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All Journal PHARMACON Pharmaciana: Jurnal Kefarmasian BAHASA DAN SASTRA Jurnal Farmasi Klinik Indonesia English Review: Journal of English Education Syntax Literate: Jurnal Ilmiah Indonesia Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JELL (Journal of English Language and Literature) STIBA-IEC Jakarta Silampari Bisa: Jurnal Penelitian Pendidikan Bahasa Indonesia, Daerah, dan Asing Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ JTP - Jurnal Teknologi Pendidikan Jurnal Teknik JURNAL FARMASI GALENIKA Jurnal Riset Kesehatan Poltekkes Depkes Bandung Jurnal Dinamika UMT Lingua Rima: Jurnal Pendidikan Bahasa dan Sastra Indonesia Jurnal Insan Farmasi Indonesia Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Locus Penelitian dan Pengabdian Jurnal Talenta Sipil Jurnal Pembelajaran Sastra The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Jurnal Farmasi Indonesia Edukasi Masyarakat Sehat Sejahtera (EMaSS) Guruku: Jurnal Pendidikan dan Sosial Humaniora Jurnal Sadewa: Publikasi Ilmu Pendidikan, Pembelajaran dan Ilmu Sosial Jurnal Gizi dan Dietetik Jurnal Medika Farmaka Inaba of Community Services Journal The Indonesian Journal of Computer Science Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Jurnal Teknik Sipil Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Agus Sulaeman
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Aktivitas Antidislipidemia Rebusan Daun Mangga Kultivar Manalagi (Mangifera indica L. Var. Manalagi) Sulaeman, Agus; Susilawati, Elis; Aolina, Shelin
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1046.04 KB) | DOI: 10.35617/jfionline.v14i2.104

Abstract

Abstract: Dyslipidemia is characterized by changes in lipid levels in plasma, a common indicator that is prone to the risk of cardiovascular disease. Plants that are suspected to have antidislipidemia activity, one of which is mango leaves. This study aimed to determine the effective dose in a decoction of mango manalagi leaves (Mangifera indica L. var. Manalagi) in decreasing levels of total cholesterol, triglycerides, LDL, and increasing HDL levels in high-fat feed-induced rats and propylthiouracil for 28 days. This research method was carried out preventively using 30 Wistar strain male rats which were grouped into 6 groups, namely negative control, positive control, comparison control (simvastatin 1.8mg/Kg BW), and a decoction test of manalagi mango leaves at a dose of 200, 400, 800 mg/kg BW. The parameters of the observed lipid profile are determined enzymatically using the micro lab. The results of the study on total cholesterol levels, showed the largest decreasing in the 200mg/kg BW dose group by 31.29%, in triglyceride levels the largest decreasing was found in the 400mg/kg BW dose group by 40.59%, in LDL levels the largest decreasing was found in the 200 mg/kg BW dose group by 48.03%, and in HDL levels there was the largest increasing in dose 800mg /kg BW of 97.40%. This study concludes that manalagi mango leaf decoction can be an antidyslipidemia in decreasing total cholesterol, triglyceride, and LDL levels as well as increasing HDL levels, with an effective dose of 200mg/ kg BW.
Potensi Penghambatan Enzim Αlfa-Glukosidase dan Tes Toleransi Glukosa Oral (TTGO) Ektrak Daun Dadap Serep (Erythrina subumbrans (Hassk) Merr.): Susilawati, Elis; Astuti, Ayu Dwi; Sulaeman, Agus
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 1 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.773 KB) | DOI: 10.35617/jfionline.v15i1.135

