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All Journal Indonesian Journal of Human Nutrition Jurnal Medik Veteriner Jurnal Abdi Insani Jurnal Layanan Masyarakat (Journal of Public Service) Journal of Parasite Science Ovozoa: Journal of Animal Reproduction journal of Basic Medical Veterinary Bima Abdi: Jurnal Pengabdian Masyarakat Narra J Current Biomedicine Buletin Pengabdian Borneo Journal of Pharmacy Journal of Fisheries & Marine Folia Medica Indonesiana
Rochmah Kurnijasanti
Department Of Veterinary Basic Medicine, Faculty Of Veterinary Medicine, Universitas Airlangga
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Journal : journal of Basic Medical Veterinary

 1 
UJI PENETAPAN STABILITAS RETENTION TIME Megestrole acetate DALAM ELUENT MOBILE PHASE MENGGUNAKAN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY Cholifah, Siti Chusnul; Lazuardi, Mochamad; Rahardjo, Dadik; Maslachah, Lilik; Sukmanadi, Mohammad; Kurnijasanti, Rochmah
Journal of Basic Medical Veterinary Vol. 9 No. 1 (2020): Journal of Basic Medical Veterinary, June 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v9i1.21093

Abstract

The aim of this research was to determine the level of stability of Megestrole acetate-retention time in storage period for six, eight and 12 hours using High Performance Liquid Chromatography (HPLC). The research method used posttest-only control group design by using three treatments and six repetitions. The three repetitions consist into six hours, eight hours and 12 hours. The data were obtained analyzed by Summery Independent T-Test with SPSS 24 for windows. The result showed six hours retention time of Megestrole acetate is stable and eight hours treatment and 12 hours treatment are not stable there is one unstable point of 12 hours treatment that indicates the substance is break down. Based on those result, it could be concluded that the storage time of Megestrole acetate in Eluent Mobile Phase began to show unstable at eight hours of storage.
Acute Toxicity Test Of The Green Viper Snake (Trimeresurus albolabris), Macroscopic Description Of The Kidney And Liver Of Mice (Mus musculus) Darmawan, Moch. Rizky; Rahardjo, Dadik; Tyasningsih, Wiwiek; Kurnijasanti, Rochmah; Legowo, Djoko; Setiawan, Boedi
Journal of Basic Medical Veterinary Vol. 10 No. 2 (2021): Journal of Basic Medical Veterinary, December 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v10i2.31135

Abstract

According to WHO (2010), the Trimeresurus albolabris snake is a venomous snake with a high number of bite cases in Indonesia. Information on the character and level of toxicity of snake venom in Indonesia, including Trimeresurus spp. snakes, is still minimal. This study aims to determine the LD50 value (lethal dose 50), clinical symptoms, and to determine the macroscopic appearance of the liver and kidneys of mice (Mus musculus) after being injected by a the white-lipped pit viper (Trimeresurus albolabris) venom. The LD50 value of Trimeresurus albolabris venom injected subcutaneously into mice was 5,09 mg/kgBW. Clinical symptoms that appear increased movement activity, increased respiratory rate, lethargy, decreased activity, and reduced grooming. Macroscopic appearance of the liver that looks abnormal is found (1) color changes in the form of pale, pale yellowish, and red spots (petechiae). (2) changes in surface structure found only one liver that is not flat. (3) changes in consistency in the form of brittle easily. In the kidney that looks abnormal, found (1) changes in color in the form of pale. (2) changes in surface structure were only found in one kidney in the form of nodules. (3) changes in consistency in the form of brittle easily and soft.
The Anthelmintic Activity Of Etanol Extract of Porang Tubers Against Fasciola gigantica In Vitro Agustina, Firanda; Kurnijasanti, Rochmah; Suwanti, Lucia Tri; Lastuti, Nunuk Dyah Retno; Rachmawati, Kadek; Maslachah, Lilik
Journal of Basic Medical Veterinary Vol. 10 No. 2 (2021): Journal of Basic Medical Veterinary, December 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v10i2.31235

