/day dose. In this context, dahlia tuber inulin extract demonstrated a tendency to reduce TIM thickness in T2DM-induced rats.
Co-Authors Adriansyah, Reksi Bimawan Afrizal, Stevany Agistia, Nesa Agung S, Timotius Ahmad Hamim Sadewa Amalia, Rahma Ahsani Amir Awaluddin Anandari, Dian Anas Sumeru Anggraini, Suci Annisa, Mumtaz Ardhi, Aulia Arhamawati, Sufia Arif Imam Hidayat ARIF KURNIAWAN Arif Setyo Upoyo Arrum Firda Ayu Maqfiroch, Arrum Firda Ayu Atikah Proverawati Atikah Proverawati, Atikah Aufa, Athiatul Aulia, Dany Aulia, Putri Regina Ayuni, Sharah Budi Aji, Budi Cahyaningrum, Eka Nur Caryanto, Valerio Basuni Carlo Cipto Leksono, Cipto Damayanti, Talitha Danang Pujo Broto Dayu Putri, Veni Deanra, Cantika Natswa Desby Juananda, Desby Desiyani Nani Dian Fajarwati, Dian Doni Fitri Firdaus, Doni Fitri Dyah Umiyarni Purnamasari Dyna, Fitri Edy Fachrial Eka Andriani, Eka Endiyono, Stylla Vonch Endo Dardjito Endo Dardjito Enikarmila Asni Fadila Fadila, Fadila faza, umi Febriani, Aan Febrina, Wetri Fitri Kurniati, Fitri Gemael, Qorry Armen Habeahan, Dita Bina Julianti Hendra, Rudi Henri Setiawan Heritomo, Heritomo Hikmi Muharromah Pratiwi, Hikmi Muharromah Hilwan Yuda Teruna Hopi, Zikrilla mayuli Ilhami Romus, Ilhami Indah Nuraeni Indriyani, Tutut Rizki Iriansyah, Herinto Sidik Irma, Dasih Irnawati, Amelya Irwan Irwan Ismawati Ismawati Ismawati ismawati Itnawita, Itnawita Izzuddin, Deden Akbar Jamilah Jamilah Jasril Jasril Jehloh, Latifah Joko Nurkamto Karsih, Okta Rizal Kesya, Lunari Komarudin Komarudin Kurniasari, Meli Alviana Kurniati, Pat Kusuma, Muhammad Nanang Himawan kusumawardani, lita heni Laxmi Mustika Cakrawati Lestari, Retno Puji Lovenia, Nia M Almurdani Made Sumarwati Maemunah, Sari Masru'ah, Iim Imas Masruah, Iim Imas Melina Melina, Melina Muh. Furqon Hidayatullah Muharromah Pratiwi, Hikmi Mukhlis Mukhlis Mukhyarjon Mustopa, Acep Hidayatul Musyirna Rahmah Nst Muszali, Rozaireen Nabila, Ananda Natswa Deanra, Cantika Nawasul, Faid Nopitarose, Lia NOVA WAHYU PRATIWI, NOVA WAHYU Novita Anggraeni Nuraenah, Nuraenah Nurafriza, Widya Nurhadi, Maha Dewi Afifah Prasaja, Sehat Dwi Prasasi, Nabila Jihan Pudjiastuti, Sri Rahayu Putri, Khoirunnisa Rahmania Putri, Mas Fierna Janvierna Lusie Putri, Yollanda Ardhitya qohhar, wildan Retnani H. Retnani H., Retnani Rizky Abdulah Rizvi, Fharisa Putri Rochadi Rochadi, Rochadi Ronal Kurniawan Rubai, Windri Lesmana Rumiati, Sri rusana, rusana Salsabila, Dinda Santoso D. Santoso D., Santoso Sasmita, Ellen Rosyelina Septipane, Dwi shinta, dewi yudiana Shofia Amin Shorea Khaswarina Sidik Awaludin Silvera Devi Siregar, Deviana Ayushinta Sani Siti Masfiah SIWI PRAMATAMA MARS WIJAYANTI Sonata MS, Herix Sri Yanti Sridadi Sridadi Sulistiawati, Tiara suraya, nabella susi susi syahmardi yacob Syaifullah, Mhd Muslim Syamsul Arifin Titania Tjandrawati Nugroho Trianto, Endang Utami, Purwani Puji Veni Dayu Putri Vidi Ahmad Raafi Vioreza, Niken Wawan Setiawan wayan T Artama Widiati, Veronika Mutiara Wijaya, Habibi Hadi Wiryatun Lestariana, Wiryatun Yasmin, Alya Yuana Nurulita Yunita Sari Yusmarini Yusmarini Zahra Setiawan, Binta Febriana Zona Octarya Zuchra Helwani, Zuchra