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Afriwardi Afriwardi
Bagian Fisiologi, Fakultas Kedokteran, Universitas Andalas
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POTENSI SENYAWA BROMELIN DALAM BEBERAPA PENGUJIAN TOKSISITAS FARMAKOLOGI Rama Feriska Putra; Salman Umar; Yufri Aldi; Afriwardi Afriwardi
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.865

Abstract

Bromelin merupakan enzim dengan aktivitas proteolitik khusus yang dapat diperoleh dari batang nanas (Ananas comosus), dimana telah menarik perhatian dalam berbagai aplikasi farmakologis dan medis. Studi ini menggambarkan potensi senyawa bromelin dalam beberapa uji toksisitas praklinis. Bromelin telah terbukti memiliki aktivitas antiedematous, antitrombotik, antiinflamasi, dan antikanker. Meskipun khasiatnya telah banyak diteliti, evaluasi toksisitas farmakologinya perlu diperhatikan untuk memahami batas dosis yang aman dan potensi efek samping. Dengan menggunakan desain literatur review, studi ini menyajikan temuan-temuan positif toksisitas rendah bromelin pada beberapa hewan uji, termasuk efek perlindungan terhadap sistem reproduksi pria dan potensi neuroprotektif. Meskipun hasil positif ini menunjukkan potensi terapeutik, perlu dilakukan penelitian lebih lanjut pada tingkat klinis dan preklinis untuk memvalidasi temuan ini sebelum mengaplikasikannya secara luas dalam konteks medis.
Hubungan Intensitas Aktivitas Fisik dengan Siklus Menstruasi Pada Mahasiswi Fakultas Ilmu Keolahragaan Universitas Negeri Padang Salwi, Hanifah Emilia; Afriwardi, Afriwardi; Handayani, Tuti
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 1 (2025): Maret 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i1.1378

Abstract

Latar Belakang: Aktivitas fisik merupakan setiap gerakan tubuh yang dihasilkan otot rangka dan membutuhkan energi. Aktivitas fisik dengan intensitas yang tinggi dapat menimbulkan gangguan siklus menstruasi akibat ketidakseimbangan energi dan supresi GnRH. Objektif: Tujuan penelitian ini adalah mengetahui hubungan intensitas aktivitas fisik dengan siklus menstruasi pada mahasiswi Fakultas Ilmu Keolahragaan. Metode: Penelitian ini dilakukan pada bulan Desember 2023 – Januari 2024. Jenis penelitian ini bersifat analitik observasional dengan pendekatan potong lintang. Populasi penelitian ini adalah mahasiswi Program Studi Kepelatihan Olahraga dan Pendidikan Olahraga pada salah satu Universitas di Kota Padang dengan total sampel sebanyak 131 responden yang dipilih dengan teknik purposive sampling. Data selanjutnya dianalisis dengan menggunakan uji chi-square. Hasil: 54,2% responden mengalami intensitas aktivitas fisik tinggi dan 33,6% responden mengalami gangguan menstruasi. Kesimpulan: Tidak terdapat korelasi antara intensitas aktivitas fisik dengan siklus menstruasi pada mahasiswi Fakultas Ilmu Keolahragaan.  
Elevation of miR-210 Expression and Mean Arterial Pressure as Early-onset Pre-eclampsia Biomarkers, while Elevation of Matrix Metalloproteinase-2 as Late-onset Pre-eclampsia Biomarker Nelson, Nelvianti; Yusrawati, Yusrawati; Serudji, Joserizal; Jamsari, Jamsari; Amir, Arni; Afriwardi, Afriwardi; Gumilar, Erry
The Indonesian Biomedical Journal Vol 17, No 2 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i2.3490

