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Analisis Kuantitatif dan Kualitatif Penggunaan Antibiotik pada Pasien Rawat Inap di Ruang Penyakit Dalam RSUD Dr. R. Sosodoro Djatikoesoemo Bojonegoro Anwar, M. Rosichan; Hutahaen, Titi Agni; Basith, Abdul; Noer, Sebilah Sabil
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.826

Abstract

Infeksi merupakan salah satu permasalahan kesehatan yang masih menjadi perhatian utama karena berdampak luas terhadap masyarakat. Antibiotik merupakan terapi untuk penyakit infeksi yang diakibatkan oleh bakteri. Penggunaan antibiotik yang tidak tepat dengan indikasi, dosis, dan lama pemberian dapat mengakibatkan resistensi antibiotik. Penelitian ini bertujuan untuk menganalisis penggunaan antibiotik secara kuantitatif dan kualitatif guna mendukung penggunaan antibiotik menjadi lebih bijak dan rasional. Penelitian ini bersifat observasional dengan pendekatan deskriptif secara retrospektif menggunakan teknik purposive sampling yang dilakukan di ruang penyakit dalam RSUD Dr. R. Sosodoro Djatikoesoemo Bojonegoro selama periode Juli hingga Desember 2024. Analisis secara kuantitatif dilakukan menggunakan metode ATC/DDD serta analisis DU90%, sementara analisis kualitatif dilakukan berdasarkan Pedoman Penggunaan Antibiotik Kemenkes RI 2021, Formularium RSUD, serta referensi klinis internasional seperti Johns Hopkins Antibiotic Guidelines, Drug Information Handbook dan British National Formulary. Hasil menunjukkan bahwa total DDD/100 hari rawat adalah 80,83, dengan seftriakson adalah antibiotik yang sering digunakan sebesar 26,97 atau 33,37%. Antibiotik dalam segmen DU90% meliputi seftriakson, prokain benzil penisilin, metronidazol, sefepim, dan meropenem. Analisis kualitatif pada 107 pasien menunjukkan ketepatan indikasi dan pasien sebesar 100%, ketepatan pemilihan obat 81,31%, dan ketepatan dosis sebesar 67,29%. Hasil ini menekankan bahwa pentingnya upaya berkelanjutan dalam mengoptimalkan praktik pemberian dosis serta mendukung program pengendalian resistensi antimikroba untuk meningkatkan penggunaan antibiotik yang rasional dan menurunkan risiko terjadinya resistensi.
FURTHER STUDY ON TWO SPECIES OF LOACH FISHES (Cypriniformes: Nemacheilidae: Nemacheilus) BASED ON MORPHOLOGY AND MOLECULAR DATA Rahayu, Dwi Anggorowati; Kuntjoro, Sunu; Budijastuti, Widowati; Winarsih, Winarsih; Ambarwati, Reni; Nugroho, Endik Deni; Basith, Abdul; Kurniawan, Nia; Haryono, Haryono
BIOTROPIA Vol. 30 No. 3 (2023): BIOTROPIA Vol. 30 No. 3 December 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.2.1942

