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Pande Ayu Naya Kasih Permatananda

Bagian Farmakologi Dan Farmasi Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Warmadewa

Author-ID : 296667

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Overview of knowledge, attitudes and behavior of housewives in Denpasar City towards self-medication Ruspita Sari, Ni Ketut Adelia; Kasih Permatananda, Pande Ayu Naya; Cahyawati, Putu Nita; Aryastuti, Sri Agung; Lestarini, Asri
Science Midwifery Vol 12 No 6 (2025): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i6.1840

Self-medication is an effort to prevent and treat diseases without consulting a doctor, with housewives as the main actors. Factors that influence self-medication are knowledge, attitudes, and behavior. This study aims to determine the level of knowledge, attitudes, and behavior of housewives in Denpasar towards self-medication. The method used is descriptive observational with a cross-sectional approach. Respondents numbered 100 people who were selected based on inclusion and exclusion criteria. Data were collected through questionnaires and analyzed in the form of a frequency distribution table. The majority of respondents were 26-35 years old (60%), had a college/diploma education (68%), and worked as private employees (39%). The most frequently used medicine was cough and cold medicine (37%). The results showed that 67% of respondents had high knowledge, 58% had a positive attitude, and 92% had good behavior in self-medication. It is hoped that the results of this study will encourage rational self-medication practices, with the support of the government and health institutions in comprehensive education programs, including drug classification. The government and related agencies, including health education institutions, are trying to strengthen self-medication knowledge improvement programs, which not only focus on DAGUSIBU (can, use, store, dispose), but also drug classification and others.

PENGARUH FAKTOR LINGKUNGAN TERHADAP KESEHATAN IBU DAN BAYI SAAT MELAHIRKAN Kusumawati, Prima Dewi; Deivita, Yan; Winarningsih, Rahayu Arum; Permatananda, Pande Ayu Naya Kasih; Maidelwita, Yani
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 1 (2025): APRIL 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i1.43582

Lingkungan memiliki pengaruh yang signifikan terhadap kesehatan ibu dan bayi, terutama selama masa kehamilan hingga proses melahirkan. Artikel ini bertujuan untuk menganalisis hubungan antara faktor lingkungan dengan kesehatan ibu dan bayi menggunakan pendekatan kualitatif. Penelitian ini mengkaji literatur yang relevan untuk mengidentifikasi tema utama terkait dampak sanitasi, polusi udara, akses terhadap fasilitas kesehatan, serta kualitas lingkungan binaan terhadap hasil kehamilan. Hasil analisis menunjukkan bahwa sanitasi yang buruk, seperti kurangnya akses air bersih dan pengelolaan limbah yang tidak memadai, meningkatkan risiko infeksi yang dapat menyebabkan komplikasi kehamilan. Polusi udara, terutama paparan partikel halus (PM2.5), dikaitkan dengan kelahiran prematur dan berat badan lahir rendah. Selain itu, keterbatasan akses ke fasilitas kesehatan di daerah terpencil menghambat layanan prenatal yang esensial, sehingga meningkatkan risiko komplikasi saat melahirkan. Kualitas lingkungan binaan juga memainkan peran penting; rumah dengan ventilasi buruk dan minimnya ruang hijau dapat memengaruhi kesehatan fisik dan mental ibu hamil. Faktor sosial-ekonomi memperburuk dampak lingkungan negatif ini, terutama pada kelompok masyarakat berpenghasilan rendah. Artikel ini menekankan pentingnya intervensi berbasis kebijakan untuk meningkatkan sanitasi, mengurangi polusi udara, memperluas akses layanan kesehatan, dan menciptakan lingkungan binaan yang mendukung kesehatan ibu dan bayi. Dengan demikian, upaya multidisiplin diperlukan untuk memastikan hasil kehamilan yang lebih baik dan menurunkan angka morbiditas serta mortalitas ibu dan bayi.

Antibiotic use at the ear, nose, and throat outpatient clinic in Bangli Regional Hospital, Bali Sudiadewi, Ni Putu Eka; Permatananda, Pande Ayu Naya Kasih; Udiyani, Desak Putu Citra; Cahyawati, Putu Nita; Aryastuti, Sri Agung
Indonesian Journal of Pharmacology and Therapy Vol 6 No 2 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.20992

