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Review Artikel Pengembangan Penyalutan Tablet Terhadap Kualitas dan Mekanisme Obat: Review Artikel Pengembangan Penyalutan Tablet Terhadap Kualitas dan Mekanisme Obat Pratama, Reza; Rodinah, Ina; Bokotei, Martini; willis, Hawa; Oktapiani, Selvia; Hostati, Febri; Pahlevi, Muhammad Reza
Jurnal Medika Farmaka Vol 2 No 2 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i2.24

Abstract

Introduction: Tablets are the most popular dosage form to be given to patients, with most of the tablets produced having a thin layer of film coating. Method: used in studying the development of tablets with coating is Systematic Literature Review (SLR). Result: There are various methods to reduce product failure and development costs. Real-time assessment of coating quality is essential, especially in automated production. Therefore, the implementation of PAT is the latest trend for more effective monitoring and control of pharmaceutical unit operations. In addition to PAT, computational modeling is also actively used to aid in understanding, prediction, and problem-solving in film coating operations. Conclusion. Based on the journal review, it can be concluded that coating can be done for various purposes, ranging from improving the physical properties of tablets to improving the stability of tablets in the tablet manufacturing process. Keywords: tablet coating, tablet development, coating development, tablet coating development.
Review : Pengembangan Sediaan Padat Dengan Penghantaran Sistem Target Pratama, Reza; Febryanthi, Anggita Yayuk; Sau, Barth Larson Boling; Cahyani, Dhiana Eka; Soares, Fidelia Gabriela Da Costa; Pahlevi, Muhammad Reza
Jurnal Medika Farmaka Vol 2 No 2 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i2.25

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Pendahuluan : Pengembangan sediaan padat dengan sistem penghantaran target merupakan salah satu inovasi dalam bidang farmasi yang bertujuan untuk meningkatkan efikasi dan keamanan obat. Sistem penghantaran target memungkinkan obat untuk secara selektif mencapai situs aksi tertentu dalam tubuh, sehingga mengurangi efek samping dan meningkatkan konsentrasi obat pada area yang diinginkan. Sistem ini mengintegrasikan teknologi formulasi terkini dan bahan pembantu untuk merancang sediaan obat yang mampu melepaskan bahan aktif secara terkontrol dan terarah. Dalam kajian ini, berbagai metode penghantaran target dieksplorasi, termasuk penggunaan nanopartikel dan liposom yang dapat mengenali reseptor pada sel target. Metode : Studi literatur menggunakan jurnal nasional dan jurnal internasional. Hasil : Penelitian menunjukkan bahwa sistem penghantaran target dapat secara signifikan meningkatkan bioavailabilitas obat, mengurangi efek samping, dan meningkatkan kepatuhan pasien terhadap regimen pengobatan. Kesimpulan : Sistem penghantaran target sediaan padat berpotensi untuk meningkatkan efektivitas dan keamanan terapi obat. Sistem penghantaran tablet dapat memungkinkan obat secara selektif. mencapai dan bekerja bekerja pada lokasi tertentu dalam tubuh, yang secara signifikan dapat mengurangi efek samping, dan meningkatkan konsentrasi obat pada area target seperti pada lambung, ginjal dan usus.
Uji Aktivitas Antioksidan Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) Yang Diformulasikan Kedalam Sediaan Masker Gel Zaelani, Diki; Pratama, Reza; Japar Sodik, Jajang; Hilda Restu, Afria
JURNAL FARMASI GALENIKA Vol 11 No 1 (2024): Jurnal Farmasi Galenika Vol 11 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i1.330

