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All Journal e-GIGI e-CliniC LEX CRIMEN JAKPI Jurnal Manajemen Bisnis JSM (Jurnal SIFO Mikroskil) TATANAN Media Penelitian Pendidikan : Jurnal Penelitian dalam Bidang Pendidikan dan Pengajaran Jurnal Manajemen Pendidikan Omni-Akuatika Jurnal Penelitian Pendidikan IPA (JPPIPA) EBSJ SENTRALISASI BALANCE: Jurnal Akuntansi, Auditing dan Keuangan Jurnal PROTEKSI (Proyeksi Teknik Sipil) Jurnal Masyarakat Merdeka (JMM) HIKMAH : JURNAL PENDIDIKAN AGAMA ISLAM Inovasi: Jurnal Ilmiah Ilmu Manajemen Jusikom: Jurnal Sistem Informasi Ilmu Komputer SCAFFOLDING: Jurnal Pendidikan Islam dan Multikulturalisme MUKADIMAH: Jurnal Pendidikan, Sejarah, dan Ilmu-ilmu Sosial Community Engagement and Emergence Journal (CEEJ) SOLUSI Jurnal Ilmiah Manajemen Kesatuan Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Promotif Preventif Medical Scope Journal (MSJ) GOVERNANCE: Jurnal Ilmiah Kajian Politik Lokal dan Pembangunan Journal of Research in Social Science and Humanities Action Research Literate (ARL) Manajemen dan Bisnis Jurnal Komputer, Informasi dan Teknologi Jurnal Paradigma Akuntansi Indonesian Accounting Research Journal Modality Journal: International Journal of Linguistics and Literature Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Jurnal Penelitian Ilmu Pendidikan Indonesia Journal of Artificial Intelligence and Digital Business Journal Research of Social Science, Economics, and Management Jurnal Pendidikan Indonesia (Japendi) Eduvest - Journal of Universal Studies Innovative: Journal Of Social Science Research TOFEDU: The Future of Education Journal International Journal of Application on Economics and Business Jurnal Pengabdian Masyarakat Ekonomi dan Bisnis Digital The Indonesian Journal of General Medicine Greenation International Journal of Tourism and Management Computer & Science Industrial Engineering Journal Balance: Jurnal Akuntansi, Auditing, dan Keuangan Jurnal Sistem Informasi dan Aplikasi Jurnal Bakti UPPR
Albert Albert
Bina Nusantara University
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Journal : e-CliniC

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Neoadjuvant Lenvatinib in Advanced Unresectable Thyroid Carcinoma: Case Series and Literature Review Albert, Albert; Manginstar, Christian O.; Saleh, Denny; Merung, Marselus A.
e-CliniC Vol. 13 No. 1 (2025): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v13i1.58793

Abstract

Abstract: Lenvatinib, a tyrosine kinase inhibitor (TKI), has shown potential as a neoadjuvant therapy for inoperable thyroid cancer (TC). In this case series, we present three patients with unresectable thyroid tumors who responded favorably to lenvatinib treatment. A 60-year-old male with papillary thyroid cancer (PTC) experienced a 60% tumor volume reduction after five months of therapy. A 61-year-old male with medullary thyroid cancer (MTC) saw a 99% reduction after four months of lenvatinib and decrease of serum calcitonin and no residual disease six months after surgery. Lastly, a 67-year-old female with anaplastic thyroid cancer (ATC) showed a 70% tumor reduction and significant symptomatic relief. These cases highlight lenvatinib’s efficacy in reducing tumor size and stabilizing disease, improving surgical outcomes in patients initially deemed inoperable due to locally advanced tumors. Lenvatinib’s antitumor effects, driven by its antiangiogenic properties, suggest its potential as a valuable neoadjuvant treatment option in advanced thyroid cancer. Keywords: thyroid carcinoma; lenvatinib; case series
In Vitro Antibacterial Effectiveness of Stingless Bee Propolis against Infected Breast Cancer Ulcer Manginstar, Christian; Merung, Marselus; Albert, Albert
e-CliniC Vol. 14 No. 1 (2026): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v14i1.65682