Abstract

Abstract: Spare dadap plants contain flavonoids that can potentially lower glucose levels in the blood and reduce glucose absorption in the intestine. The purpose of the study was to determine the inhibitory activity of the α-glucosidase enzyme and the effect of giving Spare Dadap Leaf Ethanol Extract (EEDDS) on blood glucose levels of male white Wistar rats and its effective dose. The research method used the in vitro method with inhibition of α-glucosidase enzyme and the in vivo method Glucose Tolerance Test (TTGO) with amylum manihot induction using 25 rats divided into 5 groups with EEDDS doses of 100, 200, and 400 mg / kg BB, then measured blood glucose levels for 120 minutes. The results of the EEDDS α-glucosidase enzyme inhibition study showed the best % inhibition value of 41.81% at 100 ppm and the lowest % inhibition value at 10 ppm, which was 13.33% with an IC50 value of 146.30 ppm, which was included in the weak category in inhibiting α-glucosidase. The results of TTGO research induced amylum manihot, EEDDS 400 mg / KgBW have a significant effect on reducing blood glucose levels in the T60 to T120 range. The conclusion in this study is that spare dadap leaf ethanol extract has potential as an antihyperglycemic both in vitro and in vivo.
TEPUNG SUSU KAMBING, TEPUNG KACANG KEDELAI, GULA SORGHUM, TEPUNG RUMPUT LAUT COKLAT SEBAGAI FORMULA ENTERAL BAGI PASIEN PENYAKIT HATI KRONIS Azhari, Swary Anistri; Sulaeman, Agus
Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Vol. 3 No. 1 (2024): JURNAL INOVASI BAHAN LOKAL DAN PEMBERDAYAAN MASYARAKAT
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jibpm.v3i1.1822

Abstract

The World Health Organization (WHO) in 2021 shows that 1% or 71 million people worldwide are infected with the hepatitis C virus (HCV). Riset Kesehatan Dasar (Riskesdas) in 2018, the highest prevalence of hepatitis was in Papua province (0.66%) and West Java Province had a prevalence of (0.4%). Malnutrition problems often arise in patients with liver disorders. The main causes of malnutrition are multifactorial, such as loss of appetite and inadequate oral intake, malabsorption and increased nutritional requirements. Intervention in the form of enteral formula can be an alternative, generally given in commercial enteral form, which is relatively expensive. Hospital Enteral Formulas are starting to be developed but the shelf life is relatively short due to the liquid ingredients. The aim of this research was to determine the effect of Etawa goat's milk flour and soybean flour formulations on organoleptic, viscosity, flowability and price. The research design was experimental and the sample for organoleptic testing was 30 somewhat trained panelists. The results of research on the organoleptic properties of the three formulas concluded that there were significant differences p (0.035) < α (0.05) in taste, p (0.006) < α (0.05) in color and no significant differences in flavor, consistency and overall as well as flowability and viscosity with p > 0.05. F1 is the best formula that the panelists like. Keywords: Enteral Formula, Chronic Liver Disease Patients, Etawa Goat Milk Flour, Soybean Flour, Brown Seaweed Flour, Sorghum Sugar
FORMULA ENTERAL “HIKEGA” BERBASIS TEPUNG KACANG HIJAU, TEPUNG KEDELAI DAN TEPUNG MANGGA SEBAGAI ALTERNATIF MAKANAN ENTERAL BAGI PASIEN DIABETES MELLITUS Royani, Ani; Sulaeman, Agus; Fitria, Mona; Hapsari , Agustina Indri
Jurnal Inovasi Bahan Lokal dan Pemberdayaan Masyarakat Vol. 3 No. 2 (2024): JURNAL INOVASI BAHAN LOKAL DAN PEMBERDAYAAN MASYARAKAT
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jibpm.v3i2.1828