Abstract

This study utilizes the Phaleria macrocarpa fruit (Phaleria macrocarpa (Scheff.) as an active ingredient in gel mask formulation due to its widespread use as a medicinal plant and its antioxidant properties that can inhibit free radicals. The research began with the collection of the fruit from the experimental garden in Lembang-Bandung, identified as Phaleria macrocarpa (Scheff.) Boerl. Extraction was conducted using the maceration method with 96% ethanol for 3x24 hours. Phytochemical screening results indicated the presence of alkaloids, flavonoids, tannins, triterpenoids, and steroids. Antioxidant activity of the gel masks was tested using the DPPH immersion method, resulting in IC50 values of 60.18 ppm, 57.18 ppm, and 54.82 ppm for three different formulations. The pure extract had an IC50 of 45.11 ppm. The gel masks remained stable despite changes in pH and viscosity, with formulation 2 being the most preferred according to the hedonic test. In conclusion, the Phaleria macrocarpa gel mask exhibits effective antioxidant activity and good stability.
Perancangan Sistem Informasi Manajemen Berbasis Web Untuk Peningkatan Kepuasan Pelanggan Unit Pelaksana Teknis Daerah Industri Pangan Olahan Dan Kemasan Menggunakan Metode Waterfall Pratama, Reza; Dwi Anggana, Hilman; Andrawina, Luciana
eProceedings of Engineering Vol. 10 No. 5 (2023): Oktober 2023
Publisher : eProceedings of Engineering

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstrak- Unit Pelaksana Teknis Daerah Industri Pangan, Olahan, dan Kemasan adalah dinas teknis daerah yang melaksanakan kegiatan operasional penting di bidang pengembangan industri pengolahan dan pengemasan pangan. Tugas UPTD ini adalah melakukan operasi di lapangan yang berkaitan dengan produksi hasil hutan dan pengemasan, dan mengatur kegiatan operasional teknis tentang pengembangan berbagai hasil hutan. Selain keterlambatan, ada masalah lain yang muncul. Miss informasi terkait identitas pelanggan dan banyaknya keluhan juga menjadi masalah yang berulang. Penilaian berbasis kertas dan Covid-19 hal ini menyebabkan kesulitan dalam mengumpulkan data kepuasan pelanggan dan kemungkinan hilangnya data asli karena pelanggan yang mengisi secara manual tidak dapat memberikan tanggapan kepuasan layanan. Dalam perancangan Tugas Akhir ini, penulis menggunakan metode waterfall sebagai metode pembuatan proses sistem evaluasi kepuasan pelanggan, selain itu perancangan ini juga menggunakan metode pengujian sistem yaitu black box dan user acceptance testing. Hasil tugas akhir ini adalah sistem penilaian kepuasan pelanggan berbasis website yang menginformasikan dan memfasilitasi evaluasi hasil kinerja unit layanan yang tersedia yang dipantau langsung. Melalui kajian ini, penilaian kualitas layanan dapat dilihat dari perbandingan triwulanan aspek-aspek yang diidentifikasi oleh kepala dinas UPTD IPOK, karena kepala uptd dapat mengamati langsung penilaian pelanggan terhadap unit layanan penyedia layanan dari aspek yang diidentifikasi saat pelaksanaan layanan. Kata kunci — UPTD Industri Pangan Olahan dan Kemasan, Waterfall
Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Pratama, Reza; Simamora, Boy Ignatius; Oktriyani, Anissa Nadya
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Optimasi Formula Granul Effervescent Ekstrak Rimpang Temu Putih (Curcuma zedoaria) dengan Variasi Pemanis Alami sebagai Antioksidan: Optimization and Antioxidant Evaluation of Effervescent Granules Containing White Turmeric (Curcuma zedoaria) Rhizome Extract with Natural Sweeteners Zaelani, Diki; Awaliyah, Ratu Siti Robiatul; Santoso, Rahmat; Emawati, Emma; Pratama, Reza
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13193