Abstract

BACKGROUND: Pre-eclampsia has varying onset patterns, which are challenging to determine due to their association with diverse clinical parameters, including blood pressure regulation, vascular remodeling, and placental hypoxia. These parameters influence the expression of key biomarkers such as microRNAs, metalloproteinases, and arterial pressure indices. Therefore, understanding the associations is crucial for improving early diagnosis and management. This study was conducted to compare miR-210 expression, mean arterial pressure (MAP), and matrix metalloproteinase (MMP)-2 levels between early-onset pre-eclampsia (EOPE) and late-onset pre-eclampsia (LOPE).METHODS: Pregnant women with EOPE (20–34 weeks) and LOPE (35 weeks to term) were included in this cross-sectional comparative study, and their blood samples were collected. miR-210 expression was quantified with reverse transcription polymerase chain reaction (RT-PCR), MAP was measured using sphygmomanometer, while MMP-2 levels were measured using enzyme-linked immunosorbent assay (ELISA).RESULTS: miR-210 expression was more frequently observed in the EOPE group (87.5%) compared to the LOPE group (77.5%), with a significant difference identified between the two groups. The odds ratio for miR-210 expression in EOPE compared to LOPE was 2.03 (95% CI: 1.06–6.72). The MAP was notably higher in the EOPE group (121.15 mmHg) than in the LOPE group (116.15 mmHg), with a significant difference observed. Conversely, MMP-2 levels were significantly higher in the LOPE group (390.99 ng/mL) compared to the EOPE group (271.35 ng/mL).CONCLUSION: There are significant differences in miR-210 expression, MAP and MMP-2 between EOPE and LOPE. These findings suggest that miR-210, MAP, and MMP-2 could be useful biomarkers for distinguishing between EOPE and LOPE, potentially guiding more effective management and intervention strategies.KEYWORDS: miR-210, MAP, MMP-2, EOPE, LOPE, pre-eclampsia
PEMERIKSAAN DAN PENGOBATAN MATA DAN KULIT PADA KELOMPOK LANSIA DI NAGARI SUMANIAK Aisyah Elliyanti; Dian Pertiwi; Arina Widya Murni; Rina Gustia; Hendriati Hendriati; Zelly Dia Rofinda; Yulistini Yulistini; Afriwardi Afriwardi; Elmatris Sy
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 2 No. 1 (2019)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v2i1.97

Abstract

Health services for the elderly need to get special attention, because they are vulnerable for suffering from disease and tend to experience multi-pathology. Some of the health problems of the elderly in Kenagarian Sumaniak had been identified in community service activities before. Aim: The activity aims is to conduct examination and treatment of eye and skin disorders, as also to conduct counseling on the elderly. Methods: The activity is ayes and skin examination and treatment for elderly people in Kenagarian Sumaniak. Furthermore, counseling was also given regarding physical fitness and maintenance of skin health in the elderly. Results: The event was attended by 70 people aged 52-82 years, 28 men and 52 women. The results of the examination found 64 people suffering from eye disorders with diagnoses were dry eyes 24person, immature cataract 16 person and pterygium14 person. Around 52 people suffering from skin disorders with diagnoses were dermatitis 28 person such as dermatitis allergy, numularis, intertriginosa, sebaroid, and chronic). Conclusions: Health problems in the eyes and skin of the elderly identified are mostly overcome with the medicines provided. Some of them are recommended to go to primary health care to get further health services.
SKRINING PENYAKIT KECACINGAN DAN GANGGUAN VISUS PADA SISWA SD DI KELURAHAN SUNGAI PISANG KECAMATAN BUNGUS TELUK KABUNG KOTA PADANG Cimi Ilmiawati; Siti Nurhajjah; Nur Afrainin Syah; Mohamad Reza; Efrida Efrida; Eka Nofita; Hasmiwati Hasmiwati; Selfi Renita Rusjdi; Nuzulia Irawati; Sukri Rahman; Elmatris Elmatris; Desmawati Desmawati; Nur Indrawaty Lipoeto; Afriwardi Afriwardi
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 2 No. 4 (2019)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v2i4.114

Abstract

Sungai Pisang Village is a village that has only been accessible by smooth road roads in the past year in Padang City. Previously this village was only accessible by sea and by lousy road. This condition causes the Pisang River community to lag in socio-economic and health aspects. This activity aims to screen for worms in elementary school students in Sungai Pisang village because worms are closely related to environmental health and affect the quality of human resources experiencing growth and development. Screening for worms is carried out by examining fecal preparations. This activity also aims to check visual acuity in elementary students and make references for sharp vision correction to learn well. Visual acuity checks were carried out using a Snellen card. The results of the examination showed that 3/143 students had worms and 3/273 students had visual disturbances. Students with worms are recommended to go to the Puskesmas to be given deworming medicine, and students with visual impairments are facilitated for examination by an ophthalmologist and given glasses if needed.
SOSIALISASI PENINGKATAN KAPASITAS TENAGA MEDIS DALAM PEMULASARAAN JENAZAH COVID-19 Taufik Hidayat; Rika Susanti; Afriwardi Afriwardi; Citra Manela; Noverika Windasari
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 4 No. 1 (2021)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v4i1.293