Abstract

Diabetes mellitus is a non-communicable disease characterized by increased blood sugar levels due to impaired insulin action. In 2013 and 2018, there was an increased prevalence of Diabetes Mellitus in Indonesia from 6.9% to 8.5%. Enteral formulas based on mung bean flour, soybeans and mango flour can be used as an alternative enteral food for diabetes mellitus. The aim of this research is to determine the quality of enteral products based on mung bean flour, soybean flour and mango flour as an alternative for diabetes enteral food regarding organoleptic characteristics, flowability and shelf life. The design of this research was experimental and the sample for the organoleptic test was 25 panelists. The results of the organoleptic test from the two formulas concluded that there was no significant difference, p (0.561) > (0.05). The flow-rate test results for F1 were 17.16 seconds and F2 were 13.13 seconds. Test results for the shelf life of enteral powder formula are ±7 days, there is no change in color, texture and aroma.
ANALISIS TINDAK TUTUR DAN PRINSIP KERJA SAMA PADA PEMBELAJARAN DISKUSI SISWA KELAS IX SMP PGRI 400 TANGERANG Haryanti, Reni; Sulaeman, Agus; Goziyah, Goziyah
Jurnal Dinamika UMT Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31000/dinamika.v8i2.10927

Abstract

The use of utterances that contain cooperative principle maxims and speech acts, be it locutions, illocutions or perlocutions, of course, have different aims and objectives depending on the context of the utterance. In class IX student discussion activities, utterances that contain the maxim of the principle of cooperation are intended for cohesiveness or togetherness in discussion activities. So, based on this, discussion activities can run smoothly and important information discussed in the discussion will be conveyed clearly
The Value of Nationalism in the Turbulent Script of Away Enawar's Collection of Rhymes to the Torn Heart and Its Relevance to Literature Learning in High School Iqbal, Muhamad; Anggraini, Nori; Sulaeman, Agus
Jurnal Dinamika UMT Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31000/dinamika.v8i2.10924

Abstract

The value of nationalism is very important for the life of the nation and state, especially for the next generations of the nation, because this value is a manifestation of love and honor for their own nation. With that, the younger generation can do something best for their nation, maintain the integrity of national unity and unity and increase the dignity of the nation so as not to threaten and destroy the integrity of the Indonesian nation. Therefore, the application of nationalism values in the educational environment is very important to be instilled in students such as habituation to maintain the good name of the school, singing the national anthem, the use of good and correct Indonesian, and respect for the red and white flag
ANALYSIS OF ERROR WRITING ON OFFICIAL LETTER AT THE MUHAMMADIYAH TANGERANG UNIVERSITY 2023 Sayeti, Ety; Sulaeman, Agus; Goziyah, Goziyah
Jurnal Dinamika UMT Vol 8, No 2 (2023)
Publisher : Universitas Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31000/dinamika.v8i2.10925

Abstract

Based on the results and discussion that have been explained in this study, it can be seen that official letters written by writers at the University of Muhammadiyah Tangerang still have language errors, in the type of writing letters in the letters they produce. Some of these mistakes can occur due to several factors such as lack of understanding of spelling writing in accordance with Indonesian rules by official letter writers, accustomed to making the same language mistakes or have never carried out training related to official letter writing. Thus, there are still some language errors made by official letter writers at the University of Muhammadiyah Tangerang
REVIEW: PENDEKATAN TERAPI MOLEKULER PADA KANKER PAYUDARA TERHADAP PERAN EVEROLIMUS DAN TEMSIROLIMUS SEBAGAI PROTEIN KINASE INHIBITORS JALUR PI3K/AKT/MTOR Bachrudin, Panji; Sulaeman, Agus; Mulyani, Yani
Jurnal Insan Farmasi Indonesia Vol 8 No 1 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v8i1.2508