Abstract

White turmeric (Curcuma zedoaria), a member of the Zingiberaceae family, contains bioactive compounds with antioxidant potential, but its utilization remains limited due to its bitter taste and less practical traditional preparations. This study aimed to optimize the formulation of effervescent granules containing white turmeric rhizome extract using different natural sweeteners and to evaluate their physical properties and antioxidant activity. The effervescent granules were prepared by the wet granulation method using stevia (F1, 17.5%), palm sugar (F2, 10%), and corn sugar (F3, 14.5%) as sweeteners. The granules were evaluated for physical characteristics (organoleptic properties, moisture content, flow rate, angle of repose, dissolution time, pH, foam height, and hedonic test) and antioxidant activity using the DPPH method both qualitatively and quantitatively. The results showed that all formulas met the standard physical requirements of effervescent granules. The best formulation was obtained from F3 (corn sugar) with the highest acceptance score in the hedonic test. The antioxidant activity of white turmeric extract exhibited an IC₅₀ value of 53.53 ppm, while the effervescent granules showed strong antioxidant activity with IC₅₀ values of 62.53 ppm (F1), 62.62 ppm (F2), and 62.79 ppm (F3). These findings indicate that variations in natural sweeteners influence the sensory characteristics without significantly reducing the antioxidant potency of the formulation. Keywords: Effervescent granules; Curcuma zedoaria; Natural sweeteners; Antioxidant, Formulation optimization.
Determinasi Profitabilitas Pada Industri Pertanian: Tinjauan Atas Pengaruh Biaya Operasional dan Debt To Assets Ratio Nurjanah, Dara Siti; Munawar, Andri Helmi; Hadiani, Dian; Melanie, Arin; Pratama, Reza
BanKu: Jurnal Perbankan dan Keuangan Vol 6, No 1 (2025): Volume 6, Nomor 1, Februari 2025
Publisher : Program Studi Perbankan dan Keuangan Fakultas Ekonomi Universitas Siliwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37058/banku.v6i1.16191

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This study aims to answer whether operating costs, proxied by the operating expense ratio (BOPO), and the Debt to Assets Ratio (DAR) affect the profitability of agricultural sector companies, as measured by Return on Assets (ROA), both partially and simultaneously. The research employs a quantitative descriptive–verificative approach using secondary data from the annual financial statements of eight agricultural firms listed on the Indonesia Stock Exchange (IDX) for the period 2020–2022, yielding 24 firm-year observations. Samples were selected through purposive sampling. Data were analyzed using multiple linear regression with SPSS version 25, preceded by classical assumption tests including normality, linearity, multicollinearity, heteroscedasticity, and autocorrelation. The empirical results show that BOPO and DAR jointly have a significant effect on ROA, whereas individually neither BOPO nor DAR exhibits a statistically significant effect at the 5% level. The coefficient of determination (R²) of 27.2% indicates that the combination of BOPO and DAR explains only a portion of the variation in profitability, while the remaining variation is driven by other factors outside the model. These findings imply that, in the agricultural industry, cost efficiency and capital structure remain relevant, but they are not sufficient as standalone bases for managerial or investment decisions without considering additional internal and external determinants.Keywords: operating costs, Debt to Assets Ratio, Return On Asset.
Formulasi, Evaluasi, dan Stabilitas Sediaan Sirup Paracetamol: Formulasi, Evaluasi, dan Stabilitas Sediaan Sirup Paracetamol Sasaqi, Adzkia Pratami; Nggiring, Maria Imaculata Sherly; Apriyanti, Nita; Permata Sari, Aulia; Nurholisa, Neng Dera Siti; Saputro, Ramadhan; Pratama, Reza
Jurnal Medika Farmaka Vol 3 No 3 (2025): Vol 3 No 3 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i3.86

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Introduction: Paracetamol syrup is a commonly used oral liquid dosage form, especially for pediatric patients. Its physical and chemical stability is strongly influenced by formulation and storage conditions. This review aims to analyze the formulation, quality evaluation, and stability of paracetamol syrup based on several studies. Literature searches were conducted through Google Scholar, PubMed, and ResearchGate using keywords such as “paracetamol syrup stability,” “accelerated stability test,” and “formulation of paracetamol syrup.” Paracetamol syrup generally contains 125 mg/5 mL of the active ingredient, with propylene glycol and glycerin as cosolvents to enhance solubility and stability. Sweeteners such as sucrose or honey improve taste and maintain viscosity, while flavors increase acceptability for pediatric use. Evaluation results show that most formulations met physicochemical requirements, with pH values between 4.5–5.5, viscosity ranging from 1800–2200 cP, and paracetamol content above 90% of the initial amount. In both accelerated (40°C/75% RH) and long-term (25°C) stability tests, the formulations remained chemically stable with degradation less than 10%. High temperatures or light exposure increased degradation, while storage at room temperature in amber bottles ensured optimal stability. The use of propylene glycol as a cosolvent and citrate buffer as a stabilizing agent provided good physical and chemical stability. All reviewed formulations fulfilled Indonesian Pharmacopoeia requirements, with the best stability achieved when stored at room temperature and protected from light. Keywords: paracetamol, syrup, formulation, accelerated stability, evaluation test
Review Artikel: Emulgator Dengan Penggunaan Bahan Alam Terhadap Stabilitas Sediaan Farmasi: Emulgator Dengan Penggunaan Bahan Alam Pramesty, Dwinda; Siahaan, Desy; FN, Gina; TP Sella, Arinda; Saputro, M. Ramadhan; Pratama, Reza
Jurnal Medika Farmaka Vol 3 No 3 (2025): Vol 3 No 3 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i3.87