Abstract

The identities of two local loaches, Nemacheilus chrysolaimos (Valenciennes, 1846) and N. fasciatus (Valenciennes, 1846) from six rivers, were obtained through a comprehensive examination of their morphology and molecular characteristics in Biltar Regency, East Java, Indonesia. Therefore, this study identified Nemacheilus spp. from Blitar based on morphology and partial sequence of COI. The meristic data obtained for N. chrysolaimos included DII. 7–8 (dorsal fin), AI. 3–5 (anal fin), PI. 9 (pectoral fin), VI. 6–7 (ventral fin), and C. 17 (caudal fin). On the other hand, N. fasciatus exhibited the following meristic data, namely D II 7–8 (dorsal fin), AI. 6 (anal fin), PI. 9–10 (pectoral fin), VI. 6–7 (ventral fin), and C. 17 (caudal fin). A significant difference was observed in the morphometric characteristics of N. fasciatus across various sampling sites, as determined by the Kruskal-Wallis Test. Furthermore, the nucleotide base composition sequences of Nemacheilus spp. consisted of Thiamine (T), Cytosine (C), Adenine (A), and Guanine (G) with a mean of 29.565%, 32.023%, 23.88%, and 16.244%. Maximum Likelihood (ML) and Minimum Evolution (ME) phylogenetic analysis was also conducted using the Kimura 2 Parameter model to establish two major clades on Nemacheilus spp. and one out-group significantly different from the Nemacheilus spp. The results showed that these major clades exhibited a close relationship at 100% bootstrap support and were grouped under the genus Nemacheilus. The study on Nemacheilus spp. from the Blitar locality differentiated COI sequences between N. fasciatus and N. chrysolaimos. Additionally, N. chrysolaimos, as inferred from reference sequences, was identified as the ancestral species to N. chrysolaimos MZB 26540 and MZB 26539. ABGD analyses, employing a prior maximal distance of 0.025, also indicated the separation of these species into distinct partitions. The integration of morphology and genetic data for Nemacheilus spp. should provide valuable insights for future genetic population studies and conservation initiatives.
Inventory of Invasive Plant Species along the corridor of Kawah Ijen Nature Tourism Park, Banyuwangi, East Java Hapsari, Lia; Basith, Abdul; Novitasiah, Hari Rusdwi
Journal of Indonesian Tourism and Development Studies Vol. 2 No. 1 (2014)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jitode.2014.002.01.01

Abstract

A field survey was conducted in November 2013 to inventory invasive plant species present along the corridor of Kawah Ijen Nature Tourism Park exploratively. Result showed that there were 11 plant species found abundantly along the corridor. Typical native species were dominated by Cyathea contaminans, Casuarina junghuhniana and Vaccinium varingiaefolium. Three species were determined as invasive alien species i.e. Chromolaena odorata, Acacia decurrens and Blumea lacera whereas five species were determined as native species but potential invaders i.e. Rubus moluccanus, Melastoma malabatrichum, Polygonum barbatum, Debregeasia longifolia and Pteridium aquilinum. In term of tourism particularly on nature-based destinations enable moving in and out of invasive alien species due to opening the access of some natural protected areas. The environmental impact of an alien species whether it becomes invasive at its destination depends on its biological key point,  what ecological role the species may play, and on additional factors such as its tolerance of the gross features of the environment in the new range. Keywords: invasive plants, corridor, Kawah Ijen, Nature Tourism Park, Banyuwangi
Genetic Variation Analysis of Four Local Varieties of Indonesian Black Rice (Oryza sativa L.) Based on Partially rbcL cpDNA Gene Sequence Basith, Abdul; Arumingtyas, Estri Laras; Widodo, Widodo
The Journal of Experimental Life Science Vol. 11 No. 1 (2021)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jels.2021.011.01.01

Abstract

Black rice (Oryza sativa L.) varieties i.e. Toraja (South Sulawesi), Cempo Ireng (Yogyakarta), Wojalaka (East Nusa Tenggara), and Manggarai (East Nusa Tenggara) are four local black rice varieties in Indonesia whose character has not been widely studied, especially the character of genetic variation. Research aimed to determine the variation of the rbcL gene in the four local black rice varieties. The sample for testing the variation of the rbcL gene sequence in the form of black rice leaves six weeks after planting. Dendogram was carried out using the UPGMA method with the Kimura 2-parameter algorithmic calculation model using the MEGA5 version 5.2.2 program. The results showed that partially the rbcL gene sequence was successfully amplified on four black rice varieties with a sequence length of 487 bp. The partial rbcL sequence of black rice consisted of 26.58% tyrosine, 21.38% cytosine, 28.86% adenine, and 23.18% guanine. The value of G + C content was 0.446, with the frequency of invariable sites of 97.13%. The frequency of informative parsimony sites was 1.43% with a nucleotide diversity (Pi) value of 42-10, the number of haplotypes was 5, and the total number of mutations and polymorphic sites was 14. The ratio between transition and transversion (ts/tv ratio k) for purine bases was 1.741 and pyrimidine was 3.571, with the estimated overall ratio between transition and transversion (R) of 1.31. Based on the dendogram, the farthest genetic distance was found in Wojalaka and Manggarai varieties, which were 0.019 respectively.Keywords: black rice, genetic variation, local varieties, rbcL gen
Co-Authors 'Ilmi, Shofia Nafi'atul Abdul Majid Adi Pratama, Andika Afifatul, M. Khoirul Ahmad Syaifuddin Ainu Zuhriyah Ajeng pratiwi, Shoffi Akhita, Yusrifah Justi Alfan, Aris Almaududy, Khairul U. Amelya, Rizka Anwar, M. Rosichan Ari Setiawan Arifin, Muhyiddin Zainul Aristalindra, Fauzia Atriyon Julzarika Ayulanda, Ika Badriatul Jamroh, Nurmaya Bari, Akhmad Al Dewi, Agustin Yuliana Dewi, Priyantini Dian Berkah Dian Maruto Widjonarko Dona Setya Dondiarta, Ghani Yanuargo Dwi Anggorowati Rahayu Dwikarsa, Yahya Edi Pramono Endik Deni Nugroho Erick Nugraha Estri Laras Arumingtyas Fadhilah, Faris Fadlullah, Irfan Faizah, Mazidatul Faridatunnisa, Maritsa Farlina, Nur Fathul Jannah, Fathul Fauziah, Nainul Fikroh, Nuris Shofatul Firdaus, Rousul Firdhausyah, Ananda Ammathul Firmansyah, Ahmad Agung Fitria Lestari Gathot Winarso, Gathot Goenaryo, Goenaryo Handri, Handri Hari Rusdwi Novitasiah Haryono Haryono Hutajulu, Jerry Ikhwanudin Ikhwanudin Iksan Iksan Indriana Rahmawati Insaniyah, Anyes Lathifatul Ira Nurmawati Kamarudin Kamarudin Khalidah Khalidah, Khalidah Khoirotus Silfiyah Koman, Wening Aisyah Fauziana Krisiati Kurniawati, Naning Kusumo Efyjanto, Tonny Labib, Mughni Lestari, Witri Wahyu Lia Hapsari Luhur Moekti Prayogo M, Novidayanti. Ma'mun Sarma Mahmudah, Imil MAKIAH Maman Hermawan Mandala Putra, Galih Maria, Yeni Melina, Dika Caesar Milawati Milawati Moh. Anshori Aris Widya Mualim, Rahmat Muhammad Rezza Nur Rahman Muhammad Said Husin Muhammad Saleh MUHAMMAD ULIN NUHA Muna, Nadia Nailul Muri'ah, Siti Nawafila Februyani Nawawi, Mahbub Nia Kurniawan Nisak, Siti Khoirun Noer, Sebilah Sabil Noer, Shafa Noer Nofitasari, Risma Septyana Noor Diani Nurlaela, Eli Nurul Huda Oktaviani, Nadya P. Nababan, Sakti Prastyani, Ratna Prianika, Arlin Dayinta Priyasmika, Rendy Putri, Candra Avista Qurrotul Aini Rahayu Rahayu Rahmaddana, Mohamad Nazil Rahmawati, Laily Isnaini Ramlah Ramlah Reni Ambarwati Renny Oktafia, Renny Rismia Agustina Rudi Masniadi Saputra, Aman Saputri, Romadhiyana Kisno Sari Mardiah, Ratu Sayekti Wahyuningsih Sentot Budi Raharjo Siti Julaiha Sudrajat, Danu Sugriwa Husen, Eddy Suharto Suharto Suharyanto Sulistyo, Devina Anintia Sunu Kuntjoro Syamsuddin Arif Taufik Azhary Teguh Endah Saraswati Tiku, Mathius Titi Agni Hutahaen Ulinnuha, Hilmiyati Umar Sulaiman Venny, Venny Widjo Kongko, Widjo Widodo Widodo WIDOWATI BUDIJASTUTI Wijaya, Abdun Wikaningtyas, Asih Winarsih Winarsih Wulandari, Resa Wulansari, Imelia Yani’ Qoriati Yuliana Yuliana Yusrizal Yusrizal Zetadini, Reza Zuhriya, Indah Aminatuz Zuhriyyah, Ainu