Abstract

Transmission of the coronavirus that causes COVID-19 from corpses to people around, namely mortuary officers and the families of the bodies, can occur through direct contact with body fluids, objects around the body that are contaminated with the coronavirus, and aerosols formed when the body is moved or turned over. The curing of the COVID-19 corpse requires special treatment so that the custodian of the corpse avoids the transmission of this coronavirus. The purpose of this activity is to increase the knowledge and awareness of medical and mortuary staff about the importance of organizing COVID-19 bodies by taking into account the standards that the WHO has issued, professional organizations while still paying attention to the ethical, religious, and customs aspects of the local community. This capacity-building method is in the form of an online seminar on the role of medical personnel in curing COVID-19 corpses through the provision of 4 topics by four presenters. The material provided was the ethical and legal aspects of the burial of COVID-19 bodies, the management of the burial of COVID-19 corpses, religious views on the handling of COVID-19 corpses, and filling out the COVID-19 death certificate. The results of the activities obtained are the pretest and post-test results to assess the participants' knowledge. Ninety-one participants attended the pretest, and 94 participants from 150 seminar participants attended the post-test. According to standard operating procedures adopted from WHO, the funeral of the corpse is carried out by taking into account ethical, cultural, and religious aspects. The province of West Sumatra itself is primarily Muslim, so this protocol is also based on the fatwa of the Indonesian Ulema Council. The preparation of SOPs for the healing of COVID-19 patients and socialization needs to be continued with other health workers and the community to reduce the turbidity in the community regarding the handling of the bodies of COVID-19 patients.
MITIGASI DAN EVAKUASI BENCANA PADA MASA PANDEMI COVID-19 BAGI MASYARAKAT PASIE NAN TIGO KOTO TANGAH KOTA PADANG Aisyah Elliyanti; Julizar Julizar; Lili Irawati; Miftah Irrahmah; Afriwardi Afriwardi; Yose Ramda Ilhami; Fika Anggraini; Rahmad Syawqi
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 5 No. 4 (2022)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v5i4.333

Abstract

Disaster events both natural and non-natural factors such as epidemics can occur anytime and anywhere, which can affect communities and individuals. This natural or human-caused event or series of events can result in human casualties and suffering. Losses caused by disasters can be minimized or prevented if people's understanding of the disaster itself is sufficient, especially during the Covid-19 pandemic. Purpose: This activity is to conduct disaster mitigation training in the conditions of the Covid-19 pandemic for teachers at the Kanzul Ulum Islamic Boarding School, Kelurahan, in Pasie Nan Tigo, Koto Tangah District, Padang City. Activity target: the people of Pasie Nan Tigi Koto are able to carry out disaster mitigation and evacuation in the event of an earthquake followed by a tsunami, rising sea levels and waves. Method: activities in the form of lectures and exercises that begin with the distribution of masks to all participants involved in the activity, and filling out questionnaires on Covid-19 prevention and disaster management. After delivering the material, it was followed by a discussion on Covid-19 prevention, as well as drills on disaster mitigation and victim evacuation. The results of the activity were an increase in disaster mitigation and evacuation capabilities as well as an increase in participants' awareness in implementing health protocols for the prevention of Covid-19. Most of the participants' understanding of Covid-19 prevention and disaster management had increased, as evidenced by the increase in the number of correct questionnaire answers during the post-test compared to the pre-test from 50% to 80%. In addition, participants' skills have also increased regarding disaster mitigation, the implementation of evacuation techniques when a disaster occurs and how to evacuate victims when the disaster has subsided. Conclusion: Every individual left behind in a disaster-prone area needs to receive knowledge and training skills in disaster mitigation and evacuation techniques during the Covid-19 pandemic.
PROGRAM LATIHAN BAGI KELOMPOK LANSIA Afriwardi Afriwardi
Jurnal Kesehatan Masyarakat Andalas Vol 3 No 1 (2008): Jurnal Kesehatan Masyarakat Andalas
Publisher : Faculty of Public Health, Andalas University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24893/jkma.v3i1.55

