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Pande Ayu Naya Kasih Permatananda

Bagian Farmakologi Dan Farmasi Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Warmadewa

Author-ID : 296667

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The Effect of Ginger on Lowering Blood Pressure in The Elderly Widya Lusi Arisona; Pande Ayu Naya Kasih Permatananda; Cahyaning Rini Utami; Imam Jayanto; Ertati Suarni
Jurnal Teknologi dan Manajemen Industri Terapan Vol. 4 No. 3 (2025): Jurnal Teknologi dan Manajemen Industri Terapan
Publisher : Yayasan Inovasi Kemajuan Intelektual

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55826/jtmit.v4i3.1613

Hypertension is a significant global health challenge, especially in the elderly population experiencing decreased vascular physiological function. This study aims to analyze the effectiveness of ginger (Zingiber officinale) intervention as a complementary therapy in lowering blood pressure in the elderly. Using a quantitative design with a quasi-experimental pre-test and post-test group approach, this study evaluated changes in systolic and diastolic blood pressure after regular administration of ginger extract. The results showed a statistically significant decrease in blood pressure ($p < 0,05$) in the intervention group compared to the control group. The hypotensive mechanism of ginger is associated with its role as a natural calcium channel blocker and angiotensin-converting enzyme (ACE) inhibitor. This study concludes that ginger can be used as a safe and effective nutraceutical alternative to help manage hypertension in the elderly, improving quality of life and reducing the risk of cardiovascular complications.

Aktivitas Antioksidan pada Ekstrak Limbah Kulit, Biji, dan Ampas Jeruk Siam Kintamani (Citrus nobilis et reticulata) dengan Pelarut Metanol Ni Kadek Novia Puspita Dewi; Pande Ayu Naya Kasih Permatananda; Desak Putu Citra Udiyani; Putu Nita Cahyawati; Ni Wayan Erly Sintya Dewi
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 8 No. 5 (2025): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/2erqy756

This study aims to analyze the antioxidant activity of waste extracts from the peel, seeds, and pulp of Kintamani tangerines and to implement a practical approach to by-product management based on a zero-waste system. The method used is a pure experimental study with a post-test only design. Extraction was carried out through repeated maceration using methanol as a solvent. Antioxidant activity was tested using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method and analyzed with a UV-Vis spectrophotometer at a wavelength of 517 nm. The results showed that the peel extract of Kintamani tangerines could fade the purple color of the DPPH solution, whereas the seed and pulp extracts did not show a significant change. The IC50 values were 136.17 ppm for the peel extract, 6727.86 ppm for the seed extract, and 497.57 ppm for the pulp extract. In conclusion, the peel extract of Kintamani tangerines exhibited the highest antioxidant activity among the three extracts, categorized as moderate based on Blois' classification. Keywords: Antioxidant Activity, Pulp, Kintamani Tangerine, Seed, DPPH, Peel

Identifikasi Computer Vision Syndrome (Cvs) pada Pegawai Kantor Pemerintahan Kuta Utara, Bali I Komang Satriya Wibawa; Pande Ayu Naya Kasih Permatananda; Ni Wayan
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.44531

Computer Vision Syndrome atau CVS merupakan sekumpulan gejala pada mata dan leher yang disebabkan oleh penggunaan komputer atau layar monitor berlebihan. Penelitian terdahulu menunjukkan hampir 60 juta orang menderita CVS dan 1 juta kasus baru terjadi setiap tahun. Penelitian ini didesain untuk mengidentifikasi keluhan CVS pada pegawai kantor pemerintah. Penelitian akan dilakukan di Kantor Desa Tibubeneng, Kecamatan Kuta Utara, Kabupaten Badung-Bali. Penelitian ini merupakan penelitian deskriptif observasional dengan desain Cross-Sectional. Desain penelitian ini bertujuan untuk dapat mendeskripsikan hasil identifikasi keluhan CVS pada pegawai di Kantor Desa Tibubeneng. Pengumpulan data dilakukan melalui prosedur wawancara menggunakan kuesioner kemudian dilakukan analisa univariate untuk mendeskripsikan distribusi frekuensi dan persentase dari masing-masing variabel. Jumlah sampel dalam penelitian ini sebanyak 33 orang berdasarkan kriteria inklusi dan eksklusi penelitian. Penelitian ini menemukan bahwa sebagian besar responden penelitian yaitu pegawai kantor pemerintahan di Desa Tibubeneng Kuta Utara memiliki Computer Vision Syndrome dengan prevalensi sebesar 57,5%. Gejala astenopia terbanyak adalah mata lelah (90,9%). Mata berair merupakan gejala permukaan okuler tertinggi (54,5%). Sebagian besar responden mengeluhkan gejala visual berupa penglihatan kabur (42,4%). Manifestasi gejala ekstraokuler seperti nyeri punggung dan nyeri Pundak/bahu memiliki persentase yang sama yaitu 50%. Hasil penelitian mendorong adanya sosialisasi penggunaan kacamata anti radiasi serta penerapan duduk ergonomis bagi pegawai yang senantiasa bekerja dengan komputer.