Ear, nose, and throat (ENT) diseases are defined as diseases that occur around the ear, nose, and throat organs, which do not recognize seasons and can affect various ages. The prevalence of ENT diseases in Indonesia is quite high, with the most common therapy being antibiotics. Irrational antibiotics use can lead to increased treatment costs, risk of side effects, and toxicity. This study aimed to evaluate the use of antibiotics among ENT outpatient. This was a cross-sectional study using medical records data from the ENT Outpatient Clinic in Bangli Regional Hospital in 2022 that meet the inclusion criteria. Data were analyzed descriptively and presented in tables or diagrams. A total of 80 samples were evaluated, predominantly aged 18-44 yo (60%), female (53.8%), and diagnosed with chronic suppurative otitis media (20%). The pattern of antibiotic prescription consisted of monotherapy antibiotics (62.5%) in solid dosage forms (58.8%), administered orally (60%), and with a duration of administration ≥ 5 d (82.5%). Patients aged 18-44 yr, both male and female, receiving either monotherapy orpolytherapy antibiotics were predominantly cases of infection (>90%). The results of this study are expected to serve as one of the sources of information for the development of practical clinical guidelines for ENT patients receiving antibiotic therapy, particularly at the Bangli Regional Hospital, Bali.

From Tradition to Translation: A Systematic Review on the Pharmacological Actions of Eugenol Extracted from Ocimum Plants in Oxidative Stress, Inflammation, and Diabetes Mellitus Permatananda, Pande Ayu Naya Kasih; I Wayan Putu Sutirta Yasa; I Wayan Sumardika; Made Ratna Saraswati; I Gde Suranaya Pandit
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 6 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i6.1302

Background: Ocimum species, commonly known as basil, have a rich history in traditional medicine for various ailments. Eugenol, a primary bioactive compound found in several Ocimum species, has garnered significant scientific attention for its potential therapeutic properties. This systematic review aimed to comprehensively evaluate the pharmacological actions of eugenol extracted from Ocimum plants in the context of oxidative stress, inflammation, and diabetes mellitus. Methods: A systematic literature search was conducted across major scientific databases for studies published between 2013 and 2024 that investigated the effects of eugenol derived from Ocimum plants on oxidative stress, inflammation, and diabetes mellitus. The search strategy included keywords such as "eugenol," "Ocimum," "antioxidant," "anti-inflammatory," and "antidiabetic." Inclusion criteria for studies involving in vitro, in vivo, and clinical studies that specifically examined the pharmacological actions of eugenol extracted from Ocimum species in the aforementioned conditions. Data on study design, intervention, outcomes, and key findings were extracted and synthesized narratively. Results: The review identified ten key studies that met the inclusion criteria. These studies collectively suggested that eugenol extracted from Ocimum plants exhibited significant antioxidant activity by scavenging free radicals and enhancing endogenous antioxidant enzymes. Furthermore, eugenol demonstrated anti-inflammatory effects by modulating pro-inflammatory cytokines and inhibiting key inflammatory pathways such as NF-κB and COX. In the context of diabetes mellitus, studies indicated that eugenol could improve glucose metabolism by enhancing insulin sensitivity, protecting pancreatic beta cells, and inhibiting carbohydrate metabolizing enzymes. Conclusion: This systematic review provided a comprehensive overview of the pharmacological actions of eugenol extracted from Ocimum plants in mitigating oxidative stress, inflammation, and diabetes mellitus. The findings from the included studies supported the traditional uses of Ocimum species and highlighted the therapeutic potential of eugenol as a natural agent in managing these conditions. Further well-designed clinical trials are warranted to validate these preclinical findings and translate them into clinical applications.

Program Pengabdian Masyarakat dalam Rangka Pencegahan Kecelakaan Rumah Tangga pada Anak di Desa Bayung Gede, Kintamani : Pengabdian Pande Ayu Naya Kasih Permatananda; I Gde Suranaya Pandit; Desak Putu Citra Udiyani; Putu Nita Cahyawati; Asri Lestarini
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 3 No. 4 (2025): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 3 Nomor 4 (April 2025
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v3i4.1119

Anak-anak merupakan korban tersering dari kecelakaan rumah tangga, yang sebagian besar terjadi pada anak-anak yang hidup di negara miskin dan berkembang. Pencegahan dan kontrol kecelakaan rumah tangga pada anak di bawah 5 tahun disebutkan cukup efektif dalam mehurunkan mortalitas akibat kecelakaan. Program pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan keluarga dalam melakukan pencegahan kecelakaan rumah tangga. Metode transfer ilmu pengetahuan yang digunakan dalam kegiatan ini meliputi penyuluhan kelas besar pada perwakilan keluarga di Desa Bayung Gede dan pendampingan keluarga kepada 5 keluarga binaan yang terpilih. Evaluasi dilakukan sebanyak 2 kali, yaitu setelah penyuluhan kelas besar berupa pertanyaan pilihan ganda, dan setelah pendampingan keluarga berupa observasi checklist perilaku ya atau tidak. Hasil program pengabdian masyarakat di Desa Bayung Gede ini cukup baik. Penyuluhan kelas besar mampu meningkatkan pemahaman peserta mengenai pencegahan kecelakaan rumah tangga pada anak. Pendampingan kepada lima keluarga binaan berhasil mengidentifikasi perilaku-perilaku yang keliru dan kembali memberi penekanan untuk penerapan perilaku preventif yang lebih optimal. Ke depan, diharapkan adanya langkah yang kolaboratif dan berkesinambungan untuk dapat mewujudkan lingkungan rumah yang aman bagi anak.