Abstract

The increase of older people can be seen in our health service .Some of the older people is living in a bad condition where they need helpfrom their children or family. The study to stay young is most interest to reduce the aging of human body that coz malfunction of human body. Training to the older people need to be given to slower down their aging and degenerative disease. The planning ofthese program is good for the older people to get the optimal effect. The training program should be to the role of exercise that is good, well, arrange, andprogressive.
The Influence Of Counseling With Audiovisual Media On The Level Of Knowledge And AttitudeAdolescent Women In Consumption Iron Supplement Iria Ningsih Busri; Afriwardi Afriwardi; Hudila Rifa Karmia
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 5, No 4 (2023): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v5i4.16099

Abstract

Giving iron supplement tablets to young women as a program to prevent and treat anemia has so far not worked as expected. To support this program, appropriate health education is needed. The aim of this research was to determine the effect of counseling using audiovisual media on the level of knowledge and attitudes of young women regarding the consumption of iron supplement tablets at Bahrul Ulum Singingi Junior High School.The research method used was quasi-experimental, and the design used was a non-equivalent control group pretest-posttest design. The research was carried out from November 2022 to July 2023 at Bahrul Ulum Singingi Junior High School with a sample size of 88 people using total sampling techniques. Data analysis was done with the Mann-Whitney test using SPSS with confidence index 95%.The results of the research show that counseling using audiovisual media has an effect on the level of knowledge of young women, with the results of the pretest difference between the experimental and control groups p-value>0.05 (p = 0.531), the posttest difference test p-value<0.05 (p = 0.001), and the difference test increasing the p-value <0.05 (p = 0.000). And counseling using audiovisual media also has an effect on the attitudes of young women, with the results of the pretest difference between the experimental and control groups p-value>0.05 (p = 0.338), the posttest difference test p-value<0.05 (p = 0.000), and the difference test increase in p-value <0.05 (p = 0.000).In conclusion, counseling using audiovisual media influences the level of knowledge and attitudes of young women regarding the consumption of iron supplement tablets. Keywords: Counseling Using Audiovisual Media, Iron Supplement Tablets, Knowledge and Attitudes
HUBUNGAN FUNGSI KOGNITIF DENGAN TINGKAT KEMANDIRIAN LANSIA DI WILAYAH PUSKESMAS PADANG KANDIS Azis, Putri Nurul Syafirah; Afriwardi, Afriwardi; Liza, Rini Gusya
SENTRI: Jurnal Riset Ilmiah Vol. 3 No. 4 (2024): SENTRI : Jurnal Riset Ilmiah, April 2024
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/sentri.v3i4.2309