Abstract

This study aims to determine the anthelmintic activity ethanol extract of porang tubers (A. oncophillus) against F. gigantica worms in vitro. There were five treatments and each treatment was done in five replications and used 10 F. gigantica. The treatments of this research were K- with CMC Na 1%, K+ with Albendazole 2.4 mg/ml, P1 with extract concentration 5%, P2 with extract concentration 10%, P3 with extract concentration 20%. The results showed that the extract of Porang tuber (A. oncophillus) had an anthelmintic effect against F. gigantica worms in vitro. In the extract with a concentration of 20%, there were anthelmintic properties that almost the same as Albendazole. The higher the extract concentration, the higher the anthelmintic properties. The longer the immersion time, the higher the number of dead worms. The morphological changes was evaluated by light microscopic examination and the results showed many histopathological changes on the morphology of F. gigantica. The results indicate that the possible use of the tubers as a potential anthelmintic against F. gigantica.
Toxicity Testing Of White Pomegranate (Punica granatum L.) Fruit Extracts Using Brine Shrimp Lethality Test Method As A Candidate Of Anti-Cancer Drug Firnanda, Ferian; Herupradoto, Eduardus Bimo Aksono; Rahmawati, Kadek; Kurnijasanti, Rochmah; Sukmanadi, Mohammad; Hidajati, Nove
Journal of Basic Medical Veterinary Vol. 10 No. 2 (2021): Journal of Basic Medical Veterinary, December 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v10i2.31810

Abstract

This research aimed to determine the effects of toxic white pomegranate fruit extract (Punica granatum L) against larvae of brine shrimp (Artemia salina Leach) indicated LC50 values below 1000 µg/ml. This study is purely experimental by using Brine Shrimp Lethality Test (BSLT). The study was divided into seven groups, namely ethanol extract of white pomegranate fruit (Punica granatum L) with a concentration of 31,25; 62,5; 125; 250; 500; 1000 µg/ml and negative control (seawater). Mortality data percentage of Artemia salina Leach analyzed by probit analysis. Results showed that the extract of white pomegranate fruit extract (Punica Granatum L) has a toxic effect with LC50 values of 248,6 µg/ml calculate from probit analysis. From these results, it can conclude that white pomegranate extract is toxic to larval shrimp (Artemia salina Leach) with Brine Shrimp Lethality Test (BSLT) method which means white pomegranate extract has the potential to be an anticancer drug.
Taurine Antioxidant Effect in Decreasing Kidney Damage in Male Mice (Mus Musculus) due to Oxidative Stress Induced by Paraquat Pratama, Ricki; Hestianah, Eka Pramyrtha; Widiyatno, Thomas Valentinus; Meles, Dewa Ketut; Kurnijasanti, Rochmah
Journal of Basic Medical Veterinary Vol. 10 No. 2 (2021): Journal of Basic Medical Veterinary, December 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v10i2.31811