Abstract

ntroduction: Emulsifiers are important components in pharmaceutical formulations, functioning to stabilize two-phase systems such as oil and water. Until now, synthetic emulsifiers have been widely used due to their effectiveness, but they have limitations in terms of safety and sustainability. Therefore, the use of natural emulsifiers is a potential alternative that is safer and more environmentally friendly. This article aims to review the potential and effectiveness of natural emulsifiers on the stability of various pharmaceutical preparations. Methods: The study was conducted through online literature searches on the Google Scholar, ScienceDirect, PubMed, and ResearchGate databases, covering publications from the last 10 years. The keywords used included “emulsifier” “natural ingredients”, and “natural emulsifiers”. Relevant articles were selected based on their relevance to the topic of pharmaceutical emulsion stability. Results: Based on the results of the review, natural emulsifiers such as polysaccharides (gum arabic, alginate, chitosan), proteins (soy lecithin, whey protein, vegetable protein), and plant saponins can improve the physical, chemical, and thermal stability of emulsion preparations. The mechanism is through the formation of a strong interface layer that prevents coalescence, flocculation, and phase separation. Additionally, some natural emulsifiers also possess additional biological activities such as antioxidant and antimicrobial properties. Conclusion: Natural emulsifiers show great potential as alternatives to synthetic emulsifiers in pharmaceutical formulations. Further research is needed to optimize the combination of natural ingredients, homogenization methods, and the development of sustainable emulsions based on natural ingredients.
A Review Review Artikel: Formulasi Evaluasi dan Stabilitas Sediaan Tablet Atorvastatin: Formulation, Evaluation, and Stability of Atorvastatin Tablet Dosage Forms Saputro, M. Ramadhan; Aulia, Reihan Zalza; Aisyah F, Nur Fajriyah; Isnen, M. Dzul Faqih; B, Maria Helentina; Pratama, Reza
Jurnal Medika Farmaka Vol 3 No 3 (2025): Vol 3 No 3 (2025): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v3i3.89

