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All Journal Journal of Food and Pharmaceutical Science Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Berkala Ilmiah Kedokteran Duta Wacana Majalah Farmaseutik Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Media Ilmu Kesehatan JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Medicamento Generics: Journal of Research in Pharmacy Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia Journal of Food and Pharmaceutical Sciences Generics : Journal of Research in Pharmacy Jurnal Kefarmasian Indonesia Indonesian Journal of Pharmacology and Therapy Journal of Pharmascience
Agung Endro Nugroho
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta Indonesia 55281
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Anti-Inflammatory Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid Derived from Patin Fish Oil on Diabetic Nephropathy: A Bioinformatics Study Purnomo, Doddy Aditya; Awidarta, Kevin; Nugroho, Agung Endro; Rohman, Abdul
Journal of Food and Pharmaceutical Sciences Vol 14, No 1 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22899

Abstract

Diabetic nephropathy is a severe complication of diabetes mellitus with a significant global impact on end-stage renal disease. Fish-derived fatty acids show promise in inflammatory disorders, but their mechanisms in diabetic nephropathy remain unclear. This study used network pharmacology and molecular docking to investigate the therapeutic targets of EPA and DHA from Patin fish oils. Potential targets of EPA and DHA were retrieved from the Swiss Target Prediction, SEA, and SuperPRED databases, identifying 160 and 185 targets, respectively. Notably, 37 and 62 of these targets overlapped with DN-related targets from GeneCards, DisGeNET, and OMIM. Protein-protein interaction (PPI) network analysis revealed hub genes, including PPARG, TLR4, and TP53, as critical mediators. Gene Ontology (GO) enrichment analysis revealed involvement in biological processes such as collagen metabolic process for EPA and regulation of inflammatory response for DHA, while KEGG pathway analysis highlighted the modulation of PPAR signaling, the renin-angiotensin system, and the AGE-RAGE signaling pathway. Molecular docking confirmed favorable binding affinities of EPA and DHA to key targets such as PPARG (-8.04 kcal/mol for DHA) and PPARD (-8.11 kcal/mol for EPA). These findings suggest that EPA and DHA may mitigate DN-associated inflammation through multi-target and multi-pathway interactions, positioning them as potential supplementary therapeutic agents.
Prevalence and factors associated with uncontrolled blood pressure in dialysis patients using antihypertensive: a narrative review Pulungan, Yulianasari; Nugroho, Agung Endro; Pramantara, I Dewa Putu
Indonesian Journal of Pharmacology and Therapy Vol 4 No 3 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.7768

Abstract

Hypertension in patients with end-stage chronic kidney disease undergoing hemodialysis is difficult to control leading to a significant risk factor for a cardiovascular event. The aimed of this review is to summarize the prevalence of uncontrolled blood pressure in dialysis patients. This review hopefully can serve as a valuable reference and source of insight for clinicians in their efforts to attain controlled blood pressure in dialysis patients. The relevant literatures was undertaken from PubMed, Scopus, and Google Scholar for studies addressing the factor associated with uncontrolled blood pressure in hemodialysis patients using antihypertensives from 2013 to 2023. Combinations of search terms were "uncontrolled" and "blood pressure" and "dialysis" and "antihypertensive”. Any study in English, including randomized control trials, cohort, case-control, and cross-sectional studies was included. Uncontrolled blood pressure is very common among hypertension in dialysis patients (28.7 - 78.33% of cases). Factors affecting blood pressure in dialysis patients include age, obesity, and comorbidity (diabetes and stage of chronic kidney disease). Although the relationship between gender, the number of antihypertensive, the number of dialysis, and the length of dialysis sessions with blood pressure varies, some studies have shown a positive association.
Decoding the role of tannic acid in wound healing: a dual‐action mechanism linking IL‐1β modulation and FGF‐driven tissue repair Swastini, Dewa Ayu; Nugroho, Agung Endro; Martien, Ronny; Fachiroh, Jajah; Khafi, Muhammad; Putra, Komang Dian Aditya
Indonesian Journal of Biotechnology Vol 31, No 1 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.113925