Merchant Empowerment at Kedonganan Culinary Tourism Center in Preventing COVID-19 Desak Putu Citra Udiyani; Pande Ayu Naya Kasih Permatananda; Anny Eka Pratiwi
SAFARI :Jurnal Pengabdian Masyarakat Indonesia Vol. 2 No. 4 (2022): Oktober : Jurnal Pengabdian Masyarakat Indonesia
Publisher : BADAN PENERBIT STIEPARI PRESS

Along with the development of pandemic situation which entered the new normal era and successful vaccination of COVID-19, community activities in Bali's tourism centers began to gradually recover, including Kedonganan Beach. However, the risk of COVID-19 transmission remains high due to congested community activities and decreased of health protocols. The solutions and methods offered in this community service are COVID-19 and health protocols refreshment, health assistance and counseling, digital payment socialization, and the provision of hand sanitizers and masks to prevent COVID-19. The implementation of this PKM activity has been going well, seen from the attendance and enthusiasm of the participants, and there has been an increase in participants' knowledge and attitudes regarding the prevention of COVID-19. Through this activity, participants are expected to be an example for the community and keep discipline in implementing health protocols.

ANALISIS BODY MASS INDEX (BMI) DAN DERAJAT PROTEINURIA PADA PASIEN DIABETES MELITUS TIPE 2 DI DENPASAR Paramitha, I Gusti Ayu Mas Diah; Lestarini, Asri; Sari, Ni Luh Putu Eka Kartika; Aryastuti, Anak Agung Sri Agung; Permatananda, Pande Ayu Naya Kasih; Cahyawati, Putu Nita
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.43217

Diabetes melitus (DM) masih menjadi permasalahan kesehatan yang serius di dunia. Salah satu komplikasi DM tipe 2 yakni nefropati diabetik yang menyebabkan kerusakan pada struktur ginjal. DM tipe 2 timbul akibat adanya berbagai faktor risiko, seperti obesitas yang menunjukkan status gizi dan dapat diukur menggunakan body mass index (BMI). BMI menunjukkan tingkat metabolisme serta memengaruhi fungsi ginjal yang tercermin dari proteinuria pada DM tipe 2. Penelitian ini bertujuan untuk mengetahui hubungan antara BMI dengan derajat proteinuria pada pasien DM tipe 2 di Denpasar. Metode yang digunakan ialah observasi analitik dengan pendekatan cross sectional serta menggunakan 50 subjek DM tipe 2 yang tersimpan di Laboratorium Biomolekuler FKIK Universitas Warmadewa. Pengumpulan data dilakukan melalui formulir yang berisi data dasar penderita, data onset, tekanan darah, kadar gula darah puasa, data BMI, serta data protein dalam urin. Analisis data dilakukan secara univariat dan bivariat (uji Spearman). Hasil dari penelitian ini didapatkan bahwa sebagian besar subjek berjenis kelamin laki-laki (56%), berusia 61-70 tahun (44%), memiliki riwayat menderita DM tipe 2 kurang dari 10 tahun (56%), memiliki tekanan darah kategori pre hipertensi (52%), dan memiliki gula darah puasa (GDP) yang tinggi (62%). Mayoritas subjek tergolong dalam kategori BMI normal (52%) dan memiliki proteinuria positif +1 (62%). Nilai p pada penelitian ini adalah 0,235 artinya terdapat hubungan yang tidak signifikan antara body mass index (BMI) dengan derajat proteinuria pada pasien DM tipe 2 di Denpasar.