Abstract

Introduction: Atorvastatin is a statin drug with low solubility and stability, resulting in limited bioavailability. This review aims to examine various formulation methods, evaluations, and stability tests of atorvastatin tablets. Methods: This study is a literature review discussing different formulation approaches and stability evaluations of atorvastatin tablets with various release systems. Articles were collected from Google Scholar, ScienceDirect, and ResearchGate, then analyzed based on formulation methods, stabilizing excipients, and stability testing techniques. Results: The use of dry granulation with basic excipients, sustained release and extended release systems, as well as cocrystal formation with coformers such as nicotinamide and ascorbic acid, effectively improved the solubility, stability, and bioavailability of atorvastatin. Conclusion: The combination of appropriate formulation strategies and optimized dosage design is key to developing atorvastatin tablets that are stable and therapeutically effective.
Co-Authors Aditya Wicaksono Afifah Rusyda Sani Aini, Putri Rizki Aisyah F, Nur Fajriyah Aiyi Asnawi Ajeng Trias Marani, Rizkyanti Al akbar, Ayatullah malik Ali Sodikin, Muhammad Ambar Cahyana, Haikal Amelia, Ferda Andriansyah, Ivan Apriyanti, Nita Arifka, Mia Ariyadi Anatasia, Alfi Asep Wahyudin Asherlia, Dwita Aulia, Reihan Zalza Aulia, Syaikah Nabilah Awaliyah, Ratu Siti Robiatul B, Maria Helentina Bokotei, Martini Budiana, Wempi Cabellon-Semense, Daisy Jane Cahyani, Dhiana Eka Dadih Supriadi, Dadih Dara Siti Nurjanah Daulay, Zharifah Zahwa Dewi Fatmasari Dwi Anggana, Hilman Emma Emawati, Emma Fahri Fahlufi, Chikal Fajarwati, Kania Fami, Amata Fatma, Ira Dwi Febryanthi, Anggita Yayuk FN, Gina Garnadi Jafar, Garnadi Gumelar, Muhammad Galuh Gustinasari, Eka Hadiani, Dian Hanifah, Nidaa Hasanah, Ida Hilda Restu, Afria Holik, Wildan Hostati, Febri Hutauruk, Desinora Natalia Ibrahim, Raihan Ilyas, Maulana Irfani, Abdul Mulki Irma Rasita Gloria Barus Isnen, M. Dzul Faqih Istiqomah, Aulia Nurfazri Jajang Japar Sodik Juanuari, Juanuari Kasihtheisya, Naida Khairi, Asyraful Kiik, Rosa Virginia Kodrat, Kimberly F. Komariansyah, Kinaya Khairunnisa Laela Sukartini, Mutiara Latifah, Zahra Alfa Lela Sulastri, Lela Lestari, Kharina Septi Lian, Kevin Efraim Luciana Andrawina Luwandi Suhartono Ma'mum, Sukron Mahsyar, Januar Habibi Manzis, Ilham Maria Elvina Tresia Butar-Butar Maryana Ulfah, Raden Roro Masri, Dedi Maulana Fansyuri Mayasari, Ulfayani Melanie, Arin Mindara, Gema Parasti Mode, Aninda Nesya Mufti Prasetiyo, Sofyan Muhammad Reza Pahlevi Muhammad Ridwan Muizzul Aziz, Aris Mumtaz, Jasmine Aulia Munawar, Andri Helmi Munir Alinu Mulki Nainggolan, Esron Rikardo Nggiring, Maria Imaculata Sherly Nurasih, Widya Nurfazri, Aulia Nurholisa, Neng Dera Siti Nurkholis Ajie Kurniawan, Muhammad Nurul Iman, Dian Oktapiani, Selvia Oktriyani, Anissa Nadya Pahlevi, Muhamad Reza Pebriawati, Silpi Permata Sari, Aulia Pramesti, Ginna Novarianti Dwi Putri Pramesty, Dwinda Prasetya, Sabdha Pratama, Arijal Purba, Risdo Sappetua Putra Mulya, Ageng Putriyanti, Al-fira Putro, Budi Laksono R. Tanjung, Linda Fitria Rafli, Tri Muhamad Rahayu Fuji Astuti Rahmat Santoso, Rahmat Rahmat Tri widodo Rahmawati, Nabila Septri Ratu Siti Robiatul Awaliyah Rinaldi, Muhammad Dodit Rizki Rahmatullah, Muhammad Rodinah, Ina Roni, Asep Sabran Buana, , Bayu Sagita, Novaliana Devianti Sanggo, Merylance Stefany Sani, Afifah Rusyda Saputro, M. Ramadhan Saputro, Ramadhan Sarah Ramadhani, Sarah Sasaqi, Adzkia Pratami Sau, Barth Larson Boling Selifiana, Nita Shahrudin Siahaan, Desy Sibuea, Siti Rahmah Silviana, Neneng Simamora, Boy Ignatius Sinaga, Yakobus Lau De Yung Situmeang, Diancrisy Situmorang, Sabina EMI Zuraidah Soares, Fidelia Gabriela Da Costa Sofian, Ryan Soni Muhsinin Susilawati, Elis Sutoro, Meylani Thahir, Raisa Mutia TP Sella, Arinda Triman Harefa, Gideon Valiza, Dinda willis, Hawa Y Gatot Sutapa Yayan Rizikiyan Yulianie, Rany Yuliyani Yuliyani, Yuliyani Yuni Kartika, Yuni Zaelani, Diki Zahra Chaniago, Fatimah