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Komariah Komariah
brawijaya university
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Journal : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

 1 
Antibacterial Activity of Nanocomposite Chitosan-Silver Nanoparticle with Cymbopogon citratus Extract as a Bioreductor Against Staphylococcus aureus Anggraeni, Rezky; Melyda, Ananda Shelly; Pakpahan, Alfred; Ranggaini, Dewi; Halim, Johni; Komariah, Komariah
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 10, No 2 (2025): June 2025
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v10.i2.112

Abstract

Nanocomposites are materials formed by combining two components, one or both of which are on the nanometer scale. The nanocomposite in this study is a combination of chitosan and silver nanoparticles produced through the synthesis of silver nitrate using Cymbopogon citratus extract. Silver nanoparticles have antibacterial abilities that can be utilized to overcome various diseases. However, their antibacterial properties may be reduced due to the tendency of silver nanoparticles to agglomerate. This can be overcome by the addition of chitosan as a stabilizing agent to prevent agglomeration and maintain the antibacterial effectiveness of silver nanoparticles. This study aims to evaluate the antibacterial activity of a nanocomposite formed by combining chitosan and silver nanoparticles synthesized using Cymbopogon citratus extract against Staphylococcus aureus through the diffusion method. The samples used included nanocomposites at concentrations of 6.25 mg/mL, 12.5 mg/mL, 15 mg/mL, 25 mg/mL, and 50 mg/mL, amoxicillin as a positive control, Acetic acid, and distilled water as negative controls. The results of antibacterial activity testing showed that all nanocomposite test concentrations had the ability to inhibit the growth of Staphylococcus aureus as evidenced by the formation of an inhibition zone around the disc paper. However, the highest antibacterial activity shown by the nanocomposites was still lower compared to the antibacterial activity of amoxicillin Keywords: Antibacterial activity, Chitosan, Cymbopogon citratus, Silver nanoparticles, Staphylococcus aureus
Co-Authors Abdul Kadir Ageng Septa Rini Agustina, Yeyen Ahmad Suriadi, Ahmad AKTAVIA HERAWATI Alfred Pakpahan, Alfred Andy Wirahadikusumah Anggelisa, Mutia Anggraeni , Rezky Anggraeni, Rezky Anggraeny Putri Sekar Palupi Anggreani, Febry Annisa, Fauziah Rahma Apriyansyah, Chandra Aribah, Nada Erica Arini, Dewi Ulfah Ariyani, Annisa Putri Aryanti, Sasty Asrial Awiyah, Awiyah Azima, Nishfa Syahira Azrianty, Annisa Azzahra, Vista Ulya Bambang Pontjo Priosoeryanto Bambang Subali Budiastuti, Maria Theresia Sri Budiati, Endang Burhanuddin Burhanuddin Bustam, Del Afriadi Carolina Marpaung, Carolina Chairunissa, Chairunissa Darma, Joshua Dayani, Sandri Deviyanti Pratiwi Dewi Fatma Suniarti Drajat, Widi Rahmawati Dwi Priyo Ariyanto Ekayanti Elline, Elline Farah Nurlidar Febry, Febry Febryana, Nesia Fernando, Theodorus Aldo Ferry Sandra Fitri Mutia, Fitri Fitri, Nurwijaya Fitria Esfandiari Fitria, Nada Florencia Livia Kurniawan Furi Furnamasari, Yayang Gunadi, Farid Gunandi, Farid Halim , Johni Halim, Johni Hanafie, Usamah Hannur, Fauziah Harahap, Asrial Harahap, Muhammad Rahim Hardian, Tiara Harryanto Wijaya Haryanto Haryanto Indah, Arfi Purnama Nur Irmawati, Viviana Istiqomah, Nanda Mei Jaka Suyana Janawi, Janawi Jauhari Syamsiyah Jenal Abidin, Jenal Jumiatin, Dedah Kautsar, Zenat L. CYRILLA Lailatur Rahmi Laksmiastuti, Sri Lambertus, Reynaldo Latief, Benny Syariefsjah Lestari, Audi Soekma Lidwina, Naomi Lies Zubardiah Linawati, Dwi Lubis, Septina Sabilla Luki Astuti Mahrani, Riza Marjuk, Rosita Marwati, Yuli Maryana Maryana, Maryana Maryani Maryani Masyithoh, Galuh Maymunah, Siti Mellawaty, Mellawaty Melyda, Ananda Shelly Mendrofa, V. A. Mintarsih Arbarini Moksidy, Jenyfer Ignatia MUHAMMAD SHOLEH Mujiyo Mujiyo Mulyadi Mulyadi Mutiah, Fitri Naufal, Muji Zain Nikmarijal, Nikmarijal Nina Budiwati Novitasari, Selvi Nugroho, Didi Nuni Widiarti Nur Putri Hidayah Nuraeni, Irawati NURBAITI, FITRI Nurul Aziza, Nurul NURUL HIDAYAH Octarina Oktarina Oktarina Ozora, Rochelle Gita Pebriyanti, Nurul Permata, A. M. Permatasari, N. Pralita, Yumar Dwi Pratama, Rizky Nur Priswita, Rahajeng Putu Widiani Pujiyarti, Mei Putera, Agustian Ramadana Putri, Dian Utama Pratiwi R. Priyanto Rahayu Rahayu Ranggaini, Dewi Ranggaini, Magfirahti Ranggaini, Monica Dewi Rezky Anggraeni Riko Nofrizal Riski Busaifi, Riski Rizawati, Rizawati Romadhon, Muhammad Rizky Rosalina Tjandrawinata Rosyadi, Rosyadi Rufii, Rufii Runisah, Runisah Sagala, Namita Salim, Richentya Feiby Santoso, K. Sari, Armelia Shinta Mona Lisca Siahaan, C. I. L. Siti Fatimah Soulisa, Abdul Gani Sri Hartati Sri Lestari Sri Watini Sukmawati Sukmawati Sumani . Surahman, Heny Susanto, Shannon Winnie Sutarno Sutarno Suwartini, Tien Taufiq Perak Sanjaya, Taufiq Perak Tauhid, Moh. Tinuk Dwi Cahyani Ujang Rohman, Ujang Ulinnuha, Ulinnuha Utami, Riska Tri Wahyudi Wahyudi Widayanti, Santi Widodo, Tatag Widyatmani Sih Dewi Yenita Roza Zulmita, Zulmita