Abstract

Paraquat toxicity occurs through the high production of reactive oxygen species (ROS) which cause damage due to oxidative stress. Antioxidants can reduce damage through prevention of oxidative stress. Taurine has shown the ability to act as an antioxidant. The aim of this research is to find a effect of antioxidant taurine to decrease kidney damage caused by oxidative stress due to paraquat by looking at the histopathology changes. 25 male adult mices from strain DDY were used and divided into five treatment groups; C(-) (Aquadest IP), C(+) (Paraquat 30mg/kg), P1 (Paraquat 30mg/kg + Taurine 250mg/kg), P2 (Paraquat 30mg/kg + Taurine 500mg/kg) and P3 (Paraquat 30mg/kg + Taurine 1000mg/kg). All groups were given treatment intraperitoneal for twenty one days. The mices were sacrificed where kidney were collected for histopathology preparation. The parameters measured were renal histopathological changes in form of degeneration and necrosis. The results show that taurine administration had an effect on decreased degrees of damage to kidney tubular cells, with a decrease in the mean degree of renal tubular degeneration and necrosis. Degeneration of renal tubular cells in groups (P2) reduced compared to the group (C+) there were significant differences (P <0.05). Necrosis of renal tubular cells in groups (P1, P2) reduced compared to the group (C+) there were significant differences (P <0.05).  In conclusion, this research proves that administration of paraquat causes renal histopathological changes which are characterized by degeneration and necrosis. It also proves that taurine dose of 500 mg/kgBB could provided optimal effect.
Protection Effectiveness Of Bit (Beta vulgaris) Fruit Extract In Maintaining Spermatogenesis Ability In White Rats (Rattus novergicus) Induced Carbon Tetracloride (CCl4) Anugrah, Alvyan Lantang; Eliyani, Hana; Utomo, Budi; Susilowati, Suherni; Mafruchati, Maslichah; Kurnijasanti, Rochmah
Journal of Basic Medical Veterinary Vol. 10 No. 2 (2021): Journal of Basic Medical Veterinary, December 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v10i2.31812

Abstract

The aim of this research was to know whether beetroot (Beta Vulgaris) extract could protect spermatogenesis by maintaining spermatogenic and sertoli cell count  in rats (Rattus novergicus) induced with CCl4. Rats were given beetroot extract daily, for 14 days and 3ml/kg BW CCl4 intraperitoneally one hour after last treatment. This study used twenty rats which were devided equally into 5 groups. K(-), the negative control group was not induced with CCL4 and only given 1% CMC-Na suspension. K(+), the positive control group was induced with CCl­4 and given 1% CMC-Na suspension. P1, P2 and P3 were given beet root extract with doses of 200, 400, and 800 mg/kg BW daily before feeding. All of the beetroot treatment were given orally (2 ml). After 24 hours CCl4 induction, rats were sacrificed and testis were collected to make histology slides. The observations showed significantly different (p<0,05) in all of variables. Result showed significant differences in spermatogenic and sertoli cells between K(-) and K(+) groups, K(+) with P2 and P3 group, and showed insignificant difference between P2 and P3 group in spermatogenic and sertoli cells. The result of this research showed that beetroot extract could protect the spermatogenic and sertoli cells in male rats induced with CCl4.
Effectiveness of Bay Leaf Extract (Syzygium polyanthum) on Uric Acid and Cholesterol Levels in Caffeine-Induced Male Mice (Mus musculus) Pratama, Fahrul Andika; Aisyafalah, Salma; Kurnijasanti, Rochmah
Journal of Basic Medical Veterinary Vol. 13 No. 2 (2024): Journal of Basic Medical Veterinary, December 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v13i2.65971

Abstract

Bay leaf (Syzygium polyanthum) is one of the plants from Indonesia that has the potential to be used as a raw material for herbal medicine. Pharmacologically, bay leaves containing flavonoids have been shown to have antioxidant activity, which can reduce hyperuricemia and blood cholesterol levels. This study aims to determine the effectiveness of bay leaf extract in reducing uric acid and cholesterol levels in the blood of mice induced by caffeine. The mice tested animals were divided into six groups, namely a positive control group of uric acid, a positive control of cholesterol, where a positive control of uric acid was given allopurinol and a positive control of cholesterol was given simvastatin, a negative control was given Na-CMC 1%, and a group that was given bay leaf extract in different dose levels, namely P1 was given 20 mg/kg BB, P2 was given 40 mg/kg BB, and P3 was given 80 mg/kg BB. The parameters used were the decrease in blood uric acid and cholesterol levels caused after the treatment was measured using a POCT strip test for uric acid and cholesterol. The data obtained were statistically processed using the One-Way Anova test. The results of the Anova test showed a significant difference (p<0.05) in the data on uric acid and cholesterol levels. Then continued with the results of Duncan's test to see the most effective dose level for bay leaf extract in reducing uric acid and cholesterol levels. In Duncan's test results, it was found that the P3 group of mice with a dose of 80 mg/kg BB was the most effective dose level in reducing uric acid and cholesterol levels in the blood of mice induced by caffeine.
Potential of Ethanol Extract of Red Curly Chili (Capsicum annuum L.) as an Antioxidant and Antidiabetic Agent in Mice Citagami, Salsabila; Setiawati, Yuani; Kurnijasanti, Rochmah; Mukono, Indri Safitri
Journal of Basic Medical Veterinary Vol. 14 No. 1 (2025): Journal of Basic Medical Veterinary, June 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i1.71635

