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Pande Ayu Naya Kasih Permatananda

Bagian Farmakologi Dan Farmasi Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Warmadewa

Author-ID : 296667

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From Tradition to Translation: A Systematic Review on the Pharmacological Actions of Eugenol Extracted from Ocimum Plants in Oxidative Stress, Inflammation, and Diabetes Mellitus Permatananda, Pande Ayu Naya Kasih; I Wayan Putu Sutirta Yasa; I Wayan Sumardika; Made Ratna Saraswati; I Gde Suranaya Pandit
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1302

Background: Ocimum species, commonly known as basil, have a rich history in traditional medicine for various ailments. Eugenol, a primary bioactive compound found in several Ocimum species, has garnered significant scientific attention for its potential therapeutic properties. This systematic review aimed to comprehensively evaluate the pharmacological actions of eugenol extracted from Ocimum plants in the context of oxidative stress, inflammation, and diabetes mellitus. Methods: A systematic literature search was conducted across major scientific databases for studies published between 2013 and 2024 that investigated the effects of eugenol derived from Ocimum plants on oxidative stress, inflammation, and diabetes mellitus. The search strategy included keywords such as "eugenol," "Ocimum," "antioxidant," "anti-inflammatory," and "antidiabetic." Inclusion criteria for studies involving in vitro, in vivo, and clinical studies that specifically examined the pharmacological actions of eugenol extracted from Ocimum species in the aforementioned conditions. Data on study design, intervention, outcomes, and key findings were extracted and synthesized narratively. Results: The review identified ten key studies that met the inclusion criteria. These studies collectively suggested that eugenol extracted from Ocimum plants exhibited significant antioxidant activity by scavenging free radicals and enhancing endogenous antioxidant enzymes. Furthermore, eugenol demonstrated anti-inflammatory effects by modulating pro-inflammatory cytokines and inhibiting key inflammatory pathways such as NF-κB and COX. In the context of diabetes mellitus, studies indicated that eugenol could improve glucose metabolism by enhancing insulin sensitivity, protecting pancreatic beta cells, and inhibiting carbohydrate metabolizing enzymes. Conclusion: This systematic review provided a comprehensive overview of the pharmacological actions of eugenol extracted from Ocimum plants in mitigating oxidative stress, inflammation, and diabetes mellitus. The findings from the included studies supported the traditional uses of Ocimum species and highlighted the therapeutic potential of eugenol as a natural agent in managing these conditions. Further well-designed clinical trials are warranted to validate these preclinical findings and translate them into clinical applications.

Program Pengabdian Masyarakat dalam Rangka Pencegahan Kecelakaan Rumah Tangga pada Anak di Desa Bayung Gede, Kintamani : Pengabdian Pande Ayu Naya Kasih Permatananda; I Gde Suranaya Pandit; Desak Putu Citra Udiyani; Putu Nita Cahyawati; Asri Lestarini
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 3 No. 4 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 3 Nomor 4 (April 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v3i4.1119

Anak-anak merupakan korban tersering dari kecelakaan rumah tangga, yang sebagian besar terjadi pada anak-anak yang hidup di negara miskin dan berkembang. Pencegahan dan kontrol kecelakaan rumah tangga pada anak di bawah 5 tahun disebutkan cukup efektif dalam mehurunkan mortalitas akibat kecelakaan. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan keluarga dalam melakukan pencegahan kecelakaan rumah tangga. Metode transfer ilmu pengetahuan yang digunakan dalam kegiatan ini meliputi penyuluhan kelas besar pada perwakilan keluarga di Desa Bayung Gede dan pendampingan keluarga kepada 5 keluarga binaan yang terpilih. Evaluasi dilakukan sebanyak 2 kali, yaitu setelah penyuluhan kelas besar berupa pertanyaan pilihan ganda, dan setelah pendampingan keluarga berupa observasi checklist perilaku ya atau tidak. Hasil program pengabdian masyarakat di Desa Bayung Gede ini cukup baik. Penyuluhan kelas besar mampu meningkatkan pemahaman peserta mengenai pencegahan kecelakaan rumah tangga pada anak. Pendampingan kepada lima keluarga binaan berhasil mengidentifikasi perilaku-perilaku yang keliru dan kembali memberi penekanan untuk penerapan perilaku preventif yang lebih optimal. Ke depan, diharapkan adanya langkah yang kolaboratif dan berkesinambungan untuk dapat mewujudkan lingkungan rumah yang aman bagi anak.

