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ANALISIS POLIFARMASI SERTA HUBUNGAN POTENSI INTERAKSI OBAT TERHADAP GLUKOSA PASIEN GERIATRI Dewi, Hasna; Agustiansyah, Lukidita; Dian Andini
Journal of Pharmacy Tiara Bunda Vol. 5 No. 2 (2025): Journal of Pharmacy Tiara Bunda (JPTB)
Publisher : Politeknik Tiara Bunda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62619/jptb.v5i2.255

Abstract

Diabetes mellitus is achronic metabolic disease that requires long-term treatment. Elderly people with multimorbidity often use multiple medications, known as polypharmacy, which can increase the risk of drug interactions. This study aims to analyze polypharmacy prescriptions and determine the relationship between drug interactions and blood glucose levels in geriatric patients with type2 diabetes. This study is non-experimental with a descriptive-analytical design through a retrospective cross-sectional approach. Sampling used random sampling in the form of medical records of171 geriatric patients with type 2 diabetes. Using univariate and bivariate analysis in the form of chi-square statistical tests with a significance level of<0.05. The results showed that the incidence of type 2 diabetes in geriatric women was higher than in men at119 (69.59%), with the largest distribution of geriatric patients in the 60-69 year age range (77.77%). Based on polypharmacy prescriptions, the most common type of polypharmacy encountered was minor polypharmacy (5-9 drugs)(95.3%), and 159 patients (92.98%) had the potential for interactions. Based on the mechanism pattern, pharmacodynamic interactions occurred in413 cases (74.95%), with the most common level of interaction severity being moderate, occurring in340 cases (61.7%). Chi-square test results showed a relationship between potential drug interactions and blood glucose levels, with p-value of 0.000<0.005.
EFEK PEMBERIAN BIJI PINANG MUDA (ARECA CATECHU L.) TERHADAP GAMBARAN HISTOPATOLOGIS LIMPA TIKUS PUTIH (RATTUS NORVEGICUS) DEWASA GALUR SPRAGUE DAWLEY Adrian, Adek; Rahman, Ave Olivia; Herlambang, Herlambang; Dewi, Hasna
Scientific Of Environmental Health and Diseases Vol. 1 No. 1 (2021): Scientific of Envitonmental Health And Diseases
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.114 KB) | DOI: 10.22437/esehad.v1i1.10764

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ABSTRACT Background: Areca’s seed is an herbal beverage that are widely consumed as a betel nut. Areca’s seed contains arecoline. High doses of arecoline can damage many organ include spleen. There has been no further histopathological research of the effects with lower doses of betel nut on spleen. Methods: Ten rats Sprague Dawley strain white rats, aged 2-3 months, with 150-200 of grams were divided into 2 groups, namely the control group given aquades and the treatment group given areca nut dose of 50mg/kgBB for 28 days by feeding tube. Histopathologi’s indicators with hematoxilin eosin staining were analyzed by light microscope with 40X for diameter white pulp, 100X for congestion, and 400X for hematopoiesis extrmedullery and necrosis. The assessment for hematopoiesis extramedullery and necrosis used 5 high power-field, congestion used 3 high power field, and changes of diameter whites pulp used 10 high power-field. The data were analyzed by T-Independent statistical test. Results: Average congestion and hematopoiesis extramedullery of treatment group greater than control with p value <0,05. Average necrosis and changes of diameter white pulp of treatment group greater than control group, but there is no significant difference statistically (p value >0,05). Conclusion: Areca’ seed doses 50 mg/KgWB that given for 28 days showed congestion and extra medullary hematopoiesis on rat’s spleen tissue. Keywords: Areca catechu L., Betel nut, Toxicity, Spleen, lien, Inflammation, hematopoiesis extramedullery. ABSTRAK Latar Belakang: Pinang muda (Areca catechu L) merupakan tumbuhan herbal yang banyak dikonsumsi sebagai campuran sirih. Pinang mengandung arecoline. Arecoline dosis tinggi dapat menyebabkan kerusakan organ termasuk limpa. Belum ada pengamatan histologis tentang efek pinang dosis rendah pada limpa. Metode: Sepuluh ekor tikus galur Sprague dawley, usia 2-3 bulan dengan berat 150-200 gram dibagi menjadi 2 kelompok, yaitu kelompok kontrol yang diberikan akuades dan kelompok perlakuan yang diberikan biji pinang dosis 50mg/kgBB selama 28 hari menggunakan sonde. Pengecatan dengan Hematoxylin Eosin. Pengamatan dilakukan dengan mikroskop cahaya perbesaran 40X (diameter pulpa), 100X (kongesti), dan 400X (nekrosis dan hematopoiesis ekstramedular). Indikator hematopoiesis ekstramedular dan nekrosis dibaca dalam 5 lapangan pandang, kongesti 3 lapangan pandang, dan perubahan diameter pulpa alba 10 lapangan pandang. Data dianalisis dengan uji statistik T-Independent. Hasil: Rerata kongesti dan hematopoiesis ekstramedular kelompok perlakuan lebih besar dibandingkan kelompok kontrol, denan nilai p<0,05. Rerata nekrosis jaringan dan perubahan diameter pulpa alba kelompok perlakuan lebih besar dibanding kelompok kontrol, namun tidak terdapat perbedaan yang bermakna secara statistik (p>0,05). Kesimpulan: Biji pinang muda dosis 50 mg/KgBB diberikan selama 28 hari dapat menimbulkan kongesti dan hematopoiesis ekstramedular pada jaringan limpa tikus. Kata Kunci: Areca catechu L., Pinang, Toksisitas, Limpa, Lien, Inflamasi, Hematopoesis ekstramedular
The The Correlation of Neutrophil-to-Lymphocyte Ratio with LupusQoL in Systemic Lupus Erythematosus Patients Mahrunnisa Rienti Sepestian; Lipinwati; Dewi, Hasna; Hanina; Nyimas Natasha Ayu Shafira
Journal of Medical Studies Vol. 5 No. 2 (2025): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v5i2.40840

