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PENGEMBANGAN FARMASIPRENEUR TABLET TAMBAH DARAH BERBAHAN DASAR FERRO SULFAT DARI SCRAP BESI BENGKEL BUBUT UNTUK SISWA SMK Soebiyanto; Nur Hidayati; Lucia Sincu Gunawan; Muhammad Dzakwan; Ilham Kuncahyo; Ana Indriyati; Nicolay Wening Audrey; Sunardi; Argoto Mahayana; Bimo Putranto; Sumardiyono; Mahardira Dewantara; Afif Afghohani
BUDIMAS : JURNAL PENGABDIAN MASYARAKAT Vol. 7 No. 3 (2025): BUDIMAS : Jurnal Pengabdian Masyarakat
Publisher : LPPM ITB AAS Indonesia Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/budimas.v7i3.18190

Abstract

The partner in this Community Service Program is the Mandala Bhakti Health Vocational School, Pharmacy Department, located at Jalan Singosari Utara II, Nusukan Village, Banjarsari District, Surakarta City. Iron deficiency is a common nutritional problem, especially among adolescents. Scrap iron waste from machine shops has the potential to be used as a source of ferrous sulfate for the manufacture of iron supplements. This activity aims to develop iron supplement tablets from ferrous sulfate synthesized from iron scrap, ensure their safety through heavy metal testing, and enhance pharmaceutical entrepreneurship knowledge (pharmaceutical entrepreneurship) among vocational high school students. A total of 20 vocational high school students were involved in training that covered ferrous sulfate synthesis, tablet formulation, and product marketing strategies. Evaluation was conducted through pre-tests and post-tests, as well as heavy metal contamination analysis (Pb, Cu, Cd). The results showed a significant increase in knowledge, with an average pre-test score of 70 and a post-test score of 100. Heavy metal analysis showed no contamination (Pb: 0 ppm, Cu: 0 ppm, Cd: 0 ppm), making the tablets safe for use. This activity proved effective in enhancing students' knowledge and skills, and demonstrated that industrial waste can be utilized to produce valuable pharmaceutical products. The program supports the development of research-based and environmentally friendly pharmaceutical entrepreneurship among the younger generation.
Optimasi Formula Emulgel SNEDDS Naringenin sebagai Sediaan Antibakteri dengan Metode D-Optimal Mixture Design Candra, Dhimas Tiya; Kuncahyo, Ilham; Rahmawati, Ismi; Sari, Putri Rovita
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.1049

Abstract

Narigenin merupakan flavonoid dengan aktivitas sebagai antimikroba, namun kenyataanya kelarutan dalam air rendah, sehingga memerlukan formulasi sediaan emulgel Self nanoemulsifying drug delivery system (SNEDDS). Tujuan penelitian ini adalah dengan menggunakan software design expert diharapkan dapat menemukam formula optimal sebagai antibakteri yang disebut emulgel naringenin SNEDDS. Penelitian ini menggunakan pendekatan D-Optimal Mixture Design untuk mengoptimalkan formula emulgel naringenin SNEDDS dengan berbagai konsentrasi Na-CMC, HPMC, dan propilen glikol dengan mempertimbangkan parameter kritis berupa daya lekat, daya sebar dan viskositas. Pengujian aktivitas antibakteri terhadap Staphylococcus aureus menggunakan metode difusi cakram selanjutnya evaluasi SNEDDS meliputi zeta potensial, ukuan partikel, dan persen transmitan dan drug load. Kombinasi emulgel naringenin SNEDDS yang paling efektif dengan Na CMC 4,2%,propilenglikol 13,2% dan HPMC 2,6%. Efektivitas antibakteri ditingkatkan oleh formulasi emulgel naringenin SNEDDS yang baru dikembangkan.
PENGARUH VARIASI KONSENTRASI AVICEL PH 101 DAN LAKTOSA SEBAGAI HOST DALAM PEMBUATAN TABLET CAMPURAN INTERAKTIF GLIMEPIRID MENGGUNAKAN METODE KEMPA LANGSUNG Nugroho, Muhammad Agung; Kuncahyo, Ilham; Harjanti, Reslely
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p80-91

Abstract

Glimepirid is an antidiabetic drug from the sulfonylurea class with low solubility, thus requiring a formulation approach to improve its bioavailability. This study aimed to examine the effect of varying concentrations of avicel pH 101 and lactose as carrier (host) materials on the physical properties and dissolution profile of glimepirid tablets prepared using the direct compression method. Three formulas were developed with avicel pH 101:lactose ratios: F1 (1:0.5), F2 (1:1), and F3 (1.5:1). Quality evaluation included tests of granule flow properties (angle of repose and flow time) and physical tablet tests (content uniformity, hardness, friability, disintegration time, and dissolution) based on the Indonesian Pharmacopoeia. ANOVA statistical analysis showed significant differences between formulas (p < 0.05). The results indicated that variations in avicel pH 101 and lactose concentrations affected the physical quality and dissolution profile of the tablets. Formula 1 had the fastest disintegration time and the highest drug release. Formula 2 demonstrated the best content uniformity, good powder flow, and stable dissolution. Formula 3 produced the hardest tablets with the lowest friability but required longer disintegration time. Formula 2 was considered the most optimal and is recommended for further development of glimepirid tablets.
Co-Authors Adam Ferdian Sigit Pratama Afif Afghohani, Afif Alfiana, Ina Ana Indrayati Ana Indriyati Anisa Devi Kharisma Wibowo Argoto Mahayana Ayuk Armadani , Valentina Bimo Putranto Candra, Dhimas Tiya Chaesti Setyo Hastuti Dewi, Fitri Jaya Santi Utami Dian Marlina Dian Puspitasari Efrilia, Erin ELISABETH APRILIA Endang Diyah Ikasari Endang Dyah Ikasari Ghani Nurfiana Fadma Sari Gunawan, Lucia Sincu Gunawan, Sahrul Hafizah, Dila Auli Hutami, Shabrina Nindya Ibnu Pratikto Ismi Rahmawati Iswandi Iswandi Kartikasari, Ayu Lifia Nur Kiki Puspitasary Kusumawati, Mulyaningtyas Ayu M Muchalal M. Andi Chandra M. Andi Chandra M. Henityo Agung As'adi Mahardira Dewantara Mahayana, Argoto Mamik Ponco Rahayu Mardiyono Mardiyono, . Mointi, Sella Septiyani Muhammad Dzakwan Muhammad Dzakwan Nicolay Wening Audrey Noval Noval Nugroho, Muhammad Agung Nur Hidayati Nur Hidayati Nuraini Harmastuti Octavia Krisma O Opstaria saptarini Prasasti, Anin Pudiastuti RSP Putri, Hana Maylinda Putri, Sukma Oktafiani Rakhmi Hidayati Reslely Harjanti Resmi, Juniar Kalpika Rini Prastiwi Rizqi Fitria Yanuar Roosma Hatmayana Rudhi Pribadi Saifullah, T.N Sari, Putri Rovita Septiawan Adi Nugroho Sesilia Putri Nandita Setyaningrum, Dewi Anggraheni setyawan, Ferdinta D Siti Aisiyah Siti Aisiyah Soebiyanto Soebiyanto, Soebiyanto Sugiyarmasto Sugiyarmasto, Sugiyarmasto Suhartinah Suhartinah, Suhartinah Sukarno Sumardiyono Sumardiyono Sumardiyono Sunardi Sunardi Sunardi Supriyadi Supriyadi Supriyadi Supriyadi Syafira Nabillah Syaiful Choiri T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman Taena, Adriani Teuku Nanda Saifullah Sulaiman Titik Sunarni Titik Sunarni TN Saifullah Sulaiman, TN Saifullah Turdiyanto, Totok Valentina Ayuk Armadani Vivin Nopiyanti Waluyo Budi Atmoko, Waluyo Budi Wijayanti, Ifa Rizki Wiwin Herdwiani Wulandari, RR Sri Yudanti, Gendis Purno Yudi Rinanto Yuliana, Sinta Zahra, Iklila