Abstract

Medicinal plants containing polyphenols (flavonoid dan tannin),  quercetin and capsaicin have strong antioxidant properties. These compounds can help inhibit oxidative stress that plays a role in various diseases, including diabetes mellitus. Capsicum annuum L is rich in phytochemicals and active compounds such as flavonoids (Quercetin, Luteolin, Kaempferol), tannins, saponins, terpenoids, carotenoids, and vitamin C. This study aimed to evaluate the potential of red curly chili (Capsicum annuum L.) ethanol extract as an antioxidant and antidiabetic agent in mice. The mice will be randomly divided into the following groups (6 mice per group): Diabetic control group (induced diabetes with streptozotocin, no treatment), and Capsicum annuum L group (Diabetic group treated with Capsicum annuum L ethanol extract at dose 100 mg/kg BW, 200 mg/kg BW, 400 mg/kg BW for 21 days). On the 21st day, the mice were anesthetized, and blood samples were collected via intracardiac puncture for the analysis of blood glucose and malondialdehyde (MDA) levels. Oral administration of Capsicum annuum L. At 400 mg/kg resulted in a significant reduction in blood glucose and MDA levels (p<0.05) compared to the diabetic group. The results approached those of the normal group, although the difference was not statistically significant. The study confirmed that Capsicum annuum L. extract effectively alleviates oxidative stress associated with type II diabetes in STZ-induced mice, as evidenced by its ability to lower blood glucose levels and reduce MDA levels.
Nephroprotective Activity of Ethanolic Extract of Papaya (Carica papaya) Seeds on Blood Urea Nitrogen and Creatinine Levels in Albino Rats Induced by Paracetamol Mubarok, Muhammad Syahrul; Yuliani, Gandul Atik; Sunarso, Agus; Hidayatik, Nanik; Kurnijasanti, Rochmah; Hisyam, Mirza Atikah Madarina
Journal of Basic Medical Veterinary Vol. 14 No. 2 (2025): Journal of Basic Medical Veterinary, December 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbmv.v14i2.78386