Merchant Empowerment at Kedonganan Culinary Tourism Center in Preventing COVID-19 Desak Putu Citra Udiyani; Pande Ayu Naya Kasih Permatananda; Anny Eka Pratiwi
SAFARI :Jurnal Pengabdian Masyarakat Indonesia Vol. 2 No. 4 (2022): Oktober : Jurnal Pengabdian Masyarakat Indonesia
Publisher : BADAN PENERBIT STIEPARI PRESS

Along with the development of pandemic situation which entered the new normal era and successful vaccination of COVID-19, community activities in Bali's tourism centers began to gradually recover, including Kedonganan Beach. However, the risk of COVID-19 transmission remains high due to congested community activities and decreased of health protocols. The solutions and methods offered in this community service are COVID-19 and health protocols refreshment, health assistance and counseling, digital payment socialization, and the provision of hand sanitizers and masks to prevent COVID-19. The implementation of this PKM activity has been going well, seen from the attendance and enthusiasm of the participants, and there has been an increase in participants' knowledge and attitudes regarding the prevention of COVID-19. Through this activity, participants are expected to be an example for the community and keep discipline in implementing health protocols.

ANALISIS BODY MASS INDEX (BMI) DAN DERAJAT PROTEINURIA PADA PASIEN DIABETES MELITUS TIPE 2 DI DENPASAR Paramitha, I Gusti Ayu Mas Diah; Lestarini, Asri; Sari, Ni Luh Putu Eka Kartika; Aryastuti, Anak Agung Sri Agung; Permatananda, Pande Ayu Naya Kasih; Cahyawati, Putu Nita
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.43217

Diabetes melitus (DM) masih menjadi permasalahan kesehatan yang serius di dunia. Salah satu komplikasi DM tipe 2 yakni nefropati diabetik yang menyebabkan kerusakan pada struktur ginjal. DM tipe 2 timbul akibat adanya berbagai faktor risiko, seperti obesitas yang menunjukkan status gizi dan dapat diukur menggunakan body mass index (BMI). BMI menunjukkan tingkat metabolisme serta memengaruhi fungsi ginjal yang tercermin dari proteinuria pada DM tipe 2. Penelitian ini bertujuan untuk mengetahui hubungan antara BMI dengan derajat proteinuria pada pasien DM tipe 2 di Denpasar. Metode yang digunakan ialah observasi analitik dengan pendekatan cross sectional serta menggunakan 50 subjek DM tipe 2 yang tersimpan di Laboratorium Biomolekuler FKIK Universitas Warmadewa. Pengumpulan data dilakukan melalui formulir yang berisi data dasar penderita, data onset, tekanan darah, kadar gula darah puasa, data BMI, serta data protein dalam urin. Analisis data dilakukan secara univariat dan bivariat (uji Spearman). Hasil dari penelitian ini didapatkan bahwa sebagian besar subjek berjenis kelamin laki-laki (56%), berusia 61-70 tahun (44%), memiliki riwayat menderita DM tipe 2 kurang dari 10 tahun (56%), memiliki tekanan darah kategori pre hipertensi (52%), dan memiliki gula darah puasa (GDP) yang tinggi (62%). Mayoritas subjek tergolong dalam kategori BMI normal (52%) dan memiliki proteinuria positif +1 (62%). Nilai p pada penelitian ini adalah 0,235 artinya terdapat hubungan yang tidak signifikan antara body mass index (BMI) dengan derajat proteinuria pada pasien DM tipe 2 di Denpasar.

Aktivitas Antioksidan pada Ekstrak Limbah Kulit, Biji, dan Ampas Jeruk Siam Kintamani (Citrus nobilis et reticulata) dengan Pelarut Metanol Dewi, Ni Kadek Novia Puspita; Permatananda, Pande Ayu Naya Kasih; Udiyani, Desak Putu Citra; Nita Cahyawati, Putu; Wayan Erly Sintya Dewi, Ni
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 8 No. 5 (2025): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/2erqy756