Relationship between physical activity and hypertension in adults in the working area of Puskesmas Tampaksiring I Wacika, Dewa Ngakan Gede Sathyananda; Permatananda, Pande Ayu Naya Kasih; Suyasa, Eka Ariawan
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.18840

Hypertension, often known as high blood pressure, is characterized by systolic blood pressure of at least 140 mmHg and/or diastolic blood pressure of at least 90 mmHg. Lack of regular physical activity is one of the risk factors for hypertension. This study aims to analyze the relationship between physical activity and the incidence of hypertension in adulthood. This study employs a cross-sectional design and analytical observational research methodology. The number of subjects in the study were 62 hypertension subjects and 62 non-hypertension subjects. Data was collected with the IPAQ-SF questionnaire to determine the level of physical activity. Data analysis was performed using the Chi-square statistical test. The results of the univariate analysis showed that the majority of research subjects were aged 41-60 years (53.2%), female (66.9%), and 91.5% of subjects with hypertension were classified as having low physical activity. There was a strong correlation between physical activity and the incidence of hypertension, as shown by the bivariate analysis, which yielded a value of p = 0,00 (p 0,05). The conclusion of this study was that there is a relationship between physical activity and the incidence of hypertension in adulthood in the working area of Tampaksiring I public health center.

Phytochemical and Antioxidant Capacity Test on Turmeric Extract (Curcuma Longa) Traditionally Processed in Bali Permatananda, Pande Ayu Naya Kasih; Aryastuti, Anak Agung Sri Agung; Cahyawati, Putu Nita; Udiyani, Desak Putu Citra; Wijaya, D.; Pandit, I Gde Suranaya; Wirajaya, Anak Agung Ngurah Mayun
Bali Membangun Bali: Jurnal Bappeda Litbang Vol 1 No 2 (2020): August 2020
Publisher : Badan Riset dan Inovasi Daerah Provinsi Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51172/jbmb.v1i2.115

Purpose: The purpose of this study was to determine the ways and objectives of the use of turmeric by Balinese, as well as the phytochemical content and antioxidant capacity of turmeric extract which is traditionally processed in Bali. Research methods: The method and purpose of utilizing turmeric were obtained through observation and interviews with 900 Balinese respondents. Quantitative phytochemical tests include starch, protein, flavonoid, tannin, phenol and vitamin C levels and qualitatively for the presence of triterpenes, steroids, alkaloids, and saponins. Antioxidant capacity was measured using the DPPH method. Findings: Through this research, we found there were only 36.8% of respondents had ever used turmeric as a traditional medicine. Utilization of turmeric was mostly in the form of loloh or traditional drinks. Phytochemical test results showed turmeric extract had 67.38% starch, 3.42% protein, 2709.39 mg/100 gr flavonoids, tannins 291.64 mg/100gr, phenol 1584.04 mg/100 gr, and vitamin C 0.06 mg/100gr. Qualitatively, turmeric extract contained triterpenes, alkaloids, and saponins, but did not contain steroids. The antioxidant capacity of turmeric extract was 70.9 mg/L GAEAC. Implications: Turmeric extract is a traditional medicine made from nature that is most commonly used by Balinese and very potential to be developed as an antibacterial, antioxidant, anti-inflammatory, or other benefits that still need further investigation.

Chemical and Microbiological Characteristics of Sei-Pindang Tuna Fish I Gde Suranaya Pandit; Pande Ayu Naya Kasih Permatananda; I Nengah Suaria
Formosa Journal of Multidisciplinary Research Vol. 2 No. 12 (2023): December 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjmr.v2i12.7258

Pindang is a fishery processing product that plays an important role in post-harvest activities. Pindang products have a relatively short shelf life, namely less than 2 days at room temperature. Smoking is a drying technique used to maintain the shelf life of fish by using wood fuel as a smoke producer. Pindang tuna that has undergone the smoking process is given the name Sei-Pindang Ikan Tongkol. The aim of this research is to determine the chemical and microbiological characteristics of Sei-Pindang Tuna Fish. The results showed that sei-pindang tuna had a water content of 44.69 ± 0.66%, histamine content of 11.88 ± 1.12 mg N/100 g, total volatile bases content of 43.23 ± 0.22 mg N/100 g and the total number of bacteria was 2.1 x104 ± 1.2 x103 cfu/g.

