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All Journal International Journal of Evaluation and Research in Education (IJERE) Jurnal Periodic Jurusan Kimia UNP Geoplanning : Journal of Geomatics and Planning Jurnal Riset Kimia JOIV : International Journal on Informatics Visualization Jurnal Penelitian Pendidikan IPA (JPPIPA) Orbital: Jurnal Pendidikan Kimia Indonesian Journal of Chemistry Jurnal Serambi Engineering JURNAL PENDIDIKAN TAMBUSAI Eksakta : Berkala Ilmiah Bidang MIPA Pelita Eksakta PAKAR Pendidikan Suluah Bendang: Jurnal Ilmiah Pengabdian Kepada Masyarakat Edukimia Entalpi Pendidikan Kimia Narra J BIOCHEPHY: Journal of Science Education Automotive Experiences Jurnal Pijar MIPA Journal of Community Service Makara Journal of Science Edu Research : Jurnal Penelitian Pendidikan MASALIQ: Jurnal Pendidikan dan Sains Entalpi Pendidikan Kimia Jurnal Kimia dan Rekayasa Ranah Research : Journal of Multidisciplinary Research and Development Chimica Didactica Acta : Journal of Chemistry and Chemistry Education Biosaintifika: Journal of Biology & Biology Education Jurnal Pendidikan MIPA Prosiding Seminar Nasional Ilmu Sosial dan Teknologi (SNISTEK) Jurnal Pendidikan Kimia, Fisika dan Biologi Genbinesia Journal of Biology
Rahadian Zainul
Department Of Chemistry, Faculty Of Mathematics And Natural Science (FMIPA), Universitas Negeri Padang, Padang, Indonesia
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Journal : Narra J

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Application of CRISPR-Cas9 genome editing technology in various fields: A review Ansori, Arif NM.; Antonius, Yulanda; Susilo, Raden JK.; Hayaza, Suhaila; Kharisma, Viol D.; Parikesit, Arli A.; Zainul, Rahadian; Jakhmola, Vikash; Saklani, Taru; Rebezov, Maksim; Ullah, Md. Emdad; Maksimiuk, Nikolai; Derkho, Marina; Burkov, Pavel
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.184

Abstract

CRISPR-Cas9 has emerged as a revolutionary tool that enables precise and efficient modifications of the genetic material. This review provides a comprehensive overview of CRISPR-Cas9 technology and its applications in genome editing. We begin by describing the fundamental principles of CRISPR-Cas9 technology, explaining how the system utilizes a single guide RNA (sgRNA) to direct the Cas9 nuclease to specific DNA sequences in the genome, resulting in targeted double-stranded breaks. In this review, we provide in-depth explorations of CRISPR-Cas9 technology and its applications in agriculture, medicine, environmental sciences, fisheries, nanotechnology, bioinformatics, and biotechnology. We also highlight its potential, ongoing research, and the ethical considerations and controversies surrounding its use. This review might contribute to the understanding of CRISPR-Cas9 technology and its implications in various fields, paving the way for future developments and responsible applications of this transformative technology.
Detection of Pseudomonas aeruginosa pus wound isolate using a polymerase chain reaction targeting 16S rRNA and gyrB genes: A case from Indonesia Jamaluddin, Indra P.; Musa, Susan H.; Ethica, Stalis N.; Ansori, Arif NM.; Yosephi, Valensa; Atmaja, Peter Y.; Murtadlo, Ahmad AA.; Sahadewa, Sukma; Durry, Fara D.; Rebezov, Maksim; Derkho, Marina; Naw, Sin W.; Zainul, Rahadian; Rachmawati, Kadek
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.774

Abstract

Infectious wounds on the skin surface are easily colonized by bacteria from pyogenic group that manifest as inflammation, such as Pseudomonas aeruginosa. P. aeruginosa is a Gram-negative bacterium and an opportunistic pathogen known for causing invasive state in critically ill and immunocompromised patients. The aim of this study was to detect the 16S rRNA and gyrB genes in P. aeruginosa using polymerase chain reaction (PCR) method. The sample in this study was pus isolate from a 5-year-old boy with leg wounds. The bacteria were isolated on brain heart infusion broth (BHIB) media and identified with molecular identification. Sequencing and BLAST analysis were carried out to determine the similarity of gene identity by comparing sample sequence with other isolate sequences on the Gene Bank. The results of molecular identification showed amplification DNA band of around 934 base pairs (bp) for 16S rRNA and 225 bp for gyrB gene. The BLAST program demonstrated that the sample had 99.89% similarity with P. aeruginosa strain XC4 (accession code ON795960.1) for the 16S rRNA gene. Meanwhile, the gyrB gene exhibited 99.10% similarity with the P. aeruginosa strain PSA-1.2 (accession code KP172300.1).
Molecular interaction analysis of ferulic acid (4-hydroxy-3-methoxycinnamic acid) as main bioactive compound from palm oil waste against MCF-7 receptors: An in silico study Herdiansyah, Mochammad A.; Rizaldy, Rafli; Alifiansyah, Mochamad RT.; Fetty, Amelia JT.; Anggraini, Dhea; Agustina, Niken; Alfian, Fariz R.; Setianingsih, Primanita NM.; Elfianah, Verah; Aulia, Halimatus S.; Putra, Justitia ERP.; Ansori, Arif NM.; Kharisma, Viol D.; Jakhmola, Vikash; Purnobasuki, Hery; Pratiwi, Intan A.; Rebezov, Maksim; Shmeleva, Svetlana; Bonkalo, Tatyana; Kovalchuk, Dmitriy F.; Zainul, Rahadian
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.775

Abstract

Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is a phytochemical compound that is commonly found in conjugated forms within mono-, di-, polysaccharides and other organic compounds in cell walls of grain, fruits, and vegetables. This compound is highly abundant in the palm oil waste. The aim of the study was to predict the anticancer activity of ferulic acid against the breast cancer cell lines (MCF-7) receptors through a computational analysis. MCF-7 receptors with PDB IDs of 1R5K, 2IOG, 4IV2, 4IW6, 5DUE, 5T92, and 5U2B were selected based on the SMILE similarity of the native ligand. Thereafter, the protein was prepared on Chimera 1.16 and docked with ferulic acid on Autodock Vina 1.2.5. The ligand-protein complex interaction was validated by computing the root mean square fluctuation (RMSF) and radius of gyration (Rg) through molecular dynamic simulation. In addition, an absorption, distribution, metabolism, excretion, and toxicity (ADMET) prediction was performed on ferulic acid using the pkCSM platform. The molecular docking revealed that the ferulic acid could interact with all receptors as indicated by the affinity energy <-5 kcal/mol. The compound had the most optimum interaction with receptor 2IOG (affinity energy=-6.96 kcal/mol), involving hydrophobic interaction (n=12) and polar hydrogen interaction (n=4). The molecular dynamic simulation revealed that the complex had an RMSF of 1.713 Å with a fluctuation of Rg value around 1.000 Å. The ADMET properties of ferulic acid suggested that the compound is an ideal drug candidate. In conclusion, this study suggested that ferulic acid, which can be isolated from palm oil waste, has the potential to interact with MCF-7 receptors.
Co-Authors -, Bahrizal Adi Sofyan Ansori, Muhammad Admin Alif Afria Yolanda Agil Aditya Dinata Agustina, Niken Ahmad Fauzi Ahmad Maulana Ardi Ahmed, Shafique Aini, Syamsi Alfian, Fariz R. Ali Amran Alif, Admin Alifiansyah, Mochamad Radika Tory Alifiansyah, Mochamad RT. Alizar Alyaa Farrah Dibha Amalia Putri Lubis Amanda, Adittya Amaq Fadholly Ananda Putra Andini, Namira Tri Andre Juliano, Muhammad Andrean, Maifil Dwi Andromeda Andromeda Andromeda Anggraini, Dhea Anggriani Sirait, Nova Anjali, Ghoury Kharisma Anni Faridah Ansori, Arif NM. Antonius, Yulanda Arif Nur Muhammad Ansori Ariusni Ariusni Ariusni Elida Arli Aditya Parikesit Artha, Dwirani Puspa Asnil Asnil Asral, Suci Sukma Taruna Atmaja, Peter Y. Aulia, Halimatus S. B, Syamsul Amar Baharudin, Muhammad Daswar A. Bahrizal - Bambang Sudarmanta Bonkalo, Tatyana Budhi Oktavia Budhi Oktavia Burkov, Pavel Butarbutar, Suryani Cika Dania Marca Deandra Savira Delsya Helvira Suci Derkho, Marina Deski Beri Desy Kurniawati Desy Kurniawati Devi Purnamasari Dhea Kharisma, Viol Dian, Farida Aryani Dinda Sahara Dings, Tim Godefridus Antonius Dony Novaliendry Dony Novaliendry Dori Yuvenda Durain Parmanoan Durry, Fara D. Dwi Finna Syolendra Edi Nasra Efran Ustia Rahmad Elfianah, Verah elida elida Elkhool, Tarek A. Ellizar ellizar Elvina Elvina Erdiwansyah Erdiwansyah Erwandri, Rianovriani Ethica, Stalis N. Ezi Anggraini Fadila Gusman Fajriah Azra Fauzan Yan Hawari Feriani, Feby Festiyed Fetty, Amelia JT. Fetty, Amelia Julia Tria Firmansyah Khairul Kamal Firmansyah, Muhammad Reffi Fitrah Mey Harmi Siregar Fitrah Mey Harmi Siregar Fitri, Ernarisa Fredy Kurniawan Goh, Khang Wen Guntur Bagus Pamungkas Hardeli Hardeli Hardeli Hary Sanjaya Hayaza, Suhaila Herdiansyah, Mochammad A. Herdiansyah, Mochammad Aqilah Hermansyah Aziz Hery Purnobasuki Hidayati, Shil Hidayatul Husna ike sabaria Ike Yusrianti Illyas Md. Isa Indah Permata Sari Indah Permata Sari Indang Dewata Irda Yunita Isa, Illyas Md Istiqamah, Siti Sarah Jakhmola, Vikash Jakmola, Vikash Jamaluddin, Indra P. Jamaludin Jamaludin Kadek Rachmawati Karlinda Karlinda Karlinda Karlinda Khairun Nisa Khairunnisa Khairunnisa Khalid, Ahmad Khudzairi Kharisma, Viol D. Kharisma, Viol Dhea Kolesnik, Evgeniy Kovalchuk, Dmitriy F. Krismadinata Krismadinata Lubis, Amalia Putri Lufri Lufri Ma'firah, Marla Maahury, Mirella Fonda Maiti Faddila Maksim Rebezov Maksimiuk, Nikolai Mardi Mardi Maria Kiseleva Marla Ma&#039;firah Muhammad Andre Juliano Muhammad Haris Effendi Hasibuan Muhammad Hermawan Widyananda Muhammad Nizar Muhammad Rizki Muhammad Rusdi Muhardi, - Muji Setiyo Mulia, Melindra Murtadlo, Ahmad AA. Murtadlo, Ahmad Affan Ali Musa, Susan H. Nadezhda Kenijz Nafika Nurullita Naw, Sin W. Nizar, Umar Kalmar Novela, Riana Novera Elsi Mudia Oki Muraza Oktarina, Cindy Parikesit, Arli A. Pera Meilita Pernadi, Niza Lian Pratiwi, Intan A. Priyono, Qiara Amelia Putri Putra, Abrar Suryadi Putra, Ananda Putra, Justitia ERP. Putra, Randi Purnama Putri Fatimah Putri, Intan Anika Qonitah Fardiyah Radeni Sukma Indra Dewi Rahma yulis lubis Rahma Zila Rahmatika Putri, Sinta Rahmi, Maulidia Arsyta Ramli Ramli Rasyadan Taufiq Probojati Ratna Sari Raudhatul Hanifa Rayandra Asyhar Rebezov, Maksim Regina Tutik Padmaningrum Remon Lapisa Revi Gina Gunawan Riga Riga Oktry Silpa Rijas, Livia Putrima Riko Romas Prayuda Rilla Gina Gunawan Risky Setiawan Risty, Chika Mei Rizaldy, Rafli Rohadatul Nadya Maurani Roza Herlina Saklani, Taru Salsabila Tri Rahmi Sari Mustika Sari, Putri Manda Sari, Yollit Permata Scherbakov, Pavel Sepiashvili, Ekaterina Seprianto Setianingsih, Primanita NM. Shmeleva, Svetlana Siltiwi Mandar Sinta Rahmatika Sinta Rahmatika Putri Skunda Diliarosta Sofia Sri Rizki Putri Primandari Sri Ulfa Sentosa Sri Wahyu Wardani Sri Wahyuningsih Sri Whayu Wardani Suci Sukma Taruna Asral Sukma Sahadewa, Sukma Sunarto Sunarto Sunarto Sunarto Susilo, Raden JK. Suyanta Suyanta Svetlana Artyukhova Syafiqoh, Iffat Syaifuddin Yana Syamsi Aini Syifa Rahma Ayunda Syukri Syukri - Syukri Arief Tacharina, Martia Rani Tafonao, Leni Anggraeni Tamara, Anindya Putri Teguh Hari Sucipto, Teguh Hari Tri Haryati Trihanto Setiadi Trisna Kumala Sari Turista, Dora Dayu Rahma Ullah, Md. Emdad Umar Kalmar Nizar Urmatul Uska Akbar Veneliza, Adila Vika Erlina Vikash Jakhmola Viol Dhea Kharisma Visca Alisia Arianti Visca Alisia Arianti Yanni, Fitri Yeni, Isra Yohandri Yosephi, Valensa Yulia Matrosova Yulia Mona Liza Yuni Aulia Putri Djasli Yusniasari, Putri Antika