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Journal : Makara Journal of Science

Molecular Simulation of B-Cell Epitope Mapping from Nipah Virus Attachment Protein to Construct Peptide-Based Vaccine Candidate: A Reverse Vaccinology Approach Kharisma, Viol Dhea; Dian, Farida Aryani; Burkov, Pavel; Scherbakov, Pavel; Derkho, Marina; Sepiashvili, Ekaterina; Sucipto, Teguh Hari; Parikesit, Arli Aditya; Murtadlo, Ahmad Affan Ali; Jakhmola, Vikash; Zainul, Rahadian
Makara Journal of Science Vol. 27, No. 2
Publisher : UI Scholars Hub

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Abstract

There are no specific drugs or vaccines for Nipah virus (NiV), which is a new Paramyxovirus that infects swine and humans. This study was conducted to investigate B-cell epitope mapping of the NiV attachment glycoprotein and to construct peptide-based vaccine candidates using the reverse vaccinology approach. To generate the linear B-cell epitope, the NiV isolates were extractad from GenBank, NCBI, using the IEDB web server; peptide modeling was conducted using PEP-FOLD3; docking was conducted using PatchDock and FireDock; and in silico cloning was designed using SnapGene. Various peptides were successfully identified from the NiV attachment glycoprotein based on B-cell epitope prediction, allergenicity prediction, similarity prediction, and toxicity prediction. An in silico cloning design of the pET plasmic was also developed. The peptide “RFENTTSDKGKIPSKVIKSYYGTMDIKKINEGLLD” (1G peptide) is predicted to be a potential candidate for the NiV vaccine as it has several good vaccine characteristics. It increases the immune response of B cells through activation, differentiation into plasma cells, the formation of memory cells, and it may increase IgM/IgG antibody titres for viral neutralization. However, the results of this study should be further verified through in vivo and in vitro analyses
Co-Authors -, Bahrizal Adi Sofyan Ansori, Muhammad Admin Alif Afria Yolanda Agil Aditya Dinata Agustina, Niken Ahmad Fauzi Ahmad Maulana Ardi Ahmed, Shafique Aini, Syamsi Alfian, Fariz R. Ali Amran Alif, Admin Alifiansyah, Mochamad Radika Tory Alifiansyah, Mochamad RT. Alizar Alyaa Farrah Dibha Amalia Putri Lubis Amanda, Adittya Amaq Fadholly Ananda Putra Andini, Namira Tri Andre Juliano, Muhammad Andrean, Maifil Dwi Andromeda Andromeda Andromeda Anggraini, Dhea Anggriani Sirait, Nova Anjali, Ghoury Kharisma Anni Faridah Ansori, Arif NM. Antonius, Yulanda Arif Nur Muhammad Ansori Ariusni Ariusni Ariusni Elida Arli Aditya Parikesit Artha, Dwirani Puspa Asnil Asnil Asral, Suci Sukma Taruna Atmaja, Peter Y. Aulia, Halimatus S. B, Syamsul Amar Baharudin, Muhammad Daswar A. Bahrizal - Bambang Sudarmanta Bonkalo, Tatyana Budhi Oktavia Budhi Oktavia Burkov, Pavel Butarbutar, Suryani Cika Dania Marca Deandra Savira Delsya Helvira Suci Derkho, Marina Deski Beri Desy Kurniawati Desy Kurniawati Devi Purnamasari Dhea Kharisma, Viol Dian, Farida Aryani Dinda Sahara Dings, Tim Godefridus Antonius Dony Novaliendry Dony Novaliendry Dori Yuvenda Durain Parmanoan Durry, Fara D. Dwi Finna Syolendra Edi Nasra Efran Ustia Rahmad Elfianah, Verah elida elida Elkhool, Tarek A. Ellizar ellizar Elvina