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Background: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations depending on disease activity. Clinical manifestations, disease activity, and side effects of treatment can affect quality of life. The LupusQoL questionnaire assesses the disease's impact on eight quality of life domains. The Neutrophil-to-Lymphocyte Ratio (NLR) is an inflammatory biomarker that correlates with SLE disease activity. Objective: This research aims to determine the correlation between NLR and various domains of the LupusQoL questionnaire in SLE patients. Methods: This observational analytic study used purposive sampling, involving 32 SLE patients treated at Raden Mattaher Hospital, Jambi, in 2024. NLR was obtained from blood counts performed within the last 4 weeks, and HRQOL was measured using the LupusQoL questionnaire. Data were analyzed using Pearson correlation. Result: The mean NLR was 6.50 (1.3–29.43). LupusQoL showed the lowest score in fatigue (58.85). Pearson analysis revealed a moderate inverse correlation between NLR and the planning domain of LupusQoL (p= 0,022). NLR shows no statistically significant correlation with physical health, pain, intimacy, burden to others, emotional health, body image, or fatigue in SLE patients, as p-values >0.05. Conclusion: Higher NLR is correlated with lower planning domain HRQoL in SLE patients and vice versa.
Ethanolic Extract of Curcuma zedoaria Enhances Burn Wound Healing in Male White Rats Yuliawati, Yuliawati; Kasmadi, Fathnur Sani; Elisma, Elisma; Dewi, Hasna; Afryandes, Amelya; Puteri, Vanya Gita
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501488

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In addition to its widespread use as a culinary spice, white turmeric rhizome (Curcuma zedoaria (Christm.) Roscoe) exhibits important pharmacological activities, including anti-inflammatory, anticancer, and antioxidant effects. The rhizome contains secondary metabolites such as flavonoids, alkaloids, saponins, phenols, tannins, and terpenoids, which are believed to contribute to its potential efficacy in treating burns. This study used a fully randomized post-test-only control group design consisting of five treatment groups: P1 (5% ethanol extract of white turmeric rhizome), P2 (10%), P3 (15%), K⁺ (positive control: Bioplacenton), and K⁻ (negative control: Vaseline flavum). Parameters observed included reduction in burn wound diameter and collagen density, which were assessed through histological analysis. The results showed significant differences between treatment groups (p < 0.05). The 10% concentration showed the highest wound healing activity, reaching a healing rate of 54.72% and producing denser collagen compared to the other treatments. However, its effect did not exceed the positive control (Bioplacenton). The 5% concentration showed moderate healing activity (43.84%) with intermediate collagen density, while the 15% concentration produced the lowest effect. Overall, the findings indicate that the ethanol extract of white turmeric rhizome, particularly at a concentration of 10%, enhances burn wound healing and increases collagen formation, supporting its potential as a natural therapeutic agent for the treatment of burns.
Efektivitas Video Pembelajaran Anatomi terhadap Pemahaman Mahasiswa Kedokteran Mursalin, Adhywira; Enis, Rina N.; Dewi, Hasna; Miftahurrahmah, Miftahurrahmah; Kusdiyah, Erny; Ramadhan, Ghozi F.
Medical Scope Journal Vol. 8 No. 1 (2026): Medical Scope Journal
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/msj.v8i1.59564