Abstract

Kanker payudara merupakan penyebab utama kematian akibat keganasan pada wanita secara global, dengan prevalensi yang terus meningkat. Jalur PI3K/AKT/mTOR memegang peran penting dalam regulasi proliferasi, metabolisme, angiogenesis, dan kelangsungan hidup sel. Aberasi genetik seperti mutasi PIK3CA dan kehilangan fungsi PTEN sering dikaitkan dengan perkembangan kanker payudara dan resistensi terapi hormonal. Review artikel ini bertujuan mengulas peran protein kinase inhibitors (PKIs), khususnya Everolimus dan Temsirolimus, yang menargetkan jalur PI3K/AKT/mTOR dalam terapi kanker payudara, mencakup mekanisme kerja, efektivitas terapeutik, dan tantangan klinis. Kajian ini merupakan tinjauan literatur sistematik terhadap publikasi ilmiah nasional dan internasional selama 2015–2025, yang membahas aspek farmakologis, molekuler, dan klinis penggunaan Everolimus dan Temsirolimus. Everolimus menunjukkan efektivitas dalam kanker payudara ER-positif resisten hormon, sering dikombinasikan dengan terapi endokrin. Temsirolimus, meskipun lebih umum digunakan untuk kanker ginjal, memiliki potensi dalam terapi kanker payudara. Tantangan mencakup resistensi, efek samping toksik, serta kurangnya biomarker prediktif. Everolimus dan Temsirolimus sebagai inhibitor mTOR menawarkan pendekatan terapi menjanjikan melalui penghambatan jalur PI3K/AKT/mTOR dalam penanganan kanker payudara.
Artikel Review: Tanaman yang Memiliki Potensi sebagai Antikanker Payudara Isybillah Ahmad, Afifah; Sulaeman, Agus; Suri Darmawan, Ammar; Yayuk Febriyanthi , Anggita; Novia Adiningsih, Arum; Malik Al Akbar, Ayatullah; Akbar Rulazi, Bagus; Larson Boling Sau, Barth; Adinda, Deistha; Eka Cahyani, Dhiana; Yunita, Dilla; Asherlia, Dwita; Ernawati, Ernawati; Hossanti Ntobu, Febri
Jurnal Medika Farmaka Vol 3 No 1 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i1.58

Abstract

Introduction: This study examines the role of pharmacotherapy in immune system diseases and cancer, highlighting the potential of natural compounds as anticancer agents. This study reviews various studies using in silico, in vitro, and in vivo approaches to activate the anticancer activity of various plant extracts and bioactive compounds. Method: This article review uses references obtained from database searches with online search instruments published nationally and internationally. Result: The results of the analysis showed that natural compounds contribute to the inhibition of cancer cell growth through apoptosis mechanisms, antioxidant activity, and reduction of inflammation. Various molecular pathways such as HER2, survivin, EGFR, Nrf2-Keap1, and PI3K/AKT/mTOR are the main targets in the development of natural compound-based therapies. The evidence collected shows that natural compounds have great potential as safer and more effective innovative cancer therapies. Conclusion: 13 plants were found to have the potential as anticancer agents in breast cancer therapy, with mechanisms of action including apoptosis induction, inhibition of cancer cell proliferation, modulation of the immune system, and regulation of molecular signaling pathways.
Analisis Perkuatan Stabilitas Struktur Dinding Penahan Tanah (Sheet Pile) Dermaga yang Tidak Sesuai Detail Engineering Design (DED) Irawan, Farid; Agus Sulaeman; Xbal Meiprasetyo
Jurnal Teknik: Media Pengembangan Ilmu dan Aplikasi Teknik Vol 24 No 1 (2025): Jurnal Teknik - Media Pengembangan Ilmu dan Aplikasi Teknik
Publisher : Fakultas Teknik - Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55893/jt.vol24no1.527

Abstract

A wharf is a key infrastructure at a port that functions as a place for ships to dock and moor while conducting the loading and unloading of cargo, as well as passenger activities. The structural integrity of the wharf, especially along the bank, must be carefully designed to ensure ships can anchor securely. In pier construction, slope reinforcement is often done using sheet piles. When designing sheet piles, important factors such as pile depth and soil type must be considered. However, in practice, challenges arise when the construction in the field does not align with the specifications outlined in the Detail Engineering Design (DED), potentially compromising the wharf’s stability. This research aims to determine whether the reinforcement already implemented meets safety standards and technical requirements to prevent structural failure. A civil engineering approach is applied by reanalyzing the stability of existing reinforcements. The method involves evaluating the strength of the pier structure using various reinforcement types, including Corrugated Concrete Sheet Pile (CCSP), Concrete Sheet Pile (CSP), and Tie Rods. These evaluations are carried out through numerical calculations and structural analysis using the Plaxis program to simulate performance and ensure the design's reliability under both normal and seismic conditions.
Co-Authors Adinda, Deistha Adzkia, Muhammad Fasya Ahmad Suherman Akbar Rulazi, Bagus Ali Sulaiman Ali Sulaiman Anne Yuliantini Aolina, Shelin Ardadinata, Raihan Arief, Mansur Ariyana Ariyana Ariyana, Ariyana Asherlia, Dwita Astuti, Ayu Dwi Aulia Nurfazri Istiqomah Aulia, Arsy Auliyaa, Millata Azhari, Swary Anistri Bachrudin, Panji Bayinah, Ai Nur Deni Iskandar Destianto, Anto Dewi, Nova Freena Dhiani, Yanni Dimas R. Pambudi Djoko Widodo Dwitantika, Bryan Eka Cahyani, Dhiana Eka Gumilang, Nurani Eka Wardatul Jannah eko putra, eko Embas Saraswati, Dewa Ayu Enawar, Enawar Ernawati Ernawati Fatmawati, Eva Fauziyah, Azkia Nurul Fauziyah, Roro Nur Garnadi Jafar, Garnadi Gatot Susilo Lawrence Ghassani, R Wulandari Goziyah Goziyah Goziyah, Goziyah gumilar, mulus Hanna Sundari Hapsari , Agustina Indri Haryanti, Reni Hasimun, Patonah Hastuti, Widi Heny Sulistyowati Herdiansah , Yudi Herdiansah, Yudi Hoon, Kim Dong Hossanti Ntobu, Febri Hun, Kim Dong Idar Ira Miranti, Ira Irawan, Farid Irman, Deni Irviansyah, Cepy Okta Isybillah Ahmad, Afifah Judiono Judiono Juli Yani Kamiri, Kamiri Larson Boling Sau, Barth Lindasari, Heni Lutfiyah, Fifih M Ramadhan Saputro Maia de Fatima Freitas, Floriana Malik Al Akbar, Ayatullah Mamat Rahmat Marita Kaniawati Marliani, Lia Maryati Dewi, Maryati Maulana, Didit Mia N. A. Fatin Mona Fitria Muhamad Agung Muhamad Iqbal mulus gumilar Mutoharoh Mutoharoh Nori Anggraini, Nori Novia Adiningsih, Arum Nurfadillah, Ilham Nurfazri Istiqomah, Aulia Nurfazri, Aulia Nurjaman, Jajang Patonah Prasasti, Tresna Dewi Purawinangun, Ira Anisa Pusparini Pusparini Putra, Hendra Mahakam Rafiansyah, Rafli Rizki Rahmat Santoso, Rahmat Rahmatullah, Muhammad Firdaus Rauda Ramdania, Diena Regi Fasya Septrian Resdiana, Rafli Aridzalrahman Reza Pratama Rizkyanto, Dheva Ferdinand Rofi’i, Agus Roni Farfian Roni Hidayat Rosmana, Dadang Rossa Rosefa Simanjuntak Royani, Ani Rum, Ira Adiyati Saleky, Yohannes Willihelm Salma Tia Salsabila Saputra, Nanda Saputro, M. Ramadhan SARI APRIYANI Sayeti, Ety Siti Supriyati Stiani, Sofi Nurmay Sumarjo, Dwi Nur Ida Islamiati Suri Darmawan, Ammar Susilawati, Elis Syaharuddin Kasim Syahrizal Syahrizal Syarifuddin Wahid Syarifuddin Wahid Tundreng, Syarifuddin Udayanto, Nugroho Sungkono Vallini, Lia Wati, Afifah Ashma Widartika Widartika Widianto, Asriadi Prihandika Winara, Zahra Winasari, Winasari Winda Dwihudhana Witri Priawantiputri Xbal Meiprasetyo Yani Mulyani Yayuk Febriyanthi , Anggita Yenny Moviana, Yenny Yermia Ademi Dedeo Yuliani, Rany Yunita, Dilla Zinan, Daula Zahra