Co-Authors Aceng Ali Awaludin Agus Santosa Anak Agung Gede Budhitresna, Anak Agung Gede Anak Agung Gede Raka Gunawarman Anak Agung Istri Kaila Kirtaniya Anak Agung Raka Budayasa Anak Agung Sri Agung Aryastut Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anak Agung Sri Agung Aryastuti Anny Eka Pratiwi Apriliasari, Komang Vitri Apriliasari Aryastuti , Anak Agung Sri Agung Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Asri Lestarini Bayuningrat I Gusti Ngurah Made Bunga Mardhotillah Cahyawati , Putu Nita Cahyawati, Putu Nita Cokorda Agung Prasetya Dwipayana D. Wijaya Dariraditya Pemayun, Tjokorda Gde Agung Deivita, Yan Desak Putu Citra Udiyani Desak Putu Citra Udiyani Dewa Ngakan Gede Sathyananda Wacika Dewi, Erly Sintya Dewi, Ni Kadek Evi Komala Dewi, Ni Wayan Erly Sintya Dewvi, Putu Ayu Savitri Didik Cahyono Dwiyami, Made Indriyani Eka Ariawan Suyasa Erlita Khrisinta Dewi Gde Candra Yogiswara Gede Budhitresna, Anak Agung Gunawan, Untung Gusti Ayu Putu Ratna Wati Heppi Syofya, Heppi Hotnida Nainggolan I Gde Suranaya Pandit I Gde Suranaya Pandit I Gede Suranaya Pandit I Gede Suranaya Pandit I Gede Suranaya Pandit I Gusti Agung Made Adnyana Putra I Gusti Ngurah Kezawa Arisurya I Ketut Irianto I Komang Satriya Wibawa I Made Wandia, I Made I Made Wira Supanji I Nengah Suaria I Putu Gede Eka Ariawan Suyasa, I Putu Gede Eka Ariawan I Putu Jaya Suputra I Putu Rustama Putra I Putu Wirasatya Eka Putra I Wayan Eka Arsana I Wayan Putu Sutirta Yasa I Wayan Sudiarta I Wayan Sumardika I Wayan Wesna Astara Ian Astarina Mas'ud Imam Jayanto Ivan Permana Putra Kobayashi, Riko Komang Vitri Apriliasari Apriliasari Lestarini, Asri Lim, Sofia Luh Gde Evayanti Luh Gede Pradnyawati Luh Gede Sri Yenny Made Indra Wijaya MADE RATNA SARASWATI . Maidelwita, Yani Meilla Ayu Suryaningsih Ni Kadek Inka Widyasastrawati Ni Kadek Novia Puspita Dewi Ni Ketut Witri Cahyani Ni Luh Anik Puspa Ningsih Ni Luh Putu Eka Kartika Sari Ni Made Wenny Novtana Dharma Putra Ni Nyoman Yuni Wiastri Ni Putu Indah Kusumadewi Riandra Ni Wayan Ni Wayan Diana Ekayani Ni Wayan Erly Sintya Dewi Ni Wayan Erly Sintya Dewi Ni Wayan Rusni Ni wayan Sedani, Ni wayan Ni Wayan Widhidewi Ningsih, Ni Luh Anik Puspa Nirmalasari, Ni Kadek Diah Ayu Nita Cahyawati, Putu Pandit I Gde Suranaya Parameswara, A A Gde Agung Paramitha, I Gusti Ayu Mas Diah Pebrianti, Kadek Tari Pradnyawati, Luh Gede Prima Dewi Kusumawati Pt Amelia Agustini Siadja Pt Amelia Agustini Siadja Putra, I Putu Rustama Putra, Made Rangga Dwinanta Putu Nita Cahyawati Putu Nita Cahyawati Putu Nita Cahyawati Putu Nita Cahyawati Putu Nita Cahyawati Rabith Madah Khulaili Harsya Ratna Juwita Ratna Juwita, Dewa Ayu Putu Restu Widyo Sasongko Ruspita Sari, Ni Ketut Adelia Sari, Made Harlina Purnama Sari, Ni Luh Putu Eka Kartika Sintya, Erly Sri Agung Aryastuti Sri Agung Aryastuti, Anak Agung Sri Agung Aryatuti Suarni, Ertati Sudiadewi, Ni Putu Eka Sumadewi, Komang Trisna Sunariasih, Ni Nyoman Suyasa, Eka Ariawan Suyasning Hastiko Indonesiani Tan, Ethan Tanjung Subrata Tjokorda Gde Agung Dariraditya Pemayun Trisnia, Putu Ayunda Udiyani , Desak Putu Citra Udiyani, Desak Putu Citra Utami, Cahyaning Rini Wacika, Dewa Ngakan Gede Sathyananda Wardana, Made Kusuma Wesna Astara, I W2 Widya Lusi Arisona Wijaya, D. Winarningsih, Rahayu Arum Wirajaya, Anak Agung Ngurah Mayun Wirajaya, Anak Agung Ngurah Mayun Yamamoto, Sota Yogiswara, Gde Candra Yoni, Putu Diah Paramitha Dwi Zulfayeni Zulfayeni

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