Aktivitas Larvasida Eco-Enzyme Berbasis Limbah Kulit Jeruk Siam (Citrus nobilis) Dwiyami, Made Indriyani; Permatananda, Pande Ayu Naya Kasih; Sintya, Erly; Lestarini, Asri; Pandit, I Gde Suranaya
Jurnal Kesehatan Lingkungan Indonesia Vol 25, No 1 (2026): Februari 2026 (In process)
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.77435

Latar belakang: Demam Berdarah Dengue (DBD) termasuk dalam masalah kesehatan kompleks dengan angka kematian yang tinggi. Penatalaksanaan yang adekuat hingga saat ini belum optimal, sehingga modalitas yang tersisa adalah pencegahan. Namun program pencegahan konvensional melalui gerakan 3M+ termasuk penggunaan larvasida konvensional belum sepenuhnya efektif menekan kejadian DBD. Salah satu alternatif yang potensial adalah pemanfaatan larvasida berbahan limbah organik yaitu eco-enzyme. Riset ini memiliki tujuan untuk menganalisis potensi aktivitas larvasida dari eco-enzyme berbasis limbah kulit jeruk siam.Metode: Metode eksperimental berbasis post-test only controlled group dengan subjek penelitian berupa larva Aedes aegypti instar III yang masih bergerak aktif. Larva instar I dan II, larva mati, serta larva yang sudah berubah menjadi pupa dieksklusi. Uji larvasida dilakukan pada empat kelompok perlakuan dengan konsentrasi eco-enzyme sebesar 1,5%, 3%, 9%, dan 27%, serta satu kelompok kontrol tanpa pemberian eco-enzyme. Analisis dilakukan dengan menghitung jumlah larva yang hidup dan mati. Data dianalisis menggunakan uji Kruskal Walis jika data tidak terdistribusi normal, kemudian dilanjutkan dengan analisis Probit untuk menentukan efektivitas larvasida.Hasil: Semakin tinggi konsentrasi eco-enzyme limbah kulit jeruk siam, maka angka mortalitas larva Aedes aegypti juga makin tinggi. Konsentrasi tertinggi yang diberikan adalah 27 % dengan hasil kematian total larva Aedes aegypti sebanyak 60 larva (100%). Sebaliknya, pada konsentrasi 1,5%, tidak ditemukan kematian larva (0%). Pada kelompok kontrol tanpa pemberian eco-enzyme juga tidak terdapat kematian larva Aedes aegypti. Uji analisis menemukan bahwa setiap konsentrasi perlakuan terhadap larva Aedes aegypti memiliki efek yang signifikan (P<0,05), dengan nilai LC50 sebesar 6,77 % dan LC99 adalah 13,72 %. Simpulan: Eco-enzyme dengan bahan dasar limbah kulit jeruk siam memiliki potensi aktivitas larvasida untuk larva Aedes aegypti. ABSTRACT Title: Larvicide Activity of Eco-enzyme Derived From Siamese Orange Peel Waste (Citrus nobilis)Background: Dengue Hemorrhagic Fever (DHF) is a complex health problem with a high mortality rate. Adequate management has not been optimal to date, so the remaining modality is prevention. However, conventional prevention programs through the 3M+ movement, including the use of conventional larvicides, have not been fully effective in suppressing the incidence of dengue fever. One potential alternative is the use of organic waste-based larvicides, namely eco-enzymes. This research aims to analyze the potential larvicidal activity of eco-enzymes made from Siamese orange peel waste.Method: This study employed an experimental method with a post-test only controlled group design. The research subjects were actively moving Aedes aegypti larvae at the third instar stage. Larvae at instar I and II, dead larvae, and larvae that had developed into pupae were excluded. The larvicidal test was conducted on four treatment groups with eco-enzyme concentrations of 1.5%, 3%, 9%, and 27% as well as one control group without eco-enzyme exposure. Analysis was carried out by counting number of live and dead larvae. Data were analyzed using Kruskal Wallis if not normally distributed, followed by Probit analysis to determine larvicidal effectiveness. Result: The higher the concentration of eco-enzyme from Siamese orange peel waste, the higher the mortality rate of Aedes aegypti larvae. The highest concentration administered was 27%, resulting in a total of 60 dead Aedes aegypti larvae (100%). Conversely, at a concentration of 1.5%, no larval deaths were observed (0%). In the control group without eco-enzyme administration, there were also no deaths of Aedes aegypti larvae. The analysis test found that each treatment concentration against Aedes aegypti larvae had a significant effect (P<0.05), with an LC50 value of 6.77% and an LC99 value of 13.72%..Conclusion: Eco-enzyme derived from Siamese orange peel waste (Citrus nobilis) has potential larvicidal activity against Aedes aegypti larvae.