Abstract

Abstract: Understanding human anatomy, including the digestive system, is fundamental for medical students. Educational videos are increasingly recognized as an effective teaching tool to enhance student comprehension and improve their performance in practical examinations. This study aimed to evaluate the effectiveness of using educational videos on the knowledge and performance of medical students at Universitas Jambi through the practical exam scores. This was a quasi-experimental study with a pre-test and post-test design. There were 123 medical students from the 2024 cohort chosen through purposive sampling. The students were divided into two groups: experimental and control groups. The experimental group was given a video on the anatomy of the digestive system as an instructional tool, while the control group received standard teaching. Data were collected from both groups' pre-test and post-test scores. Data were analyzed using the paired and independent t-tests, which compared the scores within and between the groups to identify any significant differences. The average pre-test and post-test scores were 28.85 and 54.75 for the control group, while of the experimental group were 29.91 and 62.74, respectively. The pre-test scores showed no significant difference (p=0.071), but the post-test scores demonstrated a significant improvement in the experimental group (p=0.032). In conclusion, the educational video of anatomy of the digestive system significantly improved student knowledge and performance at Universitas Jambi. Keywords: anatomy practicum; educational video; medical students   Abstrak: Pemahaman tentang anatomi, termasuk sistem pencernaan, merupakan fondasi yang esensial bagi mahasiswa kedokteran. Video edukasi semakin diakui sebagai media ajar yang efektif untuk meningkatkan pemahaman mahasiswa dan menunjang kinerja mereka dalam ujian praktikum. Penelitian ini bertujuan untuk menilai efektivitas penggunaan media ajar terhadap pemahaman dan kinerja mahasiswa melalui nilai ujian praktikum mahasiswa kedokteran di Universitas Jambi. Jenis penelitian ialah kuasi-eksperimental dengan pre-test dan post-test design. Sebanyak 123 mahasiswa kedokteran dari angkatan 2024 di Universitas Jambi dipilih melalui teknik purposive sampling. Subjek penelitian dibagi menjadi dua kelompok: kelompok eksperimen dan kelompok kontrol. Kelompok eksperimen diberikan video tentang anatomi sistem digestif sebagai alat bantu pembelajaran, sementara kelompok kontrol menerima pembelajaran standar. Data dikumpulkan dari skor pre-test dan post-test kedua kelompok. Efektivitas video dievaluasi dengan analisis uji t berpasangan dan uji t independen untuk membandingkan skor di dalam satu kelompok dan antar kelompok. Hasil penelitian menunjukkan skor re rata pre-test dan post-test kelompok kontrol ialah 28,85 dan 54,75, sedangkan skor kelompok eksperimen ialah 29,91 dan 62,74. Secara statistik, skor pre-test tidak menunjukkan perbedaan bermakna (p=0,071), tetapi skor post-test menunjukkan peningkatan bermakna pada kelompok eksperimen (p=0,032). Simpulan penelitian ini ialah video edukasi mengenai anatomi sistem digestif secara bermakna mampu meningkatkan kinerja mahasiswa di Universitas Jambi. Kata kunci: praktikum anatomi; video ajar; mahasiswa kedokteran
Penanganan tahap pra-analitik sampel histopatologi dan sitologi di Provinsi Jambi Fairuz, Fairuz; Dewi, Hasna; Nurhusna; Rts Netisa Martawinarti; Kintan Resqitha Ekaputri
Jurnal Pengabdian Harapan Ibu (JPHI) Vol. 8 No. 1 (2026): Jurnal Pengabdian Harapan Ibu (JPHI)
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/jphi.v8i1.1141

Abstract

Pemeriksaan sampel jaringan dan cairan di laboratrorum patologi anatomi merupakan pemeriksaan gold standard dalam penegakan diagnosis. Semua hasil operasi ataupun cairan oleh dokter klinisi berupa organ atau jaringan tubuh serta cairan harus dikirim ke laboratorium Patologi Anatomi Tahap pra-analitik merupakan tanggung jawab dokter klinisi yang mengirimkan spesimen. Spesimen jaringan operasi maupun sitologi pada prosedurnya atas mandat dokter klinisi disiapkan oleh perawat kamar operasi atau perawat asisten dokter bedah atau klinisi atau bidan yang menerima sampel sitologi, sehingga perlu dilakukan informasi yang benar dan sesuai untuk mereka dan dilakukan pelatihan penanganan sampel ini agar pengolahan sampel dapat dilakukan dengan baik di laboratorium patologi anatomi. Perawat yang bernaung dibawah organisasi Masyarakat PPNI dan Bidan dibawah organisiasi IBI Provinsi Jambi. Kegiatan ini dilaksanakan untuk meingkatkan pemahaman tenaga kesheatan dalam pengelolaan sampel dan jaringan pada tahap pra-analitik. Metode yang dilaksanakan berupa pelatihan langsung pada sampel jairngan dan cairan serta dilakukan evaluasi dengan menilai pre tes da post tes setelah kegiatan dilakukan. Pada hasil penilaian kegiatan didaptkan peningkatan yang bermakna untuk pemahaman dan pengetahuan peserta kegiatan dengan melihat kenaikan nilai pre test dan post test. Kesimpulan kegiatan ini adalah terdapat peningkatan pemahaman dan pengetahuan peserta pelatihan tentang pengelolaan sampel jaringan dan cairan pada tahap pa-analitik.
Development Strategies for Micro, Small, and Medium Enterprises (MSMEs) in Kampung Singkep Rafiansyah; Abidin, Zaenal; Dewi, Hasna; Rahmatina A. K
Zabags International Journal of Economy Vol. 4 No. 1 (2026): Economic Studies
Publisher : CV. Zabags Qu Publish

