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All Journal Jurnal Anestesi Perioperatif Media Ilmu Keolahragaan Indonesia JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Biologi Tropis Journals of Ners Community Oto Rhino Laryngologica Indonesiana Jurnal Respirasi (JR) Jurnal Keperawatan Priority SCRIPTA SCORE Scientific Medical Journal JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH JOURNAL LA MEDIHEALTICO KESANS : International Journal of Health and Science Jurnal Neuroanestesi Indonesia Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Narra X
Harahap, Juliandi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Comparison between Local Infiltration Combination of 1% 200 mg Lidocaine and 10 mg Dexametason with 0.75% 150 mg Ropivacaine on Degree of Pain in Post-Caesarian Operative Wounds Simamora, Veronica; Bangun, Chrismas Gideon; Hamdi, Tasrif; Harahap, Juliandi
Jurnal Anestesi Perioperatif Vol 13, No 3 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v13n3.3673

Abstract

Introduction: Local anesthetic wound infiltration reduces postoperative pain, promotes early mobilization, and shortens hospital stay after cesarean section. Lidocaine is widely used, and the addition of dexamethasone may prolong its analgesic effect. Ropivacaine provides longer-lasting analgesia but is more expensive and less accessible in many hospitals. This study aimed to compare the analgesic effects of local wound infiltration using 0.75% ropivacaine 150 mg versus 1% lidocaine 200 mg combined with 10 mg dexamethasone on postoperative pain following cesarean section.Methods: This randomized, double-masked, controlled clinical trial involved 38 patients undergoing cesarean section under spinal anesthesia. Participants were randomly allocated using a computer-generated sequence to receive wound infiltration with either 1% lidocaine (200 mg) plus dexamethasone (10 mg) or 0.75% ropivacaine (150 mg). Patients and outcome assessors were blinded to group allocation. Postoperative pain intensity was assessed using the Numeric Rating Scale (NRS) at rest and during passive movement at 2, 6, 12, and 24 hours after surgery.Results: The ropivacaine group had significantly lower NRS scores at rest and during passive movement at 2, 6, and 12 hours postoperatively compared with the lidocaine–dexamethasone group (p < 0.05). At 24 hours after surgery, no significant difference in pain intensity was observed between groups (p>0.05).Conclusion: Local wound infiltration with 0.75% ropivacaine 150 mg provided superior analgesia during the first 12 hours after cesarean section compared with lidocaine combined with dexamethasone. The lidocaine–dexamethasone combination remains a practical alternative where ropivacaine is unavailable.
Relationship between TIM-3 Immune Response Expression and Nasopharyngeal Carcinoma Histopathology Harahap, Vina Andita; Farhat, Farhat; Nursiah, Siti; Yudhistira, Ashri; Sitompul, Ramlan; Harahap, Juliandi
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i1.11659

Abstract

Nasopharyngeal carcinoma is a malignancy of the nasopharyngeal epithelium that is often diagnosed at an advanced stage and is associated with impaired immune regulation in the tumor microenvironment. T-cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint molecule that plays a role in suppressing the antitumor immune response. This study aims to analyze the relationship between TIM-3 immune response expression and the histopathological type of nasopharyngeal carcinoma. An analytical study with a cross-sectional design was conducted on 40 paraffin blocks of nasopharyngeal carcinoma patients at H. Adam Malik General Hospital, Medan, selected by consecutive sampling. TIM-3 expression was analyzed using real-time polymerase chain reaction (RT-PCR) with the calculation of ΔCT values against the control gene β-actin. Univariate analysis was used to describe the characteristics of the subjects, while bivariate analysis used the Kruskal–Wallis test to assess the relationship between TIM-3 expression and histopathological type. The majority of subjects were male (65%) with a mean age of 48.2 ± 11.1 years. The most common histopathological type was non-keratinizing squamous cell carcinoma (90%). The mean TIM-3 expression was 4.3 ± 1.6 with a median of 4.8 (−0.1–6.7), and 97.5% of samples showed increased expression. The Kruskal–Wallis test showed no significant correlation between TIM-3 expression and histopathological type (p = 0.452). It was concluded that TIM-3 expression is generally increased in nasopharyngeal carcinoma, but is not significantly associated with histopathological type. Further research is needed to evaluate the biological role and therapeutic potential of TIM-3 in this disease.
Co-Authors Afriadi Afriadi Alharbi, Olayan Alia, Dina Alona, Ivana Alviani, Aisyah Alvionita, Vinny Amirah, Asriwati Aprianti Lubis, Nenni Dwi Asriwati, Asriwati Aznan Lelo Bangun, Chrismas Gideon Begum Suroyo, Razia Beni Satria Chairani Chairani Damayanti, Heditya Destanul Aulia, Destanul Dewi, Ika C. Dimyati, Yazid Dwi Aprianti Lubis, Nenni Effendy, Ismail ELMAN BOY Erawati, Susina Farhat, Farhat Fitriani, Arifah Devi Fujiati, Isti Ilmiati Hamdi, Tasrif Hanidi, Hanidi Harahap, Vina Andita Haryuna, Tengku Siti Hajar Hendri Wijaya, Hendri Hidayatul Fitria Irina, Rr Sinta Jamaluddin Jamaluddin Jenny Bashiruddin Kathy, Kathy Keumala Sari, Dina Khairun Nisa Lita Sri Andayani Lubis, Andriamuri Primaputra Lubis, Mahrani Lubis, Masnelly Lubis, Nenni Dwi Aprianti Mayangsari, Ika Dewi Mayasari, Dyah Fitrah Miadi, Yesindi Nakita Mukhtar, Fatima AS. Mustika Sari, Yulin Nasution, Ramadhani Syafitri Nursiah, Siti Olga R. Siregar, Olga R. Priyono, Harim Putri Chairani Eyanoer, Putri Chairani Putri, Monica Dwi Qalbi, Kamila Harisah Ranakusuma, Respati Rina Amelia Rini Savitri Daulay, Rini Savitri Rohana Sofyana, Cut Samodra, Yoseph Leonardo Samosir, Fauzan Azmi Hasti Habibi Santi Syafril, Santi Sembiring, Rosita Juwita Silitonga, Nency Respina Simamora, Veronica Sinaga, Bintang Yinke Magdalena Siregar, Jelita Siswahyudianto Sitompul, Ramlan Soetjipto, Damayanti Sosmira, Eri Sri Sumartiningsih Suistaya, Novi A. Supartono, Natasha SUROYO, RAZIA BEGUM Syaputra, Adhika Tako, Frida Welhelmina Tamin, Susyana Tanjung, Sri Maryani Tarigan, Amira Permatasari Theo, Deli Umar Zein Umar Zein Wahyuni, Arlinda Sari Warto, Nirza Widayat Alviandi Wijaya, Vincent Yetty Machrina Yuansyah, Romi Yudhistira, Ashri yulia, Luh Anggreni Yunanda, Yuki Yusni Yusni Zachreini, Indra Zebua, Markus Sastra Eli Zizlavsky, Semiramis