Abstract

Tannic acid (TA) has been shown in a previous study to expedite cutaneous wound healing in rats; however, the precise mechanism by which it operates remains poorly understood. This research evaluates the effects of TA on wound healing using both in vitro and in silico methods. In vitro, its influence on the inflammatory cytokine interleukin‐1β (IL‐1β) and the growth factor fibroblast growth factor (FGF) throughout the healing process were assessed. In silico molecular docking was employed to predict direct ligand–protein interactions and to provide a mechanistic insight into whether these proteins represent primary molecular targets or downstream effects. Parameters evaluated included cell viability and proliferation, scratch assays, and the activity of pro‐inflammatory cytokines in the lipopolysaccharide (LPS)‐stimulated RAW 264.7 macrophage cell line, together with growth factors in the NIH 3T3 fibroblast cell line; all were evaluated using enzyme‐linked immunosorbent assay (ELISA). The results indicate that TA significantly facilitates wound closure by promoting NIH 3T3 fibroblast cell proliferation, enhancing FGF expression, and suppressing IL‐1ß synthesis in both in vitro and in silico approaches. These findings suggest that TA may hold considerable promise for wound‐healing management.
Ketidaksesuaian Penggunaan Proton Pump Inhibitors (PPIs) pada Lanjut Usia dan Interaksi Obat: Kajian Naratif Arief, Thendi Abdul; Rachmadi, Nabila Risti; Fahriah, Hanum Hasifah; Nugroho, Agung Endro
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.11519

Abstract

Background: PPIs are highly effective for treating gastrointestinal disorders, including dyspepsia, peptic ulcer disease, gastritis, and gastroesophageal reflux disease (GERD). Furthermore, for the prophylaxis of NSAIDs and to mitigate gastrointestinal bleeding in patients receiving glucocorticoids, antiplatelet agents, or anticoagulants, particularly in the elderly population. The prescribing of PPIs among elderly patients remains a widespread issue that can lead to inappropriate use, hospital admission, or discharge. Additionally, the inappropriate use of PPIs can lead to possible drug-drug interactions.Objective: This narrative review aims to comprehensively assess inappropriateness associated with PPIs use in the elderly population and drug-drug interactions.Methods: Studies published from 2014 to 2024 were identified through a comprehensive search of multiple databases, including PubMed, Google Scholar, and ScienceDirect.Results: Long-term dangers such as infections and nutritional deficits are increased by inappropriate usage, which is defined by unwarranted commencement and lengthy duration. Simultaneously, PPIs present significant DDI hazards through modulating the absorption of pH-dependent medications and blocking cytochrome P450 enzymes, particularly CYP2C19. These risks are made worse by the prevalence of polypharmacy and aging-related deterioration of renal and hepatic function.Conclusion: In clinical practice, these findings call for systematic drug reviews and organized deprescribing programs to detect and manage high-risk combos. Implementing PPI stewardship programs in hospital and community settings is highly advised at the policy and systems level to enhance pharmaceutical safety in this susceptible population and to encourage evidence-based, guideline-concordant prescription.
Bibliometric Analysis of Medicinal Plants Research for Diabetes Mellitus in Indonesia Khoerul Anwar; Nanang Fakhrudin; Retno Murwanti; Agung Endro Nugroho
Journal of Pharmascience Vol. 12 No. 2 (2025): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i2.23703