This study aims to analyze the antioxidant activity of waste extracts from the peel, seeds, and pulp of Kintamani tangerines and to implement a practical approach to by-product management based on a zero-waste system. The method used is a pure experimental study with a post-test only design. Extraction was carried out through repeated maceration using methanol as a solvent. Antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and analyzed with a UV-Vis spectrophotometer at a wavelength of 517 nm. The results showed that the peel extract of Kintamani tangerines could fade the purple color of the DPPH solution, whereas the seed and pulp extracts did not show a significant change. The IC50 values were 136.17 ppm for the peel extract, 6727.86 ppm for the seed extract, and 497.57 ppm for the pulp extract. In conclusion, the peel extract of Kintamani tangerines exhibited the highest antioxidant activity among the three extracts, categorized as moderate based on Blois' classification. Keywords: Antioxidant Activity, Pulp, Kintamani Tangerine, Seed, DPPH, Peel

Relationship between physical activity and hypertension in adults in the working area of Puskesmas Tampaksiring I Wacika, Dewa Ngakan Gede Sathyananda; Permatananda, Pande Ayu Naya Kasih; Suyasa, Eka Ariawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.18840

Hypertension, often known as high blood pressure, is characterized by systolic blood pressure of at least 140 mmHg and/or diastolic blood pressure of at least 90 mmHg. Lack of regular physical activity is one of the risk factors for hypertension. This study aims to analyze the relationship between physical activity and the incidence of hypertension in adulthood. This study employs a cross-sectional design and analytical observational research methodology. The number of subjects in the study were 62 hypertension subjects and 62 non-hypertension subjects. Data was collected with the IPAQ-SF questionnaire to determine the level of physical activity. Data analysis was performed using the Chi-square statistical test. The results of the univariate analysis showed that the majority of research subjects were aged 41-60 years (53.2%), female (66.9%), and 91.5% of subjects with hypertension were classified as having low physical activity. There was a strong correlation between physical activity and the incidence of hypertension, as shown by the bivariate analysis, which yielded a value of p = 0,00 (p 0,05). The conclusion of this study was that there is a relationship between physical activity and the incidence of hypertension in adulthood in the working area of Tampaksiring I public health center.

Phytochemical and Antioxidant Capacity Test on Turmeric Extract (Curcuma Longa) Traditionally Processed in Bali Permatananda, Pande Ayu Naya Kasih; Aryastuti, Anak Agung Sri Agung; Cahyawati, Putu Nita; Udiyani, Desak Putu Citra; Wijaya, D.; Pandit, I Gde Suranaya; Wirajaya, Anak Agung Ngurah Mayun
Bali Membangun Bali: Jurnal Bappeda Litbang Vol 1 No 2 (2020): August 2020
Publisher : Badan Riset dan Inovasi Daerah Provinsi Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51172/jbmb.v1i2.115

Purpose: The purpose of this study was to determine the ways and objectives of the use of turmeric by Balinese, as well as the phytochemical content and antioxidant capacity of turmeric extract which is traditionally processed in Bali. Research methods: The method and purpose of utilizing turmeric were obtained through observation and interviews with 900 Balinese respondents. Quantitative phytochemical tests include starch, protein, flavonoid, tannin, phenol and vitamin C levels and qualitatively for the presence of triterpenes, steroids, alkaloids, and saponins. Antioxidant capacity was measured using the DPPH method. Findings: Through this research, we found there were only 36.8% of respondents had ever used turmeric as a traditional medicine. Utilization of turmeric was mostly in the form of loloh or traditional drinks. Phytochemical test results showed turmeric extract had 67.38% starch, 3.42% protein, 2709.39 mg/100 gr flavonoids, tannins 291.64 mg/100gr, phenol 1584.04 mg/100 gr, and vitamin C 0.06 mg/100gr. Qualitatively, turmeric extract contained triterpenes, alkaloids, and saponins, but did not contain steroids. The antioxidant capacity of turmeric extract was 70.9 mg/L GAEAC. Implications: Turmeric extract is a traditional medicine made from nature that is most commonly used by Balinese and very potential to be developed as an antibacterial, antioxidant, anti-inflammatory, or other benefits that still need further investigation.