Antibacterial Activity of Tulsi Ethanolic Extract (Ocimum tenuiflorum L.) against Staphylococcus aureus Arisurya, I Gusti Ngurah Kezawa; Permatananda, Pande Ayu Naya Kasih; Dewi, Ni Wayan Erly Sintya; Pandit, I Gde Suranaya
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.14238

Infectious disease is a type of disease caused by invasion by microbiological agents, such as bacteria. One type of bacteria is Staphylococcus aureus which is a Gram-positive bacteria. The definitive therapy for bacterial infections is the administration of antibiotics. However, overuse of antibiotics leads to bacterial resistance. One of the efforts to overcome this is with alternative antibiotics made from herbs, such as Tulsi (Ocimum tenuiflorum L.). This study aims to determine the antibacterial activity of Tulsi ethanolic extract against S. aureus. This research was conducted at the Analysis Laboratory of the Faculty of Agriculture, Warmadewa University from October to November 2024. The research design used a true experimental method with a posttest only control group design model, namely by testing the antibacterial activity of Tulsi ethanolic extract with concentrations of 25%, 50%, and 75% against S. aureus. In the antibacterial test results, the diameter of the inhibition zone formed at concentrations of 25%, 50%, and 75% was 5.25 mm, 5.90 mm, and 7.22 mm, respectively. Based on the One Way ANOVA test results, the P value <0.001 was obtained, which means there is a significant difference between the treatment groups. Based on this study, it can be concluded that Tulsi ethanolic extract has moderate antibacterial activity.

The Urgency of Free Health Service Policy in Increasing Indonesia's Human Development Index Aceng Ali Awaludin; Restu Widyo Sasongko; Pande Ayu Naya Kasih Permatananda; Heppi Syofya; Untung Gunawan
Reslaj: Religion Education Social Laa Roiba Journal Vol. 7 No. 5 (2025): RESLAJ: Religion Education Social Laa Roiba Journal
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/reslaj.v7i5.8111

This study is a qualitative study with a descriptive approach, namely an approach that details one by one using descriptive text on each main topic used in this article, including Health, Human Development Index, and Free Health Check Policy. The data used in this study are secondary data that researchers obtain from second sources or indirect sources. Although obtained from indirect sources, researchers still select the research sources obtained and it can be ensured that the sources used by researchers are reliable. The research sources used in this study include books, scientific articles, magazines, and various other sources used in each study. The data obtained were analyzed by the stages of data collection, data reduction, data selection, and drawing conclusions.

Urgency of BPJS Policy Specifically for Farmers in Improving Farmer Welfare in Indonesia Harsya, Rabith Madah Khulaili; Mardhotillah, Bunga; Dewi, Erlita Khrisinta; Permatananda, Pande Ayu Naya Kasih; Nainggolan, Hotnida
Reslaj: Religion Education Social Laa Roiba Journal Vol. 7 No. 11 (2025): RESLAJ: Religion Education Social Laa Roiba Journal
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/reslaj.v7i11.10350

This research is qualitative with a descriptive approach. The data used in this study are secondary data obtained by the researcher from indirect sources such as books, scientific articles, magazines, and so on. The data obtained were analyzed through the stages of data collection, data reduction, data selection, and conclusion drawing. The conclusion in this article show that the implementation of BPJS or health insurance for farmers has a very urgent meaning for the welfare explained in several previous paragraphs, namely related to economic sovereignty, peace, and happiness. With BPJS or health insurance for farmers, it can anticipate unexpected expenses related to farmers' health. Farmers can feel safer and happier, and can focus more on business development, increasing income, and improving product creativity. Thus, the researcher concludes, the implementation of BPJS specifically for farmers has a very close urgency in creating farmer welfare.