Abstract

Diabetes mellitus (DM) memiliki hubungan yang erat dengan perubahan pola makan dan gaya hidup yang tidak sehat. Jumlah penderita diabetes di Indonesia terus meningkat. Minat masyarakat dalam mengonsumsi tanaman obat semakin berkembang karena pasien lebih memilih produk alami yang dianggap lebih aman. Penelitian tentang tanaman obat sebagai agen antidiabetes juga menunjukkan tren yang meningkat. Studi ini bertujuan untuk memetakan penelitian yang menggunakan tanaman obat terkait diabetes di Indonesia. Data subjek penelitian diperoleh dari Scopus, dan perangkat lunak statistik RStudio dengan paket bibliometric digunakan untuk menganalisis dan memvisualisasikan data. Hasil analisis menunjukkan bahwa pertumbuhan publikasi di bidang ini mencapai 36,25% per tahun. Jumlah penulis bersama per dokumen adalah 4,93 dengan tingkat kolaborasi internasional sebesar 15,12%. Sebanyak 1.548 artikel dengan 4.877 penulis diterbitkan di 429 jurnal dan prosiding terpilih. Elya B (n = 35), Universitas Airlangga (n = 435), dan IOP Conference Series: Earth and Environmental Science (n = 92) merupakan penulis, afiliasi, dan penerbit paling produktif. Dengan jumlah sitasi per artikel sebesar 7,78 menunjukkan bahwa penelitian dari Indonesia berkontribusi pada penelitian lain. Penulis artikel di Indonesia sebagian besar (89,73%) berkolaborasi dengan peneliti sesama di Indonesia, sementara sisanya (10,27%) berkolaborasi dengan peneliti di luar negeri seperti Jepang, Malaysia, Thailand, China, dan Korea. Dapat disimpulkan bahwa kuantitas dan kualitas penelitian tentang tanaman obat untuk DM di Indonesia semakin meningkat dan berkontribusi pada penelitian lebih lanjut untuk pengelolaan diabetes. Kata Kunci: Bibliometric, Diabetes Mellitus, Tumbuhan Obat, Scopus, Rstudio Diabetes mellitus (DM) strongly associated with changes in unhealthy diet and lifestyles. The number of diabetic patients in Indonesia continues to increase. Public interest in consuming medicinal plants was developing because patients prefer on natural products and are considered safer. Research on medicinal plants as antidiabetic agents also shows an increasing trend. This study aims to map research using medicinal plants related to diabetes in Indonesia. Data on research subjects were retrieved from Scopus and the bibliometric package in RStudio statistical software was used to analyze and visualize the data. The results of the analysis showed that the growth of publications in this field was 36.25% per year. The number of co-authors per document was 4.93 with an international co-authorship rate of 15.12%. A total of 1548 articles with 4877 authors were published in 429 selected journals and proceedings. Elya B (n = 35), Universitas Airlangga (n = 435), the IOP Conference Series: Earth and Environmental Science (n = 92) was the most productive author, affiliation, and publisher. With the number of citations per article of 7.78, it shows that this research from Indonesia contributes to another research. The authors of the articles in Indonesia mostly (89.73%) collaborated with fellow researchers in Indonesia, while the rest (10.27%) collaborated with researchers abroad such as Japan, Malaysia, Thailand, China, and Korea. It can be concluded that the quantity and quality of research on medicinal plants for DM in Indonesia is increasing and contributing to further research for diabetes management.
Empirical Use of Cephalosporins in Pediatric Infections in Indonesia: A Systematic Review Melisa Rezki Puspitasari; Tifany Maulida Candra; Agung Endro Nugroho; Ika Puspita Sari
Majalah Farmaseutik Vol 22, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v22i2.110356