Elvina Erdiwansyah Erdiwansyah Erwandri, Rianovriani Ethica, Stalis N. Ezi Anggraini Fadila Gusman Fajriah Azra Fauzan Yan Hawari Feriani, Feby Festiyed Fetty, Amelia JT. Fetty, Amelia Julia Tria Firmansyah Khairul Kamal Firmansyah, Muhammad Reffi Fitrah Mey Harmi Siregar Fitrah Mey Harmi Siregar Fitri, Ernarisa Fredy Kurniawan Goh, Khang Wen Guntur Bagus Pamungkas Hardeli Hardeli Hardeli Hary Sanjaya Hayaza, Suhaila Herdiansyah, Mochammad A. Herdiansyah, Mochammad Aqilah Hermansyah Aziz Hery Purnobasuki Hidayati, Shil Hidayatul Husna ike sabaria Ike Yusrianti Illyas Md. Isa Indah Permata Sari Indah Permata Sari Indang Dewata Irda Yunita Isa, Illyas Md Istiqamah, Siti Sarah Jakhmola, Vikash Jakmola, Vikash Jamaluddin, Indra P. Jamaludin Jamaludin Kadek Rachmawati Karlinda Karlinda Karlinda Karlinda Khairun Nisa Khairunnisa Khairunnisa Khalid, Ahmad Khudzairi Kharisma, Viol D. Kharisma, Viol Dhea Kolesnik, Evgeniy Kovalchuk, Dmitriy F. Krismadinata Krismadinata Lubis, Amalia Putri Lufri Lufri Ma'firah, Marla Maahury, Mirella Fonda Maiti Faddila Maksim Rebezov Maksimiuk, Nikolai Mardi Mardi Maria Kiseleva Marla Ma'firah Meksim Rebezov Muhammad Andre Juliano Muhammad Haris Effendi Hasibuan Muhammad Hermawan Widyananda Muhammad Nizar Muhammad Rizki Muhammad Rusdi Muhardi, - Muji Setiyo Mulia, Melindra Murtadlo, Ahmad AA. Murtadlo, Ahmad Affan Ali Musa, Susan H. Nadezhda Kenijz Nafika Nurullita Naw, Sin W. Nizar, Umar Kalmar Novela, Riana Novera Elsi Mudia Oki Muraza Oktarina, Cindy Parikesit, Arli A. Pera Meilita Pernadi, Niza Lian Pratiwi, Intan A. Priyono, Qiara Amelia Putri Putra, Abrar Suryadi Putra, Ananda Putra, Justitia ERP. Putra, Randi Purnama Putri Fatimah Putri, Intan Anika Qonitah Fardiyah Radeni Sukma Indra Dewi Rahma yulis lubis Rahma Zila Rahmatika Putri, Sinta Rahmi, Maulidia Arsyta Ramli Ramli Rasyadan Taufiq Probojati Ratna Sari Raudhatul Hanifa Rayandra Asyhar Rebezov, Maksim Regina Tutik Padmaningrum Remon Lapisa Revi Gina Gunawan Riga Riga Oktry Silpa Rijas, Livia Putrima Riko Romas Prayuda Rilla Gina Gunawan Risky Setiawan Risty, Chika Mei Rizaldy, Rafli Rohadatul Nadya Maurani Roza Herlina Saklani, Taru Salsabila Tri Rahmi Sari Mustika Sari, Putri Manda Sari, Yollit Permata Scherbakov, Pavel Sepiashvili, Ekaterina Seprianto Setianingsih, Primanita NM. Shmeleva, Svetlana Siltiwi Mandar Sinta Rahmatika Sinta Rahmatika Putri Skunda Diliarosta Sofia Sri Rizki Putri Primandari Sri Ulfa Sentosa Sri Wahyu Wardani Sri Wahyuningsih Sri Whayu Wardani Suci Sukma Taruna Asral Sukma Sahadewa, Sukma Sunarto Sunarto Sunarto Sunarto Susilo, Raden JK. Suyanta Suyanta Svetlana Artyukhova Syafiqoh, Iffat Syaifuddin Yana Syamsi Aini Syifa Rahma Ayunda Syukri Syukri - Syukri Arief Tacharina, Martia Rani Tafonao, Leni Anggraeni Tamara, Anindya Putri Tarek Elkhooly Teguh Hari Sucipto, Teguh Hari Tri Haryati Trihanto Setiadi Trisna Kumala Sari Turista, Dora Dayu Rahma Ullah, Md. Emdad Umar Kalmar Nizar Urmatul Uska Akbar Veneliza, Adila Vika Erlina Vikash Jakhmola Vikash Jakhmola Viol Dhea Kharisma Visca Alisia Arianti Visca Alisia Arianti Yanni, Fitri Yeni, Isra Yohandri Yosephi, Valensa Yulia Matrosova Yulia Mona Liza Yuni Aulia Putri Djasli Yusniasari, Putri Antika