Abstract

Kidney damage caused by high-dose paracetamol leads to elevated Blood Urea Nitrogen (BUN) and creatinine levels as indicators of impaired renal function. This study aimed to evaluate the dose-dependent nephroprotective effects of ethanolic Carica papaya seed extract on BUN and creatinine levels in paracetamol-induced albino rats. A posttest-only control group design was applied using 25 male Wistar rats divided into five groups: negative control (1% CMC-Na), positive control (paracetamol 1000 mg/kgBW), and three treatment groups receiving Carica papaya seed extract at doses of 100, 200, and 400 mg/kgBW. The extract was administered orally for seven consecutive days before paracetamol induction on day 8 and continued until day 11. Blood samples were collected on day 11, and serum was stored at -20 °C before BUN and creatinine concentrations were analyzed spectrophotometrically. Data were statistically analyzed using one-way ANOVA followed by Duncan’s Multiple Range Test (DMRT) at a significance level of p < 0.05. The results showed a significant and dose-dependent reduction in both parameters in all treated groups compared to the positive control, with the 400 mg/kgBW dose showing the strongest effect and restoring values close to physiological levels. The nephroprotective activity was associated with the antioxidant and anti-inflammatory mechanisms of the bioactive compounds that counteract oxidative stress and preserve renal cellular integrity. In conclusion, the ethanolic extract of Carica papaya seeds demonstrates significant dose-dependent nephroprotection against paracetamol-induced kidney injury in rats.
Co-Authors Agustina, Firanda Aisyafalah, Salma Aksono HP., Eduardus Bimo Al Arif, M Anam Al Arif, Moh. Anam Annette d’Arqom, Annette Anugrah, Alvyan Lantang Arimbi Azzahra, Farah Nabila Boedi Setiawan Budi Utomo BUDI UTOMO Cholifah, Siti Chusnul Citagami, Salsabila Dadik Rahardjo, Dadik Darmawan, Moch. Rizky Dewi, Aprilia Kurnia Dwi Puspa Sukma Viranda Eka Pramyrtha Hestianah, Eka Pramyrtha Endang Suprihati Epy Muhammad Luqman Erma Safitri Firnanda, Ferian Fitriati, Mariza Hana Eliyani Hani Plumeriastuti Harijani, Nenny Hermin Ratnani Hernanda, Ary Setya Herry Agoes Hermadi Hidajati, Nove Hidayatik, Nanik Hisyam, Mirza Atikah Madarina I'tishom, Reny IMAM MUSTOFA Indah Norma Triana, Indah Norma Indri Safitri Mukono, Indri Safitri Ira Sari Yudaniayanti Iwan Sahrial Hamid Jusak Nugraha Kadek Rachmawati Kadek Rachmawati Khairullah, Aswin Rafif Khoirunnisa, Itrah Legowo, Djoko Lilik Maslachah Lucia Tri Suwanti, Lucia Tri Ma'ruf, Anwar Mafruchati, Maslichah Maryana Siska Silviani Mas'ad, Khasmawati Meles, Dewa Ketut Meta Aprilia Mochamad Lazuardi Moh. Sukmanadi Mohammad Sukmanadi Mono Pratiko Gustomi Mubarok, Muhammad Syahrul Muhammad Faizal Adiutomo Mustafa, Mohammad R. Mustofa Helmi Effendi Nunuk Dyah Retno Lastuti Oski Illiandri Panggabean, Rosenna Tiara Paramita, Chici Ayu Poedji Hastutiek Prastyaningtyas, Kukuh Pratama, Fahrul Andika Pratama, Ricki Primarizky, Hardany Pudji Srianto Purwitasari, Neny Puspitasari, Renny N. Putri, Arninda Alfiani Rahmaniabdi, El Roy Achmad Rahmawati, Kadek Rahmi Sugihartuti, Rahmi Raindra Daksina Ramadhani, Fifi Fauziah Rimayanti Rimayanti Rohmah, Etik Ainun ROHMAH, LAILATUL Rr. Juni Triastuti Sabdoningrum, Emy Koestanti Saputra, Rakan Mahiid Soeharsono Soeharsono Sri Agus Sudjarwo Sri Mulyati Sri Pantja Madyawati Sri Pantja Madyawati, Sri Pantja Subagyo Yotopranoto Sudjarwo, Sri A. Suherni Susilowati Sukmanadi, Mohammad Sunarso, Agus Supriyadi Supriyadi Supriyadi Suwanto Suwanto Suzanita Utama Swari, Wahyu Retno Tatik Hernawati Tita Damayanti Lestari Tjuk Imam Restiadi Tri Wahyu Suprayogi Tyasningsih, Wiwiek Vladika, Maulinda Agchirilia Warsito, Sunaryo Hadi Widiyatno, Thomas Valentinus Widjiati Widjiati, Widjiati Widya Paramita Lokapirnasari Wurlina, W Yuani Setiawati Yuliani, Gandul Atik Yulianna Puspitasari Yustinasari, Lita Rakhma