Chemical and Microbiological Characteristics of Sei-Pindang Tuna Fish I Gde Suranaya Pandit; Pande Ayu Naya Kasih Permatananda; I Nengah Suaria
Formosa Journal of Multidisciplinary Research Vol. 2 No. 12 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v2i12.7258

Pindang is a fishery processing product that plays an important role in post-harvest activities. Pindang products have a relatively short shelf life, namely less than 2 days at room temperature. Smoking is a drying technique used to maintain the shelf life of fish by using wood fuel as a smoke producer. Pindang tuna that has undergone the smoking process is given the name Sei-Pindang Ikan Tongkol. The aim of this research is to determine the chemical and microbiological characteristics of Sei-Pindang Tuna Fish. The results showed that sei-pindang tuna had a water content of 44.69 ± 0.66%, histamine content of 11.88 ± 1.12 mg N/100 g, total volatile bases content of 43.23 ± 0.22 mg N/100 g and the total number of bacteria was 2.1 x104 ± 1.2 x103 cfu/g.

Pelatihan Penanganan Cedera Leher dan Patah Tulang pada Petugas Puskesmas III Denpasar Selatan Lestarini, Asri; Sumadewi, Komang Trisna; Aryastuti, Sri Agung; Permatananda, Pande Ayu Naya Kasih
INCOME: Indonesian Journal of Community Service and Engagement Vol 2 No 4 (2023)
Publisher : EDUPEDIA Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56855/income.v2i4.814

Angka kejadian patah tulang maupun cedera leher pada kecelakaan lalu lintas di Indonesia masih tinggi. Puskesmas III Denpasar Selatan menjadi salah satu tempat penanganan pasien dengan cedera leher dan patah tulang. Masalah yang dihadapi Petugas Puskesmas di bagian gawat darurat adalah kurangnya pelatihan dan penyegaran kembali mengenai penanganan cedera leher dan patah tulang, serta kurangnya peralatan yang memadai. Solusi masalah tersebut yaitu penyuluhan, pelatihan dan pendampingan penanganan cedera leher dan patah tulang, serta pemberian peralatan. Kegiatan penyuluhan, pelatihan dan pendampingan dilakukan di Puskesmas III Denpasar Selatan, dengan 14 petugas gawat darurat Puskesmas III Denpasar Selatan. Hasil program ini adalah adanya peningkatan pengetahuan yang dilihat dari hasil rerata postest (85,86) lebih tinggi dari hasil rerata pretest (70,43). Setelah diobservasi, didapatkan peningkatan kemampuan peserta untuk penanganan cedera leher dan patah tulang. Diharapkan dapat dilakukan kegiatan yang serupa sehingga menyegarkan kembali petugas Puskesmas III Denpasar Selatan dalam penanganan cedera leher dan patah tulang.

The Relationship Between Sleep Quality and Depression Level in Students During the Covid-19 Pandemic Period Permatananda, Pande Ayu Naya Kasih; Yamamoto, Sota; Kobayashi, Riko
World Psychology Vol. 4 No. 1 (2025)
Publisher : Sekolah Tinggi Agama Islam Al-Hikmah Pariangan Batusangkar, West Sumatra, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55849/wp.v4i1.799

The Covid-19 pandemic has caused significant disruptions in daily life, leading to various mental health challenges, particularly among students. Sleep quality and depression are closely related, with poor sleep often contributing to higher levels of depression. During the pandemic, changes in daily routines, increased stress, and social isolation have likely affected both sleep patterns and mental health. This study aims to investigate the relationship between sleep quality and depression levels in students during the Covid-19 pandemic period. A cross-sectional design was employed, with 300 university students completing an online survey. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and depression levels were measured with the Patient Health Questionnaire-9 (PHQ-9). The results indicated that students reporting poor sleep quality had significantly higher depression scores compared to those with better sleep quality. A negative correlation was found between sleep quality and depression levels, with poorer sleep associated with higher depression severity. The study concludes that poor sleep quality is a significant predictor of increased depression in students during the pandemic. These findings emphasize the need for interventions targeting sleep improvement as part of mental health support for students during and beyond the Covid-19 crisis.

