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All Journal Jurnal Kesehatan Masyarakat Andalas (Andalas Journal of Public Health) Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Jurnal Ilmiah Universitas Batanghari Jambi Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Jurnal Farmasi Higea Poltekita : Jurnal Ilmu Kesehatan Contagion: Scientific Periodical Journal of Public Health and Coastal Health Tatar Pasundan : Jurnal Diklat Keagamaan Journal of Telenursing (JOTING) Science Midwifery JPK: Jurnal Proteksi Kesehatan Indonesian Journal of Global Health research Jurnal Dunia Gizi Jurnal Menara Medika Poltekita: Jurnal Pengabdian Masyarakat Narra J FORTE JOURNAL Basic and Applied Nursing Research Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Andalas Dental Journal SENTRI: Jurnal Riset Ilmiah Tatar Pasundan: Jurnal Diklat Keagamaan
Afriwardi Afriwardi
Bagian Fisiologi, Fakultas Kedokteran, Universitas Andalas
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Network pharmacology, molecular docking, and molecular dynamics analyses to explore the molecular mechanism of paclitaxel in atherosclerosis therapy Oktomalioputri, Biomechy; Afriwardi, Afriwardi; Darwin, Eryati; Rita, Rauza S.
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.2140

Abstract

Atherosclerosis is a chronic arterial disease and the leading cause of vascular death. Paclitaxel has long been recognized as an anticancer agent, but recent studies have shown that paclitaxel can also potentially reduce the progression of atherosclerosis. The aim of this study was to explore the molecular mechanism of paclitaxel as an atherosclerosis therapy using in silico study. Pharmacokinetic and pharmacodynamic analyses of paclitaxel were conducted using SwissADME, ProTox v3.0, and SCFbio websites. Cytoscape software was used to construct a network of protein-protein interactions, and the key proteins involved in paclitaxel-related atherosclerosis were identified, including AKT serine/threonine kinase 1 (AKT1), Jun N-terminal kinase (JNK), and Endothelin 1 (ET1). These key proteins were then subjected to molecular docking and molecular dynamic simulation using MOE and Yasara applications. Pharmacokinetic and pharmacodynamic analyses revealed that paclitaxel has good distribution, metabolism, and excretion properties. However, paclitaxel has shortcomings in absorption, toxicity, and water solubility. According to the results of molecular docking, paclitaxel showed consistent results as the most potential inhibitor of AKT1 (-9.59 kcal/mol), ET1 (-9.16 kcal/mol), JNK (-8.72 kcal/mol) when compared to the control ligands. Molecular dynamics simulations also confirmed the interaction stability between paclitaxel with AKT1, ET1, and JNK, with paclitaxel-AKT1 demonstrating the highest conformational stability (Carbon-α Root Mean Square Deviation <3.0 Å). Even though our in-silico results are promising, more experimental studies are required to confirm the efficacy of paclitaxel as an atherosclerosis therapy.
Risk Factors for Olfactory Dysfunction in Hospital Setting Following Covid-19 Infection Among Hospital Employees Following Treatment of Covid-19 Infected Patients: A Survey Research Irfandy, Dolly; Afriwardi, Afriwardi; Budiman, Bestari J.; Putra, Andani E.; Elvira, Dwitya; Triananda, Claudia
SENTRI: Jurnal Riset Ilmiah Vol. 4 No. 7 (2025): SENTRI : Jurnal Riset Ilmiah, Juli 2025
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v4i7.4272

Abstract

Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To reveal the risk factors for olfactory dysfunction in employees with COVID-19 in the workplace of the subject hospital in Indonesia. This study was quantitative and descriptive, using data from questionnaires distributed to subject hospital in Indonesia employees who have experienced COVID-19. This study shows that anosmia (33.2%) is the most common olfactory dysfunction in COVID-19. COVID-19 infection often occurs in resident doctors (58.1%); women (55.6%); those aged 55 years (92.3%); those with comorbidities such as hypertension (4.3%) and obesity (65%); nonsmokers (91.5%) and smokers 10–20 cigarettes per day (5.1%); and nondrinkers (100%). Anosmia is the most common olfactory dysfunction in COVID-19. It is commonly experienced by resident doctors, women aged ≥55 years, employees without comorbidities, obese employees, nonsmokers, and nondrinker
Relationship Between Dried Amnion Sheet and Dry Powdered Amnion with Changes in Wound Area in Acute Wounds Ferdinand, Ferdinand; Afriwardi, Afriwardi; Perdanakusuma, David Sontani; Ali, Hirowati
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6906