Co-Authors Aceng Ali Awaludin Agus Santosa Anak Agung Gede Budhitresna, Anak Agung Gede Anak Agung Gede Raka Gunawarman Anak Agung Istri Kaila Kirtaniya Anak Agung Ngurah Mayun Wirajaya Anak Agung Raka Budayasa Anak Agung Sri Agung Aryastut Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anny Eka Pratiwi Apriliasari, Komang Vitri Apriliasari Arisurya, I Gusti Ngurah Kezawa Aryastuti , Anak Agung Sri Agung Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Bayuningrat I Gusti Ngurah Made Cahyawati , Putu Nita Cahyawati, Putu Nita Cokorda Agung Prasetya Dwipayana D. Wijaya Dariraditya Pemayun, Tjokorda Gde Agung Deivita, Yan Desak Putu Citra Udiyani Desak Putu Citra Udiyani Desak Putu Citra Udiyani Dewa Ngakan Gede Sathyananda Wacika Dewi, Erlita Khrisinta Dewi, Erly Sintya Dewi, Ni Kadek Evi Komala Dewi, Ni Wayan Erly Sintya Dewvi, Putu Ayu Savitri Didik Cahyono Dwiyami, Made Indriyani Eka Ariawan Suyasa Gede Budhitresna, Anak Agung Gunawan, Untung Gusti Ayu Putu Ratna Wati Harsya, Rabith Madah Khulaili Heppi Syofya, Heppi Hotnida Nainggolan I Gde Suranaya Pandit I Gde Suranaya Pandit I Gede Suranaya Pandit I Gede Suranaya Pandit I Gusti Agung Made Adnyana Putra I Ketut Irianto I Komang Satriya Wibawa I Made Wandia, I Made I Made Wira Supanji I Nengah Suaria I Putu Gede Eka Ariawan Suyasa, I Putu Gede Eka Ariawan I Putu Jaya Suputra I Putu Wirasatya Eka Putra I Wayan Eka Arsana I Wayan Putu Sutirta Yasa I Wayan Sudiarta I Wayan Sumardika I Wayan Wesna Astara Ian Astarina Mas'ud Imam Jayanto Ivan Permana Putra Kobayashi, Riko Lestarini, Asri Lim, Sofia Luh Gde Evayanti Luh Gde Evayanti Luh Gede Pradnyawati Luh Gede Sri Yenny Made Indra Wijaya MADE RATNA SARASWATI . Maidelwita, Yani Mardhotillah, Bunga Meilla Ayu Suryaningsih Ni Kadek Novia Puspita Dewi Ni Ketut Witri Cahyani Ni Luh Anik Puspa Ningsih Ni Luh Putu Eka Kartika Sari Ni Made Wenny Novtana Dharma Putra Ni Nyoman Yuni Wiastri Ni Putu Indah Kusumadewi Riandra Ni Wayan Ni Wayan Diana Ekayani Ni Wayan Erly Sintya Dewi Ni Wayan Erly Sintya Dewi Ni Wayan Rusni Ni wayan Sedani, Ni wayan Ni Wayan Widhidewi Ningsih, Ni Luh Anik Puspa Nirmalasari, Ni Kadek Diah Ayu Nita Cahyawati, Putu Pandit I Gde Suranaya Parameswara, A A Gde Agung Paramitha, I Gusti Ayu Mas Diah Pebrianti, Kadek Tari Pradnyawati Luh Gede Pradnyawati, Luh Gede Prima Dewi Kusumawati Pt Amelia Agustini Siadja Putra, I Putu Rustama Putri, Anak Agung Ayu Radismarani Putu Ayunda Trisnia Putu Nita Cahyawati Putu Nita Cahyawati Putu Nita Cahyawati Ratna Juwita Ratna Juwita, Dewa Ayu Putu Restu Widyo Sasongko Riandra, Ni Putu Indah Kusumadewi Ruspita Sari, Ni Ketut Adelia Sari, Made Harlina Purnama Sari, Ni Luh Putu Eka Kartika Sintya, Erly Sri Agung Aryastuti Sri Agung Aryastuti, Anak Agung Suarni, Ertati Sudiadewi, Ni Putu Eka Sumadewi, Komang Trisna Sunariasih, Ni Nyoman Suyasa, Eka Ariawan Suyasning Hastiko Indonesiani Tan, Ethan Tanjung Subrata Tjokorda Gde Agung Dariraditya Pemayun Udiyani , Desak Putu Citra Udiyani Desak Putu Citra Udiyani, Desak Putu Citra Utami, Cahyaning Rini Wacika, Dewa Ngakan Gede Sathyananda Wardana, Made Kusuma Wesna Astara, I W2 Widya Lusi Arisona Wijaya, D. Winarningsih, Rahayu Arum Wirajaya, Anak Agung Ngurah Mayun Yamamoto, Sota Yogiswara, Gde Candra Yoni, Putu Diah Paramitha Dwi Zulfayeni Zulfayeni

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