Abstract

Latar Belakang: Meningkatnya jumlah lanjut usia mencerminkan peningkatan rata-rata usia hidup, yang berpotensi menimbulkan masalah kesehatan. Termasuk di antaranya adalah penurunan fungsi kognitif yang dapat menyebabkan kesulitan dalam melaksanakan aktivitas sehari-hari. Apabila lansia tidak mampu mandiri, hal ini dapat menyebabkan mereka merasa tidak berdaya, sakit, dan bergantung pada bantuan orang lain. Tujuan penelitian ini adalah mengetahui hubungan fungsi kognitif dengan tingkat kemandirian lansia dalam melakukan Activity of Daily Living di wilayah kerja Puskesmas Padang Kandis. Metode penelitian ini adalah observasional analitik dengan desain penelitian cross sectional. Sampel penelitian ini diperoleh melalui teknik consecutive sampling dan didapatkan sebanyak 51 orang lansia yang tinggal di wilayah kerja Puskesmas Padang Kandis. Instrumen penelitian menggunakan MoCA-Ina untuk mengukur fungsi kognitif dan Indeks Katz untuk mengukur tingkat kemandirian lansia. Analisis data yang digunakan berupa analisis bivariat dengan uji statistik chi-square. Hasil penelitian ini didapatkan sebanyak 20 lansia (39,2%) mengalami penurunan fungsi kognitif serta 18 lansia (35,3%) mengalami ketergantungan sedang Hasil uji statistik mendapatkan hubungan yang signifikan antara fungsi kognitif dengan tingkat kemandirian lansia dengan p-value = 0,001 (<0,05). Kesimpulan penelitian ini adalah terdapat hubungan yang signifikan antara fungsi kognitif dengan tingkat kemandirian lansia dalam melakukan Activity of Daily Living (ADL) di wilayah kerja Puskesmas Padang Kandis.
Co-Authors Adang Bachtiar Adrul Fauzan Afrinita Eka Fitri Ahmad Wira Aisyah Elliyanti Akdri Andi Alya Misdhal Rini Amanda Besta Rizaldy Amir, Arni Antoni, Adi Arina Widya Murni Arni Amir Asril Zahari Asterina Asterina Aulia Fash Farabi Ayu Anissa Bahri Azis, Putri Nurul Syafirah Bestari J. Budiman Biomechy Oktomalioputri, Biomechy Bobby Indra Utama Brian Sri Prahastuti Citra Manela Daan Khambri Dara, Widia Dedi Sutia Dedy Kurnia Delmi Sulastri Delmi Sulastri Desmawati Desmawati Desrida Desrida Desy Nofita Sari Detty Iryani Dezi Ilham Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Didin Kustantiningtyastuti Dina Arfiani Rusjdi Dwitya Elvira, Dwitya Edison Edison Efendi, Nursyirwan Efrida Efrida Eka Nofita Eldi Sauma Elizabeth Bahar Elly Usman Elmatris Elmatris Elmatris Sy Elsa Noftalina Endang Mutiwara Endrinaldi Eny Yantri Erin Desweni Eryati Darwin Eti Yerizel Eva Decroli Eva Decroli Fadhilati Sabrina Fadilla, Utami Budhi Febby Herayono Ferdinand Ferdinand, Ferdinand Fika Anggraini Fika Anggraini Fika Tri Anggraini Ghozi Natul Isral Gumilar, Erry Gusriyani, Sri Gusti Revilla Hardisman Harie Satria ES Haslan Muhaimin Lubis Hasmiwati Hendriati, Hendriati Hidayati Hidayati Hirowati Ali Hirowati Ali, Hirowati Hudila Rifa Karmia Husna Yetti Husnil Kadri Ilmiawati, Ilmiawati Ilvira Ulpa Ismail Intan Nurwida Hayati Yasrial Iria Ningsih Busri Jamsari Jamsari Johanes C. Mose Joserizal Serudji Julizar Julizar Julizar Julizar Julizar Julizar Junira Erasta Lastri Daniati Lili Irawati Lili Irawati Masrul Syafri Mayetti Mayetti Meidiza Ariandiny Mety Dwi Putri Eszy Miftah Irrahmah Miftah Irrahmah Miftah Irramah Miftahul Jannah Milfa Sari Muzamil Mohamad Reza Mudjiran Mudjiran Mudjiran Muhammad Amirul Ihsan Saputra Musrizal Adli Mutia Lailani Najirman Najirman Nega Olavia Nelson, Nelvianti Nova Relida Samosir Noverika Windasari Nur Afrainin Syah Nur Indrawati Lipoeto Nur Indrawaty Lipoeto Nurfazlina Nurfazlina Nurhajjah, Sitti Nuzulia Irawati Perdanakusuma, David Sontani Prayitno, Irwan Prima Astuti Handayani Pudia M. Indika Putra, Andani E. Putri Anindita Putri Nurul Syafirah Azis Rahmad Syawqi Rahmad Syawqi Rahmat Syawqi Raisa Hussein Rama Feriska Putra Rani Ashari Reny Jayusfani Restu Susanti Reza Ekatama Rajasa Rika Susanti Rina Gustia Rini Gusya Liza Rini Gusya Liza, Rini Gusya Rita, Rauza S. Rizki Hidayah Rizqa Fiorendita Hadi Rose Dinda Martini Rozi Sastra Purna Rurin Ardiyanti Sabrina Hayati Safitri, Yunni Salman Umar Salman Umar Salwi, Hanifah Emilia Selfi Renita Rusjdi Setia Budi Zein Shafira Widia Putri Siska Andriani Rukmana Siti Coryniken Siti Nurhajjah Sukhri Herianto Ritonga Sukri Rahman susi susi Taufik Hidayat Taufik Hidayat Tiffany Atia Aristi Triananda, Claudia Vaulinne Basyir Vaulinne Basyir Vitresia, Havriza Wahyu Margi Sidoretno Wenny Rahmalia Rezki Wira Ditya Wirsma Arif Harahap Yessy Susanty Sabri Yolanda Syahdia Yose Ramda Ilhami Yose Ramda Ilhsmi Yufri Aldi Yuharika Pratiwi Yulistini, Yulistini Yuniar Lestari Yusnawati Yusnawati Yusrawati Yusrawati Yusri Dianne Jurnalis Zelly Dia Rofinda