Abstract

Dried sheet amnion has long been used as a wound treatment that provides better results than standard general care. In addition to dried amnion sheet, dry powdered amnion preparations have begun to be used for wound care. This study aims to evaluate the effectiveness of dry powdered amnion compared to dried amnion sheets in wound healing, and to compare both treatments with standard acute wound care. Sixty-three healthy Wistar rats were randomly divided into three groups: dried amnion sheet treatment group, dry powdered amnion treatment group, and standard wet wound care control group. The research procedure began with the administration of anesthesia using penthotal at a dose of 10mg/kgBW intramuscularly. The backs of the rats were shaved and a 2x1cm wound was designed using a GOAL razor blade after disinfection with 10% betadine solution and 1:30 savlon. Wounds were made on the backs of the rats, and treatments were given according to the group. The wound area was evaluated at time points 6 hours after treatment, day 2 and day 5. Statistical analysis was performed to compare the effectiveness of the treatments. Both treatments with dry powdered amnion and dried amnion sheets significantly reduced the wound area compared to the control group. However, treatment with dried amnion sheets showed higher efficacy in reducing wound area compared to treatment with dry powdered amnion. Statistical analysis confirmed significant differences in wound area reduction between groups. Dry powdered amnion and dried amnion sheets were effective in reducing wound area compared to standard wet wound care. Treatment with dried amnion sheets showed greater efficacy than treatment with dry powdered amnion.
Co-Authors Adang Bachtiar Adrul Fauzan Afrinita Eka Fitri Ahmad Wira Aisyah Elliyanti Akdri Andi Alya Misdhal Rini Amanda Besta Rizaldy Amir, Arni Antoni, Adi Arina Widya Murni Arni Amir Asril Zahari Asterina Asterina Aulia Fash Farabi Ayu Anissa Bahri Azis, Putri Nurul Syafirah Bestari J. Budiman Biomechy Oktomalioputri, Biomechy Bobby Indra Utama Brian Sri Prahastuti Citra Manela Daan Khambri Dara, Widia Dedi Sutia Dedy Kurnia Delmi Sulastri Delmi Sulastri Desmawati Desmawati Desrida Desrida Desy Nofita Sari Detty Iryani Dezi Ilham Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Didin Kustantiningtyastuti Dina Arfiani Rusjdi Dwitya Elvira, Dwitya Edison Edison Efendi, Nursyirwan Efrida Efrida Eka Nofita Eldi Sauma Elizabeth Bahar Elly Usman Elmatris Elmatris Elmatris Sy Elsa Noftalina Endang Mutiwara Endrinaldi Eny Yantri Erin Desweni Eryati Darwin Eti Yerizel Eva Decroli Eva Decroli Fadhilati Sabrina Fadilla, Utami Budhi Febby Herayono Ferdinand Ferdinand, Ferdinand Fika Anggraini Fika Anggraini Fika Tri Anggraini Ghozi Natul Isral Gumilar, Erry Gusriyani, Sri Gusti Revilla Hardisman Harie Satria ES Haslan Muhaimin Lubis Hasmiwati Hendriati, Hendriati Hidayati Hidayati Hirowati Ali Hirowati Ali, Hirowati Hudila Rifa Karmia Husna Yetti Husnil Kadri Ilmiawati, Ilmiawati Ilvira Ulpa Ismail Intan Nurwida Hayati Yasrial Iria Ningsih Busri Jamsari Jamsari Johanes C. Mose Joserizal Serudji Julizar Julizar Julizar Julizar Julizar Julizar Junira Erasta Lastri Daniati Lili Irawati Lili Irawati Masrul Syafri Mayetti Mayetti Meidiza Ariandiny Mety Dwi Putri Eszy Miftah Irrahmah Miftah Irrahmah Miftah Irramah Miftahul Jannah Milfa Sari Muzamil Mohamad Reza Mudjiran Mudjiran Mudjiran Muhammad Amirul Ihsan Saputra Musrizal Adli Mutia Lailani Najirman Najirman Nega Olavia Nelson, Nelvianti Nova Relida Samosir Noverika Windasari Nur Afrainin Syah Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurfazlina Nurfazlina Nurhajjah, Sitti Nuzulia Irawati Perdanakusuma, David Sontani Prayitno, Irwan Prima Astuti Handayani Pudia M. Indika Putra, Andani E. Putri Anindita Putri Nurul Syafirah Azis Rahmad Syawqi Rahmad Syawqi Rahmat Syawqi Raisa Hussein Rama Feriska Putra Rani Ashari Reny Jayusfani Restu Susanti Reza Ekatama Rajasa Rika Susanti Rina Gustia Rini Gusya Liza Rini Gusya Liza, Rini Gusya Rita, Rauza S. Rizki Hidayah Rizqa Fiorendita Hadi Rose Dinda Martini Rozi Sastra Purna Rurin Ardiyanti Sabrina Hayati Safitri, Yunni Salman Umar Salman Umar Salwi, Hanifah Emilia Selfi Renita Rusjdi Setia Budi Zein Shafira Widia Putri Siska Andriani Rukmana Siti Coryniken Siti Nurhajjah Sukhri Herianto Ritonga Sukri Rahman susi susi Taufik Hidayat Taufik Hidayat Tiffany Atia Aristi Triananda, Claudia Vaulinne Basyir Vaulinne Basyir Vitresia, Havriza Wahyu Margi Sidoretno Wenny Rahmalia Rezki Wira Ditya Wirsma Arif Harahap Yessy Susanty Sabri Yolanda Syahdia Yose Ramda Ilhami Yose Ramda Ilhsmi Yufri Aldi Yuharika Pratiwi Yulistini, Yulistini Yuniar Lestari Yusnawati Yusnawati Yusrawati Yusrawati Yusri Dianne Jurnalis Zelly Dia Rofinda