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61233/zijec.v4i1.124

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The growing competition between modern and traditional retail sectors has exerted significant pressure on the sustainability of micro, small, and medium enterprises (MSMEs), particularly those operating in staple goods within rural areas. This study aims to identify and understand the development strategies employed by MSME actors in Kampung Singkep Subdistrict to confront the dominance of minimarkets and the challenges they face in increasing profitability. Employing a qualitative approach with a phenomenological strategy, data were collected through in-depth interviews, field observations, and visual documentation, and were analyzed thematically using triangulation techniques. The findings reveal that MSME actors adopt strategies based on service differentiation, community-based distribution, traditional promotion, and the utilization of social capital as adaptive responses to local market dynamics. Key challenges include limited access to capital, low technological literacy, and insufficient institutional support. The study contributes theoretically by integrating a phenomenological approach with competitive advantage theory, product/market growth strategies, and resource-based perspectives, while offering practical insights for designing contextual and community-based MSME development strategies. The implications highlight the need for participatory policy interventions and managerial capacity building to address the complexities of digital economic transformation and intensifying market competition.
Co-Authors A Syamsi Ade Irma Suryani Adrian, Adek Afryandes, Amelya Agustiansyah, Lukidita Ahmad Hidayat Ahmad Syauqy Al Hadad, Ahmad Masyuri Ambarsari, Niati Anati Purwakanthi, Anati Anggelia Puspasari Arjmand, Reza ATTIYA ISTARINI Ave Olivia Rahman Daud Daud, Daud Dian Andini Ekaputri, Tia Wida Elisma Elisma Enis, Rina N. Erny Kusdiyah Erwina Kartika Devi Esa Indah Ayu, Esa Indah Fairuz Quzwain Fairuz, Fairuz Fauzan, Randy Febrianto, Heri Fitriyanti Fitriyanti Hanina Hanina, Hanina Hanina, Hanina Hashim, Emilda Hendra Kasmi Herlambang Herlambang Hidayat, Wildan Nur Humaryanto, Humaryanto Humaryanto, Humaryanto Husman, Lipinwati Irawan Anasta Putra, Irawan Anasta Iskandar, Mirna Marhami Ismiyanti, Anissa Juniati, Rianita Justitia, Budi Kadarsih , Sri Kartika Devi, Erwina Kemal, Amir Kintan Resqitha Ekaputri Kurniawan Kurniawan Kurniawan Lestari, Nur Afni Lipinwati ., Lipinwati Lola’ Tulak Rerung M. Arif Musthofa Mahrunnisa Rienti Sepestian Maslaini Masyanto Miftahurrahma Miftahurrahma, Miftahurrahma Miftahurrahmah Miftahurrahmah, Miftahurrahmah Miranda, Melly Muharramah, Delvia Mun'amah, Anatun Nisa Munamah , Anatun Nisa Munip, Al Mursalin, Adhywira Musthofa , M Arif Nisak, Sayida Khoiratun Nur Afni Lestari Nurhusna Nuriyah Nuriyah Nuriyah, Nuriyah Nurjali Nurul Safitri Nyimas Natasha Ayu Shafira Oktaviani, Milla Periadi, Ardiansyah Pitri, Alisyah Puji astuti, Fuji Lestari Puteri, Vanya Gita Putri Sari Wulandari Putri, Hesti Amelia Quzwain, Fairuz Chatib Quzwain, Suhair Rafiansyah Rahayu, Della Putri Rahmatina A. K Ramadhan, Ghozi F. Rina Nofri Enis Rini Kartika Riska Marvelia Romadiani, Inaya RTS Netisa Martawinarti Sani K, Fathnur Sapriandi Saputra, Ahmad Edi Sari, Rahayu Mustika Saryanti, Saryanti Siregar, Mara Imam Taufiq Siti Fatimah Sukiawati, Indah Sunarti, Zeni Teuku Mahmud Tia Wida Ekaputri Utami, Erisca Utami, Erisca Ayu Wargo Wargo, Wargo Wati, Besse Mirna Wendi Rachman Wulandari, Triyana Wulansari, Nadia Yatima, Khusnul Yuliawati Zaenal Abidin Zikri, Khairul Zulfi