Co-Authors Aceng Ali Awaludin Agus Santosa Anak Agung Gede Budhitresna, Anak Agung Gede Anak Agung Gede Raka Gunawarman Anak Agung Istri Kaila Kirtaniya Anak Agung Ngurah Mayun Wirajaya Anak Agung Raka Budayasa Anak Agung Sri Agung Aryastut Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anny Eka Pratiwi Apriliasari, Komang Vitri Apriliasari Aryastuti , Anak Agung Sri Agung Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Bayuningrat I Gusti Ngurah Made Bunga Mardhotillah Cahyawati , Putu Nita Cahyawati, Putu Nita Cokorda Agung Prasetya Dwipayana D. Wijaya Dariraditya Pemayun, Tjokorda Gde Agung Deivita, Yan Desak Putu Citra Udiyani Desak Putu Citra Udiyani Desak Putu Citra Udiyani Dewa Ngakan Gede Sathyananda Wacika Dewi, Erly Sintya Dewi, Ni Kadek Evi Komala Dewi, Ni Kadek Novia Puspita Dewi, Ni Wayan Erly Sintya Dewvi, Putu Ayu Savitri Didik Cahyono Eka Ariawan Suyasa Erlita Khrisinta Dewi Gede Budhitresna, Anak Agung Gunawan, Untung Gusti Ayu Putu Ratna Wati Heppi Syofya, Heppi Hotnida Nainggolan I Gde Suranaya Pandit I Gde Suranaya Pandit I Gede Suranaya Pandit I Gede Suranaya Pandit I Gusti Agung Made Adnyana Putra I Ketut Irianto I Made Wandia, I Made I Made Wira Supanji I Nengah Suaria I Putu Gede Eka Ariawan Suyasa, I Putu Gede Eka Ariawan I Putu Jaya Suputra I Putu Wirasatya Eka Putra I Wayan Eka Arsana I Wayan Putu Sutirta Yasa I Wayan Sudiarta I Wayan Sumardika I Wayan Wesna Astara Ian Astarina Mas'ud Ivan Permana Putra Kobayashi, Riko Lestarini, Asri Lim, Sofia Luh Gde Evayanti Luh Gde Evayanti Luh Gede Pradnyawati Luh Gede Sri Yenny Made Indra Wijaya MADE RATNA SARASWATI . Maidelwita, Yani Meilla Ayu Suryaningsih Ni Ketut Witri Cahyani Ni Luh Anik Puspa Ningsih Ni Luh Putu Eka Kartika Sari Ni Made Wenny Novtana Dharma Putra Ni Nyoman Yuni Wiastri Ni Putu Indah Kusumadewi Riandra Ni Wayan Ni Wayan Diana Ekayani Ni Wayan Erly Sintya Dewi Ni Wayan Rusni Ni wayan Sedani, Ni wayan Ni Wayan Widhidewi Ningsih, Ni Luh Anik Puspa Nirmalasari, Ni Kadek Diah Ayu Nita Cahyawati, Putu Pandit I Gde Suranaya Parameswara, A A Gde Agung Paramitha, I Gusti Ayu Mas Diah Pebrianti, Kadek Tari Pradnyawati Luh Gede Pradnyawati, Luh Gede Prima Dewi Kusumawati Pt Amelia Agustini Siadja Putra, I Putu Rustama Putri, Anak Agung Ayu Radismarani Putu Ayunda Trisnia Putu Nita Cahyawati Putu Nita Cahyawati Putu Nita Cahyawati Rabith Madah Khulaili Harsya Ratna Juwita Ratna Juwita, Dewa Ayu Putu Restu Widyo Sasongko Riandra, Ni Putu Indah Kusumadewi Ruspita Sari, Ni Ketut Adelia Sari, Made Harlina Purnama Sari, Ni Luh Putu Eka Kartika Sri Agung Aryastuti Sri Agung Aryastuti, Anak Agung Sudiadewi, Ni Putu Eka Sumadewi, Komang Trisna Sunariasih, Ni Nyoman Suyasa, Eka Ariawan Suyasning Hastiko Indonesiani Tan, Ethan Tanjung Subrata Tjokorda Gde Agung Dariraditya Pemayun Udiyani , Desak Putu Citra Udiyani Desak Putu Citra Udiyani, Desak Putu Citra Wacika, Dewa Ngakan Gede Sathyananda Wardana, Made Kusuma Wayan Erly Sintya Dewi, Ni Wesna Astara, I W2 Wibawa, I Komang Satriya Wijaya, D. Winarningsih, Rahayu Arum Wirajaya, Anak Agung Ngurah Mayun Yamamoto, Sota Yogiswara, Gde Candra Yoni, Putu Diah Paramitha Dwi Zulfayeni Zulfayeni

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