Abstract

Cephalosporins, particularly third-generation agents like ceftriaxone, remain widely used in pediatric populations in Indonesia despite declining effectiveness due to high rates of ESBL-producing pathogens. This systematic review synthesized evidence on cephalosporin use, resistance patterns, and effectiveness in Indonesian children across various clinical settings, based on five studies published between 2019–2025. Data included study characteristics, patient profiles, indications, and outcomes. Ceftriaxone was the most common empirical choice for infections such as sepsis, pneumonia, and urinary tract infections. However, susceptibility of Escherichia coli and Klebsiella pneumoniae was often below 30%, whereas amikacin and meropenem maintained over 90% activity. Notably, one tertiary pediatric ward reduced ESBL prevalence after restricting ceftriaxone use, demonstrating the potential of targeted stewardship programs. The findings reveal a disconnect between prescribing practices and resistance data, emphasizing the need for real-time microbiological surveillance, updated pediatric empirical therapy guidelines, and improved prescriber education. Strengthening pediatric antimicrobial stewardship is crucial to preserving antibiotic effectiveness and optimizing clinical outcomes in children amid rising resistance.
Co-Authors . Anindyajati Abd. Rasyid Syamsuri Abdul Rohman Agung Giri Samudra Alexxander Alexxander, Alexxander Amalia, Retno Amir Husni Amprih Martha, Amprih Andita Pra Darma Arief Nurrochmad Arief Rahman Hakim Arief, Thendi Abdul Atharini, Yanita Harliana Awidarta, Kevin Ciptasari, Debora Purwasista Dani Dwi Agistia, Dani Dwi Dewa Ayu Swastini Dewi Wulandari Dirga Dirga Dita Brenna Septhea Djoko Suhardjono, Djoko Doddy Aditya Purnomo Dyaningtyas Dewi Putri Pamungkas Ediati Sasmito Eka Prasasti Nur Rachmani Eka Siswanto Syamsul Endang Lukitaningsih Fahriah, Hanum Hasifah Farisa Luthfiana Fita Rahmawati Fredie Irijanto Gunawan Pamudji Widodo HARI PURNOMO HARI PURNOMO Harno Dwi Pranowo I Dewa Gde Mayun Permana I Dewa Putu Pramantara Ignatius Ryan Adriawan, Ignatius Ryan Ika Nurzijah IKA PUSPITA SARI Ika Puspitasari Ika Yuni Astuti Illian, Didi Nurhadi Isnaini, Puti Jajah Fachiroh, Jajah JOKO TRI WIBOWO Kasih, Nirvane Zefanya Kazutaka maeyama KAZUTAKA MAEYAMA Khafi, Muhammad Khoerul Anwar Khoerul Anwar Kiki Damayanti, Kiki Kustanto, Satya Prima Lina Widiyastuti Lini Veriony, Lini M. Djatmiko Marbun, Prajona Marchaban, Marchaban Martien, Ronny Maulana Tegar AdityaNugraha Maulita Cut Nuria Meiyanto, Edy Melisa Rezki Puspitasari Mohamad Andrie MOHAMAD ASPOLLAH SUKARI Mohamad Aspollah Sukari, Mohamad Aspollah Nanang Fakhrudin Nanang Fakhrudin, Nanang Ningsih, Diana Rachma Novena Yety Lindawati, Novena Yety Novianti, Feby Galuh Nugroho, Nidhar Ainu Faza Nurul Maziyyah Pamungkas P, Dyaningtyas Dewi Pradana, Theophani Bagas Pramantara, Dewa Putu Presticasari, Hardiyani Priyasana, I Putu Probosuseno Probosuseno, Probosuseno PUGU NOVI ARSITO Puji Astuti Pulungan, Yulianasari Purnomo, Doddy Aditya Purwantiningsih, Purwantiningsih Putra, Komang Dian Aditya Putri, Cyndi Yulanda Rachmadi, Nabila Risti Raditya, Rakta Ratna Asmah Susidarti Ratnawati, Galuh Retno Murwanti Rina Susilowati risha fillah fithria Riyanto, Ratna Dewi Setiarini Riyanto, Sugeng Rizaldy Pinzon Rommy Ronny Martien Santoso, Bilal Subchan Agus Saputra, Yuli Edy Sardjiman . Sari, Juwita Permata Sarmoko Sarmoko Saroh, Muya Siswanto, Soni Sitarina Widyarini Siti Sendari Soraya, Fenthy Soraya, Fenthy Subagus Wahyuono Sudarsono, Sudarsono Sudibyo Martono Sugeng Riyanto SUGENG RIYANTO Sukmarini, Zhafira Supardjan A. Margono Susilowati, Sri Sutji Suwidjiyo Pramono SUWIJIYO PRAMONO Tifany Maulida Candra Tivanie, Riza Ayu Tri Murti Andayani Umar Anggara Jenie Untari, Meta Kartika Wahyono Wahyono Widyati, Widyati Yance Anas Yose V. Sagala, Yose Yosi Bayu Murti Zamzani, Irfan