Abstract

Abstract: Breast cancer is the most common cancer in women and often presents with malignant ulcers prone to infection. These wounds are difficult to manage, especially during chemotherapy, due to polymicrobial colonization and rising antibiotic resistance. Stingless bee propolis, rich in bioactive flavonoids, has shown promising antibacterial properties. This study aimed to evaluate in vitro antibacterial effectiveness of stingless bee propolis against bacteria from breast cancer ulcers. This was an in vitro study conducted at the Poltekkes Kemenkes Manado Medical Laboratory (July 2024–January 2025). Methanol-extracted stingless bee propolis was tested against MRSA and P. aeruginosa using disc diffusion, MIC, and MBC methods. Antibacterial activity was evaluated through inhibition zones and bacterial growth in serial dilutions. The outcomes were analyzed based on inhibition zone diameters and bacterial growth in serial dilutions. The results showed that propolis extract demonstrated antibacterial activity against MRSA and P. aeruginosa, with inhibition zones observed in both disc diffusion and dilution methods. Strong inhibition was noted at concentrations ≥80%, while minimal or no effect occurred below 30%. MIC and MBC were estimated at around 20%. Statistical analysis confirmed a significant dose-response relationship (ANOVA, p 0.0003), with stronger correlation in MRSA (R=0.84; p<0.001) than P. aeruginosa (R=–0.09; p 0.046). The minimum effective concentration was estimated at 32% for MRSA and 37% for P. aeruginosa. In conclusion, stingless bee propolis demonstrated concentration-dependent antibacterial activity against both Gram-positive (MRSA) and Gram-negative (P. aeruginosa) bacteria in vitro, with increased activity observed at higher concentrations. Minimum effective concentrations were 32% for MRSA and 37% for P. aeruginosa, supporting its potential use in treating infected breast cancer ulcers. These findings highlight propolis as a potential natural alternative for infection control and wound healing. Keywords: breast cancer; ulcer; stingless bee; propolis; antibacterial effect
Co-Authors Abda Abda Achmad Noerkhaerin Putra Agus Susanto Aifu, Dewi Kurniati Alfarizy, Tomy Aminingtyas, Septi Andini Andayani, Lia H. Andini, Lilla Andyka Andyka, Andyka Angkasa, Marco Anita Damajanti Aprih Santoso Arman Husni Asih, Situ Aurelia, Clarecia Bonnarty Steven Silalahi Budianto, Justin Chairisni Lubis Chandra, Felixco Chandriani, Casslyn Collins Willim, Zackrey Dewayani , Ery Dewi Apipah, Wulan Djohan, Deva Djohan, Stevannie Duti Volya Elbistian, Kevin Putra Emaya Kurniawati, Emaya Endah Dwi Kusumastuti, Endah Dwi Ermatita - Etty Widyastuti Gawei, Apria Brita Pandohop Girsang, Ermi Hairinsyah, Kesuma Halawa, Misdayanti Hamidjaja, Beverly C. Harahap, Zainy Kholis Muda Hariyanti , Tri Yuli Hartanto, Janssen Yohana Putri Hartati Hartati Hartoto, Witjaksono Eko Haryadi, Nicko Hassim, Affendy Abu Helmy Thendean Hutabarat, Chintya Yohana Putri Hwang, James IKA PUSPA SATRIANNY Indarto Indarto Iratutisisilia, Iratutisisilia Irmawati, B Irwandi Irwandi Ita Fionita Izza, Ainul Jacqueline, Jacqueline Jawari, Irvan Kosasih, Hengky Kridasusila, Andy Kuswardani, Dc Laoli, Tierlin Gustin Kristiani Lestari , Rohmini Indah Liana Susanto Lim, Jennifer Lisna Lisna, Lisna Lowins, Leandro Maimori, Romi Male, Minarti Manginstar, Christian Manginstar, Christian O. Manik, Rifqa Yolandha Efreymind Marissa, Novaria Marselus A. Merung, Marselus A. Marselus Merung, Marselus Masduki Masduki Meliala, Juli Elisabet Mayen br Muhamad Fajri, Muhamad Mulyono, Jovan Naga , Dali Santun Nangsih, Ayu Nasib Nefianto, Tirton Nely Arif Nengsih, Widya Nesia, Yesha Nunung Fajaryani, Nunung Nurhayati Nurhayati Okta Jaya Harmaja Pasaribu, Ester YYN Pranata, Hamdi Pranyoto, Edi Prasetio, Meriyawaty Amelia Prastyaningsih, Nila Robin Robin, Robin Rochimah, Heni Rojuaniah Rojuaniah Rudi Waluyo SAFITRI, CANDRA Sagala, Lapiti Gokmatua Sahat Simbolon Saing, Fatmawati M Saleh, Denny SALMAN FARIS Santoso, Thomas Budi Santy Deasy Siregar Sanwar, Sitti Nurlyanti Saragih, Saut Pintubipar Sari, Elna Sarumi, Rasniah Savitri, Fania Mutiara Sina, Wa Soelistiyono, Anitiyo Sucandra, I Made Agus Kresna Sulistiani Sulistiani, Sulistiani Sunario Megawan Surya Surya SUSANTI Sutanto, Fernando Thamrin Thamrin Tita Elfitasari Tjokorda Gde Agung Senapathi Tommy Setiawan Ruslim, Tommy Setiawan Trijani Suwandi Ugang, Yandi Valerie, Valerie Wahid, Ayi Wedra Aprison Wiguna, Teguh Nusa Wijaya, Elyzabeth William, Justin Sebastian Winda Rika Lestari Wizmar, Dickie A. Yani, Tri Endang Yohana Yohana Yuli Budiati Yusmei, Nining Zulfani Sesmiarni