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Budhi Setiawan
Program Studi Teknik Geologi, Universitas Sriwijaya
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Synergistic Anti-Biofilm Activity of Klanceng Honey and Probiotics against Candida albicans Setiawan, Budhi; Masfufatun, Masfufatun; Tjandra, Lusiani; Ishartadiati, Kartika
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.123-127

Abstract

Candida albicans is a common cause of fungal infections, especially in hospitals. Biofilm formation by this fungus is a significant problem as it leads to increased drug resistance and complications in treatment. The biofilm's extracellular matrix protects the fungal cells, making it difficult for antifungal drugs to penetrate and clear the infection. Aim: This study investigates the potential of honey and probiotic formulations to inhibit the biofilm matrix formation in Candida albicans. Result: Klanceng honey showed the strongest inhibition of Candida albicans biofilm formation, reducing it by 89.39% (OD = 0.34 ± 0.10), compared to yogurt (29.43%, OD = 2.25 ± 0.16) and Yakult (67.95%, OD = 1.02 ± 0.25) (p < 0.05). When mixed with yogurt in a 5:1:2 ratio (honey:yogurt: water), Klanceng honey reduced biofilm formation by 84.92% (OD = 0.50 ± 0.12). Manuka and Melifera honey in the same ratio also showed strong inhibition, reducing biofilm formation by 77.84% (OD = 0.73 ± 0.08) and 90.52% (OD = 0.31 ± 0.07), respectively. This performance exceeded fluconazole’s, which achieved a 65.52% reduction (OD = 1.14 ± 0.02). For all three honey types, the 4:1:3 and 2:1:5 ratios (honey:Yakult: water) were more effective, with reductions of up to 80.96% for Melifera and 75.64% for Klanceng (p < 0.05). Conclusion: This research suggests that honey and probiotic formulations hold promise as natural alternatives in combating Candida albicans infections. The study found that the ratio of honey to probiotics in the formulations significantly influenced their effectiveness.
Co-Authors Abdurrahman Hanif Albaihaqi Abimanyu, Gilang Aldri Frinaldi Alfiati Alfuazri, M. Gilang Ama, Fuad Andayani Andayani Andayani Andili, Agshal Almachzumi Ani Rakhmawati Anton Wijaya Arief Setyawan Arieffiandhany, Riezal Asof, H. Marwan Atikah Anindyarini Atthoriq, Muhammad Hafidz Az Zahra, Salsabila Azzahra, Fade Risa Azzahra, Fadea Risa Bakri Bakri Cahyaningrum, Fitria Chaesar, Ari Suryawati Secio Chafit Ulya Charlos Togi Stevanus, Charlos Togi Dedi Rohendi Dyah Hastuti, Endang Wiwik Eddy Ibrahim Edi Riawan Edy Sutriyono Ernawati Faradila, Nanda Argi Noer Farahdila, Silvie Felicity, Felicity Firstya Evi Dianastiti Fitriani, Aula Gallant Dwi Pangestu Nugroho Akbar Gurada Capah, Ade Indra Harfiandri, Muhammad Said Harnani Harnani Harnani, Harnani Hartati, Restiana Dwi Haryanti, Rini Dwi Hastuti, Nuri Puji Hermawan, Muhammad Alfian Hibatullah, Kevin Nabil Islam, Muhammad Izzul Ismaryanto, Ismaryanto KAMIL, FADHELLATUL Kartika Ishartadiati Karyadi, Rian Khakim, Mokhamad Yusup Nur Kundharu Saddhono Kurniawan, Deviyanto Landia, Karmila Putri Lee, Jason Lusiani Tjandra Marswati, Ceria Masfufatun Masfufatun Muhammad Rohmadi Muhammad Taufik Toha Mukhlis, Muhammad Munib Ikhwatun Iman Nardi, Rajhi Febri Nugraheni Eko Wardani Oman Abdurahman Pebby Putra Juenda Pebrianto, Rosihan Permana, Lano Adhitya Pranata, Ridho Pratika Yuhyi Hernanda Putri, Atika Nabila Putri, Helen Dwi Putri, Zahrah Belinda RAHARJO, BUDIONO Rahaya, Ivana Septia Raheni Suhita Rahmatullah, Arif Ramadhani, Asri Kamila Rifki Aditya, Rifki Rio, Ferdinan Rizki, Kurnia Rahma Rizkie, Dania Rosihan, Pebrianto Sabaruddin Sabaruddin Safrihady, Safrihady Santoso, Nugroho Ponco Santoso, Nugroho Ponco Sari, Fatrina Aprilia Sarwiji Suwandi Setyaningsih, Arinda Oktariski Simanjuntak, Presli Panusunan Slamet Subiyantoro Sumarwati Suyeda, Fadhil D. Tri Indrayanti Utami, Sri Lestari Wahdini, Lisa Wahyu Wardana, Muhammad Aditya Wisnu Wicaksono, M. Dwiki Satrio Wijaya, Wildan Maulana Wulandari, Atik Sri Wulandari, Zhalsa Yogie Zulkurnia Rochmana Yuliningsih, Yuliningsih