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Anti-Inflammatory Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid Derived from Patin Fish Oil on Diabetic Nephropathy: A Bioinformatics Study Doddy Aditya Purnomo; Awidarta, Kevin; Nugroho, Agung Endro; Rohman, Abdul
Journal of Food and Pharmaceutical Sciences Article In Press 2026
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22899

Abstract

Diabetic nephropathy is a severe complication of diabetes mellitus with a significant global impact on end-stage renal disease. Fish-derived fatty acids show promise in inflammatory disorders, but their mechanisms in diabetic nephropathy remain unclear. This study used network pharmacology and molecular docking to investigate the therapeutic targets of EPA and DHA from Patin fish oils. Potential targets of EPA and DHA were retrieved from the Swiss Target Prediction, SEA, and SuperPRED databases, identifying 160 and 185 targets, respectively. Notably, 37 and 62 of these targets overlapped with DN-related targets from GeneCards, DisGeNET, and OMIM. Protein-protein interaction (PPI) network analysis revealed hub genes, including PPARG, TLR4, and TP53, as critical mediators. Gene Ontology (GO) enrichment analysis revealed involvement in biological processes such as collagen metabolic process for EPA and regulation of inflammatory response for DHA, while KEGG pathway analysis highlighted the modulation of PPAR signaling, the renin-angiotensin system, and the AGE-RAGE signaling pathway. Molecular docking confirmed favorable binding affinities of EPA and DHA to key targets such as PPARG (-8.04 kcal/mol for DHA) and PPARD (-8.11 kcal/mol for EPA). These findings suggest that EPA and DHA may mitigate DN-associated inflammation through multi-target and multi-pathway interactions, positioning them as potential supplementary therapeutic agents.
Co-Authors . Anindyajati Abd. Rasyid Syamsuri Abdul Rohman Agung Giri Samudra Alexxander Alexxander, Alexxander Amalia, Retno Amir Husni Amprih Martha, Amprih Andita Pra Darma Arief Nurrochmad Arief Rahman Hakim Atharini, Yanita Harliana Awidarta, Kevin Ciptasari, Debora Purwasista Dani Dwi Agistia, Dani Dwi Dewi Wulandari Dirga Dirga Dita Brenna Septhea Djoko Suhardjono, Djoko Doddy Aditya Purnomo Dyaningtyas Dewi Putri Pamungkas Ediati Sasmito Eka Prasasti Nur Rachmani Eka Siswanto Syamsul Endang Lukitaningsih Farisa Luthfiana Fita Rahmawati Fredie Irijanto Gunawan Pamudji Widodo HARI PURNOMO HARI PURNOMO Harno Dwi Pranowo I Dewa Gde Mayun Permana I Dewa Putu Pramantara Ignatius Ryan Adriawan, Ignatius Ryan Ika Nurzijah Ika Puspitasari Ika Yuni Astuti Illian, Didi Nurhadi Isnaini, Puti JOKO TRI WIBOWO Kasih, Nirvane Zefanya KAZUTAKA MAEYAMA Kazutaka maeyama Khoerul Anwar Kiki Damayanti, Kiki Kustanto, Satya Prima Lina Widiyastuti Lini Veriony, Lini M. Djatmiko Marbun, Prajona Marchaban, Marchaban Martien, Ronny Maulana Tegar AdityaNugraha Maulita Cut Nuria Meiyanto, Edy Mohamad Andrie MOHAMAD ASPOLLAH SUKARI Mohamad Aspollah Sukari, Mohamad Aspollah Nanang Fakhrudin, Nanang Ningsih, Diana Rachma Novena Yety Lindawati, Novena Yety Novianti, Feby Galuh Nugroho, Nidhar Ainu Faza Nurul Maziyyah Pamungkas P, Dyaningtyas Dewi Pradana, Theophani Bagas Pramantara, Dewa Putu Presticasari, Hardiyani Priyasana, I Putu Probosuseno Probosuseno, Probosuseno PUGU NOVI ARSITO Puji Astuti Pulungan, Yulianasari Purwantiningsih, Purwantiningsih Putri, Cyndi Yulanda Raditya, Rakta Ratna Asmah Susidarti Ratnawati, Galuh Retno Murwanti Rina Susilowati risha fillah fithria Riyanto, Ratna Dewi Setiarini Riyanto, Sugeng Rizaldy Pinzon Rommy Ronny Martien Santoso, Bilal Subchan Agus Saputra, Yuli Edy Sardjiman . Sari, Juwita Permata Sarmoko Sarmoko Saroh, Muya Siswanto, Soni Sitarina Widyarini Siti Sendari Soraya, Fenthy Soraya, Fenthy Subagus Wahyuono Sudarsono, Sudarsono Sudibyo Martono SUGENG RIYANTO Sugeng Riyanto Sukmarini, Zhafira Supardjan A. Margono Susilowati, Sri Sutji Suwidjiyo Pramono SUWIJIYO PRAMONO Tivanie, Riza Ayu Tri Murti Andayani Umar Anggara Jenie Untari, Meta Kartika Wahyono Wahyono Widyati, Widyati Yance Anas Yose V. Sagala, Yose Yosi Bayu Murti Zamzani, Irfan