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All Journal International Journal of Evaluation and Research in Education (IJERE) Al-Manar : English and Arabic Journal J-Simbol: Jurnal Magister Pendidikan Bahasa dan Sastra Indonesia Jurnal Kata: Bahasa, Sastra, dan Pembelajarannya LOKABASA Lingua Franca: Jurnal Bahasa, Sastra, dan Pengajarannya JMKSP (Jurnal Manajemen, Kepemimpinan, dan Supervisi Pendidikan) ESTETIK : Jurnal Bahasa Indonesia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Edukasi Lingua Sastra KARMAWIBANGGA: Historical Studies Journal Jurnal Teknologi Pendidikan : Jurnal Penelitian dan Pengembangan Pembelajaran Narra J Kaisa: Jurnal Pendidikan dan Pembelajaran Jurnal Seni dan Pembelajaran AKSARA: Jurnal Bahasa dan Sastra Education, Language, and Arts: Jurnal Pengabdian Kepada Masyarakat ENDLESS : International Journal of Future Studies Nuwo Abdimas Jurnal Produk Pengabdian Masyarakat Indonesia Jurnal Pendidikan Progresif
Edi Suyanto
Universitas Lampung
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Narra J

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Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Maimunah, Ummi; Maharani, Andi RK.; Soegiarto, Gatot; Rahniayu, Alphania; Gunawan, Vania A.; Wiratama, Priangga A.; Djuanda, Stephanie N.; Supriadi, Supriadi; Marhana, Isnin A.; Semedi, Bambang P.; Lefi, Achmad; Kusumastuti, Etty H.; Suyanto, Edi; Lilihata, Jilientasia G.; Anggoro, Adhitri; Rinjani, Lalu GP.; Rosyid, Alfian N.; Wahyu, Dwi; Fauziah, Dyah; Rahaju, Anny S.; Kurniasari, Nila; Ariani, Grace; Nugroho, Gilang MS.; Yandi, I KR.; Nugraha, Ricardo A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.463

Abstract

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.
Co-Authors Ade Anggraini Agung Kurniawan Ahmad Riduwan Ahmad Zuhri Ali Mustofa Ali Mustofa Ali Mustofa Alphania Rahniayu Amala, Istiqomah Ahsanu Amy Sabila Ana Juwita Anak Agung Gede Sugianthara Anaria Gunani Andre Setyawan Anggi Tia Suryani Anggoro, Adhitri Ari Pahala Hutabarat Ari Rohmawati Ariani, Grace Atti Yudiernawati, Atti Ayu Setiyo Putri Ayu Setiyo Putri Aziz Firdaus Bambang Setiyadi Bayu Andika Bayu Antrakusuma, Bayu Betnawati Betnawati Bryan Tioro Gisri Budi Risnawati Dede Putri Dekas Miyanti Didit Aryani Djuanda, Stephanie N. Dwi Prihatini DYAH FAUZIAH, DYAH Eka Sofia Agustina Eka Sofia Agustina Endah Prihastuti Eni Hastuti Epri Fitriyani Era Octafiona Evita Fratiwi Fahreza Chandra W farida ariyani Farida Ariyani Farida Ariyani Fathimah Nurhalimah S Fathly Husnawan Febri Ramadani Fikri Ariyanto Fisnia Pratami Fitri Angraini Fitri Dwi Mahardika Fransiska Pratiwi Prasakti Fransiska Retno Widiarti Gatot Soegiarto Gunawan, Vania A. Herlina Herlina Hernaini Hernaini Heru Prasetyo Hesti Hesti Husna, Siti Asmaul Ibnu Hajar Indah Mayasari Indar Agus Susilowati Iqbal Hilal Iqbal Hilal Istiqomah Ahsanu Amala Joko Setyo Nugroho Juwita Sari Pebriani K Sugeng Prijono Kahfie Nazaruddin Kahfie Nazaruddin Kahfie Nazarudin Karomani Karomani Kasiyah Kasiyah Klara Ken Laras Kusumastuti, Etty H. Lefi, Achmad Lilihata, Jilientasia G. Lisda Syary Lyoni Elvandari M Yanuardi Zain Maharani, Andi RK. Mardiah Hayati Marhana, Isnin A. Masturi Rulia Maya Oktavia Megawati Megawati Meita Hapsari Melinda, Denassa Miftahul Jannah Milwati, Susi Mira Salviani Muhammad Fuad Muhammad Fuad Muhammad Fuad Muhammad Fuad MUHAMMAD FUAD Muhammad, Ulul Azmi Muharsyam Dwi Anantama Mujiono Mujiono Mukti Arum Kusumadewi Mulyanto Widodo Munaris Munaris Munaris . Nalan Meilia Sisi Nalan Meilia Sisi Nazimah Nazimah Nelly Yustinawati Nenden Lilis Aisyah Neneng Sulasmi Neni Agustin Nety Syafithri ni made mulyasari Ni Nyoman Wetty Suliani Nia Purnamasari Nila Candra Nila Kurniasari Nindy Eka Putri Ningsih, Iraliya Nova Delyanti Nugraha, Ricardo A. Nugroho, Gilang MS. Nur Fadilla Nurdin Putra Jaya Nurlaksana Eko Rusminto Paingan Paingan Pangestika, Zola Nurmadya Prayodi, Rahmat Puspita Cahya Rivai Puspita Trie Utami Rahaju, Anny S. Rahmat Prayogi, Rahmat Rahmawati, Lenny Rangga Yudha Ratih Amalia Wulandari Ratna Dewi Rengga Pinaris Riadi, Bambang Riana Dwi Putra Riana, Hana Ribut Wibowo Rifany Maulidya Rinjani, Lalu GP. Rizki Dilla Sintia Roni Mustofa Rosdiasari Pane Rosyid, Alfian N. Rudi Hermawan Ruri Resmiana Sari Saadah Saadah Safira Nabila Sahrani, Silvina Aulia Semedi, Bambang P. Shera Lovina Shinta Larasati Siagian, Mutiara Indah Sisi, Nalan Meilia Siti Nurhamidah Siti Nurlaili Siti Samhati Sri Wahyuni Ekowati Sriana Ezabella Sudaryo Sudaryo Sukistiono Sukistiono Sulistiawati sulistiawati Sumarti Sumarti Suparman Suparman Supriadi Supriadi Supu Hernawiah Surasa Surasa Surya Agus Cahyanti Susilawati Susilawati Susilowati, Indar Agus Syafina Tavip Dwi Wahyuni Teguh Teguh Tika Qurratun Hasanah TRI WULANDARI Ulul Azmi Muhammad Ulul Azmi Muhammad Ummi Maimunah Uti Utari Mutiara Vili Yanthi Wahyu, Dwi Widiyawati Widiyawati Windu Budiarta Wira Widyas Tuty Wiratama, Priangga A. Yandi, I KR. Yessi Eva Nora Yoga Fernando Rizqi Yuli Hariyanto Yusfa Fitri Meza Zusi Ardiana