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Yustina Yustina
Biology Education Study Program, Faculty Of Teachers Training And Education Universitas Riau, Pekanbaru, Riau
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Journal : AL KAUNIYAH

 1 
PENGARUH PEMBERIAN EKSTRAK UMBI BAWANG DAYAK (Eleutherine americana Merr.) TERHADAP PENURUNAN KOLESTEROL PADA TIKUS JANTAN PUTIH GALUR WISTAR Nurul Jannah; Yustina Yustina; Depimei Nita Mahedra; Tommy Satria Sumantri; Rizqa Alfajri Husna
Al-Kauniyah: Jurnal Biologi Vol 11, No 1 (2018): Al-Kauniyah Jurnal Biologi
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v11i1.5656

Abstract

AbstrakHiperkolesterol merupakan gangguan kadar lipid yang ditandai dengan meningkatnya kadar kolesterol di dalam tubuh. Kadar kolesterol yang tinggi menyebabkan timbulnya beberapa penyakit diantaranya penyakit jantung. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak bawang dayak (Eleutherine americana Merr.) terhadap penurunan kolesterol pada tikus jantan putih galur Wistar. Hasil penelitian menunjukkan kelompok kontrol negatif (K0) memiliki kadar kolesterol total sebesar 73,50±8,81 mg/dL darah, yang lebih tinggi daripada kelompok kontrol positif (K1), sebesar (73,25±22,70 mg/dL); dan kelompok dengan pemberian ekstrak umbi bawang dayak sebanyak 100 mg/KgBB (P1), yaitu 68,50±8,81 mg/dL, lebih tinggi daripada kelompok pemberian ekstrak umbi bawang dayak sebanyak 200 mg/KgBB, yaitu 53,25±5,61 mg/dL. Analisis variansi satu-arah pada kolesterol total menunjukkan bahwa tidak ada perbedaan signifikan di antara kelompok-kelompok perlakuan (p= 0,158). Sementara itu, pada kadar kolesterol HDL terdapat penurunan setiap kelompok dari hasil uji Kruskal Wallis (p= 0,134), dan kadar kolesterol LDL kelompok (P2) lebih rendah daripada kelompok (P1), yaitu 15±5,41 mg/dL (P1) dan 12,75±6,02 (P2), dengan p= 0,450. Disimpulkan bahwa pemberian ekstrak umbi bawang dayak dengan dosis 200mg/KgBB memiliki pengaruh dalam penurunan kadar kolesterol total dan kolesterol LDL, tapi tidak pada kolesterol HDL, terhadap tikus putih jantan galur Wistar.  Abstract Hypercholesterolemia is a disorder of lipid levels characterized by increased levels of cholesterol in the body. High cholesterol levels cause the incidence of several diseases such as coronary heart disease. This study aims to determine the effect of dayak onion (Eleutherine americana Merr.) extract in decreasing cholesterol in male Wistar white rats. The results showed that the negative control group (K0) had total cholesterol level of 73.50±8.81 mg/dL that higher than those in the positive control group (K1) which was 73.25±22.70 mg/dL of blood, and the group with the addition of dayak bulb extract of 100 mg/Kg body weight (P1) in the amount of 68.50±8.81 mg/dL was higher than the group of dayak bulb extract of 200 mg/Kg body weight which was (53.25±5.61 mg/dL). One-way analysis of varians on total cholesterol showed that there was no significant difference between the treatment groups (p= 0.158). Meanwhile, on HDL cholesterol level there was a decrease in each group from a result of Kruskal Wallis test (p= 0.134), and LDL cholesterol group (P2) was lower than group P1, i.e. 15±5.41 mg/dL (P1) and 12.75±6.02 (P2) with p= 0.450. In conclusion, the addition of dayak onion bulb extract at the dose of 200 mg/ kg has an effect in decreasing total cholesterol, LDL cholesterol, but not HDL cholesterol levels, in Wistar white rats.  Permalink/DOI: http://dx.doi.org/10.15408/kauniyah.v11i1.5656 
Co-Authors Abd. Rasyid Syamsuri Abdurrouf, Muh. Afriyani, Afriyani ani Alaniyah Syafaren Anastasia Anastasia Anggrahini, Fify Aourah, Putri Apriani, Ade Apriliana, Vina Arif Riandra Ariska, Devi Arnentis Arnentis Arnentis Arnentis, Arnentis Arpan, Susan Gracia Aulia Dwi Utami Ayulia Hermayuni Bachtiar Simatupang Br Purba, Salmiah Clara Dwiyen Rombeallo Dahnilsyah, Dahnilsyah Dahnilsyah, Dahnilsyah Damayanti, Ervina Darmadi Ahmad Darmadi Darmadi Darmawati Darmawati Darmawati Darmawati Daryani, Rena Dasni Elsa Meilianti Depimei Nita Mahedra Depimei Nita Mahedra Desi Anggraini Desi Handayani Dewi Anggi Pratiwi Dharma, Anton Budhi Dharma, Anton Budi Diana Anggraini Dini Handayani, Dini Dipuja, Diah Anugrah Djamilu, Berneta Rendiana Dyah Wiji Puspita Sari, Dyah Wiji Puspita Efrinanda Afrianti Esy Meila Kurnia Evi Suryawati Evi Suryawati Febblina Daryanes Febri Yuliani Firman Syah Fitra Suzanti Fitriya, Anisa Fraditia Wiranti Gafur, Irfan Andi Gamiarsih, Antika Gaung Bebby Pithaloka Habib, Farid Alif Harapan Tua R. F. S Hasim Asyari Hasti Kusuma hastuti, Weni Puji Hendra Taufik Husna, Rizqa Alfajri Imam Mahadi Indra Suharman Irda Sayuti Iwan Ardian, Iwan Juana Prawita Julianti, Putri Jumarti Jumarti Kushadiwijayanto, Arie Antasari Lasri Susanti Latifah Latifah Lilia Halim Lius, Indah Rahmawati Lusianti, Erita Maidin Gultom Mardatilla, Mardatilla Mariani Natalina Mariani Natalina Mariani Natalina Mas Arya, Andi Meilianti, Dasni Elsa Mitri Irianti Molandia Widi Agustin Mulyani Tri Rahayu Nelvia Nelvia Nita Nita Nurdiansyah, Syarif Irwan Nursal Nursal Nursal Nursal Nursal Nursal, Nursal Nurul Jannah Nurul Jannah Oky Priawan Oky Priawan Pangastuti, Adha Ingga Pauzi, Achmad Peni Defita Sari Pranto Wati Pratiwi, Dewi Anggi Priawan, Oky Putra, Riki Apriyandi Putri Adita Wulandari Putri Handayani Putri, Eka Meilinda R. Hussien Arief Raden Mohamad Herdian Bhakti Rahardjo, Hartono Regina, Angel Renita Ratte Riki Apriyandi Putra Rita Anugerah Rizqa Alfajri Husna Ronny Irawan Rosalina, Yarlis Rosmila Tuharea, Rosmila Safitri, Wulan Indri Saputra, Rio Rasdian Silvia Reni Yenti Sitanggang, Grety Thessalonica Situmorang, Minar Sophian, Alfi SRI WULANDARI Sri Wulandari Sri Wulandari Suci Wulandari Suhara, . Sujianto Sujianto Sukini, Sukini Suparmi Suparmi Suryadi Islami Susanti, Delpi Suwondo Suwondo suwondo suwondo Syafaren, Alaniyah Syafi’i, Wan Syamsul Arifin Syapsan Syapsan Tamara, Annisa Gusri Tommy Satria Sumantri Turrahmah, Laila Umi Salfia Umi Salfia Vanessa Patria Pinandita Vebrianto, Rian Vestinaliyou, Nanda Wahyuni, Resma Wan Syafii Wan Syafi’i Wansyafii Wansyafii Wasisto Utomo Weni Harnisa Misdana Winda Sari Winda Sari Wirayudha Sinaga, Raja Yuslim Fauziah Zulfarina , Zulfarina Zulfarina Zulfarina Zulfarina Zulfarina Zulfarina, Zulfarina