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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Biomedical Journal of Indonesia Manuju : Malahayati Nursing Journal SRIWIJAYA JOURNAL OF MEDICINE Community Development Journal: Jurnal Pengabdian Masyarakat MAHESA : Malahayati Health Student Journal Community Medicine and Education Journal KREATIF: Jurnal Pengabdian Masyarakat Nusantara Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Safari : Jurnal Pengabdian Masyarakat Indonesia Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Masyarakat Mengabdi Nusantara Jurnal Pelayanan dan Pengabdian Masyarakat Indonesia Jurnal Kesehatan Amanah Cakrawala: Jurnal Pengabdian Masyarakat Global Jurnal Keperawatan Bunda Delima Jurnal Pengabdian Masyarakat Bunda Delima Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Jurnal Pengabdian West Science Jurnal Muara Medika dan Psikologi Klinis Journal of Community Service and Society Empowerment Compromise Journal : Community Proffesional Science and Technology: Jurnal Pengabdian Masyarakat Wissen: Jurnal Ilmu Sosial dan Humaniora Prosiding Seminar Nasional COSMIC Kedokteran
Wijaya, Bryan Anna
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Journal : Biomedical Journal of Indonesia

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The Role of Diabetes Mellitus Panel on Kidney Function Decline in Elderly Population: Cross-Sectional Study Gunawan, Shirly; Kosasih, Robert; Firmansyah, Yohanes; Santoso, Alexander Halim; Wijaya, Bryan Anna; Bambang, Kresna; Pratomo, Farhan
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026 (In Press)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.293

Abstract

Introduction. Chronic kidney disease (CKD) is a major public health issue, particularly among the elderly, where metabolic disturbances accelerate renal decline. Diabetes mellitus contributes to kidney dysfunction through insulin resistance and altered glycemic control. This study investigates the relationship between diabetes-related parameters—fasting blood glucose, HbA1c, fasting insulin, HOMA-IR, and kidney function, as measured by estimated glomerular filtration rate (eGFR) in an elderly population. Methods. A cross-sectional analytic study was conducted among 82 elderly residents of Bina Bhakti Nursing Home. Venous blood samples were collected to assess fasting blood glucose, HbA1c, fasting insulin, and HOMA-IR. Kidney function was estimated using the CKD-EPI equation. Results. Age showed a significant negative correlation with eGFR (r = –0.266, p = 0.016), indicating age-related renal decline. HOMA-IR (r = 0.247, p = 0.025) and fasting insulin (r = 0.224, p = 0.043) demonstrated weak but significant positive correlations with eGFR. Conversely, fasting glucose (r = 0.055, p = 0.623) and HbA1c (r = 0.029, p = 0.795) had negligible, non-significant correlations with eGFR, suggesting limited predictive value for renal impairment. Insulin growth factor exhibited a weak, non-significant negative correlation (r = –0.104, p = 0.355). Conclusion. Age remains a key determinant of declining kidney function in the elderly. Insulin resistance markers showed mild but unexpected associations, warranting further longitudinal studies to confirm these findings and explore underlying mechanisms.
Co-Authors Aditya Pratama Alexander Halim Santoso Alexandro, Cristian Alexin, Corry Calista Alvianto, Fidelia Alwini, Muhammad Rifat Umar Amertha, Anak Agung Ngurah Putrayoga Andersan, Jonathan Aziel, Disya Gwyneth Bachri, Fiqi Afrizal Bambang, Kresna Biromo, Anastasia Ratnawati Charissa, Olivia Daniel Ruslim David Ariwibowo Destra, Edwin Dewanto, Naomi Esthernita Fauzia Dewanto, Paulus Gegana Thery Dinali, Diana Enike, Syilvia Cendy Ernawati Ernawati EVELYN EVELYN Fadil Hidayat Fajarivaldi, Kresna Bambang Fransisca I. R. Dewi Frisca Frisca Gracienne, Gracienne Gunaidi, Farell Christian Hadisono, Hadisono Harsono, Axsel Hartono, Vincent Aditya Budi Haryanto, Ines Hekmatyar, Haritsyah Hendrianto, Rafindra Raja Adi Hendrianto, Rifandra Rifqi Adi Herdiman, Julia Jaya, I Made Satya Pramana Johan Johan Johan Johan Johan, Richver Framanto Khoto, Anthon Eka Prayoga Kosasih, Robert Kristianto, Angeline Florencia Grace Kurniawan, Joshua Kurniawan, Junius Lo, Geoffrey Christian Lontoh, Susy Olivia Lucius, Steven Hizkia Lumintang, Valentino Gilbert Mahendri, Ryan Daffano Putra Mano S., Donatila Mijaata, Djoko Micni Moniaga, Catharina Sagita Nathaniel, Fernando Noer Saelan Tadjudin Olivia Charissa Peter Ian Limas Philo, Andrew Pranata, Catherine Christiana Pratama, Muhammad Kevin Dava Pratana, Catherine Christiana Pratomo, Farhan Purnomo, Yonathan Adi Putra, Muhammad Dzakwan Dwi Rafi, Muhammad Adam Abizar Ranonto, Steve Vallery Ruslim, Welly Hartono S., Donatila Mano Saerah, Stefanus Handy Santoso, Alexander Halim Sari Mariyati Dewi Nataprawira Satyo, Yovian Timothy Setiady, Brandon Alexander Setiawan, Fiona Valencia Shirly Gunawan Sidarta, Erick Sim, Alfred Sutrisno Singh, Arwinder Soebrata, Linginda Soni, Yulfitra Suros, Angel Sharon Syarifah, Andini Ghina Tambunan, Nicholas Albert Tan, Sukmawati Tansil Tantoso, Lydia Triyana Sari W., Linda Julianti Waltoni, Bobby Marshel Ancheloti Warsito, Jonathan Hadi Wijaya, Dean Ascha Wijaya, Inge Friska Yohanes